K1958_HUMAN
ID K1958_HUMAN Reviewed; 716 AA.
AC Q8N8K9; B7ZKW6; Q2M336; Q5T252; Q8TF43; Q96N02;
DT 16-AUG-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2002, sequence version 1.
DT 03-AUG-2022, entry version 138.
DE RecName: Full=Uncharacterized protein KIAA1958;
GN Name=KIAA1958;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Brain, and Teratocarcinoma;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15164053; DOI=10.1038/nature02465;
RA Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L.,
RA Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R.,
RA Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S.,
RA Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K.,
RA Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y.,
RA Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C.,
RA Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E.,
RA Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M.,
RA Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J.,
RA Frankish A., Frankland J.A., French L., Fricker D.G., Garner P.,
RA Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S.,
RA Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E.,
RA Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D.,
RA Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E.,
RA Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K.,
RA Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S.,
RA Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J.,
RA Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E.,
RA McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V.,
RA Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S.,
RA Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K.,
RA Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J.,
RA Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M.,
RA West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L.,
RA Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M.,
RA Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J.,
RA Dunham I.;
RT "DNA sequence and analysis of human chromosome 9.";
RL Nature 429:369-374(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3).
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 110-716 (ISOFORM 1).
RX PubMed=11853319; DOI=10.1093/dnares/8.6.319;
RA Nagase T., Kikuno R., Ohara O.;
RT "Prediction of the coding sequences of unidentified human genes. XXII. The
RT complete sequences of 50 new cDNA clones which code for large proteins.";
RL DNA Res. 8:319-327(2001).
RN [5]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-97, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Leukemic T-cell;
RX PubMed=19690332; DOI=10.1126/scisignal.2000007;
RA Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,
RA Rodionov V., Han D.K.;
RT "Quantitative phosphoproteomic analysis of T cell receptor signaling
RT reveals system-wide modulation of protein-protein interactions.";
RL Sci. Signal. 2:RA46-RA46(2009).
RN [6]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma;
RX PubMed=23186163; DOI=10.1021/pr300630k;
RA Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J.,
RA Mohammed S.;
RT "Toward a comprehensive characterization of a human cancer cell
RT phosphoproteome.";
RL J. Proteome Res. 12:260-271(2013).
RN [7]
RP SUMOYLATION [LARGE SCALE ANALYSIS] AT LYS-201; LYS-204; LYS-237; LYS-283
RP AND LYS-626, AND IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE
RP ANALYSIS].
RX PubMed=28112733; DOI=10.1038/nsmb.3366;
RA Hendriks I.A., Lyon D., Young C., Jensen L.J., Vertegaal A.C.,
RA Nielsen M.L.;
RT "Site-specific mapping of the human SUMO proteome reveals co-modification
RT with phosphorylation.";
RL Nat. Struct. Mol. Biol. 24:325-336(2017).
CC -!- INTERACTION:
CC Q8N8K9; P29972: AQP1; NbExp=3; IntAct=EBI-10181113, EBI-745213;
CC Q8N8K9; Q96LK0: CEP19; NbExp=3; IntAct=EBI-10181113, EBI-741885;
CC Q8N8K9; Q13057-2: COASY; NbExp=3; IntAct=EBI-10181113, EBI-10227704;
CC Q8N8K9; Q9H5Z6: FAM124B; NbExp=3; IntAct=EBI-10181113, EBI-741626;
CC Q8N8K9; P60520: GABARAPL2; NbExp=7; IntAct=EBI-10181113, EBI-720116;
CC Q8N8K9; P61968: LMO4; NbExp=6; IntAct=EBI-10181113, EBI-2798728;
CC Q8N8K9; Q96EZ8: MCRS1; NbExp=3; IntAct=EBI-10181113, EBI-348259;
CC Q8N8K9; P57060: RWDD2B; NbExp=3; IntAct=EBI-10181113, EBI-724442;
CC Q8N8K9; O14543: SOCS3; NbExp=6; IntAct=EBI-10181113, EBI-714146;
CC Q8N8K9; Q8WUK8: STAC; NbExp=3; IntAct=EBI-10181113, EBI-10276615;
CC Q8N8K9; Q99469: STAC; NbExp=3; IntAct=EBI-10181113, EBI-2652799;
CC Q8N8K9; Q15560: TCEA2; NbExp=6; IntAct=EBI-10181113, EBI-710310;
CC Q8N8K9; Q8N8B7-2: TCEANC; NbExp=3; IntAct=EBI-10181113, EBI-11955057;
CC Q8N8K9; O43422: THAP12; NbExp=3; IntAct=EBI-10181113, EBI-2828217;
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=1;
CC IsoId=Q8N8K9-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8N8K9-2; Sequence=VSP_015146;
CC Name=3;
CC IsoId=Q8N8K9-3; Sequence=VSP_054654;
CC -!- SEQUENCE CAUTION:
CC Sequence=BAB71114.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AK096613; BAC04827.1; -; mRNA.
