K1C27_HUMAN
ID K1C27_HUMAN Reviewed; 459 AA.
AC Q7Z3Y8;
DT 04-DEC-2007, integrated into UniProtKB/Swiss-Prot.
DT 18-MAY-2010, sequence version 2.
DT 03-AUG-2022, entry version 136.
DE RecName: Full=Keratin, type I cytoskeletal 27;
DE AltName: Full=Cytokeratin-27;
DE Short=CK-27;
DE AltName: Full=Keratin-25C;
DE Short=K25C;
DE AltName: Full=Keratin-27;
DE Short=K27;
DE AltName: Full=Type I inner root sheath-specific keratin-K25irs3;
GN Name=KRT27 {ECO:0000312|HGNC:HGNC:30841};
GN Synonyms=KRT25C {ECO:0000312|EMBL:CAD91906.1};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1] {ECO:0000305, ECO:0000312|EMBL:CAD91906.1}
RP NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, AND VARIANTS THR-52;
RP LYS-144 AND THR-305.
RC TISSUE=Scalp {ECO:0000312|EMBL:CAD91906.1};
RX PubMed=15617563; DOI=10.1111/j.1432-0436.2004.07209006.x;
RA Rogers M.A., Winter H., Langbein L., Bleiler R., Schweizer J.;
RT "The human type I keratin gene family: characterization of new hair
RT follicle specific members and evaluation of the chromosome 17q21.2 gene
RT domain.";
RL Differentiation 72:527-540(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16625196; DOI=10.1038/nature04689;
RA Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R.,
RA Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A.,
RA Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J.,
RA Chang J.L., Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J.,
RA DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S.,
RA Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E.,
RA Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K.,
RA LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J.,
RA Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A.,
RA Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K.,
RA Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D.,
RA Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A.,
RA Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.;
RT "DNA sequence of human chromosome 17 and analysis of rearrangement in the
RT human lineage.";
RL Nature 440:1045-1049(2006).
RN [3] {ECO:0000305}
RP TISSUE SPECIFICITY.
RX PubMed=16874310; DOI=10.1038/sj.jid.5700494;
RA Langbein L., Rogers M.A., Praetzel-Wunder S., Helmke B., Schirmacher P.,
RA Schweizer J.;
RT "K25 (K25irs1), K26 (K25irs2), K27 (K25irs3), and K28 (K25irs4) represent
RT the type I inner root sheath keratins of the human hair follicle.";
RL J. Invest. Dermatol. 126:2377-2386(2006).
CC -!- FUNCTION: Essential for the proper assembly of type I and type II
