K10_DROME
ID K10_DROME Reviewed; 463 AA.
AC P13468; O46075; Q9W505;
DT 01-JAN-1990, integrated into UniProtKB/Swiss-Prot.
DT 15-JUL-1998, sequence version 2.
DT 03-AUG-2022, entry version 157.
DE RecName: Full=DNA-binding protein K10;
DE AltName: Full=Female sterile protein K10;
GN Name=fs(1)K10; ORFNames=CG3218;
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1]
RP NUCLEOTIDE SEQUENCE.
RX PubMed=12553295; DOI=10.1101/gad.2.7.891;
RA Prost E., Deryckere F., Roos C., Haenlin M., Pantesco V., Mohier V.;
RT "Role of the oocyte nucleus in determination of the dorsoventral polarity
RT of Drosophila as revealed by molecular analysis of the K10 gene.";
RL Genes Dev. 2:891-900(1988).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley;
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Oregon-R;
RX PubMed=10731137; DOI=10.1126/science.287.5461.2220;
RA Benos P.V., Gatt M.K., Ashburner M., Murphy L., Harris D., Barrell B.G.,
RA Ferraz C., Vidal S., Brun C., Demailles J., Cadieu E., Dreano S., Gloux S.,
RA Lelaure V., Mottier S., Galibert F., Borkova D., Minana B., Kafatos F.C.,
RA Louis C., Siden-Kiamos I., Bolshakov S., Papagiannakis G., Spanos L.,
RA Cox S., Madueno E., de Pablos B., Modolell J., Peter A., Schoettler P.,
RA Werner M., Mourkioti F., Beinert N., Dowe G., Schaefer U., Jaeckle H.,
RA Bucheton A., Callister D.M., Campbell L.A., Darlamitsou A., Henderson N.S.,
RA McMillan P.J., Salles C., Tait E.A., Valenti P., Saunders R.D.C.,
RA Glover D.M.;
RT "From sequence to chromosome: the tip of the X chromosome of D.
RT melanogaster.";
RL Science 287:2220-2222(2000).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Berkeley; TISSUE=Embryo;
RX PubMed=12537569; DOI=10.1186/gb-2002-3-12-research0080;
RA Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A.,
RA Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M.,
RA Celniker S.E.;
RT "A Drosophila full-length cDNA resource.";
RL Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002).
CC -!- FUNCTION: May have a regulatory function.
CC -!- SUBCELLULAR LOCATION: Nucleus.
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DR EMBL; X12836; CAA31321.1; -; Genomic_DNA.
DR EMBL; AE014298; AAF45758.1; -; Genomic_DNA.
DR EMBL; AL009195; CAA15702.1; -; Genomic_DNA.
DR EMBL; AY060415; AAL25454.1; -; mRNA.
DR PIR; T13425; T13425.
DR RefSeq; NP_477491.1; NM_058143.4.
DR AlphaFoldDB; P13468; -.
DR SMR; P13468; -.
DR BioGRID; 70938; 23.
DR DIP; DIP-18135N; -.
DR STRING; 7227.FBpp0070380; -.
DR PaxDb; P13468; -.
DR PRIDE; P13468; -.
DR EnsemblMetazoa; FBtr0070396; FBpp0070380; FBgn0000810.
DR GeneID; 47781; -.
DR KEGG; dme:Dmel_CG3218; -.
DR CTD; 47781; -.
DR FlyBase; FBgn0000810; fs(1)K10.
DR VEuPathDB; VectorBase:FBgn0000810; -.
DR eggNOG; ENOG502SZ5I; Eukaryota.
DR HOGENOM; CLU_053404_0_0_1; -.
DR InParanoid; P13468; -.
DR OMA; DKPWVTE; -.
DR OrthoDB; 1472477at2759; -.
DR PhylomeDB; P13468; -.
DR BioGRID-ORCS; 47781; 0 hits in 1 CRISPR screen.
DR GenomeRNAi; 47781; -.
DR PRO; PR:P13468; -.
DR Proteomes; UP000000803; Chromosome X.
DR Bgee; FBgn0000810; Expressed in eye disc (Drosophila) and 22 other tissues.
DR Genevisible; P13468; DM.
DR GO; GO:0005634; C:nucleus; IDA:FlyBase.
DR GO; GO:0003677; F:DNA binding; ISS:FlyBase.
DR GO; GO:0009953; P:dorsal/ventral pattern formation; TAS:FlyBase.
DR GO; GO:0008298; P:intracellular mRNA localization; TAS:FlyBase.
DR GO; GO:0017148; P:negative regulation of translation; TAS:FlyBase.
DR GO; GO:0048477; P:oogenesis; IMP:FlyBase.
DR GO; GO:0030707; P:ovarian follicle cell development; IMP:FlyBase.
DR GO; GO:0019094; P:pole plasm mRNA localization; IMP:FlyBase.
DR GO; GO:0008104; P:protein localization; TAS:FlyBase.
PE 2: Evidence at transcript level;
KW DNA-binding; Nucleus; Reference proteome; Repeat.
FT CHAIN 1..463
FT /note="DNA-binding protein K10"
FT /id="PRO_0000084292"
FT REPEAT 87..94
FT /note="1"
FT REPEAT 95..102
FT /note="2"
FT REPEAT 103..110
FT /note="3"
FT REPEAT 111..118
FT /note="4"
FT REPEAT 119..126
FT /note="5"
FT REPEAT 127..134
FT /note="6"
FT REPEAT 135..142
FT /note="7"
FT DNA_BIND 397..416
FT /note="H-T-H motif"
FT /evidence="ECO:0000255"
FT REGION 1..304
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 87..142
FT /note="7 X approximate tandem repeats"
FT REGION 426..463
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..52
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 69..98
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 146..218
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 225..304
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 426..440
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 277..278
FT /note="PM -> HH (in Ref. 1; CAA31321)"
FT /evidence="ECO:0000305"
FT CONFLICT 282..286
FT /note="GGPPP -> VDHHR (in Ref. 1; CAA31321)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 463 AA; 51267 MW; D03C097192D1FDD0 CRC64;
MVSKNQFYQN WTMQSQQQHP HQMQQQFQQQ QQPNLQHRNN QSNNNNCNNN PRAAAAPYRK
PFRSGKINSG PGGNGNGNRV NGNNQMMFSS SQMPSDPLYI DFSSPPPGFK HNQVGSPKKK
SMKGIKQQQH PSPNQQQPPS PNQQQHPSPN QQQHPSPNQQ QHPNSNQQQH LSPNQQQGKM
NNQNNNHMNQ SQQPFNNQMN GSDWQRHPGN NPNQIRGGFN GFQRGPPPNR PPPRLMMGPP
MGPMGPGPRG PGPMGPGGPY PQMPFPPPVP GMRGPGPMGP MGGPPPPPPP LFMRRNGPGP
GPMMGVPPPM HMMGPRMPPR GIPPVGPYGP MNMNGGRIMK PNPKLIKQVV KGKSSIKTLK
NLINQYPIEK PWVTDEIRSE HDKKVDIENR LKGHKDDELF AQYKGQRDKF VSLYEAAREE
YLKQEAATVK AKDAKSDKDK NAISSQSAAP KAGSAKDATI PNP
