K1671_HUMAN
ID K1671_HUMAN Reviewed; 1806 AA.
AC Q9BY89; B0QYF2; B7ZW08; Q5THZ5;
DT 15-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT 15-MAY-2007, sequence version 2.
DT 03-AUG-2022, entry version 133.
DE RecName: Full=Uncharacterized protein KIAA1671;
GN Name=KIAA1671;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Brain;
RX PubMed=11258795; DOI=10.1093/dnares/8.1.1;
RA Hirosawa M., Nagase T., Murahashi Y., Kikuno R., Ohara O.;
RT "Identification of novel transcribed sequences on human chromosome 22 by
RT expressed sequence tag mapping.";
RL DNA Res. 8:1-9(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=10591208; DOI=10.1038/990031;
RA Dunham I., Hunt A.R., Collins J.E., Bruskiewich R., Beare D.M., Clamp M.,
RA Smink L.J., Ainscough R., Almeida J.P., Babbage A.K., Bagguley C.,
RA Bailey J., Barlow K.F., Bates K.N., Beasley O.P., Bird C.P., Blakey S.E.,
RA Bridgeman A.M., Buck D., Burgess J., Burrill W.D., Burton J., Carder C.,
RA Carter N.P., Chen Y., Clark G., Clegg S.M., Cobley V.E., Cole C.G.,
RA Collier R.E., Connor R., Conroy D., Corby N.R., Coville G.J., Cox A.V.,
RA Davis J., Dawson E., Dhami P.D., Dockree C., Dodsworth S.J., Durbin R.M.,
RA Ellington A.G., Evans K.L., Fey J.M., Fleming K., French L., Garner A.A.,
RA Gilbert J.G.R., Goward M.E., Grafham D.V., Griffiths M.N.D., Hall C.,
RA Hall R.E., Hall-Tamlyn G., Heathcott R.W., Ho S., Holmes S., Hunt S.E.,
RA Jones M.C., Kershaw J., Kimberley A.M., King A., Laird G.K., Langford C.F.,
RA Leversha M.A., Lloyd C., Lloyd D.M., Martyn I.D., Mashreghi-Mohammadi M.,
RA Matthews L.H., Mccann O.T., Mcclay J., Mclaren S., McMurray A.A.,
RA Milne S.A., Mortimore B.J., Odell C.N., Pavitt R., Pearce A.V., Pearson D.,
RA Phillimore B.J.C.T., Phillips S.H., Plumb R.W., Ramsay H., Ramsey Y.,
RA Rogers L., Ross M.T., Scott C.E., Sehra H.K., Skuce C.D., Smalley S.,
RA Smith M.L., Soderlund C., Spragon L., Steward C.A., Sulston J.E.,
RA Swann R.M., Vaudin M., Wall M., Wallis J.M., Whiteley M.N., Willey D.L.,
RA Williams L., Williams S.A., Williamson H., Wilmer T.E., Wilming L.,
RA Wright C.L., Hubbard T., Bentley D.R., Beck S., Rogers J., Shimizu N.,
RA Minoshima S., Kawasaki K., Sasaki T., Asakawa S., Kudoh J., Shintani A.,
RA Shibuya K., Yoshizaki Y., Aoki N., Mitsuyama S., Roe B.A., Chen F., Chu L.,
RA Crabtree J., Deschamps S., Do A., Do T., Dorman A., Fang F., Fu Y., Hu P.,
RA Hua A., Kenton S., Lai H., Lao H.I., Lewis J., Lewis S., Lin S.-P., Loh P.,
RA Malaj E., Nguyen T., Pan H., Phan S., Qi S., Qian Y., Ray L., Ren Q.,
RA Shaull S., Sloan D., Song L., Wang Q., Wang Y., Wang Z., White J.,
RA Willingham D., Wu H., Yao Z., Zhan M., Zhang G., Chissoe S., Murray J.,
RA Miller N., Minx P., Fulton R., Johnson D., Bemis G., Bentley D.,
RA Bradshaw H., Bourne S., Cordes M., Du Z., Fulton L., Goela D., Graves T.,
RA Hawkins J., Hinds K., Kemp K., Latreille P., Layman D., Ozersky P.,
RA Rohlfing T., Scheet P., Walker C., Wamsley A., Wohldmann P., Pepin K.,
RA Nelson J., Korf I., Bedell J.A., Hillier L.W., Mardis E., Waterston R.,
RA Wilson R., Emanuel B.S., Shaikh T., Kurahashi H., Saitta S., Budarf M.L.,
RA McDermid H.E., Johnson A., Wong A.C.C., Morrow B.E., Edelmann L., Kim U.J.,
RA Shizuya H., Simon M.I., Dumanski J.P., Peyrard M., Kedra D., Seroussi E.,
RA Fransson I., Tapia I., Bruder C.E., O'Brien K.P., Wilkinson P.,
RA Bodenteich A., Hartman K., Hu X., Khan A.S., Lane L., Tilahun Y.,
RA Wright H.;
RT "The DNA sequence of human chromosome 22.";
RL Nature 402:489-495(1999).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP AUTOANTIBODIES.
