K1C24_HUMAN
ID K1C24_HUMAN Reviewed; 525 AA.
AC Q2M2I5; Q9NXG7;
DT 15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT 21-FEB-2006, sequence version 1.
DT 03-AUG-2022, entry version 135.
DE RecName: Full=Keratin, type I cytoskeletal 24;
DE AltName: Full=Cytokeratin-24;
DE Short=CK-24;
DE AltName: Full=Keratin-24;
DE Short=K24;
DE AltName: Full=Type I keratin-24;
GN Name=KRT24; Synonyms=KA24;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Colon mucosa;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP TISSUE SPECIFICITY.
RX PubMed=12230514; DOI=10.1046/j.1523-1747.2002.01855.x;
RA Sprecher E., Itin P., Whittock N.V., McGrath J.A., Meyer R.,
RA DiGiovanna J.J., Bale S.J., Uitto J., Richard G.;
RT "Refined mapping of Naegeli-Franceschetti-Jadassohn syndrome to a 6 cM
RT interval on chromosome 17q11.2-q21 and investigation of candidate genes.";
RL J. Invest. Dermatol. 119:692-698(2002).
RN [4]
RP INDUCTION.
RX PubMed=17317818; DOI=10.1158/1078-0432.ccr-06-1633;
RA Hong Y., Ho K.S., Eu K.W., Cheah P.Y.;
RT "A susceptibility gene set for early onset colorectal cancer that
RT integrates diverse signaling pathways: implication for tumorigenesis.";
RL Clin. Cancer Res. 13:1107-1114(2007).
RN [5]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T.,
RA Bennett K.L., Superti-Furga G., Colinge J.;
RT "Initial characterization of the human central proteome.";
RL BMC Syst. Biol. 5:17-17(2011).
CC -!- SUBUNIT: Heterotetramer of two type I and two type II keratins.
CC -!- INTERACTION:
CC Q2M2I5; Q4LEZ3: AARD; NbExp=3; IntAct=EBI-2952736, EBI-5463075;
CC Q2M2I5; Q9NYB9-2: ABI2; NbExp=3; IntAct=EBI-2952736, EBI-11096309;
CC Q2M2I5; Q9P2A4: ABI3; NbExp=3; IntAct=EBI-2952736, EBI-742038;
CC Q2M2I5; A2BDD9: AMOT; NbExp=3; IntAct=EBI-2952736, EBI-17286414;
CC Q2M2I5; Q13515: BFSP2; NbExp=3; IntAct=EBI-2952736, EBI-10229433;
CC Q2M2I5; Q9NX04: C1orf109; NbExp=3; IntAct=EBI-2952736, EBI-8643161;
CC Q2M2I5; Q8TAB5: C1orf216; NbExp=5; IntAct=EBI-2952736, EBI-747505;
CC Q2M2I5; Q8IYE0: CCDC146; NbExp=3; IntAct=EBI-2952736, EBI-10749669;
CC Q2M2I5; Q8TD31-3: CCHCR1; NbExp=3; IntAct=EBI-2952736, EBI-10175300;
CC Q2M2I5; O14964: HGS; NbExp=3; IntAct=EBI-2952736, EBI-740220;
CC Q2M2I5; P04264: KRT1; NbExp=3; IntAct=EBI-2952736, EBI-298429;
CC Q2M2I5; P35900: KRT20; NbExp=3; IntAct=EBI-2952736, EBI-742094;
CC Q2M2I5; P12035: KRT3; NbExp=3; IntAct=EBI-2952736, EBI-2430095;
CC Q2M2I5; P19013: KRT4; NbExp=3; IntAct=EBI-2952736, EBI-2371606;
CC Q2M2I5; P13647: KRT5; NbExp=3; IntAct=EBI-2952736, EBI-702187;
CC Q2M2I5; P48668: KRT6C; NbExp=3; IntAct=EBI-2952736, EBI-2564105;
CC Q2M2I5; Q3SY84: KRT71; NbExp=5; IntAct=EBI-2952736, EBI-2952676;
CC Q2M2I5; Q14CN4: KRT72; NbExp=3; IntAct=EBI-2952736, EBI-1221280;
CC Q2M2I5; O95678: KRT75; NbExp=3; IntAct=EBI-2952736, EBI-2949715;
CC Q2M2I5; Q5XKE5: KRT79; NbExp=3; IntAct=EBI-2952736, EBI-2514135;