DR EMBL; AK056181; BAB71114.1; ALT_INIT; mRNA.
DR EMBL; AL162732; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL390067; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL445187; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC105048; AAI05049.1; -; mRNA.
DR EMBL; BC113515; AAI13516.1; -; mRNA.
DR EMBL; BC143424; AAI43425.1; -; mRNA.
DR EMBL; AB075838; BAB85544.1; -; mRNA.
DR CCDS; CCDS35108.1; -. [Q8N8K9-1]
DR CCDS; CCDS69642.1; -. [Q8N8K9-3]
DR RefSeq; NP_001273965.1; NM_001287036.1. [Q8N8K9-3]
DR RefSeq; NP_001273967.1; NM_001287038.1.
DR RefSeq; NP_597722.1; NM_133465.3. [Q8N8K9-1]
DR RefSeq; XP_011516613.1; XM_011518311.2. [Q8N8K9-2]
DR AlphaFoldDB; Q8N8K9; -.
DR BioGRID; 127680; 18.
DR IntAct; Q8N8K9; 15.
DR STRING; 9606.ENSP00000440504; -.
DR iPTMnet; Q8N8K9; -.
DR PhosphoSitePlus; Q8N8K9; -.
DR BioMuta; KIAA1958; -.
DR DMDM; 73621119; -.
DR EPD; Q8N8K9; -.
DR jPOST; Q8N8K9; -.
DR MassIVE; Q8N8K9; -.
DR MaxQB; Q8N8K9; -.
DR PaxDb; Q8N8K9; -.
DR PeptideAtlas; Q8N8K9; -.
DR PRIDE; Q8N8K9; -.
DR ProteomicsDB; 7199; -.
DR ProteomicsDB; 72432; -. [Q8N8K9-1]
DR ProteomicsDB; 72433; -. [Q8N8K9-2]
DR Antibodypedia; 15233; 38 antibodies from 14 providers.
DR DNASU; 158405; -.
DR Ensembl; ENST00000337530.11; ENSP00000336940.6; ENSG00000165185.15. [Q8N8K9-1]
DR Ensembl; ENST00000374244.3; ENSP00000363362.3; ENSG00000165185.15. [Q8N8K9-2]
DR Ensembl; ENST00000536272.5; ENSP00000440504.1; ENSG00000165185.15. [Q8N8K9-3]
DR GeneID; 158405; -.
DR KEGG; hsa:158405; -.
DR MANE-Select; ENST00000337530.11; ENSP00000336940.6; NM_133465.4; NP_597722.1.
DR UCSC; uc004bgf.3; human. [Q8N8K9-1]
DR CTD; 158405; -.
DR DisGeNET; 158405; -.
DR GeneCards; KIAA1958; -.
DR HGNC; HGNC:23427; KIAA1958.
DR HPA; ENSG00000165185; Tissue enhanced (brain).
DR MIM; 617390; gene.
DR neXtProt; NX_Q8N8K9; -.
DR OpenTargets; ENSG00000165185; -.
DR PharmGKB; PA134937806; -.
DR VEuPathDB; HostDB:ENSG00000165185; -.
DR eggNOG; KOG3612; Eukaryota.
DR GeneTree; ENSGT00440000039527; -.
DR HOGENOM; CLU_022431_0_0_1; -.
DR InParanoid; Q8N8K9; -.
DR OMA; YWCMTKG; -.
DR OrthoDB; 1347426at2759; -.
DR PhylomeDB; Q8N8K9; -.
DR TreeFam; TF332895; -.
DR PathwayCommons; Q8N8K9; -.
DR SignaLink; Q8N8K9; -.
DR BioGRID-ORCS; 158405; 11 hits in 1082 CRISPR screens.
DR ChiTaRS; KIAA1958; human.
DR GeneWiki; KIAA1958; -.
DR GenomeRNAi; 158405; -.
DR Pharos; Q8N8K9; Tdark.
DR PRO; PR:Q8N8K9; -.
DR Proteomes; UP000005640; Chromosome 9.
DR RNAct; Q8N8K9; protein.
DR Bgee; ENSG00000165185; Expressed in inferior vagus X ganglion and 161 other tissues.
DR Genevisible; Q8N8K9; HS.
DR InterPro; IPR021893; DUF3504.
DR InterPro; IPR042838; KIAA1958.
DR PANTHER; PTHR46963; PTHR46963; 1.
DR Pfam; PF12012; DUF3504; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Isopeptide bond; Phosphoprotein; Reference proteome;
KW Ubl conjugation.
