K1549_HUMAN
ID K1549_HUMAN Reviewed; 1950 AA.
AC Q9HCM3; B6HY55; B6HY56; B6HY58; B6HY60; B6HY61; B6HY62; B6HY63; B6HY64;
AC B6HY65; B6HY66; Q5BJD6; Q8IY15; Q9H0M3;
DT 01-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT 05-APR-2011, sequence version 4.
DT 03-AUG-2022, entry version 134.
DE RecName: Full=UPF0606 protein KIAA1549;
GN Name=KIAA1549 {ECO:0000312|HGNC:HGNC:22219};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORMS 1; 2; 3 AND 4), DISEASE,
RP AND CHROMOSOMAL REARRANGEMENT.
RC TISSUE=Brain;
RX PubMed=18974108; DOI=10.1158/0008-5472.can-08-2097;
RA Jones D.T.W., Kocialkowski S., Liu L., Pearson D.M., Backlund L.M.,
RA Ichimura K., Collins V.P.;
RT "Tandem duplication producing a novel oncogenic BRAF fusion gene defines
RT the majority of pilocytic astrocytomas.";
RL Cancer Res. 68:8673-8677(2008).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=12853948; DOI=10.1038/nature01782;
RA Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H.,
RA Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K.,
RA Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A.,
RA Delehaunty K.D., Miner T.L., Nash W.E., Cordes M., Du H., Sun H.,
RA Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A.,
RA Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P.,
RA Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M.,
RA Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S.,
RA Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R.,
RA Strowmatt C., Latreille P., Miller N., Johnson D., Murray J.,
RA Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W.,
RA Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E.,
RA Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A.,
RA Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E.,
RA Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E.,
RA Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A.,
RA Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A.,
RA Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R.,
RA McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H.,
RA Wilson R.K.;
RT "The DNA sequence of human chromosome 7.";
RL Nature 424:157-164(2003).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 70-1950 (ISOFORM 2), AND VARIANT
RP LEU-652.
RC TISSUE=Brain;
RX PubMed=10997877; DOI=10.1093/dnares/7.4.271;
RA Nagase T., Kikuno R., Nakayama M., Hirosawa M., Ohara O.;
RT "Prediction of the coding sequences of unidentified human genes. XVIII. The
RT complete sequences of 100 new cDNA clones from brain which code for large
RT proteins in vitro.";
RL DNA Res. 7:273-281(2000).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1128-1950 (ISOFORM 1).
RC TISSUE=Brain, and Duodenum;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1811-1950 (ISOFORM 2).
RC TISSUE=Testis;
RX PubMed=11230166; DOI=10.1101/gr.gr1547r;
RA Wiemann S., Weil B., Wellenreuther R., Gassenhuber J., Glassl S.,
RA Ansorge W., Boecher M., Bloecker H., Bauersachs S., Blum H., Lauber J.,
RA Duesterhoeft A., Beyer A., Koehrer K., Strack N., Mewes H.-W.,
RA Ottenwaelder B., Obermaier B., Tampe J., Heubner D., Wambutt R., Korn B.,
RA Klein M., Poustka A.;
RT "Towards a catalog of human genes and proteins: sequencing and analysis of
RT 500 novel complete protein coding human cDNAs.";
RL Genome Res. 11:422-435(2001).
RN [6]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1395, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma;
RX PubMed=17081983; DOI=10.1016/j.cell.2006.09.026;
RA Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.;
RT "Global, in vivo, and site-specific phosphorylation dynamics in signaling
RT networks.";
RL Cell 127:635-648(2006).
RN [7]
RP GLYCOSYLATION.
RX PubMed=28512129; DOI=10.1074/jbc.m117.794487;
RA Larsen I.S.B., Narimatsu Y., Joshi H.J., Yang Z., Harrison O.J., Brasch J.,
RA Shapiro L., Honig B., Vakhrushev S.Y., Clausen H., Halim A.;
RT "Mammalian O-mannosylation of cadherins and plexins is independent of
RT protein O-mannosyltransferases 1 and 2.";
RL J. Biol. Chem. 292:11586-11598(2017).
RN [8]
RP INVOLVEMENT IN RP86, FUNCTION, ALTERNATIVE SPLICING, TISSUE SPECIFICITY,
RP AND VARIANT RP86 GLN-1562.