CC keratin protein complexes and formation of keratin intermediate
CC filaments in the inner root sheath (irs).
CC {ECO:0000250|UniProtKB:Q9Z320}.
CC -!- SUBUNIT: Heterotetramer of two type I and two type II keratins.
CC Interacts with KRT6A to form filaments (By similarity).
CC {ECO:0000250|UniProtKB:Q9Z320, ECO:0000305}.
CC -!- INTERACTION:
CC Q7Z3Y8; Q4LEZ3: AARD; NbExp=6; IntAct=EBI-3044087, EBI-5463075;
CC Q7Z3Y8; Q9NYB9-2: ABI2; NbExp=3; IntAct=EBI-3044087, EBI-11096309;
CC Q7Z3Y8; A2BDD9: AMOT; NbExp=3; IntAct=EBI-3044087, EBI-17286414;
CC Q7Z3Y8; P53367: ARFIP1; NbExp=3; IntAct=EBI-3044087, EBI-2808808;
CC Q7Z3Y8; Q15052: ARHGEF6; NbExp=3; IntAct=EBI-3044087, EBI-1642523;
CC Q7Z3Y8; Q9Y5K8: ATP6V1D; NbExp=3; IntAct=EBI-3044087, EBI-2684998;
CC Q7Z3Y8; O75934: BCAS2; NbExp=3; IntAct=EBI-3044087, EBI-1050106;
CC Q7Z3Y8; Q9BXY8: BEX2; NbExp=3; IntAct=EBI-3044087, EBI-745073;
CC Q7Z3Y8; Q12934-2: BFSP1; NbExp=3; IntAct=EBI-3044087, EBI-12123320;
CC Q7Z3Y8; Q13515: BFSP2; NbExp=3; IntAct=EBI-3044087, EBI-10229433;
CC Q7Z3Y8; Q9H6X5-2: C19orf44; NbExp=3; IntAct=EBI-3044087, EBI-12061599;
CC Q7Z3Y8; Q8TAB5: C1orf216; NbExp=3; IntAct=EBI-3044087, EBI-747505;
CC Q7Z3Y8; Q0VAL7: C21orf58; NbExp=3; IntAct=EBI-3044087, EBI-10226774;
CC Q7Z3Y8; Q6UXH8-3: CCBE1; NbExp=3; IntAct=EBI-3044087, EBI-12013534;
CC Q7Z3Y8; Q96M89-2: CCDC138; NbExp=3; IntAct=EBI-3044087, EBI-10972887;
CC Q7Z3Y8; Q8IYE0: CCDC146; NbExp=3; IntAct=EBI-3044087, EBI-10749669;
CC Q7Z3Y8; Q8N715: CCDC185; NbExp=3; IntAct=EBI-3044087, EBI-740814;
CC Q7Z3Y8; O60826: CCDC22; NbExp=3; IntAct=EBI-3044087, EBI-3943153;
CC Q7Z3Y8; Q9H2F9: CCDC68; NbExp=3; IntAct=EBI-3044087, EBI-2813327;
CC Q7Z3Y8; Q8TD31-3: CCHCR1; NbExp=3; IntAct=EBI-3044087, EBI-10175300;
CC Q7Z3Y8; P24863: CCNC; NbExp=3; IntAct=EBI-3044087, EBI-395261;
CC Q7Z3Y8; Q96GE4: CEP95; NbExp=3; IntAct=EBI-3044087, EBI-372775;
CC Q7Z3Y8; Q5T655: CFAP58; NbExp=3; IntAct=EBI-3044087, EBI-10245749;
CC Q7Z3Y8; P10606: COX5B; NbExp=3; IntAct=EBI-3044087, EBI-1053725;
CC Q7Z3Y8; Q6W0C5: DPPA3; NbExp=3; IntAct=EBI-3044087, EBI-12082590;
CC Q7Z3Y8; O60941-5: DTNB; NbExp=3; IntAct=EBI-3044087, EBI-11984733;
CC Q7Z3Y8; Q9BV47: DUSP26; NbExp=3; IntAct=EBI-3044087, EBI-2924519;
CC Q7Z3Y8; Q86VI1: EXOC3L1; NbExp=3; IntAct=EBI-3044087, EBI-2813180;
CC Q7Z3Y8; Q9NQT4: EXOSC5; NbExp=3; IntAct=EBI-3044087, EBI-371876;
CC Q7Z3Y8; O95990-4: FAM107A; NbExp=3; IntAct=EBI-3044087, EBI-11977223;
CC Q7Z3Y8; Q9BQ89: FAM110A; NbExp=3; IntAct=EBI-3044087, EBI-1752811;
