K1C40_HUMAN
ID K1C40_HUMAN Reviewed; 431 AA.
AC Q6A162; Q6IFU5;
DT 15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT 15-JAN-2008, sequence version 2.
DT 03-AUG-2022, entry version 146.
DE RecName: Full=Keratin, type I cytoskeletal 40;
DE AltName: Full=Cytokeratin-40;
DE Short=CK-40;
DE AltName: Full=Keratin-40;
DE Short=K40;
DE AltName: Full=Type I hair keratin Ka36;
GN Name=KRT40; Synonyms=KA36;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, AND VARIANTS SER-85 AND
RP TYR-265.
RC TISSUE=Scalp;
RX PubMed=15617563; DOI=10.1111/j.1432-0436.2004.07209006.x;
RA Rogers M.A., Winter H., Langbein L., Bleiler R., Schweizer J.;
RT "The human type I keratin gene family: characterization of new hair
RT follicle specific members and evaluation of the chromosome 17q21.2 gene
RT domain.";
RL Differentiation 72:527-540(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP IDENTIFICATION.
RX PubMed=15085952; DOI=10.1078/0171-9335-00354;
RA Hesse M., Zimek A., Weber K., Magin T.M.;
RT "Comprehensive analysis of keratin gene clusters in humans and rodents.";
RL Eur. J. Cell Biol. 83:19-26(2004).
RN [4]
RP POSSIBLE FUNCTION, TISSUE SPECIFICITY, AND DEVELOPMENTAL STAGE.
RX PubMed=17301834; DOI=10.1038/sj.jid.5700734;
RA Langbein L., Rogers M.A., Praetzel-Wunder S., Boeckler D., Schirmacher P.,
RA Schweizer J.;
RT "Novel type I hair keratins K39 and K40 are the last to be expressed in
RT differentiation of the hair: completion of the human hair keratin
RT catalog.";
RL J. Invest. Dermatol. 127:1532-1535(2007).
CC -!- FUNCTION: May play a role in late hair differentiation.
CC -!- SUBUNIT: Heterotetramer of two type I and two type II keratins.
CC -!- INTERACTION:
CC Q6A162; Q4G176: ACSF3; NbExp=3; IntAct=EBI-10171697, EBI-10714818;
CC Q6A162; Q9UHI8: ADAMTS1; NbExp=3; IntAct=EBI-10171697, EBI-2511802;
CC Q6A162; P82987: ADAMTSL3; NbExp=3; IntAct=EBI-10171697, EBI-10221726;
CC Q6A162; Q8WTP8: AEN; NbExp=3; IntAct=EBI-10171697, EBI-8637627;
CC Q6A162; P21549: AGXT; NbExp=3; IntAct=EBI-10171697, EBI-727098;
CC Q6A162; Q02040-3: AKAP17A; NbExp=3; IntAct=EBI-10171697, EBI-10222656;
CC Q6A162; P43353: ALDH3B1; NbExp=3; IntAct=EBI-10171697, EBI-2558314;
CC Q6A162; Q96IX9: ANKRD36BP1; NbExp=3; IntAct=EBI-10171697, EBI-744859;
CC Q6A162; Q9BXS5: AP1M1; NbExp=6; IntAct=EBI-10171697, EBI-541426;
CC Q6A162; P29972: AQP1; NbExp=3; IntAct=EBI-10171697, EBI-745213;
CC Q6A162; P55064: AQP5; NbExp=3; IntAct=EBI-10171697, EBI-746103;
CC Q6A162; Q9H6L4: ARMC7; NbExp=6; IntAct=EBI-10171697, EBI-742909;
CC Q6A162; Q5FYB1: ARSI; NbExp=3; IntAct=EBI-10171697, EBI-10243706;
CC Q6A162; O95671: ASMTL; NbExp=3; IntAct=EBI-10171697, EBI-743231;
CC Q6A162; Q8N5M1: ATPAF2; NbExp=7; IntAct=EBI-10171697, EBI-1166928;
CC Q6A162; Q5T686: AVPI1; NbExp=3; IntAct=EBI-10171697, EBI-8640233;
CC Q6A162; O15169: AXIN1; NbExp=3; IntAct=EBI-10171697, EBI-710484;
CC Q6A162; Q8TBE0: BAHD1; NbExp=3; IntAct=EBI-10171697, EBI-742750;
CC Q6A162; Q99728: BARD1; NbExp=3; IntAct=EBI-10171697, EBI-473181;
CC Q6A162; O75934: BCAS2; NbExp=3; IntAct=EBI-10171697, EBI-1050106;
CC Q6A162; Q9BXY8: BEX2; NbExp=3; IntAct=EBI-10171697, EBI-745073;
CC Q6A162; Q0VDD7: BRME1; NbExp=3; IntAct=EBI-10171697, EBI-741210;
CC Q6A162; Q13895: BYSL; NbExp=8; IntAct=EBI-10171697, EBI-358049;
CC Q6A162; Q5T681: C10orf62; NbExp=3; IntAct=EBI-10171697, EBI-744052;
CC Q6A162; Q6NUJ2: C11orf87; NbExp=3; IntAct=EBI-10171697, EBI-6660291;
CC Q6A162; B2RAB7: C18orf45; NbExp=3; IntAct=EBI-10171697, EBI-743338;
CC Q6A162; Q9NVV2: C19orf73; NbExp=3; IntAct=EBI-10171697, EBI-2859285;
CC Q6A162; Q9NX04: C1orf109; NbExp=3; IntAct=EBI-10171697, EBI-8643161;
CC Q6A162; Q8TAB5: C1orf216; NbExp=3; IntAct=EBI-10171697, EBI-747505;
CC Q6A162; Q53TS8: C2CD6; NbExp=3; IntAct=EBI-10171697, EBI-739879;
CC Q6A162; Q2NKX9: C2orf68; NbExp=3; IntAct=EBI-10171697, EBI-11603468;
CC Q6A162; Q96LM5: C4orf45; NbExp=3; IntAct=EBI-10171697, EBI-12020542;
CC Q6A162; A6NFR6-4: C5orf60; NbExp=3; IntAct=EBI-10171697, EBI-10173955;
CC Q6A162; Q5I0X4: C6orf226; NbExp=3; IntAct=EBI-10171697, EBI-10244057;
CC Q6A162; Q96LL4: C8orf48; NbExp=3; IntAct=EBI-10171697, EBI-751596;
CC Q6A162; Q8N4G4: CA6; NbExp=3; IntAct=EBI-10171697, EBI-10265475;