RX PubMed=30120214; DOI=10.1136/jmedgenet-2018-105364;
RA de Bruijn S.E., Verbakel S.K., de Vrieze E., Kremer H., Cremers F.P.M.,
RA Hoyng C.B., van den Born L.I., Roosing S.;
RT "Homozygous variants in KIAA1549, encoding a ciliary protein, are
RT associated with autosomal recessive retinitis pigmentosa.";
RL J. Med. Genet. 55:705-712(2018).
CC -!- FUNCTION: May play a role in photoreceptor function.
CC {ECO:0000269|PubMed:30120214}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}. Cell projection, cilium
CC {ECO:0000250|UniProtKB:Q68FD9}. Note=In the retinal photoreceptor
CC cells, localizes at the connecting cilium, a thin bridge linking the
CC cell body and the light-sensing outer segment.
CC {ECO:0000250|UniProtKB:Q68FD9}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative promoter usage, Alternative splicing; Named isoforms=4;
CC Name=1; Synonyms=v2 long-form;
CC IsoId=Q9HCM3-1; Sequence=Displayed;
CC Name=2; Synonyms=v1 long-form;
CC IsoId=Q9HCM3-2; Sequence=VSP_034448;
CC Name=3; Synonyms=v1 short-form;
CC IsoId=Q9HCM3-3; Sequence=VSP_040885, VSP_040886, VSP_034448;
CC Name=4; Synonyms=v2 short-form;
CC IsoId=Q9HCM3-4; Sequence=VSP_040885, VSP_040886;
CC -!- TISSUE SPECIFICITY: [Isoform 1]: Expression is low to moderate in
CC retina and tissues, such as heart and kidney, and is predominantly
CC expressed in brain. {ECO:0000269|PubMed:30120214}.
CC -!- TISSUE SPECIFICITY: [Isoform 4]: Abundantly expressed in the retina,
CC compared with only minimal expression in brain and other tissues.
CC {ECO:0000269|PubMed:30120214}.
CC -!- PTM: O-glycosylated. O-mannosylated by POMT1 and POMT2 and elongated by
CC POMGNT1. {ECO:0000269|PubMed:28512129}.
CC -!- DISEASE: Retinitis pigmentosa 86 (RP86) [MIM:618613]: A form of
CC retinitis pigmentosa, a retinal dystrophy belonging to the group of
CC pigmentary retinopathies. Retinitis pigmentosa is characterized by
CC retinal pigment deposits visible on fundus examination and primary loss
CC of rod photoreceptor cells followed by secondary loss of cone
CC photoreceptors. Patients typically have night vision blindness and loss
CC of midperipheral visual field. As their condition progresses, they lose
CC their far peripheral visual field and eventually central vision as
CC well. RP86 is an autosomal recessive form.
CC {ECO:0000269|PubMed:30120214}. Note=The disease is caused by variants
CC affecting the gene represented in this entry.
CC -!- DISEASE: Note=A chromosomal aberration involving KIAA1549 is found in
CC pilocytic astrocytoma. A tandem duplication of 2 Mb at 7q34 leads to
CC the expression of a KIAA1549-BRAF fusion protein with a constitutive
CC kinase activity and inducing cell transformation.
CC {ECO:0000269|PubMed:18974108}.
CC -!- MISCELLANEOUS: [Isoform 3]: Produced by alternative promoter usage.
CC {ECO:0000305}.
CC -!- MISCELLANEOUS: [Isoform 4]: Produced by alternative promoter usage.
CC {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the UPF0606 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAH38232.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
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DR EMBL; AM989467; CAQ43105.1; -; Genomic_DNA.
DR EMBL; AM989467; CAQ43106.1; -; Genomic_DNA.
DR EMBL; AM989468; CAQ43107.1; -; mRNA.
DR EMBL; AM989469; CAQ43108.1; -; mRNA.
DR EMBL; AM989470; CAQ43109.1; -; mRNA.
DR EMBL; AM989471; CAQ43110.1; -; mRNA.
DR EMBL; AM989472; CAQ43111.1; ALT_TERM; mRNA.
DR EMBL; AM989473; CAQ43112.1; ALT_TERM; mRNA.
DR EMBL; AM989474; CAQ43113.1; ALT_TERM; mRNA.