CC Q7Z3Y8; Q8TAE8: GADD45GIP1; NbExp=3; IntAct=EBI-3044087, EBI-372506;
CC Q7Z3Y8; O95995: GAS8; NbExp=3; IntAct=EBI-3044087, EBI-1052570;
CC Q7Z3Y8; P14136: GFAP; NbExp=3; IntAct=EBI-3044087, EBI-744302;
CC Q7Z3Y8; Q9P2W3: GNG13; NbExp=3; IntAct=EBI-3044087, EBI-11427343;
CC Q7Z3Y8; Q92805: GOLGA1; NbExp=3; IntAct=EBI-3044087, EBI-6164177;
CC Q7Z3Y8; Q13227: GPS2; NbExp=3; IntAct=EBI-3044087, EBI-713355;
CC Q7Z3Y8; Q9Y2Q3-2: GSTK1; NbExp=3; IntAct=EBI-3044087, EBI-12013556;
CC Q7Z3Y8; Q9GZV7: HAPLN2; NbExp=3; IntAct=EBI-3044087, EBI-11956675;
CC Q7Z3Y8; P56524-2: HDAC4; NbExp=3; IntAct=EBI-3044087, EBI-11953488;
CC Q7Z3Y8; O14964: HGS; NbExp=3; IntAct=EBI-3044087, EBI-740220;
CC Q7Z3Y8; Q86VS8: HOOK3; NbExp=3; IntAct=EBI-3044087, EBI-1777078;
CC Q7Z3Y8; P17482: HOXB9; NbExp=3; IntAct=EBI-3044087, EBI-745290;
CC Q7Z3Y8; Q8NDH6-2: ICA1L; NbExp=3; IntAct=EBI-3044087, EBI-12141931;
CC Q7Z3Y8; Q15040: JOSD1; NbExp=3; IntAct=EBI-3044087, EBI-2510602;
CC Q7Z3Y8; Q63ZY3: KANK2; NbExp=3; IntAct=EBI-3044087, EBI-2556193;
CC Q7Z3Y8; Q5T5P2-6: KIAA1217; NbExp=3; IntAct=EBI-3044087, EBI-10188326;
CC Q7Z3Y8; Q2WGJ6: KLHL38; NbExp=3; IntAct=EBI-3044087, EBI-6426443;
CC Q7Z3Y8; P04264: KRT1; NbExp=3; IntAct=EBI-3044087, EBI-298429;
CC Q7Z3Y8; P35908: KRT2; NbExp=3; IntAct=EBI-3044087, EBI-1247312;
CC Q7Z3Y8; P35900: KRT20; NbExp=3; IntAct=EBI-3044087, EBI-742094;
CC Q7Z3Y8; P12035: KRT3; NbExp=3; IntAct=EBI-3044087, EBI-2430095;
CC Q7Z3Y8; P19013: KRT4; NbExp=3; IntAct=EBI-3044087, EBI-2371606;
CC Q7Z3Y8; P13647: KRT5; NbExp=3; IntAct=EBI-3044087, EBI-702187;
CC Q7Z3Y8; P02538: KRT6A; NbExp=3; IntAct=EBI-3044087, EBI-702198;
CC Q7Z3Y8; P04259: KRT6B; NbExp=3; IntAct=EBI-3044087, EBI-740907;
CC Q7Z3Y8; P48668: KRT6C; NbExp=3; IntAct=EBI-3044087, EBI-2564105;
CC Q7Z3Y8; Q3SY84: KRT71; NbExp=3; IntAct=EBI-3044087, EBI-2952676;
CC Q7Z3Y8; Q14CN4: KRT72; NbExp=3; IntAct=EBI-3044087, EBI-1221280;
CC Q7Z3Y8; Q7RTS7: KRT74; NbExp=3; IntAct=EBI-3044087, EBI-968660;
CC Q7Z3Y8; O95678: KRT75; NbExp=3; IntAct=EBI-3044087, EBI-2949715;
CC Q7Z3Y8; Q01546: KRT76; NbExp=3; IntAct=EBI-3044087, EBI-2952745;
CC Q7Z3Y8; Q7Z794: KRT77; NbExp=3; IntAct=EBI-3044087, EBI-3045529;
CC Q7Z3Y8; Q8N1N4: KRT78; NbExp=3; IntAct=EBI-3044087, EBI-1056564;
CC Q7Z3Y8; Q5XKE5: KRT79; NbExp=4; IntAct=EBI-3044087, EBI-2514135;
CC Q7Z3Y8; P05787: KRT8; NbExp=3; IntAct=EBI-3044087, EBI-297852;
CC Q7Z3Y8; Q14533: KRT81; NbExp=3; IntAct=EBI-3044087, EBI-739648;
CC Q7Z3Y8; Q9NSB4: KRT82; NbExp=3; IntAct=EBI-3044087, EBI-1045341;
