K1109_MOUSE
ID K1109_MOUSE Reviewed; 5005 AA.
AC A2AAE1; A2AAD2; A2AAD4; E9Q376; Q05BP8; Q3UG08; Q3UYB7; Q571C4; Q69ZR8;
AC Q6AXD9; Q8BWF1; Q8BY77; Q8CEA4; Q8R0A8;
DT 05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 27-JUL-2011, sequence version 4.
DT 03-AUG-2022, entry version 100.
DE RecName: Full=Transmembrane protein KIAA1109 {ECO:0000305};
DE AltName: Full=Fragile site-associated protein homolog;
GN Name=Kiaa1109; Synonyms=Fsa, Kiaa1371;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 5), NUCLEOTIDE SEQUENCE
RP [LARGE SCALE MRNA] OF 4183-4995 (ISOFORM 1), AND NUCLEOTIDE SEQUENCE [LARGE
RP SCALE MRNA] OF 3903-5005 (ISOFORM 6).
RC STRAIN=C57BL/6J;
RC TISSUE=Kidney, Medulla oblongata, Skin, Testis, and Thymus;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-1415 (ISOFORM 4).
RC TISSUE=Pancreatic islet;
RA Okazaki N., Kikuno R.F., Ohara R., Inamoto S., Nagase T., Ohara O.,
RA Koga H.;
RT "Prediction of the coding sequences of mouse homologues of KIAA gene. The
RT complete nucleotide sequences of mouse KIAA-homologous cDNAs identified by
RT screening of terminal sequences of cDNA clones randomly sampled from size-
RT fractionated libraries.";
RL Submitted (FEB-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 261-1421 AND 4332-5005 (ISOFORM
RP 1), AND NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 3442-5005 (ISOFORM 2).
RC STRAIN=C57BL/6J, and FVB/N; TISSUE=Brain, Eye, and Mammary tumor;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 3385-5005 (ISOFORM 3).
RC TISSUE=Embryonic intestine;
RX PubMed=15368895; DOI=10.1093/dnares/11.3.205;
RA Okazaki N., Kikuno R., Ohara R., Inamoto S., Koseki H., Hiraoka S.,
RA Saga Y., Seino S., Nishimura M., Kaisho T., Hoshino K., Kitamura H.,
RA Nagase T., Ohara O., Koga H.;
RT "Prediction of the coding sequences of mouse homologues of KIAA gene: IV.
RT The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs
RT identified by screening of terminal sequences of cDNA clones randomly
RT sampled from size-fractionated libraries.";
RL DNA Res. 11:205-218(2004).
RN [6]
RP TISSUE SPECIFICITY, AND DEVELOPMENTAL STAGE.
RX PubMed=16545529; DOI=10.1016/j.gene.2005.12.024;
RA Wei Y., Lin-Lee Y.-C., Yang X., Dai W., Zhao S., Rassool F.V., Elgart G.W.,
RA Feun L., Savaraj N., Kuo M.T.;
RT "Molecular cloning of Chinese hamster 1q31 chromosomal fragile site DNA
RT that is important to mdr1 gene amplification reveals a novel gene whose
RT expression is associated with spermatocyte and adipocyte differentiation.";
RL Gene 372:44-52(2006).
RN [7]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-2755 AND SER-3653, AND
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=19144319; DOI=10.1016/j.immuni.2008.11.006;
RA Trost M., English L., Lemieux S., Courcelles M., Desjardins M.,
RA Thibault P.;
RT "The phagosomal proteome in interferon-gamma-activated macrophages.";
RL Immunity 30:143-154(2009).
RN [8]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1323; SER-1355; SER-1805;
RP SER-1808; SER-2601 AND SER-4124, PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT
RP SER-3577 (ISOFORM 3), AND IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE
RP ANALYSIS].
RC TISSUE=Brain, Heart, Kidney, Lung, Pancreas, and Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- FUNCTION: Plays a role in endosomal trafficking and endosome recycling.
CC Also involved in the actin cytoskeleton and cilia structural dynamics.