DR EMBL; AM989475; CAQ43114.1; ALT_TERM; mRNA.
DR EMBL; AM989476; CAQ43115.1; ALT_TERM; mRNA.
DR EMBL; AM989477; CAQ43116.1; ALT_TERM; mRNA.
DR EMBL; AC018663; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC083868; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC093144; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AB046769; BAB13375.2; -; mRNA.
DR EMBL; BC038232; AAH38232.1; ALT_INIT; mRNA.
DR EMBL; BC091523; AAH91523.1; -; mRNA.
DR EMBL; AL136736; CAB66670.2; -; mRNA.
DR CCDS; CCDS47723.2; -. [Q9HCM3-2]
DR CCDS; CCDS56513.1; -. [Q9HCM3-1]
DR RefSeq; NP_001158137.1; NM_001164665.1. [Q9HCM3-1]
DR RefSeq; NP_065961.2; NM_020910.2. [Q9HCM3-2]
DR AlphaFoldDB; Q9HCM3; -.
DR BioGRID; 121702; 78.
DR IntAct; Q9HCM3; 24.
DR MINT; Q9HCM3; -.
DR STRING; 9606.ENSP00000416040; -.
DR iPTMnet; Q9HCM3; -.
DR PhosphoSitePlus; Q9HCM3; -.
DR BioMuta; KIAA1549; -.
DR DMDM; 327478603; -.
DR EPD; Q9HCM3; -.
DR jPOST; Q9HCM3; -.
DR MassIVE; Q9HCM3; -.
DR MaxQB; Q9HCM3; -.
DR PaxDb; Q9HCM3; -.
DR PeptideAtlas; Q9HCM3; -.
DR PRIDE; Q9HCM3; -.
DR ProteomicsDB; 81759; -. [Q9HCM3-1]
DR ProteomicsDB; 81760; -. [Q9HCM3-2]
DR ProteomicsDB; 81761; -. [Q9HCM3-3]
DR ProteomicsDB; 81762; -. [Q9HCM3-4]
DR Antibodypedia; 9863; 27 antibodies from 12 providers.
DR DNASU; 57670; -.
DR Ensembl; ENST00000422774.2; ENSP00000416040.2; ENSG00000122778.10. [Q9HCM3-1]
DR Ensembl; ENST00000440172.5; ENSP00000406661.1; ENSG00000122778.10. [Q9HCM3-2]
DR GeneID; 57670; -.
DR KEGG; hsa:57670; -.
DR MANE-Select; ENST00000422774.2; ENSP00000416040.2; NM_001164665.2; NP_001158137.1.
DR UCSC; uc011kqj.3; human. [Q9HCM3-1]
DR CTD; 57670; -.
DR DisGeNET; 57670; -.
DR GeneCards; KIAA1549; -.
DR HGNC; HGNC:22219; KIAA1549.
DR HPA; ENSG00000122778; Low tissue specificity.
DR MalaCards; KIAA1549; -.
DR MIM; 613344; gene.
DR MIM; 618613; phenotype.
DR neXtProt; NX_Q9HCM3; -.
DR OpenTargets; ENSG00000122778; -.
DR Orphanet; 251615; Pilomyxoid astrocytoma.
DR Orphanet; 791; Retinitis pigmentosa.
DR PharmGKB; PA162393138; -.
DR VEuPathDB; HostDB:ENSG00000122778; -.
DR eggNOG; ENOG502QT4E; Eukaryota.
DR GeneTree; ENSGT00530000063472; -.
DR HOGENOM; CLU_002218_0_0_1; -.
DR InParanoid; Q9HCM3; -.
DR OMA; SLFHTFR; -.
DR OrthoDB; 33154at2759; -.
DR PhylomeDB; Q9HCM3; -.
DR TreeFam; TF332690; -.
DR PathwayCommons; Q9HCM3; -.
DR Reactome; R-HSA-6802952; Signaling by BRAF and RAF1 fusions.
DR SignaLink; Q9HCM3; -.
DR BioGRID-ORCS; 57670; 5 hits in 1018 CRISPR screens.
DR ChiTaRS; KIAA1549; human.
DR GenomeRNAi; 57670; -.
DR Pharos; Q9HCM3; Tbio.