CC Q6A162; Q9H257: CARD9; NbExp=3; IntAct=EBI-10171697, EBI-751319;
CC Q6A162; Q7Z7H3: CATIP; NbExp=3; IntAct=EBI-10171697, EBI-10258233;
CC Q6A162; Q9HC52: CBX8; NbExp=6; IntAct=EBI-10171697, EBI-712912;
CC Q6A162; Q8NEF3: CCDC112; NbExp=3; IntAct=EBI-10171697, EBI-745040;
CC Q6A162; Q8IYX3: CCDC116; NbExp=3; IntAct=EBI-10171697, EBI-744311;
CC Q6A162; Q96HB5-4: CCDC120; NbExp=4; IntAct=EBI-10171697, EBI-10185348;
CC Q6A162; Q8IYE0-2: CCDC146; NbExp=3; IntAct=EBI-10171697, EBI-10247802;
CC Q6A162; Q8N715: CCDC185; NbExp=6; IntAct=EBI-10171697, EBI-740814;
CC Q6A162; Q9NVL8: CCDC198; NbExp=3; IntAct=EBI-10171697, EBI-10238351;
CC Q6A162; Q8TAB7: CCDC26; NbExp=3; IntAct=EBI-10171697, EBI-10271580;
CC Q6A162; Q8TC90: CCER1; NbExp=3; IntAct=EBI-10171697, EBI-746041;
CC Q6A162; Q8TD31-3: CCHCR1; NbExp=6; IntAct=EBI-10171697, EBI-10175300;
CC Q6A162; P51959: CCNG1; NbExp=3; IntAct=EBI-10171697, EBI-3905829;
CC Q6A162; P20138: CD33; NbExp=3; IntAct=EBI-10171697, EBI-3906571;
CC Q6A162; Q86Y33: CDC20B; NbExp=3; IntAct=EBI-10171697, EBI-10260504;
CC Q6A162; Q07002: CDK18; NbExp=3; IntAct=EBI-10171697, EBI-746238;
CC Q6A162; Q8N619: CDK5R1; NbExp=3; IntAct=EBI-10171697, EBI-10266998;
CC Q6A162; Q86XR8: CEP57; NbExp=3; IntAct=EBI-10171697, EBI-308614;
CC Q6A162; Q8IYX8: CEP57L1; NbExp=3; IntAct=EBI-10171697, EBI-1104570;
CC Q6A162; Q8IYX8-2: CEP57L1; NbExp=3; IntAct=EBI-10171697, EBI-10181988;
CC Q6A162; Q8IYR0: CFAP206; NbExp=6; IntAct=EBI-10171697, EBI-749051;
CC Q6A162; Q9Y6H1: CHCHD2; NbExp=3; IntAct=EBI-10171697, EBI-2321769;
CC Q6A162; Q9NX63: CHCHD3; NbExp=3; IntAct=EBI-10171697, EBI-743375;
CC Q6A162; Q9UKJ5: CHIC2; NbExp=3; IntAct=EBI-10171697, EBI-741528;
CC Q6A162; A5D8T8: CLEC18A; NbExp=3; IntAct=EBI-10171697, EBI-10173491;
CC Q6A162; Q8NE01: CNNM3; NbExp=3; IntAct=EBI-10171697, EBI-741032;
CC Q6A162; P26441: CNTF; NbExp=3; IntAct=EBI-10171697, EBI-1050897;
CC Q6A162; P27658: COL8A1; NbExp=3; IntAct=EBI-10171697, EBI-747133;
CC Q6A162; P21964-2: COMT; NbExp=3; IntAct=EBI-10171697, EBI-10200977;
CC Q6A162; P20674: COX5A; NbExp=3; IntAct=EBI-10171697, EBI-715032;
CC Q6A162; Q02930-3: CREB5; NbExp=6; IntAct=EBI-10171697, EBI-10192698;
CC Q6A162; Q49AN0: CRY2; NbExp=3; IntAct=EBI-10171697, EBI-2212355;
CC Q6A162; Q9UBR2: CTSZ; NbExp=3; IntAct=EBI-10171697, EBI-8636823;
CC Q6A162; Q2TBE0: CWF19L2; NbExp=3; IntAct=EBI-10171697, EBI-5453285;
CC Q6A162; P99999: CYCS; NbExp=6; IntAct=EBI-10171697, EBI-446479;
CC Q6A162; Q8WWE8: CYTH4; NbExp=3; IntAct=EBI-10171697, EBI-10277443;
CC Q6A162; Q6DCB0: DAAM2; NbExp=3; IntAct=EBI-10171697, EBI-10249414;
CC Q6A162; A2VCK2: DCDC2B; NbExp=3; IntAct=EBI-10171697, EBI-10173222;
CC Q6A162; O43602: DCX; NbExp=3; IntAct=EBI-10171697, EBI-8646694;
CC Q6A162; P26196: DDX6; NbExp=3; IntAct=EBI-10171697, EBI-351257;
CC Q6A162; Q6P158: DHX57; NbExp=3; IntAct=EBI-10171697, EBI-1051531;
CC Q6A162; Q9P1A6: DLGAP2; NbExp=4; IntAct=EBI-10171697, EBI-1753397;
CC Q6A162; Q9NQL9: DMRT3; NbExp=6; IntAct=EBI-10171697, EBI-9679045;
CC Q6A162; Q92608: DOCK2; NbExp=6; IntAct=EBI-10171697, EBI-448771;
CC Q6A162; Q8NF50: DOCK8; NbExp=3; IntAct=EBI-10171697, EBI-2548605;
CC Q6A162; O60941: DTNB; NbExp=3; IntAct=EBI-10171697, EBI-740402;
CC Q6A162; O60573: EIF4E2; NbExp=3; IntAct=EBI-10171697, EBI-398610;
CC Q6A162; Q6ISP9: ELA2B; NbExp=3; IntAct=EBI-10171697, EBI-10250477;
CC Q6A162; Q14241: ELOA; NbExp=3; IntAct=EBI-10171697, EBI-742350;
CC Q6A162; Q9H0I2: ENKD1; NbExp=3; IntAct=EBI-10171697, EBI-744099;
CC Q6A162; Q8N2X6: EXOC3-AS1; NbExp=3; IntAct=EBI-10171697, EBI-749333;
CC Q6A162; O95864-3: FADS2; NbExp=3; IntAct=EBI-10171697, EBI-12057609;
CC Q6A162; O95990-3: FAM107A; NbExp=3; IntAct=EBI-10171697, EBI-10192902;
CC Q6A162; Q9H5Z6: FAM124B; NbExp=3; IntAct=EBI-10171697, EBI-741626;
CC Q6A162; Q32MH5: FAM214A; NbExp=3; IntAct=EBI-10171697, EBI-2866142;
CC Q6A162; Q08E93: FAM27E3; NbExp=3; IntAct=EBI-10171697, EBI-2602739;
CC Q6A162; Q8NEG0: FAM71C; NbExp=3; IntAct=EBI-10171697, EBI-752049;
CC Q6A162; Q5TZK3: FAM74A6; NbExp=3; IntAct=EBI-10171697, EBI-10247271;
CC Q6A162; Q86YD7: FAM90A1; NbExp=6; IntAct=EBI-10171697, EBI-6658203;
CC Q6A162; O95363: FARS2; NbExp=6; IntAct=EBI-10171697, EBI-2513774;