CC Acts as regulator of phagocytosis. {ECO:0000250|UniProtKB:Q2LD37}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Single-pass membrane
CC protein {ECO:0000255}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=6;
CC Name=1;
CC IsoId=A2AAE1-1; Sequence=Displayed;
CC Name=2;
CC IsoId=A2AAE1-2; Sequence=VSP_031037;
CC Name=3;
CC IsoId=A2AAE1-3; Sequence=VSP_031036, VSP_031037, VSP_031038;
CC Name=4;
CC IsoId=A2AAE1-4; Sequence=VSP_031032, VSP_031033;
CC Name=5;
CC IsoId=A2AAE1-5; Sequence=VSP_031034, VSP_031035;
CC Name=6;
CC IsoId=A2AAE1-6; Sequence=VSP_031038;
CC -!- TISSUE SPECIFICITY: Highly expressed in testis and ovary. Weakly or not
CC expressed in other tissues. {ECO:0000269|PubMed:16545529}.
CC -!- DEVELOPMENTAL STAGE: Expressed during spermatogenesis and adipogenesis.
CC {ECO:0000269|PubMed:16545529}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAH27125.3; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC Sequence=AAH79623.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC Sequence=BAC31019.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC Sequence=BAC31019.1; Type=Frameshift; Evidence={ECO:0000305};
CC Sequence=BAC35104.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC Sequence=BAD90190.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
CC Sequence=CAM28060.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC Sequence=CAM28069.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AK028716; BAC26080.1; -; mRNA.
DR EMBL; AK041642; BAC31019.1; ALT_SEQ; mRNA.
DR EMBL; AK052702; BAC35104.1; ALT_INIT; mRNA.
DR EMBL; AK134811; BAE22295.1; -; mRNA.
DR EMBL; AK148181; BAE28401.1; -; mRNA.
DR EMBL; AL627102; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL691425; CAM18175.4; -; Genomic_DNA.
DR EMBL; AL645759; CAM18175.4; JOINED; Genomic_DNA.
DR EMBL; AL662823; CAM18175.4; JOINED; Genomic_DNA.
DR EMBL; AL662823; CAM18416.3; -; Genomic_DNA.
DR EMBL; AL645759; CAM18416.3; JOINED; Genomic_DNA.
DR EMBL; AL691425; CAM18416.3; JOINED; Genomic_DNA.
DR EMBL; AL645759; CAM24476.3; -; Genomic_DNA.
DR EMBL; AL662823; CAM24476.3; JOINED; Genomic_DNA.
DR EMBL; AL691425; CAM24476.3; JOINED; Genomic_DNA.
DR EMBL; AL645753; CAM28060.1; ALT_SEQ; Genomic_DNA.
DR EMBL; AL645806; CAM28060.1; JOINED; Genomic_DNA.
DR EMBL; AL645753; CAM28062.1; -; Genomic_DNA.
DR EMBL; AL645806; CAM28062.1; JOINED; Genomic_DNA.
DR EMBL; AL645806; CAM28069.1; ALT_SEQ; Genomic_DNA.
DR EMBL; AL645753; CAM28069.1; JOINED; Genomic_DNA.
DR EMBL; AL645806; CAM28070.1; -; Genomic_DNA.
DR EMBL; AL645753; CAM28070.1; JOINED; Genomic_DNA.
DR EMBL; AK220265; BAD90190.1; ALT_INIT; mRNA.
DR EMBL; BC027125; AAH27125.3; ALT_INIT; mRNA.
DR EMBL; BC034738; AAH34738.1; -; mRNA.
DR EMBL; BC079623; AAH79623.1; ALT_INIT; mRNA.
DR EMBL; AK173100; BAD32378.1; -; mRNA.
DR CCDS; CCDS50894.1; -. [A2AAE1-1]
DR RefSeq; NP_766267.2; NM_172679.2. [A2AAE1-1]
DR SMR; A2AAE1; -.
DR BioGRID; 230823; 10.
DR IntAct; A2AAE1; 5.
DR STRING; 10090.ENSMUSP00000060199; -.
DR iPTMnet; A2AAE1; -.
DR PhosphoSitePlus; A2AAE1; -.