DR PRO; PR:Q9HCM3; -.
DR Proteomes; UP000005640; Chromosome 7.
DR RNAct; Q9HCM3; protein.
DR Bgee; ENSG00000122778; Expressed in cortical plate and 149 other tissues.
DR Genevisible; Q9HCM3; HS.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0032391; C:photoreceptor connecting cilium; ISS:UniProtKB.
DR GO; GO:0005886; C:plasma membrane; TAS:Reactome.
DR InterPro; IPR024606; DUF3827.
DR PANTHER; PTHR21590; PTHR21590; 1.
DR Pfam; PF12877; DUF3827; 1.
PE 1: Evidence at protein level;
KW Alternative promoter usage; Alternative splicing; Cell projection;
KW Chromosomal rearrangement; Membrane; Phosphoprotein; Reference proteome;
KW Retinitis pigmentosa; Transmembrane; Transmembrane helix.
FT CHAIN 1..1950
FT /note="UPF0606 protein KIAA1549"
FT /id="PRO_0000342405"
FT TRANSMEM 998..1018
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 1299..1319
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 1..37
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 378..402
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 875..919
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1373..1463
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1702..1740
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1837..1923
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 875..894
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1420..1438
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1448..1463
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1720..1740
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1871..1893
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1908..1922
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT SITE 1643..1644
FT /note="Breakpoint for translocation to form KIAA1549-BRAF
FT fusion protein"
FT SITE 1749..1750
FT /note="Breakpoint for translocation to form KIAA1549-BRAF
FT fusion protein"
FT MOD_RES 1388
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q68FD9"
FT MOD_RES 1395
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:17081983"
FT MOD_RES 1554
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q68FD9"
FT MOD_RES 1555
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q68FD9"
FT MOD_RES 1622
FT /note="Phosphothreonine"
FT /evidence="ECO:0000250|UniProtKB:Q68FD9"
FT MOD_RES 1624
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q68FD9"
FT VAR_SEQ 1..1216
FT /note="Missing (in isoform 3 and isoform 4)"
FT /evidence="ECO:0000303|PubMed:18974108"
FT /id="VSP_040885"
FT VAR_SEQ 1217..1222
FT /note="AGNSVV -> MVSAIF (in isoform 3 and isoform 4)"
FT /evidence="ECO:0000303|PubMed:18974108"
FT /id="VSP_040886"
FT VAR_SEQ 1867..1882
FT /note="Missing (in isoform 2 and isoform 3)"
FT /evidence="ECO:0000303|PubMed:10997877,
FT ECO:0000303|PubMed:11230166, ECO:0000303|PubMed:18974108"
FT /id="VSP_034448"
FT VARIANT 448
FT /note="A -> P (in dbSNP:rs2718131)"