RX PubMed=15289310; DOI=10.1158/0008-5472.can-03-0932;
RA Fernandez-Madrid F., Tang N., Alansari H., Granda J.L., Tait L.,
RA Amirikia K.C., Moroianu M., Wang X., Karvonen R.L.;
RT "Autoantibodies to annexin XI-A and other autoantigens in the diagnosis of
RT breast cancer.";
RL Cancer Res. 64:5089-5096(2004).
RN [6]
RP ERRATUM OF PUBMED:15289310.
RA Fernandez-Madrid F., Tang N., Alansari H., Granda J.L., Tait L.,
RA Amirikia K.C., Moroianu M., Wang X., Karvonen R.L.;
RL Cancer Res. 66:5526-5526(2006).
RN [7]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-79; SER-87; SER-88; SER-128;
RP SER-384; SER-508; SER-749; THR-1059; SER-1063; SER-1224; SER-1366;
RP SER-1441; SER-1488; SER-1757; SER-1760 AND SER-1786, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma;
RX PubMed=18669648; DOI=10.1073/pnas.0805139105;
RA Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,
RA Elledge S.J., Gygi S.P.;
RT "A quantitative atlas of mitotic phosphorylation.";
RL Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
RN [8]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1701, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Liver;
RX PubMed=18318008; DOI=10.1002/pmic.200700884;
RA Han G., Ye M., Zhou H., Jiang X., Feng S., Jiang X., Tian R., Wan D.,
RA Zou H., Gu J.;
RT "Large-scale phosphoproteome analysis of human liver tissue by enrichment
RT and fractionation of phosphopeptides with strong anion exchange
RT chromatography.";
RL Proteomics 8:1346-1361(2008).
RN [9]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=19413330; DOI=10.1021/ac9004309;
RA Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.;
RT "Lys-N and trypsin cover complementary parts of the phosphoproteome in a
RT refined SCX-based approach.";
RL Anal. Chem. 81:4493-4501(2009).
RN [10]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-92; THR-378; SER-384;
RP SER-458; SER-508; SER-749; SER-969; THR-1059; SER-1154; THR-1163; SER-1441;
RP SER-1488; SER-1701 AND SER-1786, AND IDENTIFICATION BY MASS SPECTROMETRY
RP [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma;
RX PubMed=20068231; DOI=10.1126/scisignal.2000475;
RA Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L.,
RA Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.;
RT "Quantitative phosphoproteomics reveals widespread full phosphorylation
RT site occupancy during mitosis.";
RL Sci. Signal. 3:RA3-RA3(2010).
RN [11]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-52; SER-56; SER-128; SER-284;
RP SER-366; SER-404; SER-508; SER-749; SER-981; THR-1179; THR-1185; SER-1224;
RP THR-1226; SER-1441; SER-1488; SER-1506; SER-1757 AND SER-1760, AND
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma;
RX PubMed=23186163; DOI=10.1021/pr300630k;
RA Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J.,
RA Mohammed S.;
RT "Toward a comprehensive characterization of a human cancer cell
RT phosphoproteome.";
RL J. Proteome Res. 12:260-271(2013).
RN [12]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-244; THR-600; SER-1555 AND
RP SER-1662, AND IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Liver;
RX PubMed=24275569; DOI=10.1016/j.jprot.2013.11.014;
RA Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L.,
RA Ye M., Zou H.;
RT "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver
RT phosphoproteome.";
RL J. Proteomics 96:253-262(2014).