CC Q6A162; P48023: FASLG; NbExp=3; IntAct=EBI-10171697, EBI-495538;
CC Q6A162; Q8TES7-6: FBF1; NbExp=3; IntAct=EBI-10171697, EBI-10244131;
CC Q6A162; Q96D16: FBXL18; NbExp=3; IntAct=EBI-10171697, EBI-744419;
CC Q6A162; Q9NWN3: FBXO34; NbExp=3; IntAct=EBI-10171697, EBI-719816;
CC Q6A162; Q969U6: FBXW5; NbExp=3; IntAct=EBI-10171697, EBI-741068;
CC Q6A162; A0PJY2: FEZF1; NbExp=3; IntAct=EBI-10171697, EBI-11988727;
CC Q6A162; P68106: FKBP1B; NbExp=3; IntAct=EBI-10171697, EBI-6693977;
CC Q6A162; Q9H5C5: FLJ23584; NbExp=3; IntAct=EBI-10171697, EBI-7226406;
CC Q6A162; Q9BVV2: FNDC11; NbExp=3; IntAct=EBI-10171697, EBI-744935;
CC Q6A162; Q99853: FOXB1; NbExp=3; IntAct=EBI-10171697, EBI-3916225;
CC Q6A162; Q14331: FRG1; NbExp=3; IntAct=EBI-10171697, EBI-2515248;
CC Q6A162; A0A0S2Z4D9: GAD1; NbExp=3; IntAct=EBI-10171697, EBI-16430771;
CC Q6A162; Q8TAE8: GADD45GIP1; NbExp=3; IntAct=EBI-10171697, EBI-372506;
CC Q6A162; P23769: GATA2; NbExp=3; IntAct=EBI-10171697, EBI-2806671;
CC Q6A162; Q86YP4-3: GATAD2A; NbExp=3; IntAct=EBI-10171697, EBI-10261080;
CC Q6A162; P55040: GEM; NbExp=3; IntAct=EBI-10171697, EBI-744104;
CC Q6A162; Q9NXC2: GFOD1; NbExp=3; IntAct=EBI-10171697, EBI-8799578;
CC Q6A162; Q86UU5: GGN; NbExp=3; IntAct=EBI-10171697, EBI-10259069;
CC Q6A162; P04899: GNAI2; NbExp=3; IntAct=EBI-10171697, EBI-353997;
CC Q6A162; Q9Y223-2: GNE; NbExp=3; IntAct=EBI-10171697, EBI-11975289;
CC Q6A162; P63218: GNG5; NbExp=3; IntAct=EBI-10171697, EBI-10220734;
CC Q6A162; Q8N9W4-2: GOLGA6L2; NbExp=3; IntAct=EBI-10171697, EBI-10268729;
CC Q6A162; Q9NWQ4: GPATCH2L; NbExp=3; IntAct=EBI-10171697, EBI-5666657;
CC Q6A162; Q9Y5Q8: GTF3C5; NbExp=3; IntAct=EBI-10171697, EBI-1045409;
CC Q6A162; Q96NT3: GUCD1; NbExp=3; IntAct=EBI-10171697, EBI-8293751;
CC Q6A162; Q9GZV7: HAPLN2; NbExp=3; IntAct=EBI-10171697, EBI-11956675;
CC Q6A162; Q96CS2: HAUS1; NbExp=3; IntAct=EBI-10171697, EBI-2514791;
CC Q6A162; P69905: HBA2; NbExp=3; IntAct=EBI-10171697, EBI-714680;
CC Q6A162; P02008: HBZ; NbExp=3; IntAct=EBI-10171697, EBI-719843;
CC Q6A162; P08631: HCK; NbExp=3; IntAct=EBI-10171697, EBI-346340;
CC Q6A162; P08631-2: HCK; NbExp=3; IntAct=EBI-10171697, EBI-9834454;
CC Q6A162; P56524: HDAC4; NbExp=3; IntAct=EBI-10171697, EBI-308629;
CC Q6A162; P56524-2: HDAC4; NbExp=3; IntAct=EBI-10171697, EBI-11953488;
CC Q6A162; V9HWJ5: HEL-S-90n; NbExp=3; IntAct=EBI-10171697, EBI-10330335;
CC Q6A162; O14964: HGS; NbExp=6; IntAct=EBI-10171697, EBI-740220;
CC Q6A162; P49639: HOXA1; NbExp=3; IntAct=EBI-10171697, EBI-740785;
CC Q6A162; P17482: HOXB9; NbExp=3; IntAct=EBI-10171697, EBI-745290;
CC Q6A162; P31273: HOXC8; NbExp=3; IntAct=EBI-10171697, EBI-1752118;
CC Q6A162; Q9H2F3: HSD3B7; NbExp=3; IntAct=EBI-10171697, EBI-3918847;
CC Q6A162; Q9ULV5-2: HSF4; NbExp=3; IntAct=EBI-10171697, EBI-12056251;
CC Q6A162; Q96MM6: HSPA12B; NbExp=3; IntAct=EBI-10171697, EBI-10291310;
CC Q6A162; P10809: HSPD1; NbExp=3; IntAct=EBI-10171697, EBI-352528;
CC Q6A162; Q8WYH8: ING5; NbExp=3; IntAct=EBI-10171697, EBI-488533;
CC Q6A162; Q9C086: INO80B; NbExp=3; IntAct=EBI-10171697, EBI-715611;
CC Q6A162; Q92835: INPP5D; NbExp=3; IntAct=EBI-10171697, EBI-1380477;
CC Q6A162; Q8NA54: IQUB; NbExp=3; IntAct=EBI-10171697, EBI-10220600;
CC Q6A162; Q9H1K1: ISCU; NbExp=3; IntAct=EBI-10171697, EBI-1047335;
CC Q6A162; P16144-2: ITGB4; NbExp=3; IntAct=EBI-10171697, EBI-11051601;
CC Q6A162; L7RT22: ITGB5; NbExp=3; IntAct=EBI-10171697, EBI-10178729;
CC Q6A162; Q15040: JOSD1; NbExp=6; IntAct=EBI-10171697, EBI-2510602;
CC Q6A162; Q63ZY3: KANK2; NbExp=3; IntAct=EBI-10171697, EBI-2556193;
CC Q6A162; Q92993: KAT5; NbExp=3; IntAct=EBI-10171697, EBI-399080;
CC Q6A162; Q7L273: KCTD9; NbExp=3; IntAct=EBI-10171697, EBI-4397613;
CC Q6A162; O60341: KDM1A; NbExp=3; IntAct=EBI-10171697, EBI-710124;
CC Q6A162; Q9BVG8: KIFC3; NbExp=3; IntAct=EBI-10171697, EBI-2125614;
CC Q6A162; Q2WGJ6: KLHL38; NbExp=3; IntAct=EBI-10171697, EBI-6426443;
CC Q6A162; P52292: KPNA2; NbExp=3; IntAct=EBI-10171697, EBI-349938;
CC Q6A162; P35908: KRT2; NbExp=11; IntAct=EBI-10171697, EBI-1247312;
CC Q6A162; P35900: KRT20; NbExp=3; IntAct=EBI-10171697, EBI-742094;
CC Q6A162; P19013: KRT4; NbExp=7; IntAct=EBI-10171697, EBI-2371606;
