K0825_MOUSE
ID K0825_MOUSE Reviewed; 1272 AA.
AC Q3UPC7; E9Q2V0; Q3TPR6; Q5FWD2; Q8BQF4; Q9D7T8;
DT 10-JUN-2008, integrated into UniProtKB/Swiss-Prot.
DT 27-JUL-2011, sequence version 3.
DT 03-AUG-2022, entry version 95.
DE RecName: Full=Uncharacterized protein KIAA0825 homolog;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC STRAIN=C57BL/6J; TISSUE=Embryo, Hippocampus, Spleen, and Stomach;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q3UPC7-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q3UPC7-2; Sequence=VSP_039419, VSP_039420;
CC -!- SEQUENCE CAUTION:
CC Sequence=BAB25933.1; Type=Erroneous termination; Note=Truncated C-terminus.; Evidence={ECO:0000305};
CC Sequence=BAB25933.1; Type=Frameshift; Evidence={ECO:0000305};
CC Sequence=BAC34444.1; Type=Frameshift; Evidence={ECO:0000305};
CC Sequence=BAE37669.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
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DR EMBL; AK008859; BAB25933.1; ALT_SEQ; mRNA.
DR EMBL; AK050886; BAC34444.1; ALT_FRAME; mRNA.
DR EMBL; AK143619; BAE25469.1; -; mRNA.
DR EMBL; AK164185; BAE37669.1; ALT_INIT; mRNA.
DR EMBL; AC099692; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC122418; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC124737; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC141892; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC158511; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC089469; AAH89469.1; -; mRNA.
DR CCDS; CCDS49316.1; -. [Q3UPC7-1]
DR CCDS; CCDS88493.1; -. [Q3UPC7-2]
DR RefSeq; NP_001074822.1; NM_001081353.1. [Q3UPC7-2]
DR RefSeq; NP_001139148.1; NM_001145676.1. [Q3UPC7-1]
DR AlphaFoldDB; Q3UPC7; -.
DR STRING; 10090.ENSMUSP00000127449; -.
DR iPTMnet; Q3UPC7; -.
DR PhosphoSitePlus; Q3UPC7; -.
DR PaxDb; Q3UPC7; -.
DR PRIDE; Q3UPC7; -.
DR Antibodypedia; 24939; 41 antibodies from 12 providers.
DR Ensembl; ENSMUST00000168779; ENSMUSP00000127449; ENSMUSG00000071252. [Q3UPC7-1]
DR Ensembl; ENSMUST00000225605; ENSMUSP00000153096; ENSMUSG00000071252. [Q3UPC7-2]
DR GeneID; 72371; -.
DR KEGG; mmu:72371; -.
DR UCSC; uc007rgw.1; mouse. [Q3UPC7-2]
DR UCSC; uc007rgx.2; mouse. [Q3UPC7-1]
DR MGI; MGI:1919621; 2210408I21Rik.
DR VEuPathDB; HostDB:ENSMUSG00000071252; -.
DR eggNOG; ENOG502QUZJ; Eukaryota.
DR GeneTree; ENSGT00610000086112; -.
DR HOGENOM; CLU_006665_0_0_1; -.
DR InParanoid; Q3UPC7; -.
DR OMA; FDTCDNL; -.
DR TreeFam; TF324703; -.
DR BioGRID-ORCS; 72371; 5 hits in 72 CRISPR screens.
DR PRO; PR:Q3UPC7; -.
DR Proteomes; UP000000589; Chromosome 13.
DR RNAct; Q3UPC7; protein.
DR Bgee; ENSMUSG00000071252; Expressed in spermatid and 79 other tissues.
DR ExpressionAtlas; Q3UPC7; baseline and differential.
DR InterPro; IPR027993; DUF4495.
DR PANTHER; PTHR33960; PTHR33960; 1.
DR Pfam; PF14906; DUF4495; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Reference proteome.
