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K1107_MOUSE
ID   K1107_MOUSE             Reviewed;        1239 AA.
AC   Q80TK0; E9PUC9; E9QLA8; Q3TPG8; Q8BRQ7; Q8BRS6;
DT   26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   16-JAN-2019, sequence version 6.
DT   03-AUG-2022, entry version 98.
DE   RecName: Full=AP2-interacting clathrin-endocytosis protein {ECO:0000303|PubMed:29262337};
DE            Short=APache {ECO:0000303|PubMed:29262337};
GN   Name=Kiaa1107;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C57BL/6J;
RX   PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA   Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA   Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA   Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA   Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA   Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA   Eichler E.E., Ponting C.P.;
RT   "Lineage-specific biology revealed by a finished genome assembly of the
RT   mouse.";
RL   PLoS Biol. 7:E1000112-E1000112(2009).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-969.
RC   STRAIN=C57BL/6J; TISSUE=Brain cortex, and Spinal ganglion;
RX   PubMed=16141072; DOI=10.1126/science.1112014;
RA   Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA   Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA   Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA   Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA   Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA   Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA   Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA   Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA   Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA   Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA   Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA   Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA   Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA   Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA   Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA   Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA   Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA   Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA   Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA   Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA   Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA   Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA   Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA   Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA   Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA   van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA   Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA   Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA   Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA   Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA   Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA   Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA   Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA   Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT   "The transcriptional landscape of the mammalian genome.";
RL   Science 309:1559-1563(2005).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 4-1239.
RX   PubMed=12693553; DOI=10.1093/dnares/10.1.35;
RA   Okazaki N., Kikuno R., Ohara R., Inamoto S., Aizawa H., Yuasa S.,
RA   Nakajima D., Nagase T., Ohara O., Koga H.;
RT   "Prediction of the coding sequences of mouse homologues of KIAA gene: II.
RT   The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs
RT   identified by screening of terminal sequences of cDNA clones randomly
RT   sampled from size-fractionated libraries.";
RL   DNA Res. 10:35-48(2003).
RN   [4]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   TISSUE=Brain;
RX   PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA   Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA   Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT   "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL   Cell 143:1174-1189(2010).
RN   [5]
RP   FUNCTION, INTERACTION WITH AP2A1 AND AP2B1, SUBCELLULAR LOCATION, TISSUE
RP   SPECIFICITY, AND DEVELOPMENTAL STAGE.
RX   PubMed=29262337; DOI=10.1016/j.celrep.2017.11.073;
RA   Piccini A., Castroflorio E., Valente P., Guarnieri F.C., Aprile D.,
RA   Michetti C., Bramini M., Giansante G., Pinto B., Savardi A., Cesca F.,
RA   Bachi A., Cattaneo A., Wren J.D., Fassio A., Valtorta F., Benfenati F.,
RA   Giovedi S.;
RT   "APache is an AP2-interacting protein involved in synaptic vesicle
RT   trafficking and neuronal development.";
RL   Cell Rep. 21:3596-3611(2017).
CC   -!- FUNCTION: Involved in clathrin-mediated endocytosis at the synapse.
CC       Plays a role in neuronal development and in synaptic vesicle recycling
CC       in mature neurons, a process required for normal synaptic transmission.
CC       {ECO:0000269|PubMed:29262337}.
CC   -!- SUBUNIT: Interacts (via N-terminus) with adaptor protein complex AP-2
CC       subunits alpha (AP2A1) and beta (AP2B1). {ECO:0000269|PubMed:29262337}.
CC   -!- SUBCELLULAR LOCATION: Cell projection, axon
CC       {ECO:0000269|PubMed:29262337}. Presynapse
CC       {ECO:0000269|PubMed:29262337}. Cytoplasmic vesicle, clathrin-coated
CC       vesicle {ECO:0000250|UniProtKB:D4A0X3}. Note=In primary cultures,
CC       mainly present at axonal and presynaptic terminal levels of mature
CC       neurons. In immature neurons, localizes to the cell body and growing
CC       processes, including axons. {ECO:0000269|PubMed:29262337}.
CC   -!- TISSUE SPECIFICITY: Neuron-specific protein. Primarily expressed in
CC       brain, with the highest levels in the cerebral cortex, hippocampus, and
CC       striatum (at protein level). Not detected in glial cells.
