K1C40_RAT
ID K1C40_RAT Reviewed; 431 AA.
AC Q6IFW2;
DT 15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 03-AUG-2022, entry version 83.
DE RecName: Full=Keratin, type I cytoskeletal 40;
DE AltName: Full=Cytokeratin-40;
DE Short=CK-40;
DE AltName: Full=Keratin-40;
DE Short=K40;
DE AltName: Full=Type I hair keratin Ka36;
GN Name=Krt40; Synonyms=Ka36;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Brown Norway;
RX PubMed=15057822; DOI=10.1038/nature02426;
RA Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J.,
RA Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G.,
RA Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G.,
RA Morgan M., Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G.,
RA Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S.,
RA Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T.,
RA Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D.,
RA Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L.,
RA Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D.,
RA Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M.,
RA Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C.,
RA Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J.,
RA Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H.,
RA Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X.,
RA Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q.,
RA Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P.,
RA Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A.,
RA Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C.,
RA Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J.,
RA Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J.,
RA Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F.,
RA Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A.,
RA Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A.,
RA Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J.,
RA Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E.,
RA Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M.,
RA Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C.,
RA Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L.,
RA Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W.,
RA Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y.,
RA Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V.,
RA Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M.,
RA Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S.,
RA Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B.,
RA Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R.,
RA Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J.,
RA Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D.,
RA Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S.,
RA Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S.,
RA Mockrin S., Collins F.S.;
RT "Genome sequence of the Brown Norway rat yields insights into mammalian
RT evolution.";
RL Nature 428:493-521(2004).
RN [2]
RP IDENTIFICATION.
RX PubMed=15085952; DOI=10.1078/0171-9335-00354;
RA Hesse M., Zimek A., Weber K., Magin T.M.;
RT "Comprehensive analysis of keratin gene clusters in humans and rodents.";
RL Eur. J. Cell Biol. 83:19-26(2004).
CC -!- FUNCTION: May play a role in late hair differentiation. {ECO:0000250}.
CC -!- SUBUNIT: Heterotetramer of two type I and two type II keratins.
CC -!- MISCELLANEOUS: There are two types of cytoskeletal and microfibrillar
CC keratin, I (acidic) and II (neutral to basic) (40-55 and 56-70 kDa,
CC respectively).
CC -!- SIMILARITY: Belongs to the intermediate filament family.
CC {ECO:0000255|PROSITE-ProRule:PRU01188}.
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DR EMBL; AABR03073663; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BK004036; DAA04470.1; -; mRNA.
DR RefSeq; NP_001008821.1; NM_001008821.1.
DR AlphaFoldDB; Q6IFW2; -.
DR SMR; Q6IFW2; -.
DR STRING; 10116.ENSRNOP00000018804; -.
DR PhosphoSitePlus; Q6IFW2; -.
DR jPOST; Q6IFW2; -.
DR PaxDb; Q6IFW2; -.
DR PRIDE; Q6IFW2; -.
DR Ensembl; ENSRNOT00000018804; ENSRNOP00000018804; ENSRNOG00000013896.
DR GeneID; 287679; -.
DR KEGG; rno:287679; -.
DR UCSC; RGD:1359145; rat.
DR CTD; 125115; -.
DR RGD; 1359145; Krt40.
DR eggNOG; ENOG502SHG0; Eukaryota.
DR GeneTree; ENSGT00940000161968; -.
DR HOGENOM; CLU_012560_8_0_1; -.
DR InParanoid; Q6IFW2; -.
DR OMA; LNQQQLC; -.
DR OrthoDB; 798081at2759; -.
DR PhylomeDB; Q6IFW2; -.
DR Reactome; R-RNO-6805567; Keratinization.
DR Reactome; R-RNO-6809371; Formation of the cornified envelope.
DR PRO; PR:Q6IFW2; -.
DR Proteomes; UP000002494; Chromosome 10.
DR Bgee; ENSRNOG00000013896; Expressed in esophagus and 1 other tissue.
DR GO; GO:0005856; C:cytoskeleton; IBA:GO_Central.
DR GO; GO:0005882; C:intermediate filament; IEA:UniProtKB-KW.
DR GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
DR GO; GO:0030855; P:epithelial cell differentiation; IBA:GO_Central.
DR GO; GO:0045109; P:intermediate filament organization; IBA:GO_Central.
DR InterPro; IPR018039; IF_conserved.
DR InterPro; IPR039008; IF_rod_dom.
DR InterPro; IPR002957; Keratin_I.
DR PANTHER; PTHR23239; PTHR23239; 1.
DR Pfam; PF00038; Filament; 1.
DR PRINTS; PR01248; TYPE1KERATIN.
DR SMART; SM01391; Filament; 1.
DR PROSITE; PS00226; IF_ROD_1; 1.
DR PROSITE; PS51842; IF_ROD_2; 1.
PE 3: Inferred from homology;
KW Coiled coil; Intermediate filament; Keratin; Reference proteome.
FT CHAIN 1..431
FT /note="Keratin, type I cytoskeletal 40"
FT /id="PRO_0000314859"
FT DOMAIN 89..400
FT /note="IF rod"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01188"
FT REGION 1..89
FT /note="Head"
FT REGION 90..124
FT /note="Coil 1A"
FT REGION 125..135
FT /note="Linker 1"
FT REGION 136..236
FT /note="Coil 1B"
FT REGION 237..252
FT /note="Linker 12"
FT REGION 253..396
FT /note="Coil 2"
FT REGION 397..431
FT /note="Tail"
FT SITE 338
FT /note="Stutter"
SQ SEQUENCE 431 AA; 48296 MW; EBD3E8B1A8FB0ACD CRC64;
MASEGSPDCC SSEPYAGASS CTTASFCPTS TTYLPSTCAT SRCQTPSFLC RAHLPAGCLS
PCYLTGGCNS PCLVGNCAWC EEGTFNSNEK ETMQFLNDRL ASYLERVRSL EENNAELECR
IREQCEPDAT PVCPDYQRYF DTIEELQQKI LCTKAENSRL AVQVDNCKLA ADDFRSKYES
ELSLRQLVEN DISGLRGILG ELTLCKSDLE AHVESLKDDL LCLKKDHEEE VNLLREQLGD
RLNVELDTAP TVDLNKVLDE MRCQYERVLA NNRRDAEEWF AAQTEELNQQ QMSSAEQLQG
CQTEMLELKR TANTLEIELQ AQQTLTESLE CTVAETEAQY STQLAQMQCL IDSVEHQLAE
IRCDLERQNQ EYKVLLDTKA RLECEINTYR GLLEKEDSRL PCNPGSTASI SNSACEPCSA
YVICTVENCC A