CC Q7Z3Y8; P78385: KRT83; NbExp=3; IntAct=EBI-3044087, EBI-10221390;
CC Q7Z3Y8; P78386: KRT85; NbExp=3; IntAct=EBI-3044087, EBI-1049371;
CC Q7Z3Y8; O43790: KRT86; NbExp=3; IntAct=EBI-3044087, EBI-9996498;
CC Q7Z3Y8; Q8TD35-2: LKAAEAR1; NbExp=3; IntAct=EBI-3044087, EBI-12159375;
CC Q7Z3Y8; Q8IXW0: LMNTD2; NbExp=3; IntAct=EBI-3044087, EBI-12028858;
CC Q7Z3Y8; P43243: MATR3; NbExp=3; IntAct=EBI-3044087, EBI-352602;
CC Q7Z3Y8; Q8NHZ7: MBD3L2; NbExp=3; IntAct=EBI-3044087, EBI-11989378;
CC Q7Z3Y8; Q8IVT4: MGC50722; NbExp=3; IntAct=EBI-3044087, EBI-14086479;
CC Q7Z3Y8; Q9UJV3-2: MID2; NbExp=3; IntAct=EBI-3044087, EBI-10172526;
CC Q7Z3Y8; Q8NDC4: MORN4; NbExp=3; IntAct=EBI-3044087, EBI-10269566;
CC Q7Z3Y8; P00540: MOS; NbExp=3; IntAct=EBI-3044087, EBI-1757866;
CC Q7Z3Y8; Q96QG7: MTMR9; NbExp=3; IntAct=EBI-3044087, EBI-744593;
CC Q7Z3Y8; O14777: NDC80; NbExp=3; IntAct=EBI-3044087, EBI-715849;
CC Q7Z3Y8; Q9BU61: NDUFAF3; NbExp=3; IntAct=EBI-3044087, EBI-2114801;
CC Q7Z3Y8; Q96HA8: NTAQ1; NbExp=3; IntAct=EBI-3044087, EBI-741158;
CC Q7Z3Y8; Q7Z3B4: NUP54; NbExp=3; IntAct=EBI-3044087, EBI-741048;
CC Q7Z3Y8; Q9BVL2: NUP58; NbExp=3; IntAct=EBI-3044087, EBI-2811583;
CC Q7Z3Y8; A5D8V7: ODAD3; NbExp=3; IntAct=EBI-3044087, EBI-8466445;
CC Q7Z3Y8; O43482: OIP5; NbExp=3; IntAct=EBI-3044087, EBI-536879;
CC Q7Z3Y8; Q96AL5: PBX3; NbExp=3; IntAct=EBI-3044087, EBI-741171;
CC Q7Z3Y8; Q9Y5E9: PCDHB14; NbExp=3; IntAct=EBI-3044087, EBI-10329013;
CC Q7Z3Y8; Q9H307: PNN; NbExp=3; IntAct=EBI-3044087, EBI-681904;
CC Q7Z3Y8; Q9UGP5-2: POLL; NbExp=3; IntAct=EBI-3044087, EBI-10320765;
CC Q7Z3Y8; Q6NYC8: PPP1R18; NbExp=3; IntAct=EBI-3044087, EBI-2557469;
CC Q7Z3Y8; P41219: PRPH; NbExp=3; IntAct=EBI-3044087, EBI-752074;
CC Q7Z3Y8; P62195: PSMC5; NbExp=3; IntAct=EBI-3044087, EBI-357745;
CC Q7Z3Y8; Q86YV0: RASAL3; NbExp=3; IntAct=EBI-3044087, EBI-3437896;
CC Q7Z3Y8; Q96IZ5: RBM41; NbExp=3; IntAct=EBI-3044087, EBI-740773;
CC Q7Z3Y8; Q9P2K3-2: RCOR3; NbExp=3; IntAct=EBI-3044087, EBI-1504830;
CC Q7Z3Y8; Q9H2S5: RNF39; NbExp=3; IntAct=EBI-3044087, EBI-12235180;
CC Q7Z3Y8; Q14D33: RTP5; NbExp=3; IntAct=EBI-3044087, EBI-10217913;
CC Q7Z3Y8; Q06455-2: RUNX1T1; NbExp=3; IntAct=EBI-3044087, EBI-11984663;
CC Q7Z3Y8; Q9BWG6: SCNM1; NbExp=3; IntAct=EBI-3044087, EBI-748391;
CC Q7Z3Y8; A6NFY7: SDHAF1; NbExp=3; IntAct=EBI-3044087, EBI-12011488;
CC Q7Z3Y8; Q9C0C4: SEMA4C; NbExp=3; IntAct=EBI-3044087, EBI-10303490;
CC Q7Z3Y8; Q96ES7: SGF29; NbExp=3; IntAct=EBI-3044087, EBI-743117;
CC Q7Z3Y8; O76082: SLC22A5; NbExp=3; IntAct=EBI-3044087, EBI-9846338;