CC -!- INTERACTION:
CC Q9BY89; Q00987: MDM2; NbExp=3; IntAct=EBI-8796741, EBI-389668;
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q9BY89-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q9BY89-2; Sequence=VSP_025337, VSP_025338;
CC -!- MISCELLANEOUS: Antibodies against KIAA1671 are present in sera from
CC patients with breast cancer who developed several autoantibodies.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAB33341.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AB051458; BAB33341.1; ALT_INIT; mRNA.
DR EMBL; AL022323; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; Z99916; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471095; EAW59684.1; -; Genomic_DNA.
DR EMBL; BC171801; AAI71801.1; -; mRNA.
DR CCDS; CCDS46676.1; -. [Q9BY89-1]
DR RefSeq; NP_001138678.1; NM_001145206.1. [Q9BY89-1]
DR RefSeq; XP_005261850.1; XM_005261793.2. [Q9BY89-1]
DR RefSeq; XP_005261851.1; XM_005261794.4. [Q9BY89-1]
DR RefSeq; XP_006724409.1; XM_006724346.2. [Q9BY89-1]
DR AlphaFoldDB; Q9BY89; -.
DR BioGRID; 124506; 174.
DR IntAct; Q9BY89; 55.
DR MINT; Q9BY89; -.
DR STRING; 9606.ENSP00000351207; -.
DR iPTMnet; Q9BY89; -.
DR PhosphoSitePlus; Q9BY89; -.
DR SwissPalm; Q9BY89; -.
DR BioMuta; KIAA1671; -.
DR DMDM; 147647261; -.
DR EPD; Q9BY89; -.
DR jPOST; Q9BY89; -.
DR MassIVE; Q9BY89; -.
DR MaxQB; Q9BY89; -.
DR PaxDb; Q9BY89; -.
DR PeptideAtlas; Q9BY89; -.
DR PRIDE; Q9BY89; -.
DR ProteomicsDB; 79603; -. [Q9BY89-1]
DR ProteomicsDB; 79604; -. [Q9BY89-2]
DR Antibodypedia; 5419; 12 antibodies from 8 providers.
DR DNASU; 85379; -.
DR Ensembl; ENST00000358431.8; ENSP00000351207.3; ENSG00000197077.14. [Q9BY89-1]
DR Ensembl; ENST00000401395.1; ENSP00000385377.1; ENSG00000197077.14. [Q9BY89-2]
DR Ensembl; ENST00000406486.8; ENSP00000385152.3; ENSG00000197077.14. [Q9BY89-1]
DR GeneID; 85379; -.
DR KEGG; hsa:85379; -.
DR MANE-Select; ENST00000358431.8; ENSP00000351207.3; NM_001145206.2; NP_001138678.1.
DR UCSC; uc003abl.4; human. [Q9BY89-1]
DR CTD; 85379; -.
DR GeneCards; KIAA1671; -.
DR HGNC; HGNC:29345; KIAA1671.
DR HPA; ENSG00000197077; Low tissue specificity.
DR neXtProt; NX_Q9BY89; -.
DR OpenTargets; ENSG00000197077; -.
DR PharmGKB; PA165378342; -.
DR VEuPathDB; HostDB:ENSG00000197077; -.
DR eggNOG; ENOG502QWAQ; Eukaryota.
DR GeneTree; ENSGT00940000154184; -.
DR HOGENOM; CLU_002443_0_0_1; -.
DR InParanoid; Q9BY89; -.
DR OMA; ADQSGHC; -.
DR OrthoDB; 490894at2759; -.
DR PhylomeDB; Q9BY89; -.
DR TreeFam; TF336029; -.
DR PathwayCommons; Q9BY89; -.
DR SignaLink; Q9BY89; -.
DR BioGRID-ORCS; 85379; 16 hits in 1065 CRISPR screens.
DR ChiTaRS; KIAA1671; human.
DR GenomeRNAi; 85379; -.
DR Pharos; Q9BY89; Tdark.
DR PRO; PR:Q9BY89; -.
DR Proteomes; UP000005640; Chromosome 22.
DR RNAct; Q9BY89; protein.
DR Bgee; ENSG00000197077; Expressed in upper arm skin and 188 other tissues.
DR ExpressionAtlas; Q9BY89; baseline and differential.
DR Genevisible; Q9BY89; HS.
DR InterPro; IPR032764; Tankyrase-bd_C.
DR InterPro; IPR040006; TNKS1BP1-like.
