K1210_MOUSE
ID K1210_MOUSE Reviewed; 1637 AA.
AC E9Q0C6;
DT 07-JUN-2017, integrated into UniProtKB/Swiss-Prot.
DT 05-APR-2011, sequence version 1.
DT 03-AUG-2022, entry version 52.
DE RecName: Full=Acrosomal protein KIAA1210 {ECO:0000305};
GN Name=Kiaa1210 {ECO:0000303|PubMed:28203736};
GN Synonyms=Gm14569 {ECO:0000312|MGI:MGI:3705243};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [2]
RP SUBCELLULAR LOCATION, TISSUE SPECIFICITY, AND INTERACTION WITH TOP2B.
RX PubMed=28203736; DOI=10.1095/biolreprod.116.145458;
RA Iwamori T., Iwamori N., Matsumoto M., Ono E., Matzuk M.M.;
RT "Identification of KIAA1210 as a novel X-chromosome-linked protein that
RT localizes to the acrosome and associates with the ectoplasmic
RT specialization in testes.";
RL Biol. Reprod. 96:469-477(2017).
CC -!- SUBUNIT: Interacts with TOP2B. {ECO:0000269|PubMed:28203736}.
CC -!- SUBCELLULAR LOCATION: Cytoplasmic vesicle, secretory vesicle, acrosome
CC {ECO:0000269|PubMed:28203736}. Note=Localizes to the sex body in
CC spermatocyte, acrosome, and near the ectoplasmic specialization.
CC {ECO:0000269|PubMed:28203736}.
CC -!- TISSUE SPECIFICITY: Predominantly expressed in testis (at protein
CC level). {ECO:0000269|PubMed:28203736}.
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DR EMBL; AL450395; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; E9Q0C6; -.
DR STRING; 10090.ENSMUSP00000126231; -.
DR PhosphoSitePlus; E9Q0C6; -.
DR MaxQB; E9Q0C6; -.
DR PaxDb; E9Q0C6; -.
DR PRIDE; E9Q0C6; -.
DR ProteomicsDB; 269044; -.
DR Antibodypedia; 63509; 12 antibodies from 7 providers.
DR Ensembl; ENSMUST00000169499; ENSMUSP00000126231; ENSMUSG00000091556.
DR MGI; MGI:3705243; Gm14569.
DR VEuPathDB; HostDB:ENSMUSG00000091556; -.
DR eggNOG; ENOG502QXCA; Eukaryota.
DR GeneTree; ENSGT00940000163031; -.
DR HOGENOM; CLU_002901_0_0_1; -.
DR InParanoid; E9Q0C6; -.
DR OMA; QPLMNPK; -.
DR TreeFam; TF328810; -.
DR PRO; PR:E9Q0C6; -.
DR Proteomes; UP000000589; Chromosome X.
DR RNAct; E9Q0C6; protein.
DR Bgee; ENSMUSG00000091556; Expressed in testis and 15 other tissues.
DR GO; GO:0001669; C:acrosomal vesicle; IDA:UniProtKB.
DR InterPro; IPR026713; CRACD-like.
DR InterPro; IPR028030; DUF4592.
DR PANTHER; PTHR47743; PTHR47743; 4.
DR Pfam; PF15262; DUF4592; 1.
PE 1: Evidence at protein level;
KW Cytoplasmic vesicle; Reference proteome.