FT CHAIN 1..1272
FT /note="Uncharacterized protein KIAA0825 homolog"
FT /id="PRO_0000340690"
FT VAR_SEQ 324
FT /note="V -> G (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334,
FT ECO:0000303|PubMed:16141072"
FT /id="VSP_039419"
FT VAR_SEQ 325..1272
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334,
FT ECO:0000303|PubMed:16141072"
FT /id="VSP_039420"
FT CONFLICT 193
FT /note="S -> V (in Ref. 1; BAB25933)"
FT /evidence="ECO:0000305"
FT CONFLICT 197
FT /note="K -> N (in Ref. 1; BAB25933)"
FT /evidence="ECO:0000305"
FT CONFLICT 203
FT /note="Y -> N (in Ref. 1; BAB25933)"
FT /evidence="ECO:0000305"
FT CONFLICT 207
FT /note="E -> K (in Ref. 1; BAB25933)"
FT /evidence="ECO:0000305"
FT CONFLICT 390
FT /note="E -> G (in Ref. 1; BAE25469)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 1272 AA; 145556 MW; 62B6C430242758BA CRC64;
MDALQEYSHN SFDLQCLLNS FPGDLEFKQI FSDIGEQMEQ NAASIEHCIE EIQSEVNKLC
PDAQLQTTSD CFKWLTSYNY NLSKSPSISH GDLINFLKTM KDLLNNEDNH EEMILDLLWD
LSCQSSISFL SSLGGTTFCH LSRTSIHSVE DFSSVDVKSV WDDVRLHLRR FLVNRLERYN
EINNSQQKIE LKSQCMKQFL LLYSESEVLV KYQSIQKRLL DTFLQDSFPS CNRESDLERI
VCGYQSTMLM LYSMIKEDFN VLCEILAPSS LVQFFNETYL DTVTEEMTKI LEYFCELQFK
ENAVPVVKTS KSCNKRRGAV HALVSPECSQ KERRPSLSLE ELRFLSQLTE SFVKLENSIQ
ELFAETLSLL QMPRSSPGIL EKSKKEVMVE KLIANENNKP PEALLPVKEA TLLEFGWRNA
FKEVPLAIAH CISAAIEGFS TQVLQQEQTE RTSSVSYTIN LVNVPQLCPE GHIFPEEEQP
KRVAKFCSDI IEKLDTMLLL ALACRDDSPQ EIKENLVEAY SKVATAVLER LQERGKEVPS
RAPLKNLHSI LSSATYVSQR FTHYDNLMKE TTKKPIFLVP VQRYQEFINT VQFQVTDYCA
RVCAMSILQD AESHHWDDYK AFYEGERCSF AIQMWHYFSL ALHHDLWTIL PPKLAQEILA
EMLEKSLGLL ASRYARAHPS PKRTAQIRLD VMAILIFTEN MLWSICSSGQ EILNPHKFNN
HKIFKIHTHC NNLFTTLAIL TSPLTELYKT FQHGVDESPS NSLTPLFNQP LHWISCMSQF
YPSLLRPPSV GGLTAQGQLK LLLSQPCCKW NLLLDTLLHS GGLIPRILLK SSKQAAGMES
KQSAGGSLVG AIFEVLYHCH LSSQTFGNVF MSHMEEEQLW DFLFNIPVSS FTESQPEVIH
CLRLALMDSV KDTVQQIISI MRCRRNSETN LNKPRVPDHL LQSIPQGWNY IPRDSRGKES
NKGITELAAQ AVSIVLSKLP TVIACLPPTI KYFFFLSERK MSKNLAELKK AGLLVWNLII
IICRIFEDGN TVERLTGSSL DRWSKEKLGL ICLCLESILG KQSNPSQLTQ KVILSIERQK
PNWMEQQLLK ARTLSIQCAF TRMEENSGSE GEAALELTEQ KTNAMVLDLC HKPGGSKYLQ
QIYHIMQLNE EYLKEQLFAM NGSEEKPLLI RPLKVALRDE DQPPAFNPFH VHKVVSESML
DQVATVTWCC DWSNLLPNYL GLNKMTFGAL FKNRWEMRKD ETLEEKEKMM LEHLKQNCTI
QDFSTSDSKT EQ
