K1C40_MOUSE
ID K1C40_MOUSE Reviewed; 439 AA.
AC Q6IFX3; A0AUL0; Q3B7Y6;
DT 15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 03-AUG-2022, entry version 118.
DE RecName: Full=Keratin, type I cytoskeletal 40;
DE AltName: Full=Cytokeratin-40;
DE Short=CK-40;
DE AltName: Full=Keratin-40;
DE Short=K40;
DE AltName: Full=Type I hair keratin Ka36;
GN Name=Krt40; Synonyms=Ka36;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP IDENTIFICATION.
RX PubMed=15085952; DOI=10.1078/0171-9335-00354;
RA Hesse M., Zimek A., Weber K., Magin T.M.;
RT "Comprehensive analysis of keratin gene clusters in humans and rodents.";
RL Eur. J. Cell Biol. 83:19-26(2004).
CC -!- FUNCTION: May play a role in late hair differentiation. {ECO:0000250}.
CC -!- SUBUNIT: Heterotetramer of two type I and two type II keratins.
CC -!- MISCELLANEOUS: There are two types of cytoskeletal and microfibrillar
CC keratin, I (acidic) and II (neutral to basic) (40-55 and 56-70 kDa,
CC respectively).
CC -!- SIMILARITY: Belongs to the intermediate filament family.
CC {ECO:0000255|PROSITE-ProRule:PRU01188}.
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DR EMBL; AL591417; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC107359; AAI07360.1; -; mRNA.
DR EMBL; BC107360; AAI07361.1; -; mRNA.
DR EMBL; BC119522; AAI19523.1; -; mRNA.
DR EMBL; BK004023; DAA04490.1; -; mRNA.
DR CCDS; CCDS36307.1; -.
DR RefSeq; NP_001034755.1; NM_001039666.2.
DR AlphaFoldDB; Q6IFX3; -.
DR SMR; Q6IFX3; -.
DR BioGRID; 240431; 7.
DR IntAct; Q6IFX3; 1.
DR STRING; 10090.ENSMUSP00000073869; -.
DR PhosphoSitePlus; Q6IFX3; -.
DR jPOST; Q6IFX3; -.
DR MaxQB; Q6IFX3; -.
DR PaxDb; Q6IFX3; -.
DR PeptideAtlas; Q6IFX3; -.
DR PRIDE; Q6IFX3; -.
DR ProteomicsDB; 268938; -.
DR Antibodypedia; 28766; 72 antibodies from 16 providers.
DR DNASU; 406221; -.
DR Ensembl; ENSMUST00000074253; ENSMUSP00000073869; ENSMUSG00000059169.
DR GeneID; 406221; -.
DR KEGG; mmu:406221; -.
DR UCSC; uc007liy.1; mouse.
DR CTD; 125115; -.
DR MGI; MGI:3629968; Krt40.
DR VEuPathDB; HostDB:ENSMUSG00000059169; -.
DR eggNOG; ENOG502SHG0; Eukaryota.
DR GeneTree; ENSGT00940000161968; -.
DR HOGENOM; CLU_012560_8_0_1; -.
DR InParanoid; Q6IFX3; -.
DR OMA; LNQQQLC; -.
DR OrthoDB; 798081at2759; -.
DR PhylomeDB; Q6IFX3; -.
DR TreeFam; TF332742; -.
DR Reactome; R-MMU-6805567; Keratinization.
DR Reactome; R-MMU-6809371; Formation of the cornified envelope.
DR BioGRID-ORCS; 406221; 1 hit in 71 CRISPR screens.
DR PRO; PR:Q6IFX3; -.
DR Proteomes; UP000000589; Chromosome 11.
DR RNAct; Q6IFX3; protein.
DR Bgee; ENSMUSG00000059169; Expressed in lip and 3 other tissues.
DR ExpressionAtlas; Q6IFX3; baseline and differential.
DR GO; GO:0005856; C:cytoskeleton; IBA:GO_Central.
DR GO; GO:0005882; C:intermediate filament; IEA:UniProtKB-KW.
DR GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
DR GO; GO:0030855; P:epithelial cell differentiation; IBA:GO_Central.
DR GO; GO:0045109; P:intermediate filament organization; IBA:GO_Central.
DR InterPro; IPR018039; IF_conserved.
DR InterPro; IPR039008; IF_rod_dom.
DR InterPro; IPR002957; Keratin_I.
DR PANTHER; PTHR23239; PTHR23239; 1.
DR Pfam; PF00038; Filament; 1.
DR PRINTS; PR01248; TYPE1KERATIN.
DR SMART; SM01391; Filament; 1.
DR PROSITE; PS00226; IF_ROD_1; 1.
DR PROSITE; PS51842; IF_ROD_2; 1.
PE 2: Evidence at transcript level;
KW Coiled coil; Intermediate filament; Keratin; Reference proteome.
FT CHAIN 1..439
FT /note="Keratin, type I cytoskeletal 40"
FT /id="PRO_0000314858"
FT DOMAIN 89..400
FT /note="IF rod"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01188"
FT REGION 1..89
FT /note="Head"
FT REGION 90..124
FT /note="Coil 1A"
FT REGION 125..135
FT /note="Linker 1"
FT REGION 136..236
FT /note="Coil 1B"
FT REGION 237..252
FT /note="Linker 12"
FT REGION 253..396
FT /note="Coil 2"
FT REGION 397..439
FT /note="Tail"
FT SITE 338
FT /note="Stutter"
FT CONFLICT 271
FT /note="N -> D (in Ref. 2; AAI07360/AAI07361)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 439 AA; 48928 MW; 95CF93759DD28509 CRC64;
MASDGSPSCC SSEPCAGASG CATASFCPTN TTCLPNTCST SRCQTPSFLC RASLPACCLS
PCYLAGGCNS PCLVGSCAWC EEGSFNSNEK ETMQFLNDRL ASYLERVRSL EENNAELECR
IREQCEPNAP LVCPDYQRYF DTIEELQQKI LCTKAENSRL AVQVDNCKLA ADDFRSKYES
ELSLRQLVEN DITGLRGILG ELTLCKSDLE AHVESMKDDL ICLKKGHEEE VNLLREQLGD
RLSVELDTAP TVDLNKVLDE MRCQYERVLA NNRRDAEEWF AAQTEELNQQ QKSSAEQLEG
CQTEMLELKR KANTLEIELQ AQQTLTESLE CTVAETEAQY STQLAQMQCL IDSVEHQLAE
IRCDLERQNQ EYQVLLDTKA RLECEINTYR GLLEKEDSRL PCNPGSGAPM PNSTCEPCSN
SMCEPCSAYV ICTVENCCA