DR PANTHER; PTHR22042; PTHR22042; 1.
DR Pfam; PF15327; Tankyrase_bdg_C; 1.
DR SMART; SM01319; Tankyrase_bdg_C; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Phosphoprotein; Reference proteome.
FT CHAIN 1..1806
FT /note="Uncharacterized protein KIAA1671"
FT /id="PRO_0000287145"
FT REGION 38..131
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 158..282
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 299..320
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 355..431
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 456..604
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 627..696
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 860..901
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 969..989
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1000..1019
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1134..1178
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1216..1265
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1291..1493
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1512..1627
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1642..1806
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 81..95
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 386..402
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 487..503
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 510..527
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 528..550
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 663..678
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1000..1017
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1138..1168
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1240..1254
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1320..1335
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1371..1407
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1423..1439
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1463..1481
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1533..1592
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1648..1662
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1663..1711
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1774..1799
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 52
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:23186163"
FT MOD_RES 56
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:23186163"
FT MOD_RES 79
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:18669648"
FT MOD_RES 87
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:18669648"
FT MOD_RES 88
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:18669648"
FT MOD_RES 92
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:20068231"
FT MOD_RES 128
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:18669648,
FT ECO:0007744|PubMed:23186163"
FT MOD_RES 244
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:24275569"
FT MOD_RES 284
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:23186163"
FT MOD_RES 366
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:23186163"
FT MOD_RES 378
FT /note="Phosphothreonine"
FT /evidence="ECO:0007744|PubMed:20068231"
FT MOD_RES 384
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:18669648,
FT ECO:0007744|PubMed:20068231"
FT MOD_RES 404
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:23186163"
FT MOD_RES 458
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:20068231"
FT MOD_RES 508
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:18669648,
FT ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:23186163"
FT MOD_RES 600
FT /note="Phosphothreonine"
FT /evidence="ECO:0007744|PubMed:24275569"
FT MOD_RES 749
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:18669648,
FT ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:23186163"
FT MOD_RES 969
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:20068231"
FT MOD_RES 981
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:23186163"
FT MOD_RES 1059
FT /note="Phosphothreonine"
FT /evidence="ECO:0007744|PubMed:18669648,
FT ECO:0007744|PubMed:20068231"
