K1C42_RAT
ID K1C42_RAT Reviewed; 452 AA.
AC Q6IFU7;
DT 13-NOV-2007, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 03-AUG-2022, entry version 96.
DE RecName: Full=Keratin, type I cytoskeletal 42;
DE AltName: Full=Cytokeratin-42;
DE Short=CK-42;
DE AltName: Full=Keratin-42;
DE Short=K42;
DE AltName: Full=Type I keratin Ka22;
GN Name=Krt42 {ECO:0000250|UniProtKB:Q6SEK1};
GN Synonyms=Ka22 {ECO:0000312|EMBL:DAA04485.1};
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1] {ECO:0000305}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Brown Norway {ECO:0000269|PubMed:15057822};
RX PubMed=15057822; DOI=10.1038/nature02426;
RA Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J.,
RA Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G.,
RA Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G.,
RA Morgan M., Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G.,
RA Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S.,
RA Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T.,
RA Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D.,
RA Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L.,
RA Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D.,
RA Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M.,
RA Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C.,
RA Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J.,
RA Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H.,
RA Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X.,
RA Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q.,
RA Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P.,
RA Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A.,
RA Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C.,
RA Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J.,
RA Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J.,
RA Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F.,
RA Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A.,
RA Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A.,
RA Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J.,
RA Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E.,
RA Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M.,
RA Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C.,
RA Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L.,
RA Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W.,
RA Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y.,
RA Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V.,
RA Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M.,
RA Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S.,
RA Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B.,
RA Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R.,
RA Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J.,
RA Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D.,
RA Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S.,
RA Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S.,
RA Mockrin S., Collins F.S.;
RT "Genome sequence of the Brown Norway rat yields insights into mammalian
RT evolution.";
RL Nature 428:493-521(2004).
RN [2] {ECO:0000305, ECO:0000312|EMBL:DAA04485.1}
RP IDENTIFICATION.
RC STRAIN=Brown Norway {ECO:0000312|EMBL:DAA04485.1};
RX PubMed=15085952; DOI=10.1078/0171-9335-00354;
RA Hesse M., Zimek A., Weber K., Magin T.M.;
RT "Comprehensive analysis of keratin gene clusters in humans and rodents.";
RL Eur. J. Cell Biol. 83:19-26(2004).
CC -!- SUBUNIT: Heterodimer of a type I and a type II keratin. Colocalizes
CC with KRT8/KRT18 filament network (By similarity).
CC {ECO:0000250|UniProtKB:Q6SEK1, ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q6SEK1}.
CC -!- MISCELLANEOUS: There are two types of cytoskeletal and microfibrillar
CC keratin: I (acidic; 40-55 kDa) and II (neutral to basic; 56-70 kDa).
CC {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the intermediate filament family.
CC {ECO:0000255|PROSITE-ProRule:PRU01188}.
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DR EMBL; AABR03075599; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BK004051; DAA04485.1; -; mRNA.
DR RefSeq; NP_001008816.1; NM_001008816.1.
DR AlphaFoldDB; Q6IFU7; -.
DR SMR; Q6IFU7; -.
DR STRING; 10116.ENSRNOP00000048162; -.
DR iPTMnet; Q6IFU7; -.
DR PhosphoSitePlus; Q6IFU7; -.
DR jPOST; Q6IFU7; -.
DR PaxDb; Q6IFU7; -.
DR PRIDE; Q6IFU7; -.
DR Ensembl; ENSRNOT00000046956; ENSRNOP00000048162; ENSRNOG00000034087.
DR GeneID; 450231; -.
DR KEGG; rno:450231; -.
DR UCSC; RGD:1359182; rat.
DR CTD; 68239; -.
DR RGD; 1359182; Krt42.
DR eggNOG; ENOG502R8V7; Eukaryota.
DR GeneTree; ENSGT00940000163247; -.
DR HOGENOM; CLU_012560_8_1_1; -.
DR InParanoid; Q6IFU7; -.
DR OMA; CVPGGGF; -.
DR OrthoDB; 798081at2759; -.
DR PhylomeDB; Q6IFU7; -.
DR TreeFam; TF332742; -.
DR PRO; PR:Q6IFU7; -.
DR Proteomes; UP000002494; Chromosome 10.
DR Bgee; ENSRNOG00000034087; Expressed in ovary and 5 other tissues.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005856; C:cytoskeleton; IBA:GO_Central.
DR GO; GO:0005882; C:intermediate filament; IEA:UniProtKB-KW.
DR GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
DR GO; GO:0030855; P:epithelial cell differentiation; IBA:GO_Central.
DR GO; GO:0045109; P:intermediate filament organization; IBA:GO_Central.
DR InterPro; IPR018039; IF_conserved.
DR InterPro; IPR039008; IF_rod_dom.
DR InterPro; IPR002957; Keratin_I.
DR PANTHER; PTHR23239; PTHR23239; 1.
DR Pfam; PF00038; Filament; 1.
DR PRINTS; PR01248; TYPE1KERATIN.
DR SMART; SM01391; Filament; 1.
DR PROSITE; PS00226; IF_ROD_1; 1.
DR PROSITE; PS51842; IF_ROD_2; 1.
PE 3: Inferred from homology;
KW Coiled coil; Cytoplasm; Intermediate filament; Keratin; Reference proteome.
FT CHAIN 1..452
FT /note="Keratin, type I cytoskeletal 42"
FT /id="PRO_0000311715"
FT DOMAIN 94..405
FT /note="IF rod"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01188"
FT REGION 4..93
FT /note="Head"
FT /evidence="ECO:0000255"
FT REGION 94..129
FT /note="Coil 1A"
FT /evidence="ECO:0000255"
FT REGION 130..147
FT /note="Linker 1"
FT /evidence="ECO:0000255"
FT REGION 148..239
FT /note="Coil 1B"
FT /evidence="ECO:0000255"
FT REGION 240..262
FT /note="Linker 12"
FT /evidence="ECO:0000255"
FT REGION 263..401
FT /note="Coil 2"
FT /evidence="ECO:0000255"
FT REGION 402..452
FT /note="Tail"
FT /evidence="ECO:0000255"
FT COILED 93..132
FT /evidence="ECO:0000255"
FT COILED 188..407
FT /evidence="ECO:0000255"
SQ SEQUENCE 452 AA; 50213 MW; 9DBCCB57A5C7838C CRC64;
MASTTSIRQF STSGSVKGLC APGMGFSRMS SVRIGGACRA PSLLGGGSCS NMSVTSSRFS
AGLGGSYGGG YTCSLGGGFG SSFGVSDALL GGSEKETMQN LNDRLATYLD RVRALEEANT
DLEVKIREWY KKQGPGPARD YSPYFKTIED LRNKILAATI DNASIVLQID NARLAADDFR
TKYETELNLR MSVEADINGL RRVLDELTLA RADLEMQIET LKEELAYLKK NHEEEMNALR
GQVGGDVNVE MDAAPGVDLS RILNEMRDQY EKMAEKNRKD AEEWFFTKTE ELNREVATNT
EALQSSRTEI TELRRSVQNL EIELQSQLSM KASLENSLAE TEARYGAQLA QLQGLISSME
QQLCELRCDM ERQNHEYQVL LDVKTRLEQE IATYRRLLEG EDAHLATQYS SSLASQASRE
GTVTSRQVRT IVEEVQDGKV VSSREQVHRS TH