CC Q6A162; P13647: KRT5; NbExp=6; IntAct=EBI-10171697, EBI-702187;
CC Q6A162; P02538: KRT6A; NbExp=14; IntAct=EBI-10171697, EBI-702198;
CC Q6A162; P04259: KRT6B; NbExp=3; IntAct=EBI-10171697, EBI-740907;
CC Q6A162; P48668: KRT6C; NbExp=6; IntAct=EBI-10171697, EBI-2564105;
CC Q6A162; Q3SY84: KRT71; NbExp=6; IntAct=EBI-10171697, EBI-2952676;
CC Q6A162; Q14CN4: KRT72; NbExp=3; IntAct=EBI-10171697, EBI-1221280;
CC Q6A162; O95678: KRT75; NbExp=3; IntAct=EBI-10171697, EBI-2949715;
CC Q6A162; Q01546: KRT76; NbExp=3; IntAct=EBI-10171697, EBI-2952745;
CC Q6A162; P05787: KRT8; NbExp=6; IntAct=EBI-10171697, EBI-297852;
CC Q6A162; Q14533: KRT81; NbExp=8; IntAct=EBI-10171697, EBI-739648;
CC Q6A162; Q9NSB4: KRT82; NbExp=3; IntAct=EBI-10171697, EBI-1045341;
CC Q6A162; P78385: KRT83; NbExp=3; IntAct=EBI-10171697, EBI-10221390;
CC Q6A162; P78386: KRT85; NbExp=3; IntAct=EBI-10171697, EBI-1049371;
CC Q6A162; O43790: KRT86; NbExp=3; IntAct=EBI-10171697, EBI-9996498;
CC Q6A162; Q14657: LAGE3; NbExp=6; IntAct=EBI-10171697, EBI-1052105;
CC Q6A162; Q5T5B0: LCE3E; NbExp=3; IntAct=EBI-10171697, EBI-10245456;
CC Q6A162; Q96BZ8: LENG1; NbExp=6; IntAct=EBI-10171697, EBI-726510;
CC Q6A162; A0A0S2Z5S9: LHX4; NbExp=3; IntAct=EBI-10171697, EBI-16429099;
CC Q6A162; Q7Z4I7-5: LIMS2; NbExp=3; IntAct=EBI-10171697, EBI-10257651;
CC Q6A162; Q96GY3: LIN37; NbExp=3; IntAct=EBI-10171697, EBI-748884;
CC Q6A162; Q9BU23: LMF2; NbExp=3; IntAct=EBI-10171697, EBI-10298556;
CC Q6A162; P25800: LMO1; NbExp=3; IntAct=EBI-10171697, EBI-8639312;
CC Q6A162; P25791: LMO2; NbExp=3; IntAct=EBI-10171697, EBI-739696;
CC Q6A162; P61968: LMO4; NbExp=3; IntAct=EBI-10171697, EBI-2798728;
CC Q6A162; O75427: LRCH4; NbExp=3; IntAct=EBI-10171697, EBI-718707;
CC Q6A162; Q9Y586: MAB21L2; NbExp=3; IntAct=EBI-10171697, EBI-6659161;
CC Q6A162; Q96A72: MAGOHB; NbExp=3; IntAct=EBI-10171697, EBI-746778;
CC Q6A162; O60336: MAPKBP1; NbExp=3; IntAct=EBI-10171697, EBI-947402;
CC Q6A162; Q6IPE9: MARK4; NbExp=3; IntAct=EBI-10171697, EBI-10250211;
CC Q6A162; Q96G25-2: MED8; NbExp=3; IntAct=EBI-10171697, EBI-10286267;
CC Q6A162; Q9H7H0: METTL17; NbExp=4; IntAct=EBI-10171697, EBI-749353;
CC Q6A162; Q9H7H0-2: METTL17; NbExp=3; IntAct=EBI-10171697, EBI-11098807;
CC Q6A162; P55081: MFAP1; NbExp=3; IntAct=EBI-10171697, EBI-1048159;
CC Q6A162; Q4ZG74: MGC13033; NbExp=3; IntAct=EBI-10171697, EBI-10241963;
CC Q6A162; Q9UJV3-2: MID2; NbExp=3; IntAct=EBI-10171697, EBI-10172526;
CC Q6A162; Q70IA8: MOB3C; NbExp=3; IntAct=EBI-10171697, EBI-9679267;
CC Q6A162; Q13875: MOBP; NbExp=3; IntAct=EBI-10171697, EBI-10230628;
CC Q6A162; P00540: MOS; NbExp=3; IntAct=EBI-10171697, EBI-1757866;
CC Q6A162; Q9Y3B7: MRPL11; NbExp=3; IntAct=EBI-10171697, EBI-5453723;
CC Q6A162; Q96E11: MRRF; NbExp=3; IntAct=EBI-10171697, EBI-2855755;
CC Q6A162; Q8IXL7-2: MSRB3; NbExp=3; IntAct=EBI-10171697, EBI-10699187;
CC Q6A162; Q13330: MTA1; NbExp=4; IntAct=EBI-10171697, EBI-714236;
CC Q6A162; P50539-3: MXI1; NbExp=3; IntAct=EBI-10171697, EBI-10211940;
CC Q6A162; P50539-4: MXI1; NbExp=3; IntAct=EBI-10171697, EBI-16436111;
CC Q6A162; Q86VE0: MYPOP; NbExp=3; IntAct=EBI-10171697, EBI-2858213;
CC Q6A162; Q6XQN6-2: NAPRT; NbExp=3; IntAct=EBI-10171697, EBI-10254820;
CC Q6A162; Q9GZM8: NDEL1; NbExp=3; IntAct=EBI-10171697, EBI-928842;
CC Q6A162; Q9HC98: NEK6; NbExp=3; IntAct=EBI-10171697, EBI-740364;
CC Q6A162; Q9HC98-4: NEK6; NbExp=3; IntAct=EBI-10171697, EBI-11750983;
CC Q6A162; Q8NI38: NFKBID; NbExp=3; IntAct=EBI-10171697, EBI-10271199;
CC Q6A162; Q92982: NINJ1; NbExp=3; IntAct=EBI-10171697, EBI-2802124;
CC Q6A162; P48146: NPBWR2; NbExp=3; IntAct=EBI-10171697, EBI-10210114;
CC Q6A162; P16860: NPPB; NbExp=3; IntAct=EBI-10171697, EBI-747044;
CC Q6A162; Q6NSM0: NR1D2; NbExp=3; IntAct=EBI-10171697, EBI-10250949;
CC Q6A162; Q9UBU9: NXF1; NbExp=3; IntAct=EBI-10171697, EBI-398874;
CC Q6A162; Q96NG3: ODAD4; NbExp=3; IntAct=EBI-10171697, EBI-1046387;
CC Q6A162; O43482: OIP5; NbExp=3; IntAct=EBI-10171697, EBI-536879;
CC Q6A162; A8K0Y0: OPCML; NbExp=3; IntAct=EBI-10171697, EBI-10174172;
CC Q6A162; Q9BWI9: OTUB2; NbExp=3; IntAct=EBI-10171697, EBI-10300896;
CC Q6A162; Q96HC4: PDLIM5; NbExp=3; IntAct=EBI-10171697, EBI-751267;