DR SwissPalm; A2AAE1; -.
DR EPD; A2AAE1; -.
DR jPOST; A2AAE1; -.
DR MaxQB; A2AAE1; -.
DR PaxDb; A2AAE1; -.
DR PeptideAtlas; A2AAE1; -.
DR PRIDE; A2AAE1; -.
DR ProteomicsDB; 269431; -. [A2AAE1-1]
DR ProteomicsDB; 269432; -. [A2AAE1-2]
DR ProteomicsDB; 269433; -. [A2AAE1-3]
DR ProteomicsDB; 269434; -. [A2AAE1-4]
DR ProteomicsDB; 269435; -. [A2AAE1-5]
DR ProteomicsDB; 269436; -. [A2AAE1-6]
DR Antibodypedia; 26783; 16 antibodies from 8 providers.
DR Ensembl; ENSMUST00000057272; ENSMUSP00000060199; ENSMUSG00000037270. [A2AAE1-1]
DR Ensembl; ENSMUST00000152564; ENSMUSP00000117808; ENSMUSG00000037270. [A2AAE1-1]
DR GeneID; 229227; -.
DR KEGG; mmu:229227; -.
DR UCSC; uc008ozw.2; mouse. [A2AAE1-5]
DR UCSC; uc008pab.2; mouse. [A2AAE1-1]
DR MGI; MGI:2444631; 4932438A13Rik.
DR VEuPathDB; HostDB:ENSMUSG00000037270; -.
DR eggNOG; KOG3596; Eukaryota.
DR GeneTree; ENSGT00640000091487; -.
DR HOGENOM; CLU_000118_0_0_1; -.
DR InParanoid; A2AAE1; -.
DR OMA; MEGNAPL; -.
DR OrthoDB; 77777at2759; -.
DR PhylomeDB; A2AAE1; -.
DR TreeFam; TF105915; -.
DR BioGRID-ORCS; 229227; 6 hits in 72 CRISPR screens.
DR ChiTaRS; 4932438A13Rik; mouse.
DR PRO; PR:A2AAE1; -.
DR Proteomes; UP000000589; Chromosome 3.
DR RNAct; A2AAE1; protein.
DR Bgee; ENSMUSG00000037270; Expressed in spermatocyte and 246 other tissues.
DR ExpressionAtlas; A2AAE1; baseline and differential.
DR Genevisible; A2AAE1; MM.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005634; C:nucleus; NAS:BHF-UCL.
DR GO; GO:0098793; C:presynapse; IEA:GOC.
DR GO; GO:0060612; P:adipose tissue development; NAS:BHF-UCL.
DR GO; GO:0032456; P:endocytic recycling; ISS:UniProtKB.
DR GO; GO:0016197; P:endosomal transport; ISS:UniProtKB.
DR GO; GO:0045444; P:fat cell differentiation; NAS:BHF-UCL.
DR GO; GO:0006629; P:lipid metabolic process; NAS:BHF-UCL.
DR GO; GO:0019915; P:lipid storage; NAS:BHF-UCL.
DR GO; GO:0051647; P:nucleus localization; NAS:BHF-UCL.
DR GO; GO:0006909; P:phagocytosis; ISS:UniProtKB.
DR GO; GO:0001558; P:regulation of cell growth; NAS:BHF-UCL.
DR GO; GO:0007283; P:spermatogenesis; NAS:BHF-UCL.
DR GO; GO:0048488; P:synaptic vesicle endocytosis; IBA:GO_Central.
DR InterPro; IPR018863; Fragile_site-assoc_C.
DR InterPro; IPR033616; KIAA1109.
DR PANTHER; PTHR31640; PTHR31640; 1.
DR Pfam; PF10479; FSA_C; 2.
