K1C40_BOVIN
ID K1C40_BOVIN Reviewed; 431 AA.
AC A7YWM2;
DT 15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT 23-OCT-2007, sequence version 1.
DT 03-AUG-2022, entry version 79.
DE RecName: Full=Keratin, type I cytoskeletal 40;
DE AltName: Full=Cytokeratin-40;
DE Short=CK-40;
DE AltName: Full=Keratin-40;
DE Short=K40;
GN Name=KRT40;
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Hereford; TISSUE=Fetal skin;
RG NIH - Mammalian Gene Collection (MGC) project;
RL Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: May play a role in late hair differentiation. {ECO:0000250}.
CC -!- SUBUNIT: Heterotetramer of two type I and two type II keratins.
CC -!- MISCELLANEOUS: There are two types of cytoskeletal and microfibrillar
CC keratin, I (acidic) and II (neutral to basic) (40-55 and 56-70 kDa,
CC respectively).
CC -!- SIMILARITY: Belongs to the intermediate filament family.
CC {ECO:0000255|PROSITE-ProRule:PRU01188}.
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DR EMBL; BC134653; AAI34654.1; -; mRNA.
DR RefSeq; NP_001098888.1; NM_001105418.1.
DR AlphaFoldDB; A7YWM2; -.
DR SMR; A7YWM2; -.
DR STRING; 9913.ENSBTAP00000023156; -.
DR PaxDb; A7YWM2; -.
DR PeptideAtlas; A7YWM2; -.
DR PRIDE; A7YWM2; -.
DR Ensembl; ENSBTAT00000023156; ENSBTAP00000023156; ENSBTAG00000017408.
DR GeneID; 538611; -.
DR KEGG; bta:538611; -.
DR CTD; 125115; -.
DR VEuPathDB; HostDB:ENSBTAG00000017408; -.
DR VGNC; VGNC:30733; KRT40.
DR eggNOG; ENOG502SHG0; Eukaryota.
DR GeneTree; ENSGT00940000161968; -.
DR HOGENOM; CLU_012560_8_0_1; -.
DR InParanoid; A7YWM2; -.
DR OMA; LNQQQLC; -.
DR OrthoDB; 798081at2759; -.
DR TreeFam; TF332742; -.
DR Reactome; R-BTA-6805567; Keratinization.
DR Proteomes; UP000009136; Chromosome 19.
DR Bgee; ENSBTAG00000017408; Expressed in zone of skin and 3 other tissues.
DR GO; GO:0005856; C:cytoskeleton; IBA:GO_Central.
DR GO; GO:0005882; C:intermediate filament; IEA:UniProtKB-KW.
DR GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
DR GO; GO:0030855; P:epithelial cell differentiation; IBA:GO_Central.
DR GO; GO:0045109; P:intermediate filament organization; IBA:GO_Central.
DR InterPro; IPR039008; IF_rod_dom.
DR InterPro; IPR002957; Keratin_I.
DR PANTHER; PTHR23239; PTHR23239; 1.
DR Pfam; PF00038; Filament; 1.
DR PRINTS; PR01248; TYPE1KERATIN.
DR SMART; SM01391; Filament; 1.
DR PROSITE; PS51842; IF_ROD_2; 1.
PE 2: Evidence at transcript level;
KW Coiled coil; Intermediate filament; Keratin; Reference proteome.
FT CHAIN 1..431
FT /note="Keratin, type I cytoskeletal 40"
FT /id="PRO_0000314856"
FT DOMAIN 89..400
FT /note="IF rod"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01188"
FT REGION 1..89
FT /note="Head"
FT REGION 90..124
FT /note="Coil 1A"
FT REGION 125..135
FT /note="Linker 1"
FT REGION 136..236
FT /note="Coil 1B"
FT REGION 237..252
FT /note="Linker 12"
FT REGION 253..396
FT /note="Coil 2"
FT REGION 397..431
FT /note="Tail"
FT SITE 338
FT /note="Stutter"
SQ SEQUENCE 431 AA; 47820 MW; 2318246722DE9E91 CRC64;
MASDCSPTGC SSESSARASD CALASTCSVE TTCLPSACAT SSCQTPSFPS GARLPTGCLP
PACFAGSCNI PCVVGNCAWC EDGVFNSNEK ETMQFLNDRL ASYLEKVRGL EELNAELECR
IREQCEEDVP LVCPDYQCYF DTIEDLQQKI LCTKAENCRL AVQLDNCKLA ADDFRSKYES
ELSLRQLVET DISGLRGILG ELTVCRSDLE AHVESLKDDL LCLKKSHEEE VNVLRGQLGD
RLSVELDTAP TTDLNRVLDE MRCQYETVLA NNRRDVEEWF AAQTEELNQQ QLSSAEQLQG
CQTEILELKR TANTLEIELQ AQQSLTESLE CTVAETEAQY SSELAQIQCL IDNVENQLAE
IRCDLERQNQ EYRVLLDTKA RLECEINTYQ GLLDSEDSRL PCNPCSATSM SNDTCEPCSA
YVICTVENSC P
