K1958_MOUSE
ID K1958_MOUSE Reviewed; 716 AA.
AC Q8C4P0; B1AX79; Q8BN62; Q8K1X8;
DT 16-AUG-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 03-AUG-2022, entry version 108.
DE RecName: Full=Uncharacterized protein KIAA1958 homolog;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC STRAIN=C57BL/6J; TISSUE=Eye, and Head;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC STRAIN=FVB/N-3; TISSUE=Mammary gland;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q8C4P0-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8C4P0-2; Sequence=VSP_015147;
CC -!- SEQUENCE CAUTION:
CC Sequence=BAC39905.1; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; AK081604; BAC38268.1; -; mRNA.
DR EMBL; AK087509; BAC39905.1; ALT_FRAME; mRNA.
DR EMBL; AL806512; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC037070; AAH37070.1; -; mRNA.
DR CCDS; CCDS18223.1; -. [Q8C4P0-1]
DR CCDS; CCDS18224.1; -. [Q8C4P0-2]
DR RefSeq; NP_001015681.1; NM_001015681.2. [Q8C4P0-1]
DR RefSeq; NP_694798.1; NM_153158.5. [Q8C4P0-2]
DR RefSeq; XP_006537923.1; XM_006537860.2. [Q8C4P0-2]
DR RefSeq; XP_006537924.1; XM_006537861.2. [Q8C4P0-2]
DR AlphaFoldDB; Q8C4P0; -.
DR iPTMnet; Q8C4P0; -.
DR PhosphoSitePlus; Q8C4P0; -.
DR PRIDE; Q8C4P0; -.
DR Antibodypedia; 15233; 38 antibodies from 14 providers.
DR DNASU; 230259; -.
DR Ensembl; ENSMUST00000052420; ENSMUSP00000062493; ENSMUSG00000045071. [Q8C4P0-2]
DR Ensembl; ENSMUST00000070150; ENSMUSP00000065702; ENSMUSG00000045071. [Q8C4P0-1]
DR GeneID; 230259; -.
DR KEGG; mmu:230259; -.
DR UCSC; uc008taa.2; mouse. [Q8C4P0-2]
DR UCSC; uc008tab.2; mouse. [Q8C4P0-1]
DR MGI; MGI:2442164; E130308A19Rik.
DR VEuPathDB; HostDB:ENSMUSG00000045071; -.
DR GeneTree; ENSGT00440000039527; -.
DR HOGENOM; CLU_022431_0_0_1; -.
DR InParanoid; Q8C4P0; -.
DR OMA; YWCMTKG; -.
DR OrthoDB; 1347426at2759; -.
DR PhylomeDB; Q8C4P0; -.
DR TreeFam; TF332895; -.
DR BioGRID-ORCS; 230259; 1 hit in 71 CRISPR screens.
DR PRO; PR:Q8C4P0; -.
DR Proteomes; UP000000589; Chromosome 4.
DR RNAct; Q8C4P0; protein.
DR Bgee; ENSMUSG00000045071; Expressed in otolith organ and 222 other tissues.
DR ExpressionAtlas; Q8C4P0; baseline and differential.
DR Genevisible; Q8C4P0; MM.
DR InterPro; IPR021893; DUF3504.
DR InterPro; IPR042838; KIAA1958.
DR PANTHER; PTHR46963; PTHR46963; 1.
DR Pfam; PF12012; DUF3504; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Isopeptide bond; Phosphoprotein; Reference proteome;
KW Ubl conjugation.
