K1755_HUMAN
ID K1755_HUMAN Reviewed; 1200 AA.
AC Q5JYT7; Q9C0A8;
DT 05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 20-FEB-2007, sequence version 2.
DT 03-AUG-2022, entry version 117.
DE RecName: Full=Uncharacterized protein KIAA1755;
GN Name=KIAA1755;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=11780052; DOI=10.1038/414865a;
RA Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R.,
RA Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L.,
RA Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P.,
RA Bird C.P., Blakey S.E., Bridgeman A.M., Brown A.J., Buck D., Burrill W.D.,
RA Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G.,
RA Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E.,
RA Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D.,
RA Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P.,
RA Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E.,
RA Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J.,
RA Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D.,
RA Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S.,
RA Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D.,
RA Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A.,
RA Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T.,
RA Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I.,
RA Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M.,
RA Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D.,
RA Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M.,
RA Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A.,
RA Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L.,
RA Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L.,
RA Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.;
RT "The DNA sequence and comparative analysis of human chromosome 20.";
RL Nature 414:865-871(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 91-1200, AND VARIANTS ASN-339;
RP LYS-940 AND TRP-1045.
RX PubMed=11214970; DOI=10.1093/dnares/7.6.347;
RA Nagase T., Kikuno R., Hattori A., Kondo Y., Okumura K., Ohara O.;
RT "Prediction of the coding sequences of unidentified human genes. XIX. The
RT complete sequences of 100 new cDNA clones from brain which code for large
RT proteins in vitro.";
RL DNA Res. 7:347-355(2000).
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DR EMBL; AL031651; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471077; EAW76038.1; -; Genomic_DNA.
DR EMBL; AB051542; BAB21846.1; -; mRNA.
DR CCDS; CCDS33467.1; -.
DR RefSeq; NP_001025035.1; NM_001029864.1.
DR AlphaFoldDB; Q5JYT7; -.
DR SMR; Q5JYT7; -.
DR IntAct; Q5JYT7; 1.
DR STRING; 9606.ENSP00000279024; -.
DR iPTMnet; Q5JYT7; -.
DR PhosphoSitePlus; Q5JYT7; -.
DR BioMuta; KIAA1755; -.
DR DMDM; 166977309; -.
DR MassIVE; Q5JYT7; -.
DR PaxDb; Q5JYT7; -.
DR PeptideAtlas; Q5JYT7; -.
DR PRIDE; Q5JYT7; -.
DR ProteomicsDB; 63515; -.
DR Antibodypedia; 55264; 11 antibodies from 7 providers.
DR DNASU; 85449; -.
DR Ensembl; ENST00000279024.9; ENSP00000279024.4; ENSG00000149633.12.
DR GeneID; 85449; -.
DR KEGG; hsa:85449; -.
DR MANE-Select; ENST00000279024.9; ENSP00000279024.4; NM_001029864.2; NP_001025035.1.
DR UCSC; uc002xhy.2; human.
DR CTD; 85449; -.
DR DisGeNET; 85449; -.
DR GeneCards; KIAA1755; -.
DR HGNC; HGNC:29372; KIAA1755.
DR HPA; ENSG00000149633; Tissue enriched (brain).
DR neXtProt; NX_Q5JYT7; -.
DR OpenTargets; ENSG00000149633; -.
DR PharmGKB; PA162393181; -.
DR VEuPathDB; HostDB:ENSG00000149633; -.
DR eggNOG; KOG4240; Eukaryota.
DR GeneTree; ENSGT00940000161174; -.
DR HOGENOM; CLU_010854_0_0_1; -.
DR InParanoid; Q5JYT7; -.
DR OMA; HLHHFCK; -.
DR OrthoDB; 112611at2759; -.
DR PhylomeDB; Q5JYT7; -.
DR TreeFam; TF334329; -.
DR PathwayCommons; Q5JYT7; -.
DR SignaLink; Q5JYT7; -.
DR BioGRID-ORCS; 85449; 8 hits in 1068 CRISPR screens.
DR GenomeRNAi; 85449; -.
DR Pharos; Q5JYT7; Tdark.
DR PRO; PR:Q5JYT7; -.
DR Proteomes; UP000005640; Chromosome 20.
DR RNAct; Q5JYT7; protein.
DR Bgee; ENSG00000149633; Expressed in sural nerve and 133 other tissues.
