ID   K1C26_BOVIN             Reviewed;         469 AA.
AC   A6H712;
DT   04-DEC-2007, integrated into UniProtKB/Swiss-Prot.
DT   24-JUL-2007, sequence version 1.
DT   25-MAY-2022, entry version 86.
DE   RecName: Full=Keratin, type I cytoskeletal 26;
DE   AltName: Full=Cytokeratin-26;
DE            Short=CK-26;
DE   AltName: Full=Keratin-26;
DE            Short=K26;
DE   AltName: Full=Type I inner root sheath-specific keratin-K25irs2;
GN   Name=KRT26 {ECO:0000250|UniProtKB:Q7Z3Y9};
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1] {ECO:0000312|EMBL:AAI46075.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford {ECO:0000312|EMBL:AAI46075.1};
RC   TISSUE=Fetal skin {ECO:0000312|EMBL:AAI46075.1};
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBUNIT: Heterotetramer of two type I and two type II keratins.
CC       {ECO:0000305}.
CC   -!- MISCELLANEOUS: There are two types of cytoskeletal and microfibrillar
CC       keratin: I (acidic; 40-55 kDa) and II (neutral to basic; 56-70 kDa).
CC       {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the intermediate filament family.
CC       {ECO:0000255|PROSITE-ProRule:PRU01188}.
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DR   EMBL; BC146074; AAI46075.1; -; mRNA.
DR   RefSeq; NP_001092566.1; NM_001099096.1.
DR   AlphaFoldDB; A6H712; -.
DR   SMR; A6H712; -.
DR   STRING; 9913.ENSBTAP00000040717; -.
DR   PaxDb; A6H712; -.
DR   PeptideAtlas; A6H712; -.
DR   Ensembl; ENSBTAT00000043126; ENSBTAP00000040717; ENSBTAG00000030546.
DR   GeneID; 539216; -.
DR   KEGG; bta:539216; -.
DR   CTD; 353288; -.
DR   VEuPathDB; HostDB:ENSBTAG00000030546; -.
DR   VGNC; VGNC:30725; KRT26.
DR   eggNOG; ENOG502SMDE; Eukaryota.
DR   GeneTree; ENSGT00940000161950; -.
DR   HOGENOM; CLU_012560_8_3_1; -.
DR   InParanoid; A6H712; -.
DR   OMA; IEIYCNL; -.
DR   OrthoDB; 805081at2759; -.
DR   TreeFam; TF332742; -.
DR   Reactome; R-BTA-6805567; Keratinization.
DR   Proteomes; UP000009136; Chromosome 19.
DR   Bgee; ENSBTAG00000030546; Expressed in zone of skin and 6 other tissues.
DR   GO; GO:0005856; C:cytoskeleton; IBA:GO_Central.
DR   GO; GO:0005882; C:intermediate filament; IEA:UniProtKB-KW.
DR   GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
DR   InterPro; IPR039008; IF_rod_dom.
DR   InterPro; IPR002957; Keratin_I.
DR   PANTHER; PTHR23239; PTHR23239; 1.
DR   Pfam; PF00038; Filament; 1.
DR   PRINTS; PR01248; TYPE1KERATIN.
DR   SMART; SM01391; Filament; 1.
DR   PROSITE; PS51842; IF_ROD_2; 1.
PE   2: Evidence at transcript level;
KW   Coiled coil; Intermediate filament; Keratin; Reference proteome.
FT   CHAIN           1..469
FT                   /note="Keratin, type I cytoskeletal 26"
FT                   /id="PRO_0000312696"
FT   DOMAIN          83..398
FT                   /note="IF rod"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01188"
FT   REGION          1..82
FT                   /note="Head"
FT                   /evidence="ECO:0000255"
FT   REGION          83..118
FT                   /note="Coil 1A"
FT                   /evidence="ECO:0000255"
FT   REGION          119..140
FT                   /note="Linker 1"
FT                   /evidence="ECO:0000255"
FT   REGION          141..232
FT                   /note="Coil 1B"
FT                   /evidence="ECO:0000255"
FT   REGION          233..255
FT                   /note="Linker 12"
FT                   /evidence="ECO:0000255"
FT   REGION          256..394
FT                   /note="Coil 2"
FT                   /evidence="ECO:0000255"
FT   REGION          395..465
FT                   /note="Tail"
FT                   /evidence="ECO:0000255"
FT   REGION          398..421
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          450..469
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   469 AA;  51578 MW;  3C7F6D81765AFBA6 CRC64;
     MSFRLSSGSR RLCSPAGSGQ LTGGRTGFRA GNACGGLGAG SSFSGPLGSV SSRGSFSHGG
     GGLGSGVCTG FLENEHGLLP GNEKVTLQNL NDRLASYLDH VCTLEEANAD LEQKIKGWYE
     KYGPGSGRQL AYDCSKYFSV TEDLKRQIIS VTTCNASIAL QNENARLTAD DFRLKYENEL
     ALNQSVEADI NGLHRVMEEL TLCTSDLEIQ CEALSEELTC LKKNHQEEMK VMQGAAGGNV
     NVEINAAPGV DLTVLLNNMR AEYEDLAEQN REDAEAWFNE KSTSLHQQIS DDAGAATAAR
     NELMELKRNL QTLEIELQSL MAMKHSYECS LAETESNYCH QLQQIQEQIG ATEDQLQQIR
     METEGQKLEH ERLLDVKIFL EKEIEMYCKL IDGEGRKSKS TYCKSEGRGP KNSENQVKDS
     KEEAVVKTVV GELDQLGSVL SLRVHSVEEK SSKISNITME QRLPSKVPQ