CC Q6A162; O43189: PHF1; NbExp=3; IntAct=EBI-10171697, EBI-530034;
CC Q6A162; Q96BD5: PHF21A; NbExp=3; IntAct=EBI-10171697, EBI-745085;
CC Q6A162; A2BDE7: PHLDA1; NbExp=3; IntAct=EBI-10171697, EBI-14084211;
CC Q6A162; Q96S52: PIGS; NbExp=3; IntAct=EBI-10171697, EBI-2908273;
CC Q6A162; Q9BSJ6: PIMREG; NbExp=6; IntAct=EBI-10171697, EBI-2568609;
CC Q6A162; Q13526: PIN1; NbExp=3; IntAct=EBI-10171697, EBI-714158;
CC Q6A162; Q13563: PKD2; NbExp=3; IntAct=EBI-10171697, EBI-7813714;
CC Q6A162; Q8WUT1: POLDIP3; NbExp=3; IntAct=EBI-10171697, EBI-10276663;
CC Q6A162; Q9UGP5-2: POLL; NbExp=3; IntAct=EBI-10171697, EBI-10320765;
CC Q6A162; Q969H6: POP5; NbExp=3; IntAct=EBI-10171697, EBI-366525;
CC Q6A162; Q6NYC8: PPP1R18; NbExp=3; IntAct=EBI-10171697, EBI-2557469;
CC Q6A162; Q96QH2: PRAM1; NbExp=3; IntAct=EBI-10171697, EBI-2860740;
CC Q6A162; Q13131: PRKAA1; NbExp=3; IntAct=EBI-10171697, EBI-1181405;
CC Q6A162; O43741: PRKAB2; NbExp=6; IntAct=EBI-10171697, EBI-1053424;
CC Q6A162; Q99633: PRPF18; NbExp=3; IntAct=EBI-10171697, EBI-2798416;
CC Q6A162; Q8WWY3: PRPF31; NbExp=6; IntAct=EBI-10171697, EBI-1567797;
CC Q6A162; P25786: PSMA1; NbExp=3; IntAct=EBI-10171697, EBI-359352;
CC Q6A162; P20618: PSMB1; NbExp=3; IntAct=EBI-10171697, EBI-372273;
CC Q6A162; P62195: PSMC5; NbExp=5; IntAct=EBI-10171697, EBI-357745;
CC Q6A162; P43115-12: PTGER3; NbExp=3; IntAct=EBI-10171697, EBI-10234038;
CC Q6A162; Q8WUK0: PTPMT1; NbExp=3; IntAct=EBI-10171697, EBI-7199479;
CC Q6A162; Q8TBN0: RAB3IL1; NbExp=3; IntAct=EBI-10171697, EBI-743796;
CC Q6A162; Q96QF0: RAB3IP; NbExp=3; IntAct=EBI-10171697, EBI-747844;
CC Q6A162; P63000: RAC1; NbExp=3; IntAct=EBI-10171697, EBI-413628;
CC Q6A162; Q8WWW0: RASSF5; NbExp=3; IntAct=EBI-10171697, EBI-367390;
CC Q6A162; Q96IZ5: RBM41; NbExp=3; IntAct=EBI-10171697, EBI-740773;
CC Q6A162; Q9P2K3: RCOR3; NbExp=3; IntAct=EBI-10171697, EBI-743428;
CC Q6A162; Q6P9E2: RECK; NbExp=3; IntAct=EBI-10171697, EBI-10253121;
CC Q6A162; P57771-2: RGS8; NbExp=3; IntAct=EBI-10171697, EBI-12058229;
CC Q6A162; Q63HN8-6: RNF213; NbExp=3; IntAct=EBI-10171697, EBI-10248548;
CC Q6A162; A0A0S2Z4G9: RNF6; NbExp=3; IntAct=EBI-10171697, EBI-16428950;
CC Q6A162; P62913: RPL11; NbExp=3; IntAct=EBI-10171697, EBI-354380;
CC Q6A162; Q9UHP6: RSPH14; NbExp=3; IntAct=EBI-10171697, EBI-748350;
CC Q6A162; Q14D33: RTP5; NbExp=3; IntAct=EBI-10171697, EBI-10217913;
CC Q6A162; P57060: RWDD2B; NbExp=6; IntAct=EBI-10171697, EBI-724442;
CC Q6A162; A0A0S2Z4M5: RXRB; NbExp=3; IntAct=EBI-10171697, EBI-16436147;
CC Q6A162; P28702-3: RXRB; NbExp=3; IntAct=EBI-10171697, EBI-16429492;
CC Q6A162; P57086: SCAND1; NbExp=3; IntAct=EBI-10171697, EBI-745846;
CC Q6A162; Q9UIL1: SCOC; NbExp=3; IntAct=EBI-10171697, EBI-2686537;
CC Q6A162; Q9C0C4: SEMA4C; NbExp=3; IntAct=EBI-10171697, EBI-10303490;
CC Q6A162; Q9C0A6-2: SETD5; NbExp=3; IntAct=EBI-10171697, EBI-10303449;
CC Q6A162; Q6NXQ0: SFRS2; NbExp=3; IntAct=EBI-10171697, EBI-10251550;
CC Q6A162; Q9H788: SH2D4A; NbExp=6; IntAct=EBI-10171697, EBI-747035;
CC Q6A162; Q92529: SHC3; NbExp=6; IntAct=EBI-10171697, EBI-79084;
CC Q6A162; Q9NUL5: SHFL; NbExp=3; IntAct=EBI-10171697, EBI-10313866;
CC Q6A162; Q9NUL5-4: SHFL; NbExp=3; IntAct=EBI-10171697, EBI-11955083;
CC Q6A162; Q9UHI7-3: SLC23A1; NbExp=3; IntAct=EBI-10171697, EBI-11998660;
CC Q6A162; Q9UBX3: SLC25A10; NbExp=3; IntAct=EBI-10171697, EBI-750394;
CC Q6A162; Q9GZT3: SLIRP; NbExp=3; IntAct=EBI-10171697, EBI-1050793;
CC Q6A162; O95391: SLU7; NbExp=3; IntAct=EBI-10171697, EBI-750559;
CC Q6A162; Q969G3: SMARCE1; NbExp=6; IntAct=EBI-10171697, EBI-455078;
CC Q6A162; Q9NRQ5: SMCO4; NbExp=3; IntAct=EBI-10171697, EBI-8640191;
CC Q6A162; O95863: SNAI1; NbExp=4; IntAct=EBI-10171697, EBI-1045459;
CC Q6A162; P14678-2: SNRPB; NbExp=3; IntAct=EBI-10171697, EBI-372475;
CC Q6A162; Q13573: SNW1; NbExp=3; IntAct=EBI-10171697, EBI-632715;
CC Q6A162; Q9H0A9-2: SPATC1L; NbExp=3; IntAct=EBI-10171697, EBI-11995806;
CC Q6A162; Q9Y4P9: SPEF1; NbExp=3; IntAct=EBI-10171697, EBI-740053;
CC Q6A162; Q9UQ90: SPG7; NbExp=3; IntAct=EBI-10171697, EBI-717201;
CC Q6A162; Q16385: SSX2B; NbExp=3; IntAct=EBI-10171697, EBI-2210673;
CC Q6A162; Q9Y2D8: SSX2IP; NbExp=3; IntAct=EBI-10171697, EBI-2212028;