FT CHAIN 1..1637
FT /note="Acrosomal protein KIAA1210"
FT /id="PRO_0000440629"
FT REGION 44..121
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 141..293
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 341..404
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 438..759
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 865..896
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 935..975
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1017..1057
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1090..1137
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1182..1238
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1539..1558
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 44..60
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 143..193
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 217..231
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 232..246
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 247..271
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 356..371
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 477..491
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 506..532
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 548..574
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 600..625
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 664..678
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 679..710
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 741..759
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 874..896
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1098..1112
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1119..1135
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1206..1225
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1543..1558
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1637 AA; 181033 MW; 7AB6194FABACFB78 CRC64;
MEGFEASGEE GKKKSKFKAF KNFFSKKKKK EPEEIPEVAV LKPRFSSSSV SGSSLQPALE
KQVMESKPKS GMGVKSISHD SVFCLDPEPE KGAGKLHSSP APHRSKSLKI KSQRSQRLSI
SPLIRSEKVC EELEKFFASD RTTTTFRRRS SQCSSTPRMS SELSLDPETS ESSTQQFSGF
STPATSQGCL DSSAAKSKIA LNPRKQKKRK STSTPVKVKQ EEQLQSVPAK EKTTTKTKEA
EQGEQKVDST ELSSQEQSSK TETQDTAVDK TPSTDPALRL NPRRRRRRAK NEWEILERGL
LKSTQRYSLN TKAESSANKE IAGKEHSFLK LLLEKKDIGQ PTTTEAEVTT VQKMPSDKGD
VERELADIDV EAQKEPAPQP TSTDVAESMI SGPSPHCEDK KKKDKVGVLP WIKKSTSQKE
VTVLRKEEVQ VHVHPSRVCG EGEEASCPEL QRVQPQMKVS LESTTYHKEK HPRSGLPVPS
TSISSATAED DVSPKMNLPL PLRRRPNTGE TSSDSKSTSE YESSSEMQLS PAHSFKPTRK
PKDDAGAGTA DDEEDGDDEK EEKDNDDDDE ENVFLKSENV DVEVSKMEKQ QALRYSSKLL
GKPKAREASA KLESSSEDER SCEEMTSAHS SQSLEEFEEC SESRGFIRGS ISEERPATRC
HSQALQELEE KEVSTESSSY IEKYESSEDL SSSEQEQQVP PVSKSSLKQW SAPAKPVHPI
QTAQQQPPAM VNISGGPKKS GEPLSPTQTV KSRLRSQSEC QVLAEPEGVV AADWDILMQP
PPRPRLEQEV SAGPELTVFE KSIAVQPSGY PPQPSVKPSI KKEISLGAES APLESPPPQH
HFQPLLKPFV KQQVSAFERV ISMDPKLPTQ FQPRMKPQGK QSFSSTPEST AFEGSTSVDH
MTLTLSQPML QPYQEVPLES ETVAAKMIST GQLHSKYSAH PLSSHQSQPV PESTSAEGEE
LLPSQPSVTP KFQPLMTQGS IPSAWAIPIY SPAPRMDSKP LMGSAIALES KPSRYSLQPW
QSTPFEQVSV TPDHDPAAAA ASWSPPIDPP TSRIPSQPLM RLAVKQPTCT ELASVSVSQS
SSLERLSSRF PFQPRADPEH YGAEEGVATL RRSRRHHSQS PVRSEFKEEV SSGSRRAFGE
RSISVGKMPP KYALQPWLCP EFQQQAKEGD VLRKAWLSGH PSQTISKHKV EKTPLPPKCP
SPFLTRSKVQ EISSRLESVI AQESSKKPQR GRPPSKSFVN FMAQQVFSES APSKVVLHPK
PVARGRRRPS RSLLKPKLDD YAFLYNWDNE PKEDTTLQNL PMKQPFQLSR KPEEPQEVLP
FSEGAPVKWN TSARGISQAL GKLSVSVSLP NEWKSSEGQL PSTQPSQAFD VAKLQSPVLP
VDSANVPVKW RISEGHQPPQ SFFVDYQPQV SVDSASAAAK GASCWPMLKD SASTTNVKYS
QGYKDFTKST PTSVIKPATF TSAPAQKPMV SMGTYFKDEV PKCCDETGTS SLLPTSKADV
ENVFGVRLRS TSQKIGMKNP DPCKPFVLIS AAARKEQANK GDLQGSVGGS KQSRPAFSFE
KKQGNWPRYE GTLKKSEVFR PPVAFYDQKM LHPRTRERLT RRSLSLPPTL PQREEPEWFS
VAKKKAQAWS QIANIMQ
