K0895_HUMAN
ID K0895_HUMAN Reviewed; 520 AA.
AC Q8NCT3; B4DF35; B7ZLT4; B9EGB9; O94969; Q0VGC1; Q7Z4L2;
DT 26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 26-FEB-2008, sequence version 4.
DT 03-AUG-2022, entry version 122.
DE RecName: Full=Uncharacterized protein KIAA0895;
GN Name=KIAA0895;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
RC TISSUE=Brain;
RX PubMed=10048485; DOI=10.1093/dnares/5.6.355;
RA Nagase T., Ishikawa K., Suyama M., Kikuno R., Hirosawa M., Miyajima N.,
RA Tanaka A., Kotani H., Nomura N., Ohara O.;
RT "Prediction of the coding sequences of unidentified human genes. XII. The
RT complete sequences of 100 new cDNA clones from brain which code for large
RT proteins in vitro.";
RL DNA Res. 5:355-364(1998).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 5).
RC TISSUE=Cerebellum;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=12853948; DOI=10.1038/nature01782;
RA Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H.,
RA Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K.,
RA Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A.,
RA Delehaunty K.D., Miner T.L., Nash W.E., Cordes M., Du H., Sun H.,
RA Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A.,
RA Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P.,
RA Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M.,
RA Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S.,
RA Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R.,
RA Strowmatt C., Latreille P., Miller N., Johnson D., Murray J.,
RA Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W.,
RA Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E.,
RA Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A.,
RA Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E.,
RA Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E.,
RA Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A.,
RA Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A.,
RA Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R.,
RA McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H.,
RA Wilson R.K.;
RT "The DNA sequence of human chromosome 7.";
RL Nature 424:157-164(2003).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2; 3; 4 AND 6).
RC TISSUE=Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=6;
CC Name=1;
CC IsoId=Q8NCT3-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8NCT3-2; Sequence=VSP_031685;
CC Name=3;
CC IsoId=Q8NCT3-3; Sequence=VSP_031686;
CC Name=4;
CC IsoId=Q8NCT3-4; Sequence=VSP_031685, VSP_031687;
CC Name=5;
CC IsoId=Q8NCT3-5; Sequence=VSP_043322, VSP_043323;
CC Name=6;
CC IsoId=Q8NCT3-6; Sequence=VSP_031686, VSP_043323;
CC -!- SEQUENCE CAUTION:
CC Sequence=BAA74918.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AB020702; BAA74918.1; ALT_INIT; mRNA.
DR EMBL; AK293912; BAG57296.1; -; mRNA.
DR EMBL; AC006960; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC028678; AAH28678.3; -; mRNA.
DR EMBL; BC056191; AAH56191.2; -; mRNA.
DR EMBL; BC110422; AAI10423.1; -; mRNA.
DR EMBL; BC136362; AAI36363.1; -; mRNA.
DR EMBL; BC144032; AAI44033.1; -; mRNA.
DR CCDS; CCDS43570.1; -. [Q8NCT3-1]
DR CCDS; CCDS47573.1; -. [Q8NCT3-3]
DR CCDS; CCDS56482.1; -. [Q8NCT3-5]
DR CCDS; CCDS56483.1; -. [Q8NCT3-2]
DR CCDS; CCDS56484.1; -. [Q8NCT3-6]
DR RefSeq; NP_001093895.1; NM_001100425.1. [Q8NCT3-1]
DR RefSeq; NP_001186635.1; NM_001199706.1. [Q8NCT3-6]
DR RefSeq; NP_001186636.1; NM_001199707.1. [Q8NCT3-2]
DR RefSeq; NP_001186637.1; NM_001199708.1. [Q8NCT3-5]
DR RefSeq; NP_056129.2; NM_015314.2. [Q8NCT3-3]
DR AlphaFoldDB; Q8NCT3; -.
DR BioGRID; 116946; 13.
DR IntAct; Q8NCT3; 2.