CC Q6A162; P51687: SUOX; NbExp=3; IntAct=EBI-10171697, EBI-3921347;
CC Q6A162; Q5T7P8-2: SYT6; NbExp=3; IntAct=EBI-10171697, EBI-10246152;
CC Q6A162; Q9BSH4: TACO1; NbExp=3; IntAct=EBI-10171697, EBI-747797;
CC Q6A162; Q8IYX1: TBC1D21; NbExp=3; IntAct=EBI-10171697, EBI-12018146;
CC Q6A162; Q9NU19: TBC1D22B; NbExp=4; IntAct=EBI-10171697, EBI-8787464;
CC Q6A162; Q15560: TCEA2; NbExp=3; IntAct=EBI-10171697, EBI-710310;
CC Q6A162; Q8N8B7-2: TCEANC; NbExp=3; IntAct=EBI-10171697, EBI-11955057;
CC Q6A162; Q9BT92: TCHP; NbExp=3; IntAct=EBI-10171697, EBI-740781;
CC Q6A162; A0A0S2Z4F2: TEAD4; NbExp=3; IntAct=EBI-10171697, EBI-16429215;
CC Q6A162; Q15561: TEAD4; NbExp=6; IntAct=EBI-10171697, EBI-747736;
CC Q6A162; Q9BT49: THAP7; NbExp=3; IntAct=EBI-10171697, EBI-741350;
CC Q6A162; P35590: TIE1; NbExp=3; IntAct=EBI-10171697, EBI-2256865;
CC Q6A162; Q08117: TLE5; NbExp=3; IntAct=EBI-10171697, EBI-717810;
CC Q6A162; Q08117-2: TLE5; NbExp=3; IntAct=EBI-10171697, EBI-11741437;
CC Q6A162; Q9H6L2: TMEM231; NbExp=3; IntAct=EBI-10171697, EBI-10307654;
CC Q6A162; Q0P5Q0: TMSB4X; NbExp=3; IntAct=EBI-10171697, EBI-10226570;
CC Q6A162; Q96KP6: TNIP3; NbExp=4; IntAct=EBI-10171697, EBI-2509913;
CC Q6A162; P13805: TNNT1; NbExp=3; IntAct=EBI-10171697, EBI-726527;
CC Q6A162; Q9BUZ4: TRAF4; NbExp=6; IntAct=EBI-10171697, EBI-3650647;
CC Q6A162; Q8IWZ5: TRIM42; NbExp=3; IntAct=EBI-10171697, EBI-5235829;
CC Q6A162; Q12815: TROAP; NbExp=3; IntAct=EBI-10171697, EBI-2349743;
CC Q6A162; Q9Y260: TRPV6; NbExp=3; IntAct=EBI-10171697, EBI-750052;
CC Q6A162; Q8IV54: TSC22D4; NbExp=3; IntAct=EBI-10171697, EBI-10261521;
CC Q6A162; Q3SY00: TSGA10IP; NbExp=3; IntAct=EBI-10171697, EBI-10241197;
CC Q6A162; Q63HK5: TSHZ3; NbExp=3; IntAct=EBI-10171697, EBI-9053916;
CC Q6A162; Q5W5X9: TTC23; NbExp=3; IntAct=EBI-10171697, EBI-6447954;
CC Q6A162; Q8N5M4: TTC9C; NbExp=3; IntAct=EBI-10171697, EBI-2851213;
CC Q6A162; Q6ZVT0: TTLL10; NbExp=3; IntAct=EBI-10171697, EBI-7844656;
CC Q6A162; P40222: TXLNA; NbExp=6; IntAct=EBI-10171697, EBI-359793;
CC Q6A162; Q99757: TXN2; NbExp=3; IntAct=EBI-10171697, EBI-2932492;
CC Q6A162; Q86UY0: TXNDC5; NbExp=3; IntAct=EBI-10171697, EBI-2825190;
CC Q6A162; P29597: TYK2; NbExp=3; IntAct=EBI-10171697, EBI-1383454;
CC Q6A162; Q06418: TYRO3; NbExp=3; IntAct=EBI-10171697, EBI-3951628;
CC Q6A162; Q9BZF9: UACA; NbExp=3; IntAct=EBI-10171697, EBI-350510;
CC Q6A162; P57075: UBASH3A; NbExp=3; IntAct=EBI-10171697, EBI-2105393;
CC Q6A162; Q8N6Y0: USHBP1; NbExp=3; IntAct=EBI-10171697, EBI-739895;
CC Q6A162; O75604: USP2; NbExp=6; IntAct=EBI-10171697, EBI-743272;
CC Q6A162; Q9UK80: USP21; NbExp=3; IntAct=EBI-10171697, EBI-373242;
CC Q6A162; Q08E77: UTP14C; NbExp=3; IntAct=EBI-10171697, EBI-10225961;
CC Q6A162; Q9BRU9: UTP23; NbExp=3; IntAct=EBI-10171697, EBI-5457544;
CC Q6A162; Q9UBK9: UXT; NbExp=3; IntAct=EBI-10171697, EBI-357355;
CC Q6A162; Q14119: VEZF1; NbExp=3; IntAct=EBI-10171697, EBI-11980193;
CC Q6A162; Q64LD2: WDR25; NbExp=3; IntAct=EBI-10171697, EBI-744560;
CC Q6A162; P19544: WT1; NbExp=4; IntAct=EBI-10171697, EBI-2320534;
CC Q6A162; Q06250: WT1-AS; NbExp=3; IntAct=EBI-10171697, EBI-10223946;
CC Q6A162; Q05516: ZBTB16; NbExp=9; IntAct=EBI-10171697, EBI-711925;
CC Q6A162; O43167: ZBTB24; NbExp=3; IntAct=EBI-10171697, EBI-744471;
CC Q6A162; B2RXF5: ZBTB42; NbExp=3; IntAct=EBI-10171697, EBI-12287587;
CC Q6A162; Q53FD0: ZC2HC1C; NbExp=3; IntAct=EBI-10171697, EBI-740767;
CC Q6A162; Q15911-2: ZFHX3; NbExp=3; IntAct=EBI-10171697, EBI-10237226;
CC Q6A162; Q6P2D0: ZFP1; NbExp=3; IntAct=EBI-10171697, EBI-2555749;
CC Q6A162; Q6ZN57: ZFP2; NbExp=6; IntAct=EBI-10171697, EBI-7236323;
CC Q6A162; Q9UJL9: ZFP69B; NbExp=3; IntAct=EBI-10171697, EBI-10322364;
CC Q6A162; Q9BQ24: ZFYVE21; NbExp=3; IntAct=EBI-10171697, EBI-2849569;
CC Q6A162; Q68DK2-5: ZFYVE26; NbExp=6; IntAct=EBI-10171697, EBI-8656416;
CC Q6A162; Q8N5A5: ZGPAT; NbExp=3; IntAct=EBI-10171697, EBI-3439227;
CC Q6A162; Q8N5A5-2: ZGPAT; NbExp=6; IntAct=EBI-10171697, EBI-10183064;
CC Q6A162; Q96NC0: ZMAT2; NbExp=3; IntAct=EBI-10171697, EBI-2682299;
CC Q6A162; Q8IZC7: ZNF101; NbExp=3; IntAct=EBI-10171697, EBI-5278328;
CC Q6A162; Q15973: ZNF124; NbExp=3; IntAct=EBI-10171697, EBI-2555767;