CC Q7Z3Y8; Q9GZT3: SLIRP; NbExp=3; IntAct=EBI-3044087, EBI-1050793;
CC Q7Z3Y8; Q8TAQ2-2: SMARCC2; NbExp=3; IntAct=EBI-3044087, EBI-11990400;
CC Q7Z3Y8; Q96GM5: SMARCD1; NbExp=3; IntAct=EBI-3044087, EBI-358489;
CC Q7Z3Y8; Q969G3: SMARCE1; NbExp=3; IntAct=EBI-3044087, EBI-455078;
CC Q7Z3Y8; O95295: SNAPIN; NbExp=3; IntAct=EBI-3044087, EBI-296723;
CC Q7Z3Y8; A1L4H1: SSC5D; NbExp=3; IntAct=EBI-3044087, EBI-10172867;
CC Q7Z3Y8; Q99909: SSX3; NbExp=3; IntAct=EBI-3044087, EBI-10295431;
CC Q7Z3Y8; Q9UMX1: SUFU; NbExp=3; IntAct=EBI-3044087, EBI-740595;
CC Q7Z3Y8; P51687: SUOX; NbExp=3; IntAct=EBI-3044087, EBI-3921347;
CC Q7Z3Y8; Q969Z0: TBRG4; NbExp=3; IntAct=EBI-3044087, EBI-702328;
CC Q7Z3Y8; Q15561: TEAD4; NbExp=3; IntAct=EBI-3044087, EBI-747736;
CC Q7Z3Y8; Q7L2K0: TEDC2; NbExp=3; IntAct=EBI-3044087, EBI-8465456;
CC Q7Z3Y8; O15482: TEX28P2; NbExp=3; IntAct=EBI-3044087, EBI-751954;
CC Q7Z3Y8; Q9BT49: THAP7; NbExp=3; IntAct=EBI-3044087, EBI-741350;
CC Q7Z3Y8; P13805-3: TNNT1; NbExp=3; IntAct=EBI-3044087, EBI-12151635;
CC Q7Z3Y8; Q9Y228: TRAF3IP3; NbExp=3; IntAct=EBI-3044087, EBI-765817;
CC Q7Z3Y8; Q8N7C3: TRIML2; NbExp=3; IntAct=EBI-3044087, EBI-11059915;
CC Q7Z3Y8; Q9UJT2: TSKS; NbExp=3; IntAct=EBI-3044087, EBI-852101;
CC Q7Z3Y8; Q5W5X9-3: TTC23; NbExp=3; IntAct=EBI-3044087, EBI-9090990;
CC Q7Z3Y8; P40222: TXLNA; NbExp=3; IntAct=EBI-3044087, EBI-359793;
CC Q7Z3Y8; Q8N3L3: TXLNB; NbExp=3; IntAct=EBI-3044087, EBI-6116822;
CC Q7Z3Y8; Q99757: TXN2; NbExp=3; IntAct=EBI-3044087, EBI-2932492;
CC Q7Z3Y8; Q8N6Y0: USHBP1; NbExp=3; IntAct=EBI-3044087, EBI-739895;
CC Q7Z3Y8; O75604: USP2; NbExp=3; IntAct=EBI-3044087, EBI-743272;
CC Q7Z3Y8; A5D8V6: VPS37C; NbExp=3; IntAct=EBI-3044087, EBI-2559305;
CC Q7Z3Y8; Q9Y3C0: WASHC3; NbExp=3; IntAct=EBI-3044087, EBI-712969;
CC Q7Z3Y8; Q13426: XRCC4; NbExp=3; IntAct=EBI-3044087, EBI-717592;
CC Q7Z3Y8; Q6PJT7-6: ZC3H14; NbExp=3; IntAct=EBI-3044087, EBI-12147703;
CC Q7Z3Y8; Q68DK2-5: ZFYVE26; NbExp=3; IntAct=EBI-3044087, EBI-8656416;
CC Q7Z3Y8; P17036: ZNF3; NbExp=3; IntAct=EBI-3044087, EBI-1640965;
CC Q7Z3Y8; Q9UK33: ZNF580; NbExp=3; IntAct=EBI-3044087, EBI-746277;
CC Q7Z3Y8; Q9P0T4: ZNF581; NbExp=3; IntAct=EBI-3044087, EBI-745520;
CC Q7Z3Y8; Q96BR6: ZNF669; NbExp=3; IntAct=EBI-3044087, EBI-12006574;
CC Q7Z3Y8; P51504: ZNF80; NbExp=3; IntAct=EBI-3044087, EBI-12013828;
CC Q7Z3Y8; Q6ZN96; NbExp=3; IntAct=EBI-3044087, EBI-10255097;
CC Q7Z3Y8; PRO_0000449633 [P0DTD1]: rep; Xeno; NbExp=3; IntAct=EBI-3044087, EBI-25492395;
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q9Z320}.
