K1C39_MOUSE
ID K1C39_MOUSE Reviewed; 482 AA.
AC Q6IFX4; A2VCT4; Q0VDS4;
DT 15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT 15-JAN-2008, sequence version 2.
DT 03-AUG-2022, entry version 124.
DE RecName: Full=Keratin, type I cytoskeletal 39;
DE AltName: Full=Cytokeratin-39;
DE Short=CK-39;
DE AltName: Full=Keratin-39;
DE Short=K39;
DE AltName: Full=Type I hair keratin Ka35;
GN Name=Krt39; Synonyms=Ka35;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP IDENTIFICATION.
RX PubMed=15085952; DOI=10.1078/0171-9335-00354;
RA Hesse M., Zimek A., Weber K., Magin T.M.;
RT "Comprehensive analysis of keratin gene clusters in humans and rodents.";
RL Eur. J. Cell Biol. 83:19-26(2004).
CC -!- FUNCTION: May play a role in late hair differentiation. {ECO:0000250}.
CC -!- SUBUNIT: Heterotetramer of two type I and two type II keratins.
CC -!- MISCELLANEOUS: There are two types of cytoskeletal and microfibrillar
CC keratin, I (acidic) and II (neutral to basic) (40-55 and 56-70 kDa,
CC respectively).
CC -!- SIMILARITY: Belongs to the intermediate filament family.
CC {ECO:0000255|PROSITE-ProRule:PRU01188}.
CC -!- SEQUENCE CAUTION:
CC Sequence=DAA04489.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AL591417; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC119541; AAI19542.1; -; mRNA.
DR EMBL; BC128563; AAI28564.1; -; mRNA.
DR EMBL; BK004022; DAA04489.1; ALT_SEQ; mRNA.
DR CCDS; CCDS25383.1; -.
DR RefSeq; NP_998895.2; NM_213730.2.
DR AlphaFoldDB; Q6IFX4; -.
DR SMR; Q6IFX4; -.
DR IntAct; Q6IFX4; 1.
DR STRING; 10090.ENSMUSP00000103069; -.
DR iPTMnet; Q6IFX4; -.
DR PhosphoSitePlus; Q6IFX4; -.
DR PaxDb; Q6IFX4; -.
DR PeptideAtlas; Q6IFX4; -.
DR PRIDE; Q6IFX4; -.
DR ProteomicsDB; 269053; -.
DR Antibodypedia; 55323; 33 antibodies from 10 providers.
DR DNASU; 237934; -.
DR Ensembl; ENSMUST00000076948; ENSMUSP00000076216; ENSMUSG00000064165.
DR Ensembl; ENSMUST00000107445; ENSMUSP00000103069; ENSMUSG00000064165.
DR GeneID; 237934; -.
DR KEGG; mmu:237934; -.
DR UCSC; uc007lix.1; mouse.
DR CTD; 390792; -.
DR MGI; MGI:3588208; Krt39.
DR VEuPathDB; HostDB:ENSMUSG00000064165; -.
DR eggNOG; ENOG502SH7Y; Eukaryota.
DR GeneTree; ENSGT00940000162203; -.
DR HOGENOM; CLU_012560_8_0_1; -.
DR InParanoid; Q6IFX4; -.
DR OMA; KEHCSAC; -.
DR OrthoDB; 798081at2759; -.
DR PhylomeDB; Q6IFX4; -.
DR TreeFam; TF332742; -.
DR Reactome; R-MMU-6805567; Keratinization.
DR Reactome; R-MMU-6809371; Formation of the cornified envelope.
DR BioGRID-ORCS; 237934; 3 hits in 73 CRISPR screens.
DR PRO; PR:Q6IFX4; -.
DR Proteomes; UP000000589; Chromosome 11.
DR RNAct; Q6IFX4; protein.
DR Bgee; ENSMUSG00000064165; Expressed in tail skin and 14 other tissues.
DR GO; GO:0005856; C:cytoskeleton; IBA:GO_Central.
DR GO; GO:0005882; C:intermediate filament; IEA:UniProtKB-KW.
DR GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
DR GO; GO:0030855; P:epithelial cell differentiation; IBA:GO_Central.
DR GO; GO:0045109; P:intermediate filament organization; IBA:GO_Central.
DR InterPro; IPR018039; IF_conserved.
DR InterPro; IPR039008; IF_rod_dom.
DR InterPro; IPR002957; Keratin_I.
DR PANTHER; PTHR23239; PTHR23239; 1.
DR Pfam; PF00038; Filament; 1.
DR PRINTS; PR01248; TYPE1KERATIN.
DR SMART; SM01391; Filament; 1.
DR PROSITE; PS00226; IF_ROD_1; 1.
DR PROSITE; PS51842; IF_ROD_2; 1.
PE 2: Evidence at transcript level;
KW Coiled coil; Intermediate filament; Keratin; Reference proteome.
FT CHAIN 1..482
FT /note="Keratin, type I cytoskeletal 39"
FT /id="PRO_0000314854"
FT DOMAIN 91..402
FT /note="IF rod"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01188"
FT REGION 1..91
FT /note="Head"
FT REGION 1..24
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 92..126
FT /note="Coil 1A"
FT REGION 127..137
FT /note="Linker 1"
FT REGION 138..238
FT /note="Coil 1B"
FT REGION 239..254
FT /note="Linker 12"
FT REGION 255..398
FT /note="Coil 2"
FT REGION 399..482
FT /note="Tail"
FT SITE 340
FT /note="Stutter"
FT CONFLICT 351
FT /note="S -> G (in Ref. 2; AAI28564)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 482 AA; 54287 MW; F8E1D5861A91F151 CRC64;
MDTKGSTVTI SSSTPPQNCS GNTNFRTNSS SNKSCCHDGQ STGCALQTPQ GQGCGSSPCL
YRCPHYLIRT YSFHPCLDDG SRCTEGINTH EKETMQILNE RLANYLEKVR MLEGENADLE
DKIQEACSKA LPILCPDYLS YYTTIEELQQ KILCTKAENS RLVSQIDNTK LAADDLRANY
EAELSLRQLV EADANGLKQI LDALTLSKAD LEARVQSLTE ELLCLKTNHE EEVNSLQCQL
GDRINIEVTA APSVDLNQIL QEMRCRYESI METNRKDVEE WFNTQMEELN QQVVSSSQQQ
QCCQKDIIEL RRTISALEIE LQAQHRMRES QECILTETEA RYTALLAQIQ SLIHNLEAQV
ADIRSALQRQ SQEYEVLLDI KSRLECEIAT YRSLLESLDG RLPCNPCATK WEPSCQARAM
ECFTPVYTSS SLPGIHKPCR ASGPPSRILV KICTITKEIK DGKVISSYEH VQPCYITRAT
KV