CC Q2M2I5; P05787: KRT8; NbExp=3; IntAct=EBI-2952736, EBI-297852;
CC Q2M2I5; Q6KB66-2: KRT80; NbExp=5; IntAct=EBI-2952736, EBI-11999246;
CC Q2M2I5; A5D8V7: ODAD3; NbExp=3; IntAct=EBI-2952736, EBI-8466445;
CC Q2M2I5; P41219: PRPH; NbExp=3; IntAct=EBI-2952736, EBI-752074;
CC Q2M2I5; Q9P2K3-2: RCOR3; NbExp=3; IntAct=EBI-2952736, EBI-1504830;
CC Q2M2I5; Q96ES7: SGF29; NbExp=3; IntAct=EBI-2952736, EBI-743117;
CC Q2M2I5; O95295: SNAPIN; NbExp=6; IntAct=EBI-2952736, EBI-296723;
CC Q2M2I5; Q9BT92: TCHP; NbExp=3; IntAct=EBI-2952736, EBI-740781;
CC Q2M2I5; Q8N7C3: TRIML2; NbExp=3; IntAct=EBI-2952736, EBI-11059915;
CC Q2M2I5; Q3SY00: TSGA10IP; NbExp=3; IntAct=EBI-2952736, EBI-10241197;
CC Q2M2I5; P40222: TXLNA; NbExp=3; IntAct=EBI-2952736, EBI-359793;
CC -!- TISSUE SPECIFICITY: Highly expressed in keratinocytes, placenta, colon
CC and spleen. Expressed at lower level in thymus and testis.
CC {ECO:0000269|PubMed:12230514}.
CC -!- INDUCTION: Up-regulated in the mucosa of patients suffering of
CC colorectal cancer. {ECO:0000269|PubMed:17317818}.
CC -!- MISCELLANEOUS: There are two types of cytoskeletal and microfibrillar
CC keratin, I (acidic) and II (neutral to basic) (40-55 and 56-70 kDa,
CC respectively).
CC -!- SIMILARITY: Belongs to the intermediate filament family.
CC {ECO:0000255|PROSITE-ProRule:PRU01188}.
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DR EMBL; AK000268; BAA91044.1; -; mRNA.
DR EMBL; BC111968; AAI11969.1; -; mRNA.
DR CCDS; CCDS11372.1; -.
DR RefSeq; NP_061889.2; NM_019016.2.
DR AlphaFoldDB; Q2M2I5; -.
DR SMR; Q2M2I5; -.
DR BioGRID; 128175; 44.
DR IntAct; Q2M2I5; 48.
DR STRING; 9606.ENSP00000264651; -.
DR iPTMnet; Q2M2I5; -.
DR PhosphoSitePlus; Q2M2I5; -.
DR BioMuta; KRT24; -.
DR DMDM; 121941436; -.
DR jPOST; Q2M2I5; -.
DR MassIVE; Q2M2I5; -.
DR PaxDb; Q2M2I5; -.
DR PeptideAtlas; Q2M2I5; -.
DR PRIDE; Q2M2I5; -.
DR ProteomicsDB; 61354; -.
DR Antibodypedia; 16540; 218 antibodies from 15 providers.
DR DNASU; 192666; -.
DR Ensembl; ENST00000264651.3; ENSP00000264651.2; ENSG00000167916.5.
DR GeneID; 192666; -.
DR KEGG; hsa:192666; -.
DR MANE-Select; ENST00000264651.3; ENSP00000264651.2; NM_019016.3; NP_061889.2.
DR UCSC; uc002hvd.3; human.
DR CTD; 192666; -.
DR DisGeNET; 192666; -.
DR GeneCards; KRT24; -.
DR HGNC; HGNC:18527; KRT24.
DR HPA; ENSG00000167916; Group enriched (esophagus, lymphoid tissue).
DR MIM; 607742; gene.
DR neXtProt; NX_Q2M2I5; -.
DR OpenTargets; ENSG00000167916; -.
DR PharmGKB; PA38344; -.
DR VEuPathDB; HostDB:ENSG00000167916; -.
DR eggNOG; ENOG502QTM6; Eukaryota.
DR GeneTree; ENSGT00940000161783; -.
DR HOGENOM; CLU_012560_8_3_1; -.
DR InParanoid; Q2M2I5; -.
DR OMA; SGSTNMG; -.
DR OrthoDB; 798081at2759; -.
DR PhylomeDB; Q2M2I5; -.
DR TreeFam; TF332742; -.
DR PathwayCommons; Q2M2I5; -.
DR Reactome; R-HSA-6805567; Keratinization.
