K1C13_RAT
ID K1C13_RAT Reviewed; 438 AA.
AC Q6IFV4;
DT 22-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 03-AUG-2022, entry version 109.
DE RecName: Full=Keratin, type I cytoskeletal 13;
DE AltName: Full=Cytokeratin-13;
DE Short=CK-13;
DE AltName: Full=Keratin-13;
DE Short=K13;
DE AltName: Full=Type I keratin Ka13;
GN Name=Krt13 {ECO:0000250|UniProtKB:P13646};
GN Synonyms=Ka13 {ECO:0000312|EMBL:DAA04478.1};
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1] {ECO:0000305}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Brown Norway {ECO:0000269|PubMed:15057822};
RX PubMed=15057822; DOI=10.1038/nature02426;
RA Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J.,
RA Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G.,
RA Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G.,
RA Morgan M., Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G.,
RA Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S.,
RA Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T.,
RA Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D.,
RA Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L.,
RA Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D.,
RA Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M.,
RA Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C.,
RA Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J.,
RA Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H.,
RA Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X.,
RA Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q.,
RA Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P.,
RA Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A.,
RA Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C.,
RA Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J.,
RA Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J.,
RA Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F.,
RA Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A.,
RA Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A.,
RA Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J.,
RA Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E.,
RA Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M.,
RA Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C.,
RA Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L.,
RA Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W.,
RA Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y.,
RA Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V.,
RA Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M.,
RA Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S.,
RA Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B.,
RA Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R.,
RA Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J.,
RA Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D.,
RA Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S.,
RA Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S.,
RA Mockrin S., Collins F.S.;
RT "Genome sequence of the Brown Norway rat yields insights into mammalian
RT evolution.";
RL Nature 428:493-521(2004).
RN [2] {ECO:0000305, ECO:0000312|EMBL:DAA04478.1}
RP IDENTIFICATION.
RC STRAIN=Brown Norway {ECO:0000312|EMBL:DAA04478.1};
RX PubMed=15085952; DOI=10.1078/0171-9335-00354;
RA Hesse M., Zimek A., Weber K., Magin T.M.;
RT "Comprehensive analysis of keratin gene clusters in humans and rodents.";
RL Eur. J. Cell Biol. 83:19-26(2004).
CC -!- FUNCTION: Type 1 keratin (Probable). Maintains postnatal tongue mucosal
CC cell homeostasis and tissue organization in response to mechanical
CC stress, potentially via regulation of the G1/S phase cyclins CCNE1 and
CC CCNE2 (By similarity). {ECO:0000250|UniProtKB:P08730, ECO:0000305}.
CC -!- SUBUNIT: Heterotetramer of two type I and two type II keratins.
CC {ECO:0000305}.
CC -!- PTM: O-glycosylated; glycans consist of single N-acetylglucosamine
CC residues. {ECO:0000250|UniProtKB:P13646}.
CC -!- MISCELLANEOUS: There are two types of cytoskeletal and microfibrillar
CC keratin: I (acidic; 40-55 kDa) and II (neutral to basic; 56-70 kDa).
CC -!- SIMILARITY: Belongs to the intermediate filament family.
CC {ECO:0000255|PROSITE-ProRule:PRU01188}.
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DR EMBL; AABR03073341; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BK004044; DAA04478.1; -; mRNA.
DR RefSeq; NP_001004021.1; NM_001004021.1.
DR AlphaFoldDB; Q6IFV4; -.
DR SMR; Q6IFV4; -.
DR STRING; 10116.ENSRNOP00000018851; -.
DR PhosphoSitePlus; Q6IFV4; -.
DR jPOST; Q6IFV4; -.
DR PaxDb; Q6IFV4; -.
DR PRIDE; Q6IFV4; -.
DR Ensembl; ENSRNOT00000018851; ENSRNOP00000018851; ENSRNOG00000014070.
DR GeneID; 287699; -.
DR KEGG; rno:287699; -.
DR UCSC; RGD:1302937; rat.
DR CTD; 3860; -.
DR RGD; 1302937; Krt13.
DR eggNOG; ENOG502QTM6; Eukaryota.
DR GeneTree; ENSGT00940000154403; -.
DR HOGENOM; CLU_012560_8_3_1; -.
DR InParanoid; Q6IFV4; -.
DR OMA; DAKMTGF; -.
DR OrthoDB; 798081at2759; -.