CC -!- TISSUE SPECIFICITY: Strongly expressed in skin and scalp. In the hair
CC follicle, expressed in Henle layer, Huxley layer and in the inner root
CC sheath cuticle of the hair follicle. Expression extends from the bulb
CC region up to the point of differentiation into the three layers. Also
CC present in the medulla of beard hair (at protein level).
CC {ECO:0000269|PubMed:15617563, ECO:0000269|PubMed:16874310}.
CC -!- MISCELLANEOUS: There are two types of cytoskeletal and microfibrillar
CC keratin: I (acidic; 40-55 kDa) and II (neutral to basic; 56-70 kDa).
CC {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the intermediate filament family.
CC {ECO:0000255|PROSITE-ProRule:PRU01188}.
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DR EMBL; AJ564206; CAD91906.1; -; mRNA.
DR EMBL; AC090283; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR CCDS; CCDS11375.1; -.
DR RefSeq; NP_853515.2; NM_181537.3.
DR AlphaFoldDB; Q7Z3Y8; -.
DR SMR; Q7Z3Y8; -.
DR BioGRID; 131185; 205.
DR IntAct; Q7Z3Y8; 143.
DR STRING; 9606.ENSP00000301656; -.
DR iPTMnet; Q7Z3Y8; -.
DR PhosphoSitePlus; Q7Z3Y8; -.
DR SwissPalm; Q7Z3Y8; -.
DR BioMuta; KRT27; -.
DR DMDM; 296434549; -.
DR jPOST; Q7Z3Y8; -.
DR MassIVE; Q7Z3Y8; -.
DR PaxDb; Q7Z3Y8; -.
DR PeptideAtlas; Q7Z3Y8; -.
DR PRIDE; Q7Z3Y8; -.
DR ProteomicsDB; 69096; -.
DR TopDownProteomics; Q7Z3Y8; -.
DR Antibodypedia; 55223; 12 antibodies from 9 providers.
DR DNASU; 342574; -.
DR Ensembl; ENST00000301656.4; ENSP00000301656.3; ENSG00000171446.7.
DR GeneID; 342574; -.
DR KEGG; hsa:342574; -.
DR MANE-Select; ENST00000301656.4; ENSP00000301656.3; NM_181537.4; NP_853515.2.
DR UCSC; uc002hvg.3; human.
DR CTD; 342574; -.
DR GeneCards; KRT27; -.
DR HGNC; HGNC:30841; KRT27.
DR HPA; ENSG00000171446; Tissue enriched (skin).
DR MIM; 616676; gene.
DR neXtProt; NX_Q7Z3Y8; -.
DR OpenTargets; ENSG00000171446; -.
DR PharmGKB; PA134990976; -.
DR VEuPathDB; HostDB:ENSG00000171446; -.
DR eggNOG; ENOG502SIHJ; Eukaryota.
DR GeneTree; ENSGT00940000161982; -.
DR HOGENOM; CLU_012560_8_3_1; -.
DR InParanoid; Q7Z3Y8; -.
DR OMA; SRVHTME; -.
DR OrthoDB; 805081at2759; -.
DR PhylomeDB; Q7Z3Y8; -.
DR TreeFam; TF332742; -.
DR PathwayCommons; Q7Z3Y8; -.
DR Reactome; R-HSA-6805567; Keratinization.
DR Reactome; R-HSA-6809371; Formation of the cornified envelope.
DR SignaLink; Q7Z3Y8; -.
DR BioGRID-ORCS; 342574; 12 hits in 1071 CRISPR screens.
DR GenomeRNAi; 342574; -.
DR Pharos; Q7Z3Y8; Tdark.
DR PRO; PR:Q7Z3Y8; -.