CC Q6A162; P52744-2: ZNF138; NbExp=3; IntAct=EBI-10171697, EBI-10213071;
CC Q6A162; Q53Z40: ZNF165; NbExp=3; IntAct=EBI-10171697, EBI-10186058;
CC Q6A162; P17021: ZNF17; NbExp=3; IntAct=EBI-10171697, EBI-1105334;
CC Q6A162; P17024: ZNF20; NbExp=3; IntAct=EBI-10171697, EBI-717634;
CC Q6A162; O95125: ZNF202; NbExp=6; IntAct=EBI-10171697, EBI-751960;
CC Q6A162; Q9UIE0: ZNF230; NbExp=3; IntAct=EBI-10171697, EBI-1105361;
CC Q6A162; P15622-3: ZNF250; NbExp=6; IntAct=EBI-10171697, EBI-10177272;
CC Q6A162; P17031: ZNF26; NbExp=3; IntAct=EBI-10171697, EBI-2841331;
CC Q6A162; Q14584: ZNF266; NbExp=5; IntAct=EBI-10171697, EBI-7115319;
CC Q6A162; Q9HBT8-2: ZNF286A; NbExp=3; IntAct=EBI-10171697, EBI-10310244;
CC Q6A162; Q96PQ6-4: ZNF317; NbExp=3; IntAct=EBI-10171697, EBI-10292528;
CC Q6A162; Q9P2F9: ZNF319; NbExp=3; IntAct=EBI-10171697, EBI-11993110;
CC Q6A162; Q86UD4: ZNF329; NbExp=3; IntAct=EBI-10171697, EBI-7233259;
CC Q6A162; Q9Y3M9: ZNF337; NbExp=3; IntAct=EBI-10171697, EBI-714987;
CC Q6A162; Q9H9D4: ZNF408; NbExp=3; IntAct=EBI-10171697, EBI-347633;
CC Q6A162; Q86VK4-3: ZNF410; NbExp=3; IntAct=EBI-10171697, EBI-11741890;
CC Q6A162; Q8TAU3: ZNF417; NbExp=6; IntAct=EBI-10171697, EBI-740727;
CC Q6A162; Q7Z4V0: ZNF438; NbExp=3; IntAct=EBI-10171697, EBI-11962468;
CC Q6A162; Q8NDP4: ZNF439; NbExp=6; IntAct=EBI-10171697, EBI-747580;
CC Q6A162; Q9NWS9-2: ZNF446; NbExp=6; IntAct=EBI-10171697, EBI-740232;
CC Q6A162; Q96MN9: ZNF488; NbExp=3; IntAct=EBI-10171697, EBI-948288;
CC Q6A162; Q8TBZ8: ZNF564; NbExp=3; IntAct=EBI-10171697, EBI-10273713;
CC Q6A162; Q5MCW4: ZNF569; NbExp=3; IntAct=EBI-10171697, EBI-4395687;
CC Q6A162; Q86XF7: ZNF575; NbExp=3; IntAct=EBI-10171697, EBI-14069183;
CC Q6A162; Q9UK33: ZNF580; NbExp=3; IntAct=EBI-10171697, EBI-746277;
CC Q6A162; Q9P0T4: ZNF581; NbExp=6; IntAct=EBI-10171697, EBI-745520;
CC Q6A162; Q96SQ5: ZNF587; NbExp=6; IntAct=EBI-10171697, EBI-6427977;
CC Q6A162; Q96I27: ZNF625; NbExp=3; IntAct=EBI-10171697, EBI-4395587;
CC Q6A162; Q8N720: ZNF655; NbExp=3; IntAct=EBI-10171697, EBI-625509;
CC Q6A162; A0A0S2Z5X4: ZNF688; NbExp=3; IntAct=EBI-10171697, EBI-16429014;
CC Q6A162; Q8N508: ZNF697; NbExp=3; IntAct=EBI-10171697, EBI-10265733;
CC Q6A162; Q9H963: ZNF702P; NbExp=3; IntAct=EBI-10171697, EBI-10309738;
CC Q6A162; P36508: ZNF76; NbExp=3; IntAct=EBI-10171697, EBI-7254550;
CC Q6A162; Q3KQV3: ZNF792; NbExp=3; IntAct=EBI-10171697, EBI-10240849;
CC Q6A162; Q08AG5: ZNF844; NbExp=6; IntAct=EBI-10171697, EBI-10225757;
CC Q6A162; Q9Y5A6: ZSCAN21; NbExp=3; IntAct=EBI-10171697, EBI-10281938;
CC Q6A162; Q53FW8; NbExp=3; IntAct=EBI-10171697, EBI-10242473;
CC Q6A162; Q5BKY6; NbExp=3; IntAct=EBI-10171697, EBI-10243533;
CC Q6A162; Q5W150; NbExp=3; IntAct=EBI-10171697, EBI-10248148;
CC Q6A162; Q8N9J2; NbExp=3; IntAct=EBI-10171697, EBI-10268244;
CC Q6A162; Q96GB0; NbExp=3; IntAct=EBI-10171697, EBI-10286297;
CC Q6A162; Q9H6F0; NbExp=3; IntAct=EBI-10171697, EBI-10307481;
CC Q6A162; Q9NWL9; NbExp=3; IntAct=EBI-10171697, EBI-10315054;
CC -!- TISSUE SPECIFICITY: Expressed in skin and scalp. Also very weakly
CC expressed in tongue, breast, colon and small intestine. In the hair
CC follicle, it is specifically present in the upper hair cuticle. Not
CC present in the upper cortex (at protein level).
CC {ECO:0000269|PubMed:15617563, ECO:0000269|PubMed:17301834}.
CC -!- DEVELOPMENTAL STAGE: During differentiation of the hair, it is one of
CC the last keratins expressed. {ECO:0000269|PubMed:17301834}.
CC -!- MISCELLANEOUS: There are two types of cytoskeletal and microfibrillar
CC keratin, I (acidic) and II (neutral to basic) (40-55 and 56-70 kDa,
CC respectively).
CC -!- SIMILARITY: Belongs to the intermediate filament family.
CC {ECO:0000255|PROSITE-ProRule:PRU01188}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AJ786658; CAH10353.1; -; mRNA.
DR EMBL; BC130396; AAI30397.1; -; mRNA.
DR EMBL; BC150174; AAI50175.1; -; mRNA.
DR EMBL; BC150191; AAI50192.1; -; mRNA.
DR EMBL; BK004055; DAA04488.1; -; mRNA.
DR CCDS; CCDS42320.1; -.
DR RefSeq; NP_872303.2; NM_182497.3.
DR AlphaFoldDB; Q6A162; -.
DR SMR; Q6A162; -.
DR BioGRID; 125917; 425.
DR IntAct; Q6A162; 374.
DR STRING; 9606.ENSP00000366984; -.
DR iPTMnet; Q6A162; -.
