ID   K1C3_XENLA              Reviewed;         280 AA.
AC   P05782;
DT   01-NOV-1988, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1996, sequence version 2.
DT   25-MAY-2022, entry version 75.
DE   RecName: Full=Keratin, type I cytoskeletal 47 kDa;
DE   Flags: Fragment;
GN   Name=xk81b1;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA   Miyatani S.;
RL   Submitted (JUL-1987) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 147-280.
RX   PubMed=2430981; DOI=10.1083/jcb.103.5.1957;
RA   Miyatani S., Winkles J.A., Sargent T.D., Dawid I.B.;
RT   "Stage-specific keratins in Xenopus laevis embryos and tadpoles: the XK81
RT   gene family.";
RL   J. Cell Biol. 103:1957-1965(1986).
CC   -!- SUBUNIT: Heterotetramer of two type I and two type II keratins.
CC   -!- MISCELLANEOUS: There are two types of cytoskeletal and microfibrillar
CC       keratin: I (acidic; 40-55 kDa) and II (neutral to basic; 56-70 kDa).
CC   -!- SIMILARITY: Belongs to the intermediate filament family.
CC       {ECO:0000255|PROSITE-ProRule:PRU01188}.
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DR   EMBL; X04805; CAA28497.1; -; Genomic_DNA.
DR   AlphaFoldDB; P05782; -.
DR   SMR; P05782; -.
DR   PRIDE; P05782; -.
DR   Proteomes; UP000186698; Genome assembly.
DR   GO; GO:0005882; C:intermediate filament; IEA:UniProtKB-KW.
DR   GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
DR   InterPro; IPR039008; IF_rod_dom.
DR   InterPro; IPR002957; Keratin_I.
DR   PANTHER; PTHR23239; PTHR23239; 1.
DR   Pfam; PF00038; Filament; 1.
DR   PRINTS; PR01248; TYPE1KERATIN.
DR   SMART; SM01391; Filament; 1.
DR   PROSITE; PS51842; IF_ROD_2; 1.
PE   3: Inferred from homology;
KW   Coiled coil; Intermediate filament; Keratin; Reference proteome.
FT   CHAIN           1..>280
FT                   /note="Keratin, type I cytoskeletal 47 kDa"
FT                   /id="PRO_0000063682"
FT   DOMAIN          82..>280
FT                   /note="IF rod"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01188"
FT   REGION          1..81
FT                   /note="Head"
FT   REGION          82..117
FT                   /note="Coil 1A"
FT   REGION          118..139
FT                   /note="Linker 1"
FT   REGION          140..231
FT                   /note="Coil 1B"
FT   REGION          232..254
FT                   /note="Linker 12"
FT   REGION          255..>280
FT                   /note="Coil 2"
FT   NON_TER         280
SQ   SEQUENCE   280 AA;  29906 MW;  518F18172B210BB8 CRC64;
     MSFRSSSSYS VQSKNVSGGG GFGSSYGGGS SSSFGGGYGA GFGGGYGAGF GGGASSGFSS
     SSSGGFGAAA ASSSFSSFGG NDKQTMQNLN DRLASYLEKV RALEAANADL ELKIREWYEK
     QKGSGIGAAS KDFSKYFEII SDLRNKILFA TIDNPRVVLQ IDDAKLAADD FRLKFENELA
     LRQSVEADIN GLRRVLDELT LARGDLEMQI ESLTEELAYL KKNHEEEMSI AKGSAAGQVT
     VEMDAAPGVD LNKILSDMRA DYETLAEKNR RDAELWFNQK