FT CHAIN 1..716
FT /note="Uncharacterized protein KIAA1958"
FT /id="PRO_0000050811"
FT REGION 84..103
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 153..189
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 84..99
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 97
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:19690332"
FT CROSSLNK 201
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO2)"
FT /evidence="ECO:0007744|PubMed:28112733"
FT CROSSLNK 204
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO2)"
FT /evidence="ECO:0007744|PubMed:28112733"
FT CROSSLNK 237
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO2)"
FT /evidence="ECO:0007744|PubMed:28112733"
FT CROSSLNK 283
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO2)"
FT /evidence="ECO:0007744|PubMed:28112733"
FT CROSSLNK 626
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO2)"
FT /evidence="ECO:0007744|PubMed:28112733"
FT VAR_SEQ 390..391
FT /note="PA -> PDQDERAAELSREQNEKTIRSTQTALRNFP (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_054654"
FT VAR_SEQ 391..716
FT /note="AYSTKLNKFPVFNINDDLNDLCTSAVSPNTTKATRYALNVWRYWCMTNGLKD
FT HTDITKIPAVKLNELLENFYVTVKKSDGSDFLATSLHAIRRGLDRILKNAGVGFSITSS
FT TFSSSTKKLKEKLWVLSKAGMSGARSRNIVYFSLSDEEEMWQAGCLGDDSPITLLSTVV
FT KYNSQYLNMRTLQEHADLMYGDIELLKDPQNQPYFARTDSVKRESRSGSTRVCHGKIYH
FT EHSRGHKQCPYCLLYKYMYIHRPPTQMEAKSPFYLTARKEATDMGSVWYEEQRMGLRSL
FT RGIVPNLAKKVKLENCENFTFVSFTQVSRRLGSHSCCQ -> DQDERAAELSREQNEKT
FT IRSTQTALRNFREFLISKYPSETREIYVIPCKELDAYLASFFVDARQKDGSEYEPNSLA
FT NYQCGLERYLKEHRYGYSITRDKEFKRSQEALKQKQIELRCKGKGNKPHKSMKLTFADE
FT LILRKRGLLSRYNPEGLLNLVWLNNTKAFGHCTGFHGSTLKWGDIRLRVTETGLEYLEW
FT MGQDTGDLNAKTKRGGTDSRVYATQHAPQTCPVQDYKEYAQRRPPAMRYEDAPFYLSIK
FT PVVNLAALHWYNCQALGKNKLAKMVKTMCEKGNIPGRKTNFSVYQSCSTLSEAQSNQLV
FT LICNNLSQQAAQSVAGHSNNGNFIVSASYDSSSDTA (in isoform 2)"
FT /evidence="ECO:0000305"
FT /id="VSP_015146"
FT CONFLICT 541
FT /note="M -> V (in Ref. 1; BAB71114)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 716 AA; 79212 MW; AA5FD94A98446863 CRC64;
MEDCLHTSSE NLSKLVSWAH SHGTICSLIP NLKHLLSEGS HGNLTAMWGC SAGHAYHWPL
TATCRAGSQE RVCFQDNRSF NSDSPSIIGV PSETQTSPVE RYPGRPVKAK LDCNRTRDSC
DFSYCSEPSE LDETVEEYED ENTLFDMVCE SSVTDEDSDF EPQTQRPQSI ARKRPGVVPS
SLHSSSQTQM VDECSNDVII KKIKQEIPED YYIVANAELT GGVDGPALSL TQMAKPKPQT
HAGPSCVGSA KLIPHVTSAI STELDPHGMS ASPSVISRPI VQKTARVSLA SPNRGPPGTH
GTNQQVAMQM PVSTSHPNKQ ISIPLSALQL PGQDEQVASE EFLSHLPSQV SSCEVALSPS
VNTEPEVSSS QQQPPVAPAI TTEATAQCIP AYSTKLNKFP VFNINDDLND LCTSAVSPNT
TKATRYALNV WRYWCMTNGL KDHTDITKIP AVKLNELLEN FYVTVKKSDG SDFLATSLHA
IRRGLDRILK NAGVGFSITS STFSSSTKKL KEKLWVLSKA GMSGARSRNI VYFSLSDEEE
MWQAGCLGDD SPITLLSTVV KYNSQYLNMR TLQEHADLMY GDIELLKDPQ NQPYFARTDS
VKRESRSGST RVCHGKIYHE HSRGHKQCPY CLLYKYMYIH RPPTQMEAKS PFYLTARKEA
TDMGSVWYEE QRMGLRSLRG IVPNLAKKVK LENCENFTFV SFTQVSRRLG SHSCCQ
