ID   K1C28_BOVIN             Reviewed;         464 AA.
AC   Q148H6;
DT   04-DEC-2007, integrated into UniProtKB/Swiss-Prot.
DT   22-AUG-2006, sequence version 1.
DT   03-AUG-2022, entry version 101.
DE   RecName: Full=Keratin, type I cytoskeletal 28;
DE   AltName: Full=Cytokeratin-28;
DE            Short=CK-28;
DE   AltName: Full=Keratin-28;
DE            Short=K28;
DE   AltName: Full=Type I inner root sheath-specific keratin-K25irs4;
GN   Name=KRT28 {ECO:0000250|UniProtKB:Q7Z3Y7};
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1] {ECO:0000312|EMBL:AAI18317.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford {ECO:0000312|EMBL:AAI18317.1};
RC   TISSUE=Fetal skin {ECO:0000312|EMBL:AAI18317.1};
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (JUN-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Essential for the proper assembly of types I and II keratin
CC       protein complexes and the formation of keratin intermediate filaments
CC       in the inner root sheath (irs). {ECO:0000250|UniProtKB:A6BLY7}.
CC   -!- SUBUNIT: Heterotetramer of two type I and two type II keratins.
CC       {ECO:0000305}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:A6BLY7}.
CC   -!- MISCELLANEOUS: There are two types of cytoskeletal and microfibrillar
CC       keratin: I (acidic; 40-55 kDa) and II (neutral to basic; 56-70 kDa).
CC       {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the intermediate filament family.
CC       {ECO:0000255|PROSITE-ProRule:PRU01188}.
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DR   EMBL; BC118316; AAI18317.1; -; mRNA.
DR   RefSeq; NP_001073844.1; NM_001080375.1.
DR   AlphaFoldDB; Q148H6; -.
DR   SMR; Q148H6; -.
DR   STRING; 9913.ENSBTAP00000034743; -.
DR   PaxDb; Q148H6; -.
DR   PeptideAtlas; Q148H6; -.
DR   PRIDE; Q148H6; -.
DR   Ensembl; ENSBTAT00000034859; ENSBTAP00000034743; ENSBTAG00000030555.
DR   GeneID; 788909; -.
DR   KEGG; bta:788909; -.
DR   CTD; 162605; -.
DR   VEuPathDB; HostDB:ENSBTAG00000030555; -.
DR   VGNC; VGNC:30727; KRT28.
DR   eggNOG; ENOG502SHRG; Eukaryota.
DR   GeneTree; ENSGT00940000162192; -.
DR   HOGENOM; CLU_012560_8_3_1; -.
DR   InParanoid; Q148H6; -.
DR   OMA; KGWYDKY; -.
DR   OrthoDB; 805081at2759; -.
DR   TreeFam; TF332742; -.
DR   Proteomes; UP000009136; Chromosome 19.
DR   Bgee; ENSBTAG00000030555; Expressed in zone of skin and 8 other tissues.
DR   ExpressionAtlas; Q148H6; baseline.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005856; C:cytoskeleton; IBA:GO_Central.
DR   GO; GO:0005882; C:intermediate filament; IEA:UniProtKB-KW.
DR   GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
DR   InterPro; IPR039008; IF_rod_dom.
DR   InterPro; IPR002957; Keratin_I.
DR   PANTHER; PTHR23239; PTHR23239; 1.
DR   Pfam; PF00038; Filament; 1.
DR   PRINTS; PR01248; TYPE1KERATIN.
DR   SMART; SM01391; Filament; 1.
DR   PROSITE; PS51842; IF_ROD_2; 1.
PE   2: Evidence at transcript level;
KW   Coiled coil; Cytoplasm; Intermediate filament; Keratin; Reference proteome.
FT   CHAIN           1..464
FT                   /note="Keratin, type I cytoskeletal 28"
FT                   /id="PRO_0000312704"
FT   DOMAIN          86..401
FT                   /note="IF rod"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01188"
FT   REGION          1..85
FT                   /note="Head"
FT                   /evidence="ECO:0000255"
FT   REGION          86..121
FT                   /note="Coil 1A"
FT                   /evidence="ECO:0000255"
FT   REGION          122..143
FT                   /note="Linker 1"
FT                   /evidence="ECO:0000255"
FT   REGION          144..235
FT                   /note="Coil 1B"
FT                   /evidence="ECO:0000255"
FT   REGION          236..258
FT                   /note="Linker 12"
FT                   /evidence="ECO:0000255"
FT   REGION          259..397
FT                   /note="Coil 2"
FT                   /evidence="ECO:0000255"
FT   REGION          398..464
FT                   /note="Tail"
FT                   /evidence="ECO:0000255"
FT   REGION          402..422
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          440..464
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   464 AA;  50775 MW;  9DB5A2A0E899BBE7 CRC64;
     MSLRFSSGSR HICLRSGTES VRPSSGGTGF AGSNVYGNSG AGCGFSYALG GGLGSLPGGD
     HAGGIPGSGT CVGFAGSEGG LFSGNEKVTM QNLNDRLASY LDNVRALEEA NAELERKIKS
     WYEKHGPGSC HGLDHDYSRY HLTIEDLKNK IISSTTANAN VILQIDNARL AADDFRLKYE
     NELALHQNTE ADINGLRRVL DELTLCRTDQ ELQYESLSEE MTYLKKNHEE EVKALQCVAG
     GNVNVEMNAA PGVDLTLLLN NMRAEYEDLA EQNRRDAEAW FNEKSASLQQ QISDDAGAAS
     SARGELTEMK RTVQTLDIEL QSLLATKHSL ECSLMETEGN YCAQLAQIQA QIGALEEQLH
     QVRTETEGQK LEYEQLLDIK VHLEKEIETY CRLIDGDRNS CSKSKGFGSG SPGNSSKDLS
     RTTLVKTVVE EIDQRGKVLS SRVQSIEEKT SKMTNGKTKQ RVPF