ID   K1C5_XENLA              Reviewed;         433 AA.
AC   P08778; Q6GMB4;
DT   01-NOV-1988, integrated into UniProtKB/Swiss-Prot.
DT   31-OCT-2006, sequence version 2.
DT   03-AUG-2022, entry version 93.
DE   RecName: Full=Keratin, type I cytoskeletal 47 kDa;
GN   Name=xk70a;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=HD-1;
RX   PubMed=2458568; DOI=10.1093/nar/16.17.8728;
RA   Krasner A.S., Cheng A.K., Dawid I.B., Sargent T.D.;
RT   "The gene encoding Xenopus embryonic epidermal keratin XK70A exhibits a
RT   hybrid type I-type II intron pattern.";
RL   Nucleic Acids Res. 16:8728-8728(1988).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Kidney;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE [MRNA] OF 11-433.
RX   PubMed=2426572; DOI=10.1128/mcb.5.10.2575-2581.1985;
RA   Winkles J.A., Sargent T.D., Parry D.A.D., Jonas E., Dawid I.B.;
RT   "Developmentally regulated cytokeratin gene in Xenopus laevis.";
RL   Mol. Cell. Biol. 5:2575-2581(1985).
CC   -!- SUBUNIT: Heterotetramer of two type I and two type II keratins.
CC   -!- MISCELLANEOUS: There are two types of cytoskeletal and microfibrillar
CC       keratin: I (acidic; 40-55 kDa) and II (neutral to basic; 56-70 kDa).
CC   -!- SIMILARITY: Belongs to the intermediate filament family.
CC       {ECO:0000255|PROSITE-ProRule:PRU01188}.
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DR   EMBL; X07679; CAA30526.1; -; Genomic_DNA.
DR   EMBL; BC074154; AAH74154.1; -; mRNA.
DR   EMBL; M11032; AAA49895.1; -; mRNA.
DR   PIR; S01631; S01631.
DR   RefSeq; NP_001081288.1; NM_001087819.1.
DR   AlphaFoldDB; P08778; -.
DR   SMR; P08778; -.
DR   BioGRID; 99095; 1.
DR   MaxQB; P08778; -.
DR   GeneID; 397756; -.
DR   KEGG; xla:397756; -.
DR   CTD; 397756; -.
DR   Xenbase; XB-GENE-6252602; krt70.S.
DR   OrthoDB; 259189at7742; -.
DR   Proteomes; UP000186698; Chromosome 9_10S.
DR   Bgee; 397756; Expressed in neurula embryo and 18 other tissues.
DR   GO; GO:0005882; C:intermediate filament; IEA:UniProtKB-KW.
DR   GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
DR   InterPro; IPR018039; IF_conserved.
DR   InterPro; IPR039008; IF_rod_dom.
DR   InterPro; IPR002957; Keratin_I.
DR   PANTHER; PTHR23239; PTHR23239; 1.
DR   Pfam; PF00038; Filament; 1.
DR   PRINTS; PR01248; TYPE1KERATIN.
DR   SMART; SM01391; Filament; 1.
DR   PROSITE; PS00226; IF_ROD_1; 1.
DR   PROSITE; PS51842; IF_ROD_2; 1.
PE   2: Evidence at transcript level;
KW   Coiled coil; Intermediate filament; Keratin; Reference proteome.
FT   CHAIN           1..433
FT                   /note="Keratin, type I cytoskeletal 47 kDa"
FT                   /id="PRO_0000063683"
FT   DOMAIN          74..385
FT                   /note="IF rod"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01188"
FT   REGION          1..73
FT                   /note="Head"
FT   REGION          74..109
FT                   /note="Coil 1A"
FT   REGION          110..127
FT                   /note="Linker 1"
FT   REGION          128..219
FT                   /note="Coil 1B"
FT   REGION          220..242
FT                   /note="Linker 12"
FT   REGION          243..381
FT                   /note="Coil 2"
FT   REGION          382..433
FT                   /note="Tail"
FT   CONFLICT        18
FT                   /note="A -> S (in Ref. 1; CAA30526)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        58
FT                   /note="A -> S (in Ref. 1; CAA30526)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        72
FT                   /note="N -> H (in Ref. 1; CAA30526)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        326
FT                   /note="G -> R (in Ref. 1; CAA30526)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   433 AA;  47807 MW;  FE43BA061DE46C7B CRC64;
     MSYSTRSISQ SARFGVLASP GVNRARSVAG GASTVRMSSA NVTSSAFGGS SAFAGSSAFA
     GSPAFNVSVT SNNGKETMQN LNDRLANYLD RVRSLEQANH ELELKIREYL DKKAAVGSLD
     YSGYYNTINL LRSQINDATI DNTRLVLSID NAKLAADDFK IKYESEMAIR TGAESDIVGL
     RRVLDELTLN KTDLELEIES LKEELIYLKK NHEEELAVVR SSARGNVDVQ VDSAPPVDLA
     QIMADVRSQY ESMMEKNRQE LEACYKGQSE NLNHEVATNT AALQTSKTAI TDLKRTIQSL
     EIELQSLLSM KGALEGTLAE TEAQYGAQLN HLQAMITQVE MELQNLRSDA DHQSLEYKRL
     LDAKTRLEME IATYRRLLEG EDTRFSQTET QKAVTIVSKE QSSSSIKKVK TVIEEVVDGK
     VVSSRVEELT ETS