FT /id="VAR_044187"
FT VARIANT 652
FT /note="P -> L (in dbSNP:rs2774960)"
FT /evidence="ECO:0000269|PubMed:10997877"
FT /id="VAR_057812"
FT VARIANT 851
FT /note="V -> G (in dbSNP:rs2354336)"
FT /id="VAR_044188"
FT VARIANT 1562
FT /note="H -> Q (in RP86; unknown pathological significance;
FT dbSNP:rs776206391)"
FT /evidence="ECO:0000269|PubMed:30120214"
FT /id="VAR_083316"
FT CONFLICT 486
FT /note="P -> A (in Ref. 3; BAB13375)"
FT /evidence="ECO:0000305"
FT CONFLICT 617
FT /note="R -> G (in Ref. 3; BAB13375)"
FT /evidence="ECO:0000305"
FT CONFLICT 849
FT /note="S -> L (in Ref. 3; BAB13375)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 1950 AA; 210755 MW; 3F7FD3A94CE4EE93 CRC64;
MPGARRRRRG AAMEGKPRAG VALAPGPSGR RPSARCARRR RPGLLLPGLW LLLLARPASC
APDELSPEQH NLSLYSMELV LKKSTGHSAA QVALTETAPG SQHSSPLHVT APPSATTFDT
AFFNQGKQTK STADPSIFVA TYVSVTSKEV AVNDDEMDNF LPDTHWTTPR MVSPIQYITV
SPPGLPREAL EPMLTPSLPM VSLQDEEVTS GWQNTTRQPA AYAESASHFH TFRSAFRTSE
GIVPTPGRNL VLYPTDAYSH LSSRTLPEIV ASLTEGVETT LFLSSRSLMP QPLGDGITIP
LPSLGEVSQP PEEVWATSAD RYTDVTTVLS QSLEETISPR TYPTVTASHA ALAFSRTHSP
LLSTPLAFAS SASPTDVSSN PFLPSDSSKT SELHSNSALP GPVDNTHILS PVSSFRPYTW
CAACTVPSPQ QVLATSLMEK DVGSGDGAET LCMTVLEESS ISLMSSVVAD FSEFEEDPQV
FNTLFPSRPI VPLSSRSMEI SETSVGISAE VDMSSVTTTQ VPPAHGRLSV PASLDPTAGS
LSVAETQVTP SSVTTAFFSV ITSILLDSSF SVIANKNTPS LAVRDPSVFT PYSLVPSVES
SLFSDQERSS FSEHKPRGAL DFASSFFSTP PLELSGSISS PSEAPASLSL MPSDLSPFTS
QSFSPLVETF TLFDSSDLQS SQLSLPSSTN LEFSQLQPSS ELPLNTIMLL PSRSEVSPWS
SFPSDSLEFV EASTVSLTDS EAHFTSAFIE TTSYLESSLI SHESAVTALV PPGSESFDIL
TAGIQATSPL TTVHTTPILT ESSLFSTLTP PDDQISALDG HVSVLASFSK AIPTGTVLIT
DAYLPSGSSF VSEATPFPLP TELTVVGPSL TPTEVPLNTS TEVSTTSTGA ATGGPLDSTL
MGDAASQSPP ESSAAPPLPS LRPVTAFTLE ATVDTPTLAT AKPPYVCDIT VPDAYLITTV
LARRAVQEYI ITAIKEVLRI HFNRAVELKV YELFTDFTFL VTSGPFVYTA ISVINVLINS
KLVRDQTPLI LSVKPSFLVP ESRFQVQTVL QFVPPSVDTG FCNFTQRIEK GLMTALFEVR
KHHQGTYNLT VQILNITISS SRVTPRRGPV NIIFAVKSTQ GFLNGSEVSE LLRNLSVVEF
SFYLGYPVLQ IAEPFQYPQL NLSQLLKSSW VRTVLLGVME KQLQNEVFQA EMERKLAQLL
SEVSTRRRMW RRATVAAGNS VVQVVNVSRL EGDDNPVQLI YFVEDQDGER LSAVKSSDLI
NKMDLQRAAI ILGYRIQGVI AQPVDRVKRP SPESQSNNLW VIVGVVIPVL VVMVIVVILY
WKLCRTDKLD FQPDTVANIQ QRQKLQIPSV KGFDFAKQHL GQHNKDDILI IHEPAPLPGP
LKDHTTPSEN GDVPSPKSKI PSKNVRHRGR VSPSDADSTV SEESSERDAG DKTPGAVNDG
RSHRAPQSGP PLPSSGNEQH SSASIFEHVD RISRPPEASR RVPSKIQLIA MQPIPAPPVQ
RPSPADRVAE SNKINKEIQT ALRHKSEIEH HRNKIRLRAK RRGHYEFPVV DDLSSGDTKE
RHRVYRRAQM QIDKILDPTA SVPSVFIEPR KSSRIKRSPK PRRKHQVNGC PADAEKDRLI
TTDSDGTYRR PPGVHNSAYI GCPSDPDLPA DVQTPSSVEL GRYPALPFPA SQYIPPQPSI
EEARQTMHSL LDDAFALVAP SSQPASTAGV GPGVPPGLPA NSTPSQEERR ATQWGSFYSP
AQTANNPCSR YEDYGMTPPT GPLPRPGFGP GLLQSTELVP PDPQQPQASA EAPFAARGIY
SEEMPSVARP RPVGGTTGSQ IQHLTQVGIA SRIGAQPVEI PPSRGSQYGG PGWPSYGEDE
AGRREATHML GHQEYSSSPL FQVPRTSGRE PSAPSGNLPH RGLQGPGLGY PTSSTEDLQP
GHSSASLIKA IREELLRLSQ KQSTVQNFHS