CC       {ECO:0000269|PubMed:29262337}.
CC   -!- DEVELOPMENTAL STAGE: In the developing brain cortex, expressed at 18
CC       dpc. Expression increases during postnatal development to reach a
CC       plateau at 1 month of age. {ECO:0000269|PubMed:29262337}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=BAC31628.1; Type=Frameshift; Evidence={ECO:0000305};
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DR   EMBL; AC117574; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC126598; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC134411; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AK043587; BAC31589.1; -; mRNA.
DR   EMBL; AK043720; BAC31628.1; ALT_FRAME; mRNA.
DR   EMBL; AK164388; BAE37768.1; -; mRNA.
DR   EMBL; AK122444; BAC65726.3; -; Transcribed_RNA.
DR   RefSeq; NP_001007575.2; NM_001007574.2.
DR   AlphaFoldDB; Q80TK0; -.
DR   BioGRID; 231135; 6.
DR   IntAct; Q80TK0; 1.
DR   MINT; Q80TK0; -.
DR   iPTMnet; Q80TK0; -.
DR   PhosphoSitePlus; Q80TK0; -.
DR   MaxQB; Q80TK0; -.
DR   PaxDb; Q80TK0; -.
DR   PRIDE; Q80TK0; -.
DR   ProteomicsDB; 301711; -.
DR   ProteomicsDB; 365951; -.
DR   Ensembl; ENSMUST00000100951; ENSMUSP00000098511; ENSMUSG00000111375.
DR   GeneID; 100503185; -.
DR   CTD; 284697; -.
DR   MGI; MGI:2445097; A830010M20Rik.
DR   VEuPathDB; HostDB:ENSMUSG00000111375; -.
DR   eggNOG; ENOG502QUK4; Eukaryota.
DR   GeneTree; ENSGT00940000154382; -.
DR   HOGENOM; CLU_002418_0_0_1; -.
DR   InParanoid; Q80TK0; -.
DR   OrthoDB; 213120at2759; -.
DR   BioGRID-ORCS; 231570; 3 hits in 72 CRISPR screens.
DR   PRO; PR:Q80TK0; -.
DR   Proteomes; UP000000589; Chromosome 5.
DR   RNAct; Q80TK0; protein.
DR   Bgee; ENSMUSG00000111375; Expressed in habenula and 201 other tissues.
DR   ExpressionAtlas; Q80TK0; baseline and differential.
DR   GO; GO:0070161; C:anchoring junction; IEA:UniProtKB-KW.
DR   GO; GO:0030424; C:axon; IDA:UniProtKB.
DR   GO; GO:0044297; C:cell body; IDA:UniProtKB.
DR   GO; GO:0030136; C:clathrin-coated vesicle; IEA:UniProtKB-SubCell.
DR   GO; GO:0044306; C:neuron projection terminus; ISS:UniProtKB.
DR   GO; GO:0098793; C:presynapse; IDA:UniProtKB.
DR   GO; GO:0008021; C:synaptic vesicle; ISS:UniProtKB.
DR   GO; GO:0150007; P:clathrin-dependent synaptic vesicle endocytosis; IMP:UniProtKB.
DR   GO; GO:0031175; P:neuron projection development; IMP:UniProtKB.
DR   GO; GO:0016182; P:synaptic vesicle budding from endosome; IDA:SynGO.
DR   GO; GO:0048488; P:synaptic vesicle endocytosis; IDA:SynGO.
DR   GO; GO:0036466; P:synaptic vesicle recycling via endosome; IMP:UniProtKB.
DR   InterPro; IPR027907; DUF4596.
DR   InterPro; IPR040121; KIAA1107.
DR   PANTHER; PTHR22427:SF2; PTHR22427:SF2; 1.
DR   Pfam; PF15363; DUF4596; 1.
PE   1: Evidence at protein level;
KW   Cell projection; Cytoplasmic vesicle; Endocytosis; Reference proteome;
KW   Synapse.
