ID   K1B_METSE               Reviewed;          36 AA.
AC   P11495;
DT   01-OCT-1989, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1989, sequence version 1.
DT   25-MAY-2022, entry version 68.
DE   RecName: Full=U-metritoxin-Msn1a {ECO:0000303|PubMed:22683676};
DE            Short=U-MTTX-Msn1a {ECO:0000303|PubMed:22683676};
DE   AltName: Full=Metridin {ECO:0000303|Ref.1};
OS   Metridium senile (Brown sea anemone) (Frilled sea anemone).
OC   Eukaryota; Metazoa; Cnidaria; Anthozoa; Hexacorallia; Actiniaria;
OC   Nynantheae; Metridiidae; Metridium.
OX   NCBI_TaxID=6116;
RN   [1]
RP   PROTEIN SEQUENCE, AND FUNCTION.
RC   TISSUE=Nematoblast;
RA   Krebs H.C., Habermehl G.G.;
RT   "Isolation and structural determination of a hemolytic active peptide from
RT   the sea anemone Metridium senile.";
RL   Naturwissenschaften 74:395-396(1987).
RN   [2]
RP   NOMENCLATURE.
RX   PubMed=22683676; DOI=10.1016/j.toxicon.2012.05.020;
RA   Oliveira J.S., Fuentes-Silva D., King G.F.;
RT   "Development of a rational nomenclature for naming peptide and protein
RT   toxins from sea anemones.";
RL   Toxicon 60:539-550(2012).
CC   -!- FUNCTION: Has hemolytic activity (Ref.1). Inhibits voltage-gated
CC       potassium channels (Kv1/KCNA) (By similarity).
CC       {ECO:0000250|UniProtKB:P29186, ECO:0000269|Ref.1}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:C0HJC2}.
CC       Nematocyst {ECO:0000250|UniProtKB:C0HJC2}.
CC   -!- SIMILARITY: Belongs to the sea anemone type 1 potassium channel toxin
CC       family. Type 1b subfamily. {ECO:0000305}.
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DR   PIR; A27222; A27222.
DR   AlphaFoldDB; P11495; -.
DR   SMR; P11495; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0042151; C:nematocyst; IEA:UniProtKB-SubCell.
DR   GO; GO:0015459; F:potassium channel regulator activity; IEA:UniProtKB-KW.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR   GO; GO:0044179; P:hemolysis in another organism; IEA:UniProtKB-KW.
DR   InterPro; IPR003582; ShKT_dom.
DR   PROSITE; PS51670; SHKT; 1.
PE   1: Evidence at protein level;
KW   Cytolysis; Direct protein sequencing; Disulfide bond; Hemolysis;
KW   Ion channel impairing toxin; Nematocyst; Neurotoxin;
KW   Potassium channel impairing toxin; Secreted; Toxin;
KW   Voltage-gated potassium channel impairing toxin.
FT   PEPTIDE         1..36
FT                   /note="U-metritoxin-Msn1a"
FT                   /evidence="ECO:0000269|Ref.1"
FT                   /id="PRO_0000044862"
FT   DOMAIN          4..36
FT                   /note="ShKT"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01005"
FT   DISULFID        4..36
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01005"
FT   DISULFID        11..28
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01005"
FT   DISULFID        19..32
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01005"
SQ   SEQUENCE   36 AA;  3974 MW;  5ED9CC73509E007F CRC64;
     DSDCKDKLPA CGEYRGSFCK LEKVKSNCEK TCGVKC