DR ExpressionAtlas; Q5JYT7; baseline and differential.
DR Genevisible; Q5JYT7; HS.
PE 2: Evidence at transcript level;
KW Reference proteome.
FT CHAIN 1..1200
FT /note="Uncharacterized protein KIAA1755"
FT /id="PRO_0000317284"
FT REGION 282..302
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 323..372
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 392..491
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 510..568
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1056..1200
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 284..302
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 514..531
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1136..1150
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1159..1200
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VARIANT 339
FT /note="K -> N (in dbSNP:rs1205434)"
FT /evidence="ECO:0000269|PubMed:11214970"
FT /id="VAR_038501"
FT VARIANT 415
FT /note="P -> L (in dbSNP:rs6024235)"
FT /id="VAR_038502"
FT VARIANT 633
FT /note="A -> V (in dbSNP:rs16987188)"
FT /id="VAR_038503"
FT VARIANT 940
FT /note="E -> K (in dbSNP:rs760998)"
FT /evidence="ECO:0000269|PubMed:11214970"
FT /id="VAR_038504"
FT VARIANT 1045
FT /note="R -> W (in dbSNP:rs3746471)"
FT /evidence="ECO:0000269|PubMed:11214970"
FT /id="VAR_038505"
SQ SEQUENCE 1200 AA; 130846 MW; C43B5ABAFD00CFA1 CRC64;
MDPPSLDTAI QHALAGLYPP FEATAPTVLG QVFRLLDSGF QGDGLSFLLD FLIPAKRLCE
QVREAACAPY SHCLFLHEGW PLCLRDEVVV HLAPLNPLLL RQGDFYLQVE PQEEQSVCIM
IKCLSLDLCT VDKKPVPEPA YPILFTQEWL EAINSDFEGN PLHNCLVASE NGIAPVPWTK
ITSPEFVDDR PQVVNALCQA WGPLPLEALD LSSPQELHQA SSPDNQVLPA QSLAKGKGRT
YGSKYPGLIK VEQARCGEVA FRMDEVVSQD FEGDYVALLG FSQESRGESP SREAGTSSGC
TSGALEEIAG TKETPLFQKI LPLSEANEGP SLGNRACTKP ESSEERPYNL GFRRKVNLKA
PTHNSERPPQ GSYMNVLEDA LDCASGLRAG VSQEPAASKM QGPLGNPENM VQLRPGPRQA
SSPRLSPASP AAAASETKIE VKTKERNGRL PKPMPCPSRN TSSPEPPTPG LKFSFLRGQR
QPSVTPEKAS LQHNGPWKVL CSLYSPKPNR AKSLGKAGTT QTKTSGPATA PSPLTEEKAA
LPEASAGSPE RGPTLEEEPP GPEPRIGALG VKVFRSRIAC LPGGRDRAGR PLLLVSTTEG
AWEAPWCTVS EVTKLLSYLC TIPRPEDKAK GLAVLIDARR QPPQPGLVSA LQATQAQVPA
SIRAILFLGE KEAALQLQTL PDVQVEVLTS LKALSHHVDP SQLPAVLEGP FPYCHTEWVH
FFQKLDPFLA DLHQASSLLQ ASIEEFEKAD PPGGMQEATR CLSKSKELME AVLRDPGLLG
LQREGGATLA RLQHDASRLD FSPDVRSHLA AATALYSLVD EQLHVLVTAS NSLLGKLELR
VRLGRLEAAI HQVSDWMEQE GRRCLQSLTP KDGSLETVEK AHAEFENFFL QAAAQYRRGL
ELSKQAAQLG ATARGAGEAE RAEFPELAAF ASTQRAFQAE LTHFYMAAER QRTDLETLLH
LHRFCKRMTW FHMDCQDLMA QLRLDKTSRV SPGDQRRLHR YLQRLASEFP AEKLAAVGLQ
VASLSRAGLG QELWEEARIR HEEIRMLLEK ALTHSSCPEA PAAHSARPER RGVAAKGQGV
SVEVTSKGRW DQPPLDSLGM DHLPKSYWPP GPPRGEQNRT FQAGSPPQEA GQAAEAEDGK
GSHKLPDPAR EHLLATTFFR QQPPRQSQVP RLTGGSFSSE GTDSQTSLED SPQTSPLASL
