K154L_HUMAN
ID K154L_HUMAN Reviewed; 1849 AA.
AC Q6ZVL6; B0QYU0;
DT 06-FEB-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-JUL-2008, sequence version 2.
DT 03-AUG-2022, entry version 126.
DE RecName: Full=UPF0606 protein KIAA1549L;
GN Name=KIAA1549L; Synonyms=C11orf41, C11orf69;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Astrocyte;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16554811; DOI=10.1038/nature04632;
RA Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K.,
RA Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F., Bloom T.,
RA Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G.,
RA Jaffe D.B., LaButti K., Nicol R., Park H.-S., Seaman C., Sougnez C.,
RA Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A.,
RA Hattori M., Rogers J., Lander E.S., Sakaki Y.;
RT "Human chromosome 11 DNA sequence and analysis including novel gene
RT identification.";
RL Nature 440:497-500(2006).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane
CC protein {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q6ZVL6-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q6ZVL6-2; Sequence=VSP_034445, VSP_034446, VSP_034447;
CC -!- SIMILARITY: Belongs to the UPF0606 family. {ECO:0000305}.
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DR EMBL; AK124395; BAC85845.1; -; mRNA.
DR EMBL; AL049629; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL049575; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; NP_036326.2; NM_012194.2.
DR RefSeq; XP_011518271.1; XM_011519969.2. [Q6ZVL6-2]
DR AlphaFoldDB; Q6ZVL6; -.
DR BioGRID; 117301; 4.
DR IntAct; Q6ZVL6; 5.
DR MINT; Q6ZVL6; -.
DR STRING; 9606.ENSP00000315295; -.
DR GlyGen; Q6ZVL6; 2 sites, 2 O-linked glycans (2 sites).
DR iPTMnet; Q6ZVL6; -.
DR PhosphoSitePlus; Q6ZVL6; -.
DR BioMuta; KIAA1549L; -.
DR DMDM; 193806328; -.
DR EPD; Q6ZVL6; -.
DR jPOST; Q6ZVL6; -.
DR MassIVE; Q6ZVL6; -.
DR MaxQB; Q6ZVL6; -.
DR PaxDb; Q6ZVL6; -.
DR PeptideAtlas; Q6ZVL6; -.
DR PRIDE; Q6ZVL6; -.
DR ProteomicsDB; 68423; -. [Q6ZVL6-1]
DR ProteomicsDB; 68424; -. [Q6ZVL6-2]
DR ABCD; Q6ZVL6; 6 sequenced antibodies.
DR Antibodypedia; 2328; 2 antibodies from 2 providers.
DR DNASU; 25758; -.
DR Ensembl; ENST00000321505.9; ENSP00000315295.4; ENSG00000110427.17. [Q6ZVL6-1]
DR GeneID; 25758; -.
DR KEGG; hsa:25758; -.
DR UCSC; uc001mun.1; human. [Q6ZVL6-1]
DR CTD; 25758; -.
DR DisGeNET; 25758; -.
DR GeneCards; KIAA1549L; -.
DR HGNC; HGNC:24836; KIAA1549L.
DR HPA; ENSG00000110427; Group enriched (brain, parathyroid gland).
DR MIM; 612297; gene.
DR neXtProt; NX_Q6ZVL6; -.
DR OpenTargets; ENSG00000110427; -.
DR PharmGKB; PA142672301; -.
DR VEuPathDB; HostDB:ENSG00000110427; -.
DR eggNOG; ENOG502QU24; Eukaryota.
DR GeneTree; ENSGT00530000063472; -.
DR HOGENOM; CLU_002284_2_1_1; -.
DR InParanoid; Q6ZVL6; -.
DR OrthoDB; 52820at2759; -.
DR PhylomeDB; Q6ZVL6; -.
DR TreeFam; TF332690; -.
DR PathwayCommons; Q6ZVL6; -.
DR SignaLink; Q6ZVL6; -.
DR BioGRID-ORCS; 25758; 7 hits in 1068 CRISPR screens.
DR ChiTaRS; KIAA1549L; human.
DR GenomeRNAi; 25758; -.
DR Pharos; Q6ZVL6; Tdark.
DR PRO; PR:Q6ZVL6; -.
DR Proteomes; UP000005640; Chromosome 11.
DR RNAct; Q6ZVL6; protein.
DR Bgee; ENSG00000110427; Expressed in middle temporal gyrus and 114 other tissues.
DR ExpressionAtlas; Q6ZVL6; baseline and differential.
DR Genevisible; Q6ZVL6; HS.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR InterPro; IPR024606; DUF3827.
DR PANTHER; PTHR21590; PTHR21590; 1.