DR PhylomeDB; Q6IFV4; -.
DR TreeFam; TF332742; -.
DR Reactome; R-RNO-6805567; Keratinization.
DR Reactome; R-RNO-6809371; Formation of the cornified envelope.
DR PRO; PR:Q6IFV4; -.
DR Proteomes; UP000002494; Chromosome 10.
DR Bgee; ENSRNOG00000014070; Expressed in esophagus and 13 other tissues.
DR Genevisible; Q6IFV4; RN.
DR GO; GO:0005856; C:cytoskeleton; IBA:GO_Central.
DR GO; GO:0045095; C:keratin filament; ISO:RGD.
DR GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
DR GO; GO:0071300; P:cellular response to retinoic acid; IEP:RGD.
DR GO; GO:0007010; P:cytoskeleton organization; ISO:RGD.
DR GO; GO:0030855; P:epithelial cell differentiation; IBA:GO_Central.
DR GO; GO:0045109; P:intermediate filament organization; IBA:GO_Central.
DR GO; GO:0043555; P:regulation of translation in response to stress; ISS:UniProtKB.
DR GO; GO:0009314; P:response to radiation; IEP:RGD.
DR GO; GO:0043587; P:tongue morphogenesis; IEP:RGD.
DR InterPro; IPR018039; IF_conserved.
DR InterPro; IPR039008; IF_rod_dom.
DR InterPro; IPR002957; Keratin_I.
DR PANTHER; PTHR23239; PTHR23239; 1.
DR Pfam; PF00038; Filament; 1.
DR PRINTS; PR01248; TYPE1KERATIN.
DR SMART; SM01391; Filament; 1.
DR PROSITE; PS00226; IF_ROD_1; 1.
DR PROSITE; PS51842; IF_ROD_2; 1.
PE 3: Inferred from homology;
KW Coiled coil; Glycoprotein; Intermediate filament; Keratin; Methylation;
KW Reference proteome.
FT CHAIN 1..438
FT /note="Keratin, type I cytoskeletal 13"
FT /id="PRO_0000063649"
FT DOMAIN 96..408
FT /note="IF rod"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01188"
FT REGION 1..95
FT /note="Head"
FT /evidence="ECO:0000255"
FT REGION 96..131
FT /note="Coil"
FT /evidence="ECO:0000255"
FT REGION 132..150
FT /note="Linker 1"
FT /evidence="ECO:0000255"
FT REGION 151..242
FT /note="Coil 1B"
FT /evidence="ECO:0000255"
FT REGION 243..265
FT /note="Linker 12"
FT /evidence="ECO:0000255"
FT REGION 266..404
FT /note="Coil 2"
FT /evidence="ECO:0000255"
FT REGION 405..438
FT /note="Tail"
FT /evidence="ECO:0000255"
FT REGION 408..438
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 409..432
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 27
FT /note="Omega-N-methylarginine"
FT /evidence="ECO:0000250|UniProtKB:P13646"
FT MOD_RES 35
FT /note="Omega-N-methylarginine"
FT /evidence="ECO:0000250|UniProtKB:P13646"
SQ SEQUENCE 438 AA; 47729 MW; CFCE10BC2431519A CRC64;
MSCRFQSSSM SYGGGFGAGS CQLGGGRNIS TCSSRFVTGG SSGGYGGGMS CGFGGGAGGG
YGGGFGGGFG GSCGGGFGGG FGDFGSVDGG LLSGNEKITM QNLNDRLASY LEKVRALEAA
NADLEVKIRD WHLKQSPTSP ERDYSAYYKT IEELRIKILE ATTDNNRIVL EIDNARLAAD
DFRLKYENEL ALRQSVEADI NGLRRVLDEL TLAKTDLEMQ IESLNEELAY LKKNHEEEMK
EFSNQAVGQV NVEMDATPGI DLTRVLAEMR EQYEALAEKN RRDAEAWFQA KSAELNKEVS
SNAAMIQTSK TEITELRRTL QGLEIELQSQ LSMKAGLEST LAETECRYAL QLQQIQALIS
SIEAQLSELR SEMECQNQEY KMLLDIKTRL EQEIATYRSL LEGQDAKMTG FNTGGNSTTT
SNTSTSPSTS GRPDFRKY