DR Proteomes; UP000005640; Chromosome 17.
DR RNAct; Q7Z3Y8; protein.
DR Bgee; ENSG00000171446; Expressed in upper arm skin and 80 other tissues.
DR Genevisible; Q7Z3Y8; HS.
DR GO; GO:0005856; C:cytoskeleton; IBA:GO_Central.
DR GO; GO:0005829; C:cytosol; TAS:Reactome.
DR GO; GO:0070062; C:extracellular exosome; HDA:UniProtKB.
DR GO; GO:0005882; C:intermediate filament; IEA:UniProtKB-KW.
DR GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
DR GO; GO:0031069; P:hair follicle morphogenesis; IBA:GO_Central.
DR GO; GO:0045109; P:intermediate filament organization; IBA:GO_Central.
DR InterPro; IPR039008; IF_rod_dom.
DR InterPro; IPR002957; Keratin_I.
DR PANTHER; PTHR23239; PTHR23239; 1.
DR Pfam; PF00038; Filament; 1.
DR PRINTS; PR01248; TYPE1KERATIN.
DR SMART; SM01391; Filament; 1.
DR PROSITE; PS51842; IF_ROD_2; 1.
PE 1: Evidence at protein level;
KW Coiled coil; Cytoplasm; Intermediate filament; Keratin; Reference proteome.
FT CHAIN 1..459
FT /note="Keratin, type I cytoskeletal 27"
FT /id="PRO_0000312701"
FT DOMAIN 84..399
FT /note="IF rod"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01188"
FT REGION 1..83
FT /note="Head"
FT /evidence="ECO:0000255"
FT REGION 84..119
FT /note="Coil 1A"
FT /evidence="ECO:0000255"
FT REGION 120..141
FT /note="Linker 1"
FT /evidence="ECO:0000255"
FT REGION 142..233
FT /note="Coil 1B"
FT /evidence="ECO:0000255"
FT REGION 234..256
FT /note="Linker 12"
FT /evidence="ECO:0000255"
FT REGION 257..395
FT /note="Coil 2"
FT /evidence="ECO:0000255"
FT REGION 396..459
FT /note="Tail"
FT /evidence="ECO:0000255"
FT REGION 436..459
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 436..451
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VARIANT 52
FT /note="S -> T (in dbSNP:rs2469826)"
FT /evidence="ECO:0000269|PubMed:15617563"
FT /id="VAR_063138"
FT VARIANT 144
FT /note="E -> K (in dbSNP:rs12453124)"
FT /evidence="ECO:0000269|PubMed:15617563"
FT /id="VAR_063139"
FT VARIANT 193
FT /note="G -> S (in dbSNP:rs17558560)"
FT /id="VAR_056007"
FT VARIANT 284
FT /note="A -> T (in dbSNP:rs17558532)"
FT /id="VAR_056008"
FT VARIANT 305
FT /note="I -> T (in dbSNP:rs981684)"
FT /evidence="ECO:0000269|PubMed:15617563"
FT /id="VAR_063140"
SQ SEQUENCE 459 AA; 49822 MW; F5DD71FE7FEFFF62 CRC64;
MSVRFSSTSR RLGSCGGTGS VRLSSGGAGF GAGNTCGVPG IGSGFSCAFG GSSSAGGYGG
GLGGGSASCA AFTGNEHGLL SGNEKVTMQN LNDRLASYLE NVRALEEANA DLEQKIKGWY
EKFGPGSCRG LDHDYSRYFP IIDELKNQII SATTSNAHVV LQNDNARLTA DDFRLKFENE
LALHQSVEAD INGLRRVLDE LTLCRTDLEI QLETLSEELA YLKKNHEEEM KALQCAAGGN
VNVEMNAAPG VDLTVLLNNM RAEYEALAEQ NRRDAEAWFN EKSASLQQQI SDDAGATTSA
RNELIEMKRT LQTLEIELQS LLATKHSLEC SLTETESNYC AQLAQIQAQI GALEEQLHQV
RTETEGQKLE YEQLLDIKVH LEKEIETYCL LIDGEDGSCS KSKGYGGPGN QTKDSSKTTI
VKTVVEEIDP RGKVLSSRVH TVEEKSTKVN NKNEQRVSS