DR SMART; SM01220; FSA_C; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Membrane; Phosphoprotein; Reference proteome;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..5005
FT /note="Transmembrane protein KIAA1109"
FT /id="PRO_0000317556"
FT TRANSMEM 27..47
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 692..718
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1205..1314
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1343..1376
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1399..1425
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1521..1544
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1676..1698
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1927..1991
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2165..2192
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2265..2288
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2367..2387
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2400..2420
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2598..2677
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2928..2967
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3614..3662
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3686..3744
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3821..3843
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3935..3954
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 4089..4145
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 4325..4396
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1219..1245
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1253..1272
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1279..1314
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1357..1376
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1927..1973
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2622..2642
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2643..2677
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2946..2963
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3630..3647
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3686..3709
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3713..3744
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3821..3839
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4089..4117
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4125..4145
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 1301
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q2LD37"
FT MOD_RES 1305
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q2LD37"
FT MOD_RES 1323
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 1325
FT /note="Phosphothreonine"
FT /evidence="ECO:0000250|UniProtKB:Q2LD37"
FT MOD_RES 1355
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 1406
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q2LD37"
FT MOD_RES 1805
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 1808
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 2601
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 2603
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q2LD37"
FT MOD_RES 2755
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:19144319"
FT MOD_RES 3562
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q2LD37"
FT MOD_RES 3653
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:19144319"
FT MOD_RES 4124
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT VAR_SEQ 1..386
FT /note="Missing (in isoform 4)"
FT /evidence="ECO:0000303|Ref.3"
FT /id="VSP_031032"
FT VAR_SEQ 871
FT /note="Missing (in isoform 4)"
FT /evidence="ECO:0000303|Ref.3"
FT /id="VSP_031033"
FT VAR_SEQ 872..877
FT /note="QRPPVD -> VMSNDI (in isoform 5)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_031034"
FT VAR_SEQ 878..5005
FT /note="Missing (in isoform 5)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_031035"
FT VAR_SEQ 3513
FT /note="T -> TSSDGSSVSGDGHKLTFGQRLVNHLLGLAPPNQRYSVPAEYLCDSEM
FT RGSPQSSQSHLKACRAHSWGN (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:15368895"
FT /id="VSP_031036"
FT VAR_SEQ 3665
FT /note="T -> TLKNTVWGSSPQSRSPGEGYFQ (in isoform 2 and
FT isoform 3)"
FT /evidence="ECO:0000303|PubMed:15368895,
FT ECO:0000303|PubMed:15489334"
FT /id="VSP_031037"
FT VAR_SEQ 3915..3949
FT /note="Missing (in isoform 3 and isoform 6)"
FT /evidence="ECO:0000303|PubMed:15368895,
FT ECO:0000303|PubMed:16141072"
FT /id="VSP_031038"
FT CONFLICT 293
FT /note="L -> I (in Ref. 1; BAE28401)"
FT /evidence="ECO:0000305"
FT CONFLICT 314
FT /note="D -> E (in Ref. 1; BAE28401)"
FT /evidence="ECO:0000305"
FT CONFLICT 391
FT /note="T -> A (in Ref. 1; BAE28401)"
FT /evidence="ECO:0000305"
FT CONFLICT 706
FT /note="S -> C (in Ref. 1; BAE28401)"
FT /evidence="ECO:0000305"
FT CONFLICT 707
FT /note="M -> T (in Ref. 1; BAE28401)"
FT /evidence="ECO:0000305"
FT CONFLICT 997
FT /note="I -> V (in Ref. 3; BAD90190 and 4; AAH34738)"
FT /evidence="ECO:0000305"
FT CONFLICT 4100
FT /note="S -> N (in Ref. 5; BAD32378)"
FT /evidence="ECO:0000305"
FT CONFLICT 4450
FT /note="S -> R (in Ref. 4; AAH27125)"
FT /evidence="ECO:0000305"
FT CONFLICT 4451
FT /note="M -> V (in Ref. 4; AAH27125)"
FT /evidence="ECO:0000305"
FT CONFLICT 4582
FT /note="Q -> K (in Ref. 1; BAC35104)"
FT /evidence="ECO:0000305"
FT CONFLICT 4606
FT /note="T -> A (in Ref. 5; BAD32378)"
FT /evidence="ECO:0000305"
FT MOD_RES A2AAE1-3:3577
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
SQ SEQUENCE 5005 AA; 555365 MW; F77D939A6D681E8C CRC64;
