ID   K1C4_XENLA              Reviewed;         419 AA.
AC   P05781;
DT   01-NOV-1988, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1988, sequence version 1.
DT   25-MAY-2022, entry version 80.
DE   RecName: Full=Keratin, type I cytoskeletal 47 kDa;
GN   Name=xk81b2;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
RX   PubMed=2430981; DOI=10.1083/jcb.103.5.1957;
RA   Miyatani S., Winkles J.A., Sargent T.D., Dawid I.B.;
RT   "Stage-specific keratins in Xenopus laevis embryos and tadpoles: the XK81
RT   gene family.";
RL   J. Cell Biol. 103:1957-1965(1986).
CC   -!- SUBUNIT: Heterotetramer of two type I and two type II keratins.
CC   -!- MISCELLANEOUS: There are two types of cytoskeletal and microfibrillar
CC       keratin: I (acidic; 40-55 kDa) and II (neutral to basic; 56-70 kDa).
CC   -!- SIMILARITY: Belongs to the intermediate filament family.
CC       {ECO:0000255|PROSITE-ProRule:PRU01188}.
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DR   EMBL; X04807; CAA28498.1; -; Genomic_DNA.
DR   EMBL; X12730; CAA31223.1; -; Genomic_DNA.
DR   EMBL; X05865; CAA29293.1; -; mRNA.
DR   PIR; A25438; A25438.
DR   AlphaFoldDB; P05781; -.
DR   SMR; P05781; -.
DR   PRIDE; P05781; -.
DR   Proteomes; UP000186698; Genome assembly.
DR   GO; GO:0005882; C:intermediate filament; IEA:UniProtKB-KW.
DR   GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
DR   InterPro; IPR018039; IF_conserved.
DR   InterPro; IPR039008; IF_rod_dom.
DR   InterPro; IPR002957; Keratin_I.
DR   PANTHER; PTHR23239; PTHR23239; 1.
DR   Pfam; PF00038; Filament; 1.
DR   PRINTS; PR01248; TYPE1KERATIN.
DR   SMART; SM01391; Filament; 1.
DR   PROSITE; PS00226; IF_ROD_1; 1.
DR   PROSITE; PS51842; IF_ROD_2; 1.
PE   2: Evidence at transcript level;
KW   Coiled coil; Intermediate filament; Keratin; Reference proteome.
FT   CHAIN           1..419
FT                   /note="Keratin, type I cytoskeletal 47 kDa"
FT                   /id="PRO_0000063681"
FT   DOMAIN          82..397
FT                   /note="IF rod"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01188"
FT   REGION          1..81
FT                   /note="Head"
FT   REGION          82..117
FT                   /note="Coil 1A"
FT   REGION          118..139
FT                   /note="Linker 1"
FT   REGION          140..231
FT                   /note="Coil 1B"
FT   REGION          232..254
FT                   /note="Linker 12"
FT   REGION          255..393
FT                   /note="Coil 2"
FT   REGION          394..419
FT                   /note="Tail"
SQ   SEQUENCE   419 AA;  45653 MW;  BA16F03EE53D815A CRC64;
     MSFRSSSSYS LQSKGISGGG GYGAGFGGGS GAGFGGGSGA GFGGGYGAGF GGGASSGFSL
     SSAGGFGAAA ASSSFSNFGG NDKQTMQNLN DRLASYLEKV RALEAANADL ELKIREWYEK
     QKGSGIGAGS KDFSKYFEII SDLRNKILSA TIDNSRVVLQ IDNAKLAADD FRLKFENELA
     LRQSVETDIN GLRRVLDELT LARGDLEMQI ESLTEELAYL KKNHEEEMSI AKSSSAGQVN
     VEMDAAPGID LNKILSDMRA DYETLAEKNR RDAELWFNQK SGELKKEIQT GVEQVQTSKS
     EINDLRRSLQ SLEIELQSQL AMKKSLEDTL AETDGRYGAQ LQTIQFSLRS LEEQLLQIRS
     DMERQNMEYR QLLDIKTRLE MEIETYRRLL EGEFGSLKSS IVQATEVSTS QSSSSSKKD