K1C26_MOUSE
ID K1C26_MOUSE Reviewed; 462 AA.
AC Q3TRJ4; Q3V1H8;
DT 04-DEC-2007, integrated into UniProtKB/Swiss-Prot.
DT 11-OCT-2005, sequence version 1.
DT 03-AUG-2022, entry version 122.
DE RecName: Full=Keratin, type I cytoskeletal 26;
DE AltName: Full=Cytokeratin-26;
DE Short=CK-26;
DE AltName: Full=Keratin-26;
DE Short=K26;
DE AltName: Full=Type I inner root sheath-specific keratin-K25irs2;
GN Name=Krt26 {ECO:0000312|MGI:MGI:2444913};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1] {ECO:0000312|EMBL:BAE37035.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J {ECO:0000312|EMBL:BAE37035.1};
RC TISSUE=Neonatal skin {ECO:0000312|EMBL:BAE37035.1};
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [3] {ECO:0000312|EMBL:AAI16673.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- SUBUNIT: Heterotetramer of two type I and two type II keratins.
CC {ECO:0000305}.
CC -!- MISCELLANEOUS: There are two types of cytoskeletal and microfibrillar
CC keratin: I (acidic; 40-55 kDa) and II (neutral to basic; 56-70 kDa).
CC {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the intermediate filament family.
CC {ECO:0000255|PROSITE-ProRule:PRU01188}.
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DR EMBL; AK132445; BAE21173.1; -; mRNA.
DR EMBL; AK162718; BAE37035.1; -; mRNA.
DR EMBL; AL590991; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC116672; AAI16673.1; -; mRNA.
DR CCDS; CCDS25378.1; -.
DR RefSeq; NP_001028569.2; NM_001033397.5.
DR AlphaFoldDB; Q3TRJ4; -.
DR SMR; Q3TRJ4; -.
DR STRING; 10090.ENSMUSP00000098051; -.
DR iPTMnet; Q3TRJ4; -.
DR PhosphoSitePlus; Q3TRJ4; -.
DR MaxQB; Q3TRJ4; -.
DR PaxDb; Q3TRJ4; -.
DR PeptideAtlas; Q3TRJ4; -.
DR PRIDE; Q3TRJ4; -.
DR ProteomicsDB; 269052; -.
DR Antibodypedia; 57607; 93 antibodies from 18 providers.
DR DNASU; 320864; -.
DR Ensembl; ENSMUST00000100482; ENSMUSP00000098051; ENSMUSG00000075570.
DR GeneID; 320864; -.
DR KEGG; mmu:320864; -.
DR UCSC; uc007lio.2; mouse.
DR CTD; 353288; -.
DR MGI; MGI:2444913; Krt26.
DR VEuPathDB; HostDB:ENSMUSG00000075570; -.
DR eggNOG; ENOG502SMDE; Eukaryota.
DR GeneTree; ENSGT00940000161950; -.
DR HOGENOM; CLU_012560_8_3_1; -.
DR InParanoid; Q3TRJ4; -.
DR OMA; IEIYCNL; -.
DR OrthoDB; 805081at2759; -.
DR PhylomeDB; Q3TRJ4; -.
DR TreeFam; TF332742; -.
DR Reactome; R-MMU-6805567; Keratinization.
DR Reactome; R-MMU-6809371; Formation of the cornified envelope.
DR BioGRID-ORCS; 320864; 4 hits in 72 CRISPR screens.
DR PRO; PR:Q3TRJ4; -.
DR Proteomes; UP000000589; Chromosome 11.
DR RNAct; Q3TRJ4; protein.
DR Bgee; ENSMUSG00000075570; Expressed in hair follicle and 13 other tissues.
DR Genevisible; Q3TRJ4; MM.
DR GO; GO:0005856; C:cytoskeleton; IBA:GO_Central.
DR GO; GO:0005882; C:intermediate filament; IEA:UniProtKB-KW.
DR GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
DR InterPro; IPR039008; IF_rod_dom.
DR InterPro; IPR002957; Keratin_I.
DR PANTHER; PTHR23239; PTHR23239; 1.
DR Pfam; PF00038; Filament; 1.
DR PRINTS; PR01248; TYPE1KERATIN.
DR SMART; SM01391; Filament; 1.
DR PROSITE; PS51842; IF_ROD_2; 1.
PE 2: Evidence at transcript level;
KW Coiled coil; Intermediate filament; Keratin; Reference proteome.
FT CHAIN 1..462
FT /note="Keratin, type I cytoskeletal 26"
FT /id="PRO_0000312698"
FT DOMAIN 80..395
FT /note="IF rod"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01188"
FT REGION 1..79
FT /note="Head"
FT /evidence="ECO:0000255"
FT REGION 80..115
FT /note="Coil 1A"
FT /evidence="ECO:0000255"
FT REGION 116..137
FT /note="Linker 1"
FT /evidence="ECO:0000255"
FT REGION 138..229
FT /note="Coil 1B"
FT /evidence="ECO:0000255"
FT REGION 230..252
FT /note="Linker 12"
FT /evidence="ECO:0000255"
FT REGION 253..391
FT /note="Coil 2"
FT /evidence="ECO:0000255"
FT REGION 264..290
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 392..459
FT /note="Tail"
FT /evidence="ECO:0000255"
FT REGION 392..413
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 392..411
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 197
FT /note="L -> Q (in Ref. 1; BAE21173)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 462 AA; 51118 MW; 2436531C7ECF8412 CRC64;
MSFRFSGRSR VCSRAGSVRL SRGGAGFVAG NVCVGPGAEG SFSCTLGGLS SGGSFASEGS
GRGSSIGFLN NEPGLFSGNE KVAMQNLNDR LALYLNHVSA LEEANTDLEK KIEGWYEKCG
PGRGRRLDHD CSRYFSVIED LKRQILSMTT CNANLVLQND NARLTADDFK MKYENELALH
QSVEADTNGL RRVLDELTLS TTDLEIQREA LSEELTYLQK NHEEEMVVLQ NASGGNINVE
MNAAPSVDLT AMLNNMRAEY EDLAEQNRKD AEASFKEKSA SLQQQISDDA GAATAARNEL
MELKRNLQTL EIELQSITAM KQSYENSLAE TEGNYYAQLQ QIQEQIGARE EQLQQIRTET
EGQKLEHEQL LGIKTCLEKE IDTYCNLLDG EEQRSESTSY KPKDGKPASE FNDSAEETFA
RTVAEELDQL GNLLSLRVHS VEEKSSKISN ITMEQRVPSK AP