DR SwissPalm; Q6A162; -.
DR BioMuta; KRT40; -.
DR DMDM; 166218814; -.
DR CPTAC; CPTAC-1314; -.
DR jPOST; Q6A162; -.
DR MassIVE; Q6A162; -.
DR PaxDb; Q6A162; -.
DR PeptideAtlas; Q6A162; -.
DR PRIDE; Q6A162; -.
DR ProteomicsDB; 66176; -.
DR Antibodypedia; 28766; 72 antibodies from 16 providers.
DR DNASU; 125115; -.
DR Ensembl; ENST00000377755.9; ENSP00000366984.4; ENSG00000204889.11.
DR Ensembl; ENST00000398486.2; ENSP00000381500.2; ENSG00000204889.11.
DR Ensembl; ENST00000576967.6; ENSP00000459621.2; ENSG00000262845.7.
DR Ensembl; ENST00000610983.1; ENSP00000479080.1; ENSG00000262845.7.
DR Ensembl; ENST00000684280.1; ENSP00000506768.1; ENSG00000204889.11.
DR GeneID; 125115; -.
DR KEGG; hsa:125115; -.
DR MANE-Select; ENST00000377755.9; ENSP00000366984.4; NM_001389244.1; NP_001376173.1.
DR UCSC; uc010cxh.2; human.
DR CTD; 125115; -.
DR DisGeNET; 125115; -.
DR GeneCards; KRT40; -.
DR HGNC; HGNC:26707; KRT40.
DR HPA; ENSG00000204889; Group enriched (pituitary gland, retina, skin).
DR MIM; 616679; gene.
DR neXtProt; NX_Q6A162; -.
DR OpenTargets; ENSG00000204889; -.
DR PharmGKB; PA147357651; -.
DR VEuPathDB; HostDB:ENSG00000204889; -.
DR eggNOG; ENOG502SHG0; Eukaryota.
DR GeneTree; ENSGT00940000161968; -.
DR HOGENOM; CLU_012560_8_0_1; -.
DR InParanoid; Q6A162; -.
DR OMA; LNQQQLC; -.
DR OrthoDB; 798081at2759; -.
DR PhylomeDB; Q6A162; -.
DR TreeFam; TF332742; -.
DR PathwayCommons; Q6A162; -.
DR Reactome; R-HSA-6805567; Keratinization.
DR Reactome; R-HSA-6809371; Formation of the cornified envelope.
DR SignaLink; Q6A162; -.
DR BioGRID-ORCS; 125115; 8 hits in 1058 CRISPR screens.
DR GenomeRNAi; 125115; -.
DR Pharos; Q6A162; Tbio.
DR PRO; PR:Q6A162; -.
DR Proteomes; UP000005640; Chromosome 17.
DR RNAct; Q6A162; protein.
DR Bgee; ENSG00000204889; Expressed in islet of Langerhans and 27 other tissues.
DR ExpressionAtlas; Q6A162; baseline and differential.
DR Genevisible; Q6A162; HS.
DR GO; GO:0005856; C:cytoskeleton; IBA:GO_Central.
DR GO; GO:0005829; C:cytosol; TAS:Reactome.
DR GO; GO:0005882; C:intermediate filament; IEA:UniProtKB-KW.
DR GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
DR GO; GO:0030855; P:epithelial cell differentiation; IBA:GO_Central.
DR GO; GO:0045109; P:intermediate filament organization; IBA:GO_Central.
DR InterPro; IPR039008; IF_rod_dom.
DR InterPro; IPR002957; Keratin_I.
DR PANTHER; PTHR23239; PTHR23239; 1.
DR Pfam; PF00038; Filament; 1.
DR PRINTS; PR01248; TYPE1KERATIN.
DR SMART; SM01391; Filament; 1.
DR PROSITE; PS51842; IF_ROD_2; 1.
PE 1: Evidence at protein level;
KW Coiled coil; Intermediate filament; Keratin; Reference proteome.
FT CHAIN 1..431
FT /note="Keratin, type I cytoskeletal 40"
FT /id="PRO_0000314857"
FT DOMAIN 89..400
FT /note="IF rod"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01188"
FT REGION 1..89
FT /note="Head"
FT REGION 90..124
FT /note="Coil 1A"
FT REGION 125..135
FT /note="Linker 1"
FT REGION 136..236
FT /note="Coil 1B"
FT REGION 237..252
FT /note="Linker 12"
FT REGION 253..396
FT /note="Coil 2"
FT REGION 397..431
FT /note="Tail"
FT SITE 338
FT /note="Stutter"
FT VARIANT 37
FT /note="T -> A (in dbSNP:rs1510069)"
FT /id="VAR_038078"
FT VARIANT 85
FT /note="F -> S (in dbSNP:rs17843015)"
FT /evidence="ECO:0000269|PubMed:15617563"
FT /id="VAR_038079"
FT VARIANT 102
FT /note="S -> N (in dbSNP:rs1510068)"
FT /id="VAR_038080"
FT VARIANT 153
FT /note="T -> M (in dbSNP:rs9908304)"
FT /id="VAR_038081"
FT VARIANT 235
FT /note="R -> H (in dbSNP:rs2010027)"
FT /id="VAR_049787"
FT VARIANT 265
FT /note="C -> Y (in dbSNP:rs721957)"
FT /evidence="ECO:0000269|PubMed:15617563"
FT /id="VAR_049788"
FT VARIANT 286
FT /note="E -> D (in dbSNP:rs721958)"
FT /id="VAR_049789"
FT VARIANT 303
FT /note="M -> T (in dbSNP:rs9908389)"
FT /id="VAR_049790"
FT VARIANT 406
FT /note="S -> L (in dbSNP:rs16968862)"
FT /id="VAR_049791"
FT CONFLICT 241
FT /note="R -> C (in Ref. 1; CAH10353)"
FT /evidence="ECO:0000305"
FT CONFLICT 349
FT /note="C -> R (in Ref. 1; CAH10353)"
FT /evidence="ECO:0000305"
FT CONFLICT 408
FT /note="T -> I (in Ref. 1; CAH10353)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 431 AA; 48139 MW; D57C5153D50E7D41 CRC64;
MTSDCSSTHC SPESCGTASG CAPASSCSVE TACLPGTCAT SRCQTPSFLS RSRGLTGCLL
PCYFTGSCNS PCLVGNCAWC EDGVFTSNEK ETMQFLNDRL ASYLEKVRSL EETNAELESR
IQEQCEQDIP MVCPDYQRYF NTIEDLQQKI LCTKAENSRL AVQLDNCKLA TDDFKSKYES
ELSLRQLLEA DISSLHGILE ELTLCKSDLE AHVESLKEDL LCLKKNHEEE VNLLREQLGD
RLSVELDTAP TLDLNRVLDE MRCQCETVLA NNRREAEEWL AVQTEELNQQ QLSSAEQLQG
CQMEILELKR TASALEIELQ AQQSLTESLE CTVAETEAQY SSQLAQIQCL IDNLENQLAE
IRCDLERQNQ EYQVLLDVKA RLEGEINTYW GLLDSEDSRL SCSPCSTTCT SSNTCEPCSA
YVICTVENCC L
