K0930_MOUSE
ID K0930_MOUSE Reviewed; 404 AA.
AC Q3UE31; Q3TCU3;
DT 31-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT 31-OCT-2006, sequence version 2.
DT 03-AUG-2022, entry version 86.
DE RecName: Full=Uncharacterized protein KIAA0930 homolog;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J, and NOD; TISSUE=Bone marrow;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=19144319; DOI=10.1016/j.immuni.2008.11.006;
RA Trost M., English L., Lemieux S., Courcelles M., Desjardins M.,
RA Thibault P.;
RT "The phagosomal proteome in interferon-gamma-activated macrophages.";
RL Immunity 30:143-154(2009).
RN [3]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-276; SER-279; THR-290;
RP THR-293 AND SER-324, AND IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE
RP ANALYSIS].
RC TISSUE=Brain, Kidney, Spleen, and Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- SEQUENCE CAUTION:
CC Sequence=BAE29080.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
CC Sequence=BAE41862.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
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DR EMBL; AK149782; BAE29080.1; ALT_INIT; mRNA.
DR EMBL; AK170532; BAE41862.1; ALT_INIT; mRNA.
DR CCDS; CCDS27715.2; -.
DR RefSeq; NP_001028445.1; NM_001033273.2.
DR AlphaFoldDB; Q3UE31; -.
DR STRING; 10090.ENSMUSP00000128699; -.
DR iPTMnet; Q3UE31; -.
DR PhosphoSitePlus; Q3UE31; -.
DR jPOST; Q3UE31; -.
DR MaxQB; Q3UE31; -.
DR PaxDb; Q3UE31; -.
DR PeptideAtlas; Q3UE31; -.
DR PRIDE; Q3UE31; -.
DR Antibodypedia; 27826; 74 antibodies from 15 providers.
DR Ensembl; ENSMUST00000047144; ENSMUSP00000037011; ENSMUSG00000036046.
DR GeneID; 223739; -.
DR KEGG; mmu:223739; -.
DR MGI; MGI:2444899; 5031439G07Rik.
DR VEuPathDB; HostDB:ENSMUSG00000036046; -.
DR eggNOG; KOG2465; Eukaryota.
DR GeneTree; ENSGT00390000004190; -.
DR HOGENOM; CLU_010018_1_0_1; -.
DR InParanoid; Q3UE31; -.
DR OMA; NRTDGNF; -.
DR OrthoDB; 825254at2759; -.
DR BioGRID-ORCS; 223739; 1 hit in 59 CRISPR screens.
DR PRO; PR:Q3UE31; -.
DR Proteomes; UP000000589; Chromosome 15.
DR RNAct; Q3UE31; protein.
DR Bgee; ENSMUSG00000036046; Expressed in vestibular membrane of cochlear duct and 244 other tissues.
DR ExpressionAtlas; Q3UE31; baseline and differential.
DR Genevisible; Q3UE31; MM.
DR InterPro; IPR019141; DUF2045.
DR PANTHER; PTHR21477; PTHR21477; 1.
DR Pfam; PF09741; DUF2045; 1.
PE 1: Evidence at protein level;
KW Phosphoprotein; Reference proteome.
FT CHAIN 1..404
FT /note="Uncharacterized protein KIAA0930 homolog"
FT /id="PRO_0000255939"
FT REGION 262..307
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 319..340
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 262..300
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 268
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q6ICG6"
FT MOD_RES 276
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 279
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 290
FT /note="Phosphothreonine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 293
FT /note="Phosphothreonine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 304
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q6ICG6"
FT MOD_RES 306
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q6ICG6"
FT MOD_RES 324
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 358
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q4G008"
FT MOD_RES 362
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q6ICG6"
FT CONFLICT 153
FT /note="K -> E (in Ref. 1; BAE41862)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 404 AA; 45960 MW; 02754A9870511CC8 CRC64;
MLRAIAEERG RLSLRREVCG LGCFKDDRIV FWTWMFSTYF MEKLAPRQDD MLFYVRRKRA
YPGNEGTIDG RKAEAEPEVE VEVYRRDSKK LPGLGDPDID WEESVCLNLI LQKLDYMVTC
AVCTRADGGD IHIHRKKSQQ VFASPSKHPM DSKGEESKMS YPNIFFMIDS FEEVFSDMTV
GEGEMVCVEL VASDKTNTFQ GVIFQGSIRY EALKKVYDNR VSVAARMAQK MSFGFYKYNN
MEFVRMKGPQ GKGHAEMAVS RVSTGDTSPC GTEDSSPASP MHERVTSFST PPTPERNNRP
AFFSPSLKRK VPRNRIAEMK KSHSANDSEE FFREDDSGAD LHNATNLRSR SLSGTGRSLV
GSWLKLNRAD GNFLLYAHLT YVTLPLHRIL TDILEVRQKP ILMT