DR STRING; 9606.ENSP00000297063; -.
DR iPTMnet; Q8NCT3; -.
DR PhosphoSitePlus; Q8NCT3; -.
DR BioMuta; KIAA0895; -.
DR DMDM; 172045806; -.
DR jPOST; Q8NCT3; -.
DR MassIVE; Q8NCT3; -.
DR MaxQB; Q8NCT3; -.
DR PaxDb; Q8NCT3; -.
DR PeptideAtlas; Q8NCT3; -.
DR PRIDE; Q8NCT3; -.
DR ProteomicsDB; 72940; -. [Q8NCT3-1]
DR ProteomicsDB; 72941; -. [Q8NCT3-2]
DR ProteomicsDB; 72942; -. [Q8NCT3-3]
DR ProteomicsDB; 72943; -. [Q8NCT3-4]
DR ProteomicsDB; 72944; -. [Q8NCT3-5]
DR ProteomicsDB; 72945; -. [Q8NCT3-6]
DR Antibodypedia; 66049; 24 antibodies from 11 providers.
DR DNASU; 23366; -.
DR Ensembl; ENST00000297063.10; ENSP00000297063.6; ENSG00000164542.13. [Q8NCT3-1]
DR Ensembl; ENST00000317020.10; ENSP00000319251.6; ENSG00000164542.13. [Q8NCT3-3]
DR Ensembl; ENST00000338533.9; ENSP00000344805.5; ENSG00000164542.13. [Q8NCT3-2]
DR Ensembl; ENST00000415803.2; ENSP00000400749.2; ENSG00000164542.13. [Q8NCT3-4]
DR Ensembl; ENST00000436884.5; ENSP00000389985.1; ENSG00000164542.13. [Q8NCT3-5]
DR Ensembl; ENST00000440378.6; ENSP00000390837.1; ENSG00000164542.13. [Q8NCT3-6]
DR GeneID; 23366; -.
DR KEGG; hsa:23366; -.
DR MANE-Select; ENST00000440378.6; ENSP00000390837.1; NM_001199706.2; NP_001186635.1. [Q8NCT3-6]
DR UCSC; uc003tfb.3; human. [Q8NCT3-1]
DR CTD; 23366; -.
DR GeneCards; KIAA0895; -.
DR HGNC; HGNC:22206; KIAA0895.
DR HPA; ENSG00000164542; Tissue enhanced (testis).
DR neXtProt; NX_Q8NCT3; -.
DR OpenTargets; ENSG00000164542; -.
DR PharmGKB; PA164721801; -.
DR VEuPathDB; HostDB:ENSG00000164542; -.
DR eggNOG; ENOG502QQGI; Eukaryota.
DR GeneTree; ENSGT00390000004417; -.
DR HOGENOM; CLU_038689_1_0_1; -.
DR InParanoid; Q8NCT3; -.
DR OMA; THLLRMI; -.
DR OrthoDB; 749754at2759; -.
DR PhylomeDB; Q8NCT3; -.
DR TreeFam; TF329621; -.
DR PathwayCommons; Q8NCT3; -.
DR SignaLink; Q8NCT3; -.
DR BioGRID-ORCS; 23366; 11 hits in 1076 CRISPR screens.
DR ChiTaRS; KIAA0895; human.
DR GeneWiki; KIAA0895; -.
DR GenomeRNAi; 23366; -.
DR Pharos; Q8NCT3; Tdark.
DR PRO; PR:Q8NCT3; -.
DR Proteomes; UP000005640; Chromosome 7.
DR RNAct; Q8NCT3; protein.
DR Bgee; ENSG00000164542; Expressed in choroid plexus epithelium and 172 other tissues.
DR ExpressionAtlas; Q8NCT3; baseline and differential.
DR Genevisible; Q8NCT3; HS.
DR InterPro; IPR012548; DUF1704.
