K1C20_PIG
ID K1C20_PIG Reviewed; 107 AA.
AC Q29218;
DT 23-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1996, sequence version 1.
DT 25-MAY-2022, entry version 84.
DE RecName: Full=Keratin, type I cytoskeletal 20;
DE AltName: Full=Cytokeratin-20;
DE Short=CK-20;
DE AltName: Full=Keratin-20;
DE Short=K20;
DE Flags: Fragment;
GN Name=KRT20 {ECO:0000250|UniProtKB:P35900};
OS Sus scrofa (Pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX NCBI_TaxID=9823;
RN [1] {ECO:0000312|EMBL:CAA23268.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Small intestine {ECO:0000312|EMBL:CAA23268.1};
RX PubMed=8672129; DOI=10.1007/s003359900153;
RA Winteroe A.K., Fredholm M., Davies W.;
RT "Evaluation and characterization of a porcine small intestine cDNA library:
RT analysis of 839 clones.";
RL Mamm. Genome 7:509-517(1996).
CC -!- FUNCTION: Plays a significant role in maintaining keratin filament
CC organization in intestinal epithelia. When phosphorylated, plays a role
CC in the secretion of mucin in the small intestine (By similarity).
CC {ECO:0000250|UniProtKB:Q9D312}.
CC -!- SUBUNIT: Heterotetramer of two type I and two type II keratins.
CC Associates with KRT8 (By similarity). {ECO:0000250|UniProtKB:P35900,
CC ECO:0000305}.
CC -!- MISCELLANEOUS: There are two types of cytoskeletal and microfibrillar
CC keratin: I (acidic; 40-55 kDa) and II (neutral to basic; 56-70 kDa).
CC {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the intermediate filament family.
CC {ECO:0000255|PROSITE-ProRule:PRU01188}.
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DR EMBL; F14805; CAA23268.1; -; mRNA.
DR AlphaFoldDB; Q29218; -.
DR SMR; Q29218; -.
DR STRING; 9823.ENSSSCP00000018502; -.
DR PaxDb; Q29218; -.
DR PeptideAtlas; Q29218; -.
DR eggNOG; ENOG502QUY3; Eukaryota.
DR HOGENOM; CLU_012560_8_1_1; -.
DR InParanoid; Q29218; -.
DR ChiTaRS; KRT20; pig.
DR Proteomes; UP000008227; Unplaced.
DR Proteomes; UP000314985; Unplaced.
DR GO; GO:0005856; C:cytoskeleton; IBA:GO_Central.
DR GO; GO:0005882; C:intermediate filament; IEA:UniProtKB-KW.
DR GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
DR GO; GO:0009267; P:cellular response to starvation; ISS:UniProtKB.
DR GO; GO:0030855; P:epithelial cell differentiation; IBA:GO_Central.
DR GO; GO:0045109; P:intermediate filament organization; ISS:UniProtKB.
DR GO; GO:0050708; P:regulation of protein secretion; ISS:UniProtKB.
DR InterPro; IPR039008; IF_rod_dom.
DR InterPro; IPR002957; Keratin_I.
DR PANTHER; PTHR23239; PTHR23239; 1.
DR Pfam; PF00038; Filament; 1.
DR PROSITE; PS51842; IF_ROD_2; 1.
PE 2: Evidence at transcript level;
KW Coiled coil; Intermediate filament; Keratin; Reference proteome.
FT CHAIN <1..>107
FT /note="Keratin, type I cytoskeletal 20"
FT /id="PRO_0000308359"
FT DOMAIN 8..>107
FT /note="IF rod"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01188"
FT REGION <1..7
FT /note="Head"
FT /evidence="ECO:0000255"
FT REGION 8..43
FT /note="Coil 1A"
FT /evidence="ECO:0000255"
FT REGION 44..61
FT /note="Linker 1"
FT /evidence="ECO:0000255"
FT REGION 62..>107
FT /note="Coil 1B"
FT /evidence="ECO:0000255"
FT NON_TER 1
FT /evidence="ECO:0000312|EMBL:CAA23268.1"
FT NON_TER 107
FT /evidence="ECO:0000312|EMBL:CAA23268.1"
SQ SEQUENCE 107 AA; 12528 MW; 1B622573604AC679 CRC64;
GNLWVGNEKM TMKNLNDRLA SYLEKVRSLE QSNSKFELQI KQWYESNTPG ISRDHSAYLQ
QIQDLRNQIR DAQLQNARCV LQIDNAKLAA EDFRLKYETE RGIRLAV
