ID   K1C24_RAT               Reviewed;         491 AA.
AC   Q6IFX1;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 97.
DE   RecName: Full=Keratin, type I cytoskeletal 24;
DE   AltName: Full=Cytokeratin-24;
DE            Short=CK-24;
DE   AltName: Full=Keratin-24;
DE            Short=K24;
DE   AltName: Full=Type I keratin-24;
GN   Name=Krt24; Synonyms=Ka24;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Brown Norway;
RX   PubMed=15057822; DOI=10.1038/nature02426;
RA   Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J.,
RA   Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G.,
RA   Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G.,
RA   Morgan M., Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G.,
RA   Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S.,
RA   Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T.,
RA   Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D.,
RA   Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L.,
RA   Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D.,
RA   Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M.,
RA   Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C.,
RA   Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J.,
RA   Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H.,
RA   Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X.,
RA   Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q.,
RA   Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P.,
RA   Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A.,
RA   Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C.,
RA   Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J.,
RA   Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J.,
RA   Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F.,
RA   Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A.,
RA   Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A.,
RA   Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J.,
RA   Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E.,
RA   Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M.,
RA   Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C.,
RA   Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L.,
RA   Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W.,
RA   Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y.,
RA   Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V.,
RA   Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M.,
RA   Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S.,
RA   Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B.,
RA   Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R.,
RA   Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J.,
RA   Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D.,
RA   Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S.,
RA   Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S.,
RA   Mockrin S., Collins F.S.;
RT   "Genome sequence of the Brown Norway rat yields insights into mammalian
RT   evolution.";
RL   Nature 428:493-521(2004).
RN   [2]
RP   IDENTIFICATION.
RX   PubMed=15085952; DOI=10.1078/0171-9335-00354;
RA   Hesse M., Zimek A., Weber K., Magin T.M.;
RT   "Comprehensive analysis of keratin gene clusters in humans and rodents.";
RL   Eur. J. Cell Biol. 83:19-26(2004).
CC   -!- SUBUNIT: Heterotetramer of two type I and two type II keratins.
CC   -!- MISCELLANEOUS: There are two types of cytoskeletal and microfibrillar
CC       keratin, I (acidic) and II (neutral to basic) (40-55 and 56-70 kDa,
CC       respectively).
CC   -!- SIMILARITY: Belongs to the intermediate filament family.
CC       {ECO:0000255|PROSITE-ProRule:PRU01188}.
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DR   EMBL; AABR03074556; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AABR03075642; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BK004027; DAA04461.1; -; mRNA.
DR   RefSeq; NP_001004131.1; NM_001004131.1.
DR   AlphaFoldDB; Q6IFX1; -.
DR   SMR; Q6IFX1; -.
DR   STRING; 10116.ENSRNOP00000014851; -.
DR   jPOST; Q6IFX1; -.
DR   PaxDb; Q6IFX1; -.
DR   PRIDE; Q6IFX1; -.
DR   Ensembl; ENSRNOT00000014851; ENSRNOP00000014851; ENSRNOG00000010970.
DR   GeneID; 287675; -.
DR   KEGG; rno:287675; -.
DR   UCSC; RGD:1303157; rat.
DR   CTD; 192666; -.
DR   RGD; 1303157; Krt24.
DR   eggNOG; ENOG502QTM6; Eukaryota.
DR   GeneTree; ENSGT00940000161783; -.
DR   HOGENOM; CLU_012560_8_3_1; -.
DR   InParanoid; Q6IFX1; -.
DR   OMA; SGSTNMG; -.
DR   OrthoDB; 798081at2759; -.
DR   PhylomeDB; Q6IFX1; -.
DR   Reactome; R-RNO-6805567; Keratinization.
DR   Reactome; R-RNO-6809371; Formation of the cornified envelope.
DR   PRO; PR:Q6IFX1; -.
DR   Proteomes; UP000002494; Chromosome 10.
DR   Bgee; ENSRNOG00000010970; Expressed in heart and 1 other tissue.
DR   Genevisible; Q6IFX1; RN.
DR   GO; GO:0005856; C:cytoskeleton; IBA:GO_Central.
DR   GO; GO:0005882; C:intermediate filament; TAS:RGD.
DR   GO; GO:0045095; C:keratin filament; TAS:RGD.
DR   GO; GO:0005200; F:structural constituent of cytoskeleton; TAS:RGD.
DR   GO; GO:0045103; P:intermediate filament-based process; TAS:RGD.
DR   InterPro; IPR039008; IF_rod_dom.
DR   InterPro; IPR002957; Keratin_I.
DR   PANTHER; PTHR23239; PTHR23239; 1.
DR   Pfam; PF00038; Filament; 1.
DR   PRINTS; PR01248; TYPE1KERATIN.
DR   SMART; SM01391; Filament; 1.
DR   PROSITE; PS51842; IF_ROD_2; 1.
PE   3: Inferred from homology;
KW   Coiled coil; Intermediate filament; Keratin; Reference proteome.
FT   CHAIN           1..491
FT                   /note="Keratin, type I cytoskeletal 24"
FT                   /id="PRO_0000314852"
FT   DOMAIN          118..432
FT                   /note="IF rod"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01188"
FT   REGION          1..117
FT                   /note="Head"
FT   REGION          1..23
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          118..153
FT                   /note="Coil 1A"
FT   REGION          154..174
FT                   /note="Linker 1"
FT   REGION          175..266
FT                   /note="Coil 1B"
FT   REGION          267..289
FT                   /note="Linker 12"
FT   REGION          290..428
FT                   /note="Coil 2"
FT   REGION          429..491
FT                   /note="Tail"
SQ   SEQUENCE   491 AA;  52380 MW;  C3DA628CF04C1FAB CRC64;
     MFCSAQKGSC SSRVSSSGAV GSRGCTGSGS SYGLGGGSAW GFQGSSSSWG LSGGSKGSIG
     GGFSSCSVRG GFGAGSSFGG GSGFGGGSSG GVSSYGGSLG GGLGGIGGYD GGLLSGSEKQ
     TMQGLNDRLA NYLDKVRALE EANTDLETKI KDWYGRHGSG KDGPGRDYSQ YCSVIEDLKN
     QIISATCENA RLALQIDNAR LAADDFRMKY EHELCLRQSL EADINGLRKV LDEMTMTRCD
     LEMQIEGLTE ELVFLRKNHE EEMKCLQGSS GGDVTVEMNA TPGTDLTKLL NDMRAQYEAM
     AEQNRQEAEK QFNERSACLQ AQISTDAGAA NCAKSEVMEL RRTVQTLEIE LQSQLALKCS
     LEGTLADTEA RYVAQLSGIQ TQISSLEEQL SQIRGETQCQ SAEYECLLDI KTRLEQEIET
     YRRLLNGDGG GCDYRNLVSR QVVLNDSNFG SCSGQEKDPS KTRVTKTIIE EVVDGKVVSS
     QVSNISEVKI K