MDQRKNDSIV PSITQLEDFL TEHNSNVVWL LVATILSCGW IIYLTYYNSR NVGLILTLVL
NRLYKHGYIH IGSFSFSVLS GKVMVREIYY ITEDMSIRIQ DGFIIFRWWK MYNPKQKQHD
PKAETRLYIT VNDFEFHVYN RSDLYGRLQE LFGLEPTIIP PKKDDDKTRE NGRTRTQSKI
ERVKVKTESQ DPTSSWRSLI PVIKVNVSTG RLAFGNHYQP QTLCINFDDA FLTYTTKPPS
SHLDQFMHIV KGKLENVRVM LVPSPRYVGL QNDEPPRLMG EGFVVLQSND VDLYYYMDEP
GLVPEETEES TEGDISSEDC KLQDLPPCWG LDIVCGKGTD FNYGPWADRQ RDCLWKFFFP
PDYQVLKVSE IAQPGRPRQI LAFELRMNII TDATIDLLFT KNRETNAVHV NVGAGSYLEI
NIPMTVDENG YTPAIKGQLL HVDATTSMQY RTLLEAEMLA FHINASYPRI WNMPQTWQCE
LEVYKATYHF IFAQKNFFTD LIQDWSSDNA PDIFSFVPYT WNFKIMFHQF EMIWAANQHN
WIDCSTKQQE NVYLAACGET LNIDFSLPFT DFVPATCNTR FSLRGEDVDL HLFLPDCHPS
KYSLFMLVKN CHPNKMVPET GIPAECQSGQ KTVKPKWRNV TQEKAGWVEC WTVPSVMLTI
DYTWHPIYPQ KADEQLKQSL SEMEETMLSV LRPAQKTSER VVSSPSMSPR PPVDPSELPP
DKLHVEMELS PDSQITLYGP LLNAFLCIKE NYFGEDDMYM DFEEVISSPV LSLSTSSSSG
WTAVGMDNDK RENESSAKSI HPLALRPWDI TVLVNLYKVH GRLPVHGTTD GPECPTAFLE
RLCFEMKKGF RETMLQLVLS PLNVFVSDNY QQRPPVDEVL REGHINLSGL QLRAHAMFSA
EGLPLGSDSL EYAWLIDVQA GSLTAKVTAP QLACLLEWGQ TFVFHVVCRE YELERPKSVI
VCQHGIDRRF CESKLSCIPG PCPTSDDLKY TMTRLAIDGS DIYIVEHGCA TNIKMGAVRI
ANCNLHNQSV GEGISAAIQD FQVRQYIEQL NNCRIGLQPA VLRRAYWLEA GSANLGLITV
DIALAADHHS KHEAQRHFLE THDARTKRLW FLWPDDTLKN KRCRNKCGCL GGCRFFGGTV
TGLDFFKLEE LTPSSSSAFS STSAESDMYY GQSLLQPGEW IITKEIPKTV DGNVNSMKRK
EWENKSVGIE GERKTQHLSL QVPLRSHSSS SSSEENSSSS AAQPLLAGEK ESPSSAADDH
SVQKDLLHSA RRDDGQASVP TEISGTSPVS PNTQDKSVGQ SPLRSPLKRQ ASVCSTRLGS
TKSLTAAFYG DKQPVTVGVQ FSSDVSRSDE NVLDSPKQRR SFGSFPYTPS ADSNSFHQYR
SMDSSMSMAD SEAYFSAAEE FEPISSDEGP GTYPGRKKKK KQMQQIDYSR GSIYHSVEGP
LAVHGEGITD PRTLPFKTHP SQASFVSALG GEDEVIEHVY IVEGEKRGES EQVTSQQPVM
SCYHTYLTQF QVINWSVKHP TNKRTSKSSL HRPLDLDTPT SEESSSSFEQ LCVPTFKVIK
QGLTANSLLD RGMQLSGSTS NTPYTPLDKK IVDTTDDETL TEEWTLDQPV AQTKTTAIVE
VKGTVDVVLT PLVAEALDRY IEAMVHRVST RHPAAIVDDL HTKVLREAVQ NSKTTFSENL
SPKQDIRGTK TEHPMIGTTN QGQIQTNVTT KQDNVTIKGL QANVSIPKVN LCLLQASVEE
SPATVPSRSV THVSLVALCF DRIATQVRMN RGVVEETANN VDAGKTSNFD RYVHASKMQP
QSSGSLRSNA GAEKGKEIAA KLNIHRVHGQ LRGLDTTDIG TCAITAIPFE KSKVLFTLEE
LDEFTFVDET DQQAIPDVTR IGPSQEKWGW IMFECGLENL TIKGGRQSGA VLYNSFGIMG
KNSVTERGGV LTSNNSSDSP TGSGYNTDVS DDNLPCDRTS PSSDINGNSV SDEQDEGVES
DDLKKDLPLM PPPPDSCSMK LTIKEIWFSF AAPTNVRSPA HAFSRQLNLL STATPAVGAW
LVPIDQLKSS LNKLETEGTL RICAVMGCIM TEALENKSVH FPLRSKYNRL TKVARFLQEN
PSCLLCNILH HYLHQANYSI IDDATMSDGL PALVTLKKGL VALARQWMKF IVVTPAFKGV
SLHRPAQPLK PPATVDQEHE EGLGLDNGGG LQSDTSADGA EFEFDAATVS EHTMLLEGTA
NRPPPGSSGP VTGAEIMRKL SKTHTHSDSA LKIKGIHPYH SLSYTSGDTA TDSPVHVGRA
GMPVKESPRK ESLLSYLTGS FPSLHNLLEG TPQRSSAAVK SSSLTRTGNT VATDMLSEHP
LLSEPSSVSF YNWMSNAVGN RGSVVQESPV TKSGHNSLPT GVAPNLPTIP SASDFNTVLS
SDQNTLDGTH SQHSTSQDDV AGVEEANQGF PAVQLADAQV VFKPLLSHTG IQSQDTMPLC
YRMYFGEHLS FSGTLDCLRA DIVDSDTAKD RKGKRARRQG HVNLPPLEFK PALMLETFSI