DR Pfam; PF12877; DUF3827; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Coiled coil; Membrane; Reference proteome;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..1849
FT /note="UPF0606 protein KIAA1549L"
FT /id="PRO_0000274780"
FT TRANSMEM 1180..1200
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 1..70
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 142..166
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 213..242
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 529..586
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1258..1338
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1460..1546
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1656..1679
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1769..1819
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 958..986
FT /evidence="ECO:0000255"
FT COMPBIAS 22..49
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1288..1319
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1320..1334
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1460..1485
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1488..1531
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1532..1546
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1770..1819
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 627
FT /note="T -> TGAATNA (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_034445"
FT VAR_SEQ 1226..1229
FT /note="PVQG -> QVAQ (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_034446"
FT VAR_SEQ 1230..1849
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_034447"
SQ SEQUENCE 1849 AA; 198999 MW; C0FE96132DF8CE8F CRC64;
MDHTASQNAQ DLIGIPHLGV SGSSTKWHSE LSPTEGPHSA GSSTPGFLSP MAELSHPSPP
PPALGSLLQL PDGSPSWSML EVASGPASTQ QIKAGVPGRV HNGVSLPTFK NTETATHEAE
PPLFQTAESG AIEMTSRKLA SATANDSANP LHLSAAPENS RGPALSAEHT SSLVPSLHIT
TLGQEQAILS GAVPASPSTG TADFPSILTF LQPTENHASP SPVPEMPTLP AEGSDGSPPA
TRDLLLSSKV PNLLSTSWTF PRWKKDSVTA ILGKNEEANV TIPLQAFPRK EVLSLHTVNG
FVSDFSTGSV SSPIITAPRT NPLPSGPPLP SILSIQATQT VFPSLGFSST KPEAYAAAVD
HSGLPASASK QVRASPSSMD VYDSLTIGDM KKPATTDVFW SSLSAETGSL STESIISGLQ
QQTNYDLNGH TISTTSWETH LAPTAPPNGL TSAADAIKSQ DFKDTAGHSV TAEGFSIQDL
VLGTSIEQPV QQSDMTMVGS HIDLWPTSNN NHSRDFQTAE VAYYSPTTRH SVSHPQLQLP
NQPAHPLLLT SPGPTSTGSL QEMLSDGTDT GSEISSDINS SPERNASTPF QNILGYHSAA
ESSISTSVFP RTSSRVLRAS QHPKKWTADT VSSKVQPTAA AAVTLFLRKS SPPALSAALV
AKGTSSSPLA VASGPAKSSS MTTLAKNVTN KAASGPKRTP GAVHTAFPFT PTYMYARTGH
TTSTHTAMQG NMDTASGLLS TTYLPRKPQA MHTGLPNPTN LEMPRASTPR PLTVTAALTS
ITASVKATRL PPLRAENTDA VLPAASAAVV TTGKMASNLE CQMSSKLLVK TVLFLTQRRV
QISESLKFSI AKGLTQALRK AFHQNDVSAH VDILEYSHNV TVGYYATKGK LVYLPAVVIE
MLGVYGVSNV TADLKQHTPH LQSVAVLASP WNPQPAGYFQ LKTVLQFVSQ ADNIQSCKFA
QTMEQRLQKA FQDAERKVLN TKSNLTIQIV STSNASQAVT LVYVVGNQST FLNGTVASSL
LSQLSAELVG FYLTYPPLTI AEPLEYPNLD ISETTRDYWV ITVLQGVDNS LVGLHNQSFA
RVMEQRLAQL FMMSQQQGRR FKRATTLGSY TVQMVKMQRV PGPKDPAELT YYTLYNGKPL
LGTAAAKILS TIDSQRMALT LHHVVLLQAD PVVKNPPNNL WIIAAVLAPI AVVTVIIIII
TAVLCRKNKN DFKPDTMINL PQRAKPVQGF DYAKQHLGQQ GADEEVIPVT QETVVLPLPI
RDAPQERDVA QDGSTIKTAK STETRKSRSP SENGSVISNE SGKPSSGRRS PQNVMAQQKV
TKEEARKRNV PASDEEEGAV LFDNSSKVAA EPFDTSSGSV QLIAIKPTAL PMVPPTSDRS
QESSAVLNGE VNKALKQKSD IEHYRNKLRL KAKRKGYYDF PAVETSKGLT ERKKMYEKAP
KEMEHVLDPD SELCAPFTES KNRQQMKNSV YRSRQSLNSP SPGETEMDLL VTRERPRRGI
RNSGYDTEPE IIEETNIDRV PEPRGYSRSR QVKGHSETST LSSQPSIDEV RQQMHMLLEE
AFSLASAGHA GQSRHQEAYG SAQHLPYSEV VTSAPGTMTR PRAGVQWVPT YRPEMYQYSL
PRPAYRFSQL PEMVMGSPPP PVPPRTGPVA VASLRRSTSD IGSKTRMAES TGPEPAQLHD
SASFTQMSRG PVSVTQLDQS ALNYSGNTVP AVFAIPAANR PGFTGYFIPT PPSSYRNQAW
MSYAGENELP SQWADSVPLP GYIEAYPRSR YPQSSPSRLP RQYSQPANLH PSLEQAPAPS
TAASQQSLAE NDPSDAPLTN ISTAALVKAI REEVAKLAKK QTDMFEFQV