FT MOD_RES 1063
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:18669648"
FT MOD_RES 1154
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:20068231"
FT MOD_RES 1163
FT /note="Phosphothreonine"
FT /evidence="ECO:0007744|PubMed:20068231"
FT MOD_RES 1179
FT /note="Phosphothreonine"
FT /evidence="ECO:0007744|PubMed:23186163"
FT MOD_RES 1185
FT /note="Phosphothreonine"
FT /evidence="ECO:0007744|PubMed:23186163"
FT MOD_RES 1224
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:18669648,
FT ECO:0007744|PubMed:23186163"
FT MOD_RES 1226
FT /note="Phosphothreonine"
FT /evidence="ECO:0007744|PubMed:23186163"
FT MOD_RES 1366
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:18669648"
FT MOD_RES 1441
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:18669648,
FT ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:23186163"
FT MOD_RES 1488
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:18669648,
FT ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:23186163"
FT MOD_RES 1506
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:23186163"
FT MOD_RES 1555
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:24275569"
FT MOD_RES 1662
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:24275569"
FT MOD_RES 1701
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:18318008,
FT ECO:0007744|PubMed:20068231"
FT MOD_RES 1757
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:18669648,
FT ECO:0007744|PubMed:23186163"
FT MOD_RES 1760
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:18669648,
FT ECO:0007744|PubMed:23186163"
FT MOD_RES 1786
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:18669648,
FT ECO:0007744|PubMed:20068231"
FT VAR_SEQ 1..1493
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:11258795"
FT /id="VSP_025337"
FT VAR_SEQ 1494..1510
FT /note="PWRSHSFCKDRRSGPFV -> MEYYYCPSLLKLLRYLW (in isoform
FT 2)"
FT /evidence="ECO:0000303|PubMed:11258795"
FT /id="VSP_025338"
FT CONFLICT 644
FT /note="R -> L (in Ref. 4; AAI71801)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 1806 AA; 196711 MW; 5120F319DCE33F5D CRC64;
MATRVEVGSI TPLTAVPGLG EMGKEETLTR TYFLQAGEAS GAPPARILEA KSPLRSPARL
LPLPRLAPKP FSKEQDVKSP VPSLRPSSTG PSPSGGLSEE PAAKDLDNRM PGLVGQEVGS
GEGPRTSSPL FNKAVFLRPS SSTMILFETT KSGPALGKAV SEGAEEAKLG VSGSRPEVAA
KPALPTQKPA GTLPRSAPLS QDTKPPVPQE EAGQDHPPSK ASSVEDTARP LVEPRPRLKR
RPVSAIFTES IQPQKPGPGA AATVGKVPPT PPEKTWVRKP RPLSMDLTAR FENKEALLRK
VADEGSGPTA GDMAGLERPR AASKLDRDCL VKAEAPLHDP DLDFLEVAKK IRERKEKMLS
KPEMGSPRAL VGGSSGVTPS NDQSPWEEKA KLDPEPEKAA ESPSPRLGRG LELAEVKSRV
ADGEAAAGGE WASRRSVRKC ISLFREDSTL ALAVGSESPL ATPASPSAAP EPEKGVVSVQ
ERIRGWTAES SEAKPEVRRR TFQARPLSAD LTKLFSSSAS SNEVKYEKSA ELSGEFPKEP
REKQKEGHSL DGACIPRSPW KPGTLRDKSR QTEQKVSSNQ DPDSCRGGSS VEAPCPSDVT
PEDDRSFQTV WATVFEHHVE RHTVADQSGR CLSTTPPGDM AHARVSEPRP RPEMGSWLGR
DPPDMTKLKK ENSRGFDNPE TEKLGPTTLL NGELRPYHTP LRDKYPLSEN HNNNTFLKHL
ENPPTSQRIE PRYDIVHAVG ERVHSEAISP APEEKAVTLR SLRSWLSLKD RQLSQEVTPA
DLECGLEGQA GSVQRASLIW EARGMPEASG PKFGGNCPFP KWTGGAVVSS HKATVAVSEE
HCAPGATSVR AIKAAIWESQ HEGPEGARSK PGVGARGPPQ GCPLDPLSRA TNGPSDSQAR
THPDAFAVQK GPFIVAAREG DPGPAQVPQP AVRMRKAGAM DQRMDRWRRR TLPPNVKFDT
FSSLVPEDSP HVGHRRTDYV SPTASALRKP QLSHYRVETQ EVNPGASRDQ TSPAVKQGSP
VEPKATFFAV TYQIPNTQKA KGVVLSGAES LLEHSRKITP PSSPHSLTST LVSLGHEEAL
EMAGSKNWMK GREHENASIL KTLKPTDRPS SLGAWSLDPF NGRIIDVDAL WSHRGSEDGP
RPQSNWKESA NKMSPSGGAP QTTPTLRSRP KDLPVRRKTD VISDTFPGKI RDGYRSSVLD
IDALMAEYQE LSLKVPGEAQ ERRSPTVEPS TLPRERPVQL GGVEQRRRSL KEMPDTGGLW
KPASSAEINH SFTPGLGKQL AETLETAMGT KSSPPFWALP PSAPSERYPG GSPIPADPRK
KTGFAEDDRK AFASKHHVAK CQNYLAESKP SGREDPGSGV RVSPKSPPTD QKKGTPRKST
GRGEEDSVAQ WGDHPRDCGR VPLDIKRAYS EKGPPANIRE GLSIMHEARE RRREQPKGRP
SLTGENLEAK MGPCWWESGT GDSHKVLPRD LEKEDAPQEK ERPLQQVSPV ASVPWRSHSF
CKDRRSGPFV DQLKQCFSRQ PTEPKDTDTL VHEAGSQYGT WTEQCQSGES LATESPDSSA
TSTRKQPPSS RLSSLSSQTE PTSAGDQYDC SRDQRSTSVD HSSTDLESTD GMEGPPPPDA
CPEKRVDDFS FIDQTSVLDS SALKTRVQLS KRSRRRAPIS HSLRRSRFSE SESRSPLEDE
TDNTWMFKDS TEEKSPRKEE SDEEETASKA ERTPVSHPQR MPAFPGMDPA VLKAQLHKRP
EVDSPGETPS WAPQPKSPKS PFQPGVLGSR VLPSSMDKDE RSDEPSPQWL KELKSKKRQS
LYENQV