FT CHAIN 1..716
FT /note="Uncharacterized protein KIAA1958 homolog"
FT /id="PRO_0000050812"
FT REGION 84..103
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 153..189
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 84..99
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 97
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q8N8K9"
FT CROSSLNK 201
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO2)"
FT /evidence="ECO:0000250|UniProtKB:Q8N8K9"
FT CROSSLNK 204
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO2)"
FT /evidence="ECO:0000250|UniProtKB:Q8N8K9"
FT CROSSLNK 237
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO2)"
FT /evidence="ECO:0000250|UniProtKB:Q8N8K9"
FT CROSSLNK 283
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO2)"
FT /evidence="ECO:0000250|UniProtKB:Q8N8K9"
FT CROSSLNK 626
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO2)"
FT /evidence="ECO:0000250|UniProtKB:Q8N8K9"
FT VAR_SEQ 391..716
FT /note="AYSTKLNKFPVFNINDDLNGLCTSAVSPNTTKATRYALNVWRYWCMTNGLKD
FT HTDITKIPAVKLNELLENFYVTVKKSDGSDFLATSLHAIRRGLDRILKNAGVGFSITSS
FT TFSSSTKKLKEKLWVLSKAGMSGARSRNIVYFSLSDEEEMWQAGCLGDDSPITLLSTVV
FT KYNSQYLNMRTLQEHADLMYGDIELLKDPQNQPYFARTDSVKRESRSGSTRVCHGKIYH
FT EHSRGHKQCPYCLLYKYMYIHRPPTQMEAKSPFYLTARKEATDMGSVWYEEQRMGLRSL
FT RGIVPNLARKVKLENCENFTFVSFTQVSRRLGSHSCCQ -> DQDERAAELSREQNEKT
FT IRSTQTALRNFREFLISKYPSETREIYVIPCKELDAYLASFFVDARQKDGSEYEPNSLA
FT NYQCGLERYLKEHRYGYSITRDKEFKRSQEALKQKQIELRCKGKGNKPHKSMKLTFADE
FT LILRKRGLLSRYNPEGLLNLVWLNNTKAFGHCTGFHGSTLKWGDIRLRVTETGLEYLEW
FT IGQDTGDLNAKTKRGGTDSRVYATQHAPQTCPVQDYKEYAQRRPPAMRYEDAPFYLSIK
FT PVVNLAALHWYNCQALGKNKLAKMVKTMCEKGNIPGRKTNFSVYQSCSTLSEAQSNQLV
FT LICNNLSQQAAQSVAGHSSSGNFIVSSYDSSSDTA (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_015147"
SQ SEQUENCE 716 AA; 79148 MW; BAA5D800598FE859 CRC64;
MEDCLHTSSE NLSKLVSWAH SHGTICSLIP NLKHLLSEGS HGNLTAMWGC SAGHAYHWPL
TATCRAGSQE RVCFQDNRSF NSDSPSIIGV PSETQTSPVE RYPGRPVKAK LDCNRTRDSC
DFSYCSEPSE LDEAVEEYED ENTLFDMVCE SSVTDEDSDF EPQTQRPQSI ARKRPGIVPS
SIHSSSQGQM VDECSNDVII KKIKQEIPED YYIVANAELT GGVDGPALSL TQMAKPKPQT
HAGPSCVGSA KLIPHVTSAI NTELDPHILS ASPSVISRPI IPKTARVSLA SPNRGPPGAH
GTAHQVTMQM PVSTSHPNKQ ISIPLSALQL PGQDEQVASE EFLPHLPSQV SSCEVALSPS
VNTEPEVSSS QQQPPAAPTI TTEATAQCIP AYSTKLNKFP VFNINDDLNG LCTSAVSPNT
TKATRYALNV WRYWCMTNGL KDHTDITKIP AVKLNELLEN FYVTVKKSDG SDFLATSLHA
IRRGLDRILK NAGVGFSITS STFSSSTKKL KEKLWVLSKA GMSGARSRNI VYFSLSDEEE
MWQAGCLGDD SPITLLSTVV KYNSQYLNMR TLQEHADLMY GDIELLKDPQ NQPYFARTDS
VKRESRSGST RVCHGKIYHE HSRGHKQCPY CLLYKYMYIH RPPTQMEAKS PFYLTARKEA
TDMGSVWYEE QRMGLRSLRG IVPNLARKVK LENCENFTFV SFTQVSRRLG SHSCCQ