SAVVMEKSVC TPQNSTSALS FHDLNKRYYN TFHCNFTISC QSISQHVDMA LVRLIHQFST
MIDDIKATQT DIKLSRYTAG SASPTPTFKT RKHRDFRSSD FSRSSRGSLN GGNRVNNAKN
KRANNENNKK ESRNKNSLGR SERRTSKVSR KGSKDVVDHM TIHMDDSDSI TVSEQSEPSA
ECWQNMYKLL NFYSLISDPT GILEKSSETF GPAGVRSPTE PTCRVVFENE QDNNSLTKTQ
RKRSLVTSEP QHVTLIVFGI GMVNRTHLEA DIGGLTMESE LKRIHGSFTL KEKMKDVLHQ
KMTETCATAH IGGVNIVLLE GITPNIQLED FPTSPTSTAK QEFLTVVKCS IAKSQALYSA
QRGLKTNNAA VFKVGAISIN IPQHPATLHS MMVRSSHQLS KQISDLIRQP STAPQPMKED
IATPLPSEKT PTSVNQTPIE TNEFPQLPEG LEKKPIVLKF SAMLDGIAIG AALLPSLKAE
YKMGRMRSHG MTGAQTRFTF ELPNHRLRFT SKVSATDMST IPPSASLNLP PVTMSGKYIM
EEHDSYSDQV WSIDELPSKQ GYYLQGNYLR CVAEVGSFEH NLTTDLLNHL VFVQKVFMKE
VNEVIQKVSG GEQPIPLWNE HDGTTDGDKP KILLYSLNLQ FKGIQVTATT PSMRAVRFET
GLIELELSNR LQTKASPGSS SYLKLFGKCQ VDLNLALGQI VKHQVYEEAG SDFHQVAYFK
TRIGLRNALR EEISGSSDRE AVLITLNRPI VYAQPVAFDR AVLFWLNYKA AYDNWNEQRM
ALHKDIHMAT KEVVDMLPGI QQTSAQAFGT LFLQLTVNDL GICLPITNTA QSNHTGDLDT
GSALVLTIES TLITACSSES LVSKGHFKNF CIRFADGFET SWDDWKPEIR GDLVMNACVV
PDGTYEVCSR TTGQAAAESS SAGTWTLNVL WKMCGIDVHM DPNIGKRLNA LGNTLTTLTG
EEDIDDIADL NSVNIADLSD EDEVDTMSPT IHTEAVDYRR QGTSSSQPGE LRGRKIMKRL
VDIRELNEQA KVIDDLKKLG ASEGTINQEI QRYQQLESVA VNDIRRDVRK KLRRSSMRAA
SLKDKWGLGY KPSYSRSKSI SASGRPPLKR MERASSRIGE TDELPEIRVD AASPGPRVTF
NIQDTFPEET ELDLLSVTIE GPSHYSSNSE GSCSVFSSPK TTGGFSPSVP FQSEDGRRDD
SLSSTSEDSE KDEKDEDRER ERFYIYRKPS HTSRKKATGF AAVHQLLTER WPTTPVNRSL
SGTATERNID FELDIRVEID SGKCVLHPTT LLQEHDDISL RRSYDRSSRS LDQDSPSKKK
KFQTNYASTT HLMTGKKVPS SLQTKPSDLE TTVFYIPGVD VKLHYNSKTL KTESPNASRG
SSLPRTLSKE SKLYGMKDSA ASPSPSPLPC TVQSKTNTLL PPQPPPIPSA KGKGSGGVKT
AKLYAWVALQ SLPEEMVISP CLLDFLEKAL ETIPITPIER NYTAVSSQDE DMGHFDIPDP
MEESTTSLVS SSTSAYSSFP VDVVVYVRVQ PSQIKFSCLP VSRVECMLKL PSLDLVFSSN
RGELETLGTT YPAETVSPGS NAPQTGAKTS ASKAGMPGSS GLGSPLGRSR HSSSQSDLTG
SSSSSSGLSF TACMSDFSLY VFHPYGAGKQ KSTVSGLTSG SGGLGNVDEE PTSVTGRKDS
LSINLEFVKV SLSRIRRSGG ASFFESQSVS KSTSKMDTTL INISAVCDIG SASFKYDMRR
LSEILAFPRA WYRRSIARRL FLGDQTVNLP TSGPGTPDSI EGVSQHLSPE SSRKAYCRTW
DQPSQSASFT HMPQSPNVFN EHMTNNTMSP GTAAQSLKSP ASIRSRSVSD SSVPRRDSIS
KTSTPVNKSN KAASQQGTPW ETLVVFAINL KQLNVQMNMS NVMGNTTWTT SGLKSQGRLS
VGSNRDREIS MSVGLGRSQL DSKGGVVGGT IDVNALEMVA HISEHPNQQP NHKIQITMGS
TESRVDYMGS SILMGIFSNA DLKLQDEWKV NLYNALDSSM TDKSEIFVHG DLKWDIFQVM
ISRSTTPDLI KIGMKLQEFF TQQFDTSKRA LSTWGPVPYL PPKTMTNNLE KNSQEQLLDA
AHHRHWPGVL KVVSGCHISL FQVPLPEDGM QFGGSMSLHG NHMTLACFHG PNFRSKSWAL
FHLEEPNIAF WTEAQKIWED GSSDHSTYIV QTLDFHLGHN TMVTKPCGAL ESPMATITKI
TRRRHENPPH GVASVKEWFN YVTATRNEEL NLLRNVDANN TENSTTVKNS SLLSGFRGGS
SYNHETETIF ALPRMQLEFK SIHVQEPQEP SLQDASLKPK VECSVVTEFT DHICVTMDAE
LIMFLHDLVS AYLKEKEKAI FPPRILSTRP GQKCPLIIHD DSSSDRDRED SITYTTVDWR
DFMCNTWHLE PTLRLISWTG RKIDPVGVDY ILQKLGFHHA RTTIPKWLQR GVMDPLDKVL
SVLIKKLGTA LQDEKEKKGK DKEEH