DR PANTHER; PTHR31817; PTHR31817; 2.
DR Pfam; PF08014; DUF1704; 1.
DR SMART; SM01154; DUF1704; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Reference proteome.
FT CHAIN 1..520
FT /note="Uncharacterized protein KIAA0895"
FT /id="PRO_0000320617"
FT REGION 116..153
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 1..151
FT /note="Missing (in isoform 5)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_043322"
FT VAR_SEQ 1..60
FT /note="MAGCTRKLTHLRKRIHRPRRRTTRRWKRWFKFRKRKGEKRPRPNHKAVARRA
FT KLKFSTSE -> MVATGWARRSGLHPAPRPLRGAQEALAKNLWREERNRPLILSSLIIK
FT (in isoform 2 and isoform 4)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_031685"
FT VAR_SEQ 1..59
FT /note="MAGCTRKLTHLRKRIHRPRRRTTRRWKRWFKFRKRKGEKRPRPNHKAVARRA
FT KLKFSTS -> MLESIRVT (in isoform 3 and isoform 6)"
FT /evidence="ECO:0000303|PubMed:10048485,
FT ECO:0000303|PubMed:15489334"
FT /id="VSP_031686"
FT VAR_SEQ 289
FT /note="Q -> QSINIMELTLQKYGSYEKFEQATGGSLLSKTRIWSHVRKYMMKEGCL
FT GE (in isoform 5 and isoform 6)"
FT /evidence="ECO:0000303|PubMed:14702039,
FT ECO:0000303|PubMed:15489334"
FT /id="VSP_043323"
FT VAR_SEQ 290..520
FT /note="IVVHLTEDLLSRASMTVVNGCPTLTINVSTAREHWLEGMLRHEIGTHYFRGI
FT NNLQQPWNSWTGRKKHELKPNNPTEEGLASIHSVLFRKDPFLWRAALLYYTVYQASQMS
FT FCELFKDIGRFVKDPNTRWDYCVRAKRGWTDTSQPGCFSKDQVYLDGILQILRYRDTID
FT FHLLTALGKVSYEDVDRLKGLAVTENMRVPHFLQDHGRYMEHLEKIMEVNELTDRELKD
FT LI -> VKCHFNSGSSFLCTKTIICDLISKNKDI (in isoform 4)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_031687"
FT CONFLICT 117
FT /note="E -> K (in Ref. 1; BAA74918)"
FT /evidence="ECO:0000305"
FT CONFLICT 281..282
FT /note="HA -> P (in Ref. 4; AAH28678)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 520 AA; 60525 MW; 1803AA8CB1D8FC44 CRC64;
MAGCTRKLTH LRKRIHRPRR RTTRRWKRWF KFRKRKGEKR PRPNHKAVAR RAKLKFSTSE
KLHWPEQELA KKSILNAEDS LIIDNKRSIS HLSSGVLKDI FTTGTSSYNV LLQSKEEKKY
HSQKQSSSTY SKRCRKPSKS PNTSRSKDPR RMKALVPVTS SGTWYCLERR PAVFVTSSVS
SPVKFTHDIS VTGNGIVLPP KPKSKVKWCH FSTLPKPKPQ LSRSFEKGDD FSGKKFCILT
AIKPTNLEKE KLRFFKSDYT YNPQFEYANP ALPSVLAKHS HASDRFLKQI VVHLTEDLLS
RASMTVVNGC PTLTINVSTA REHWLEGMLR HEIGTHYFRG INNLQQPWNS WTGRKKHELK
PNNPTEEGLA SIHSVLFRKD PFLWRAALLY YTVYQASQMS FCELFKDIGR FVKDPNTRWD
YCVRAKRGWT DTSQPGCFSK DQVYLDGILQ ILRYRDTIDF HLLTALGKVS YEDVDRLKGL
AVTENMRVPH FLQDHGRYME HLEKIMEVNE LTDRELKDLI
