K199B_MOUSE
ID K199B_MOUSE Reviewed; 58 AA.
AC Q99NG9; Q80VT9;
DT 16-DEC-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 85.
DE RecName: Full=Keratin-associated protein 19-9b;
DE AltName: Full=High-glycine/tyrosine protein type I E5 {ECO:0000312|EMBL:AAK07673.1};
DE AltName: Full=Keratin-associated protein 16-10-like;
DE AltName: Full=Keratin-associated protein 16-10b;
GN Name=Krtap19-9b; Synonyms=Krtap16-10b, Krtap16.10L;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1] {ECO:0000312|EMBL:AAK07673.1}
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=C3H/HeN {ECO:0000312|EMBL:AAK07673.1};
RC TISSUE=Skin {ECO:0000312|EMBL:AAK07673.1};
RA Fujiwara K., Poirier C., Hattori A., Noro C., Yoshiki A., Kusakabe M.;
RT "cDNA cloning of a new member of mouse high-glycine/tyrosine protein.";
RL Submitted (JAN-2001) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000312|EMBL:BAC39767.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J {ECO:0000312|EMBL:BAC39767.1};
RC TISSUE=Lung {ECO:0000312|EMBL:BAC39767.1};
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [3] {ECO:0000312|EMBL:AAK07673.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [4] {ECO:0000312|EMBL:AAI19614.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP INDUCTION BY HOXC13.
RC STRAIN=FVB/NJ; TISSUE=Skin;
RX PubMed=15385554; DOI=10.1074/jbc.m404331200;
RA Pruett N.D., Tkatchenko T.V., Jave-Suarez L., Jacobs D.F., Potter C.S.,
RA Tkatchenko A.V., Schweizer J., Awgulewitsch A.;
RT "Krtap16, characterization of a new hair keratin-associated protein (KAP)
RT gene complex on mouse chromosome 16 and evidence for regulation by
RT Hoxc13.";
RL J. Biol. Chem. 279:51524-51533(2004).
RN [6] {ECO:0000305}
RP INDUCTION.
RX PubMed=17151017; DOI=10.1242/dev.02721;
RA Kurek D., Garinis G.A., van Doorninck J.H., van der Wees J., Grosveld F.G.;
RT "Transcriptome and phenotypic analysis reveals Gata3-dependent signalling
RT pathways in murine hair follicles.";
RL Development 134:261-272(2007).
CC -!- FUNCTION: In the hair cortex, hair keratin intermediate filaments are
CC embedded in an interfilamentous matrix, consisting of hair keratin-
CC associated proteins (KRTAP), which are essential for the formation of a
CC rigid and resistant hair shaft through their extensive disulfide bond
CC cross-linking with abundant cysteine residues of hair keratins. The
CC matrix proteins include the high-sulfur and high-glycine-tyrosine
CC keratins. {ECO:0000305}.
CC -!- SUBUNIT: Interacts with hair keratins. {ECO:0000250}.
CC -!- INDUCTION: Expression in skin and hair follicle is regulated by HOXC13
CC and by GATA3. {ECO:0000250|UniProtKB:Q925H6,
CC ECO:0000269|PubMed:15385554, ECO:0000269|PubMed:17151017}.
CC -!- SIMILARITY: Belongs to the KRTAP type 19 family. {ECO:0000305}.
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DR EMBL; AY026312; AAK07673.1; -; mRNA.
DR EMBL; AK086935; BAC39767.1; -; mRNA.
DR EMBL; CH466521; EDK98369.1; -; Genomic_DNA.
DR EMBL; BC119613; AAI19614.1; -; mRNA.
DR EMBL; BC119614; AAI19615.1; -; mRNA.
DR CCDS; CCDS49896.1; -.
DR RefSeq; NP_579937.1; NM_133359.2.
DR AlphaFoldDB; Q99NG9; -.
DR STRING; 10090.ENSMUSP00000076896; -.
DR PaxDb; Q99NG9; -.
DR PRIDE; Q99NG9; -.
DR DNASU; 170939; -.
DR Ensembl; ENSMUST00000077715; ENSMUSP00000076896; ENSMUSG00000057174.
DR GeneID; 170939; -.
DR KEGG; mmu:170939; -.
DR UCSC; uc007zvm.1; mouse.
DR CTD; 170939; -.
DR MGI; MGI:2181750; Krtap19-9b.
DR VEuPathDB; HostDB:ENSMUSG00000057174; -.
DR GeneTree; ENSGT00860000135680; -.
DR HOGENOM; CLU_184630_3_0_1; -.
DR OMA; FYARYWS; -.
DR BioGRID-ORCS; 170939; 2 hits in 73 CRISPR screens.
DR PRO; PR:Q99NG9; -.
DR Proteomes; UP000000589; Chromosome 16.
DR RNAct; Q99NG9; protein.
DR Bgee; ENSMUSG00000057174; Expressed in lip and 6 other tissues.
DR Genevisible; Q99NG9; MM.
DR GO; GO:0005882; C:intermediate filament; IEA:UniProtKB-KW.
PE 2: Evidence at transcript level;
KW Keratin; Reference proteome; Repeat.
FT CHAIN 1..58
FT /note="Keratin-associated protein 19-9b"
FT /id="PRO_0000356211"
FT REGION 6..52
FT /note="12 X 2 AA repeats of G-[YCGS]"
FT /evidence="ECO:0000255"
SQ SEQUENCE 58 AA; 6031 MW; 6FD440F5F9918C09 CRC64;
MSYYYGNYYG GLGYGLGGFG GFGGLGYGYG SSYGLGGYGG YGYFSPSFYG GYLSSGFY