FT   CHAIN           1..1239
FT                   /note="AP2-interacting clathrin-endocytosis protein"
FT                   /id="PRO_0000320678"
FT   REGION          1..99
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          147..170
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          186..250
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          270..490
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          552..590
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          661..861
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          893..924
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          971..997
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1008..1027
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1041..1083
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1204..1227
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..25
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        51..91
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        193..224
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        225..239
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        270..284
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        305..354
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        355..372
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        399..428
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        429..453
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        464..485
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        552..569
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        570..584
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        688..708
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        709..732
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        754..795
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        842..860
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1041..1065
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CONFLICT        11
FT                   /note="V -> A (in Ref. 3; BAC65726)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        180
FT                   /note="V -> A (in Ref. 3; BAC65726)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        257
FT                   /note="Missing (in Ref. 2; BAC31628)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        631
FT                   /note="D -> N (in Ref. 3; BAC65726)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        1011
FT                   /note="S -> N (in Ref. 3; BAC65726)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        1085..1086
FT                   /note="DI -> NV (in Ref. 3; BAC65726)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   1239 AA;  134060 MW;  E2C62E25E8139E09 CRC64;
     MHLDDQQKIQ VAALDKGDDR RLGRKPVLTS SQQRRQGSDV DVLKIKPWTE NNKKPCQTSL
     STNQKMRSDG LGASGHASST NRNSINKVSK HGDSTKMSKV VKEMKTGGKY VSGKSKTMVK
     PQTENSDHTK IEGLSSTVVG RPSRVTAAGR KDPVHGKGVQ NQEVETTGAR PKVLTANLNV
     QARAKPLQTL RGKDSTCPAS VGPSSRSTHS STELLASMGS VDETKENGSV EDKCRDGKPY
     VSDSPGQMVS NGVMSTAAVK SRAVARITNG TASNKSFTHE QDSHGNSSVI KRGDGKGLSA
     SAPQTAAKKR GSSNGCTAAQ PRTKSAPPTL AQAQGSQGES PHSVKSSVSS RQSDENVTRL
     RHGTDKQIPK RKVVKQGHTT LQKVNAKLVP MPKIPSQPKK GGTVNSKDSK QKVLPGQIML
     QSHASQRPSK PEVAEKSVLH GVSDSRNHVS KQRPHESPCT LACDTSGPEV SQIPCRPQPQ
     SPLGSQEKKR LELACQDRST LGDSVKRELR SELAGIEQSH TSAYKDSSQC NGNPNCGSIA
     ALKSVISNPN ENLINSNPVH NSDSANTEQA YLSDRERETG RENTDTEPSM SCINGKAFLC
     VPEGTSSTLN PTQSDRRLTF HGAAQSQLPD DCATEDSKCA TVTSAVSSKC LLGQPSEKNC
     KNMEMSETPE SHGTPEAPFV GPWDLNTGAT HQRESPESDT GSATTSSDDI KPRSEDYDAG
     GSQDDEGSHD RGISKCSTAL CHDFLGRSSS DTSTPEELKV HEGDLRTEVR VRKQGGGDHQ
     IHSASDDEIP RKKPEPWSRS TIGYPREKGS TPRGSIPSAQ EGDQVSSSAD ETEDERSEAE
     NVGENSSPCS SGTQQVQGII NLAFDDGAEH ESREFSATKK FRRSVLLSVD ECEEVGSDEG
     EGHTPFQPSL DSLSPSDVFD GVSYEHHGRT GYSRFFKENE ATTAEHNHNK GNGGYKNESF
     LLNSRSKDFE KQDKQCVSTD QKTRLDVPPK GSQQLFPENE EVISKREAAH SFQQHSTFMD
     GDTKSQERPC HLELHQRELS SNIPKISSVK SLDSCPSQGL PQEGQVKESR PTPPKGANNA
     VFSGDIDDCD TMAQTSMYDH RPSKTLSPIY EMSLTAACEQ EVESETHVAD RGSEDEQHFA
     KQDWTLLRQL LSEQDANLNI TSSLPEDLSL AQYLINQTLL LARDSSKPQG SAHADTWNRW
     SELSSPLDDS ATSATTASVS STDCSPQGEW TILELETQH
 
 
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