DR Reactome; R-HSA-6809371; Formation of the cornified envelope.
DR SignaLink; Q2M2I5; -.
DR BioGRID-ORCS; 192666; 13 hits in 1071 CRISPR screens.
DR GenomeRNAi; 192666; -.
DR Pharos; Q2M2I5; Tbio.
DR PRO; PR:Q2M2I5; -.
DR Proteomes; UP000005640; Chromosome 17.
DR RNAct; Q2M2I5; protein.
DR Bgee; ENSG00000167916; Expressed in amniotic fluid and 98 other tissues.
DR Genevisible; Q2M2I5; HS.
DR GO; GO:0005856; C:cytoskeleton; IBA:GO_Central.
DR GO; GO:0005829; C:cytosol; TAS:Reactome.
DR GO; GO:0070062; C:extracellular exosome; HDA:UniProtKB.
DR GO; GO:0005882; C:intermediate filament; IEA:UniProtKB-KW.
DR GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
DR InterPro; IPR018039; IF_conserved.
DR InterPro; IPR039008; IF_rod_dom.
DR InterPro; IPR002957; Keratin_I.
DR PANTHER; PTHR23239; PTHR23239; 1.
DR Pfam; PF00038; Filament; 1.
DR PRINTS; PR01248; TYPE1KERATIN.
DR SMART; SM01391; Filament; 1.
DR PROSITE; PS00226; IF_ROD_1; 1.
DR PROSITE; PS51842; IF_ROD_2; 1.
PE 1: Evidence at protein level;
KW Coiled coil; Intermediate filament; Keratin; Reference proteome.
FT CHAIN 1..525
FT /note="Keratin, type I cytoskeletal 24"
FT /id="PRO_0000314850"
FT DOMAIN 140..456
FT /note="IF rod"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01188"
FT REGION 1..139
FT /note="Head"
FT REGION 1..30
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 140..175
FT /note="Coil 1A"
FT REGION 176..198
FT /note="Linker 1"
FT REGION 199..290
FT /note="Coil 1B"
FT REGION 291..313
FT /note="Linker 12"
FT REGION 314..452
FT /note="Coil 2"
FT REGION 453..525
FT /note="Tail"
FT REGION 459..497
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 461..496
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VARIANT 115
FT /note="A -> T (in dbSNP:rs9914185)"
FT /id="VAR_038068"
FT VARIANT 250
FT /note="G -> D (in dbSNP:rs7211480)"
FT /id="VAR_038069"
FT VARIANT 267
FT /note="M -> I (in dbSNP:rs874889)"
FT /id="VAR_038070"
FT VARIANT 366
FT /note="R -> C (in dbSNP:rs16966138)"
FT /id="VAR_038071"
FT VARIANT 415
FT /note="C -> Y (in dbSNP:rs12945784)"
FT /id="VAR_038072"
FT VARIANT 418
FT /note="W -> R (in dbSNP:rs12946793)"
FT /id="VAR_038073"
FT VARIANT 429
FT /note="K -> E (in dbSNP:rs2462961)"
FT /id="VAR_038074"
FT CONFLICT 58
FT /note="G -> D (in Ref. 1; BAA91044)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 525 AA; 55087 MW; 1729C08E2277C865 CRC64;
MSCSSRASSS RAGGSSSARV SAGGSSFSSG SRCGLGGSSA QGFRGGASSC SLSGGSSGAF
GGSFGGGFGS CSVGGGFGGA SGSGTGFGGG SSFGGVSGFG RGSGFCGSSR FSSGATGGFY
SYGGGMGGGV GDGGLFSGGE KQTMQNLNDR LANYLDKVRA LEEANTDLEN KIKEWYDKYG
PGSGDGGSGR DYSKYYSIIE DLRNQIIAAT VENAGIILHI DNARLAADDF RLKYENELCL
RQSVEADING LRKVLDDLTM TRSDLEMQIE SFTEELAYLR KNHEEEMKNM QGSSGGEVTV
EMNAAPGTDL TKLLNDMRAQ YEELAEQNRR EAEERFNKQS ASLQAQISTD AGAATSAKNE
ITELKRTLQA LEIELQSQLA MKSSLEGTLA DTEAGYVAQL SEIQTQISAL EEEICQIWGE
TKCQNAEYKQ LLDIKTRLEV EIETYRRLLD GEGGGSSFAE FGGRNSGSVN MGSRDLVSGD
SRSGSCSGQG RDSSKTRVTK TIVEELVDGK VVSSQVSSIS EVKVK
