K1H1_HUMAN
ID K1H1_HUMAN Reviewed; 416 AA.
AC Q15323; Q9UE12;
DT 15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT 14-OCT-2008, sequence version 3.
DT 03-AUG-2022, entry version 172.
DE RecName: Full=Keratin, type I cuticular Ha1;
DE AltName: Full=Hair keratin, type I Ha1;
DE AltName: Full=Keratin-31;
DE Short=K31;
GN Name=KRT31; Synonyms=HHA1, HKA1, KRTHA1;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Hair;
RX PubMed=7578244; DOI=10.1016/0167-4781(95)00122-w;
RA Fink P., Rogers M.A., Krieg T., Winter H., Schweizer J.;
RT "A cDNA encoding the human type I hair keratin hHal.";
RL Biochim. Biophys. Acta 1264:12-14(1995).
RN [2]
RP SEQUENCE REVISION.
RA Rogers M.A.;
RL Submitted (MAR-1998) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND TISSUE SPECIFICITY.
RX PubMed=9756910; DOI=10.1074/jbc.273.41.26683;
RA Rogers M.A., Winter H., Wolf C., Heck M., Schweizer J.;
RT "Characterization of a 190-kilobase pair domain of human type I hair
RT keratin genes.";
RL J. Biol. Chem. 273:26683-26691(1998).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [6]
RP TISSUE SPECIFICITY.
RX PubMed=9457912; DOI=10.1046/j.1523-1747.1998.00097.x;
RA Bowden P.E., Hainey S.D., Parker G., Jones D.O., Zimonjic D., Popescu N.,
RA Hodgins M.B.;
RT "Characterization and chromosomal localization of human hair-specific
RT keratin genes and comparative expression during the hair growth cycle.";
RL J. Invest. Dermatol. 110:158-164(1998).
CC -!- INTERACTION:
CC Q15323; Q9NQ94: A1CF; NbExp=3; IntAct=EBI-948001, EBI-2809489;
CC Q15323; Q9NYB9: ABI2; NbExp=5; IntAct=EBI-948001, EBI-743598;
CC Q15323; Q9P2A4: ABI3; NbExp=3; IntAct=EBI-948001, EBI-742038;
CC Q15323; P00519-2: ABL1; NbExp=3; IntAct=EBI-948001, EBI-9254597;
CC Q15323; Q9NZ32: ACTR10; NbExp=3; IntAct=EBI-948001, EBI-2559426;
CC Q15323; O95994: AGR2; NbExp=6; IntAct=EBI-948001, EBI-712648;
CC Q15323; P21549: AGXT; NbExp=3; IntAct=EBI-948001, EBI-727098;
CC Q15323; Q13155: AIMP2; NbExp=3; IntAct=EBI-948001, EBI-745226;
CC Q15323; O95154: AKR7A3; NbExp=3; IntAct=EBI-948001, EBI-748869;
CC Q15323; P43353: ALDH3B1; NbExp=3; IntAct=EBI-948001, EBI-2558314;
CC Q15323; A2BDD9: AMOT; NbExp=3; IntAct=EBI-948001, EBI-17286414;
CC Q15323; Q4VCS5-2: AMOT; NbExp=3; IntAct=EBI-948001, EBI-3891843;
CC Q15323; Q9Y2J4-4: AMOTL2; NbExp=3; IntAct=EBI-948001, EBI-10187270;
CC Q15323; Q96IX9: ANKRD36BP1; NbExp=3; IntAct=EBI-948001, EBI-744859;
CC Q15323; Q49AR9: ANKS1A; NbExp=3; IntAct=EBI-948001, EBI-11954519;
CC Q15323; P29972: AQP1; NbExp=3; IntAct=EBI-948001, EBI-745213;
CC Q15323; P55064: AQP5; NbExp=3; IntAct=EBI-948001, EBI-746103;
CC Q15323; Q99856: ARID3A; NbExp=3; IntAct=EBI-948001, EBI-5458244;
CC Q15323; Q9H6L4: ARMC7; NbExp=6; IntAct=EBI-948001, EBI-742909;
CC Q15323; Q8N5N6: ARSJ; NbExp=3; IntAct=EBI-948001, EBI-10266832;
CC Q15323; O95671: ASMTL; NbExp=6; IntAct=EBI-948001, EBI-743231;
CC Q15323; Q9BZE9: ASPSCR1; NbExp=3; IntAct=EBI-948001, EBI-1993677;
CC Q15323; Q7Z3C6: ATG9A; NbExp=3; IntAct=EBI-948001, EBI-727146;
CC Q15323; Q7Z3C6-3: ATG9A; NbExp=3; IntAct=EBI-948001, EBI-12006308;
CC Q15323; Q9ULK2: ATXN7L1; NbExp=3; IntAct=EBI-948001, EBI-310660;
CC Q15323; Q5T686: AVPI1; NbExp=3; IntAct=EBI-948001, EBI-8640233;
CC Q15323; Q9UBV7: B4GALT7; NbExp=3; IntAct=EBI-948001, EBI-10319970;
CC Q15323; Q92934: BAD; NbExp=3; IntAct=EBI-948001, EBI-700771;
CC Q15323; O75934: BCAS2; NbExp=3; IntAct=EBI-948001, EBI-1050106;
CC Q15323; Q9HBH7: BEX1; NbExp=3; IntAct=EBI-948001, EBI-7162175;
CC Q15323; Q9BXY8: BEX2; NbExp=6; IntAct=EBI-948001, EBI-745073;
CC Q15323; Q13515: BFSP2; NbExp=3; IntAct=EBI-948001, EBI-10229433;
CC Q15323; Q7RTU4: BHLHA9; NbExp=3; IntAct=EBI-948001, EBI-17508719;
CC Q15323; Q0VDD7-2: BRME1; NbExp=3; IntAct=EBI-948001, EBI-12040255;
CC Q15323; P35070: BTC; NbExp=6; IntAct=EBI-948001, EBI-6590057;
CC Q15323; Q13895: BYSL; NbExp=3; IntAct=EBI-948001, EBI-358049;
CC Q15323; Q9NVV2: C19orf73; NbExp=3; IntAct=EBI-948001, EBI-2859285;
CC Q15323; Q9NX04: C1orf109; NbExp=6; IntAct=EBI-948001, EBI-8643161;
CC Q15323; Q8TAB5: C1orf216; NbExp=6; IntAct=EBI-948001, EBI-747505;
CC Q15323; Q53TS8: C2CD6; NbExp=6; IntAct=EBI-948001, EBI-739879;
CC Q15323; P01024: C3; NbExp=3; IntAct=EBI-948001, EBI-905851;
CC Q15323; A4QMS7: C5orf49; NbExp=3; IntAct=EBI-948001, EBI-12039847;
CC Q15323; A6NFR6-4: C5orf60; NbExp=3; IntAct=EBI-948001, EBI-10173955;
CC Q15323; Q8N4G4: CA6; NbExp=3; IntAct=EBI-948001, EBI-10265475;
CC Q15323; Q9H257: CARD9; NbExp=3; IntAct=EBI-948001, EBI-751319;
CC Q15323; Q7Z7H3: CATIP; NbExp=6; IntAct=EBI-948001, EBI-10258233;
CC Q15323; Q8NEC5: CATSPER1; NbExp=3; IntAct=EBI-948001, EBI-744545;
CC Q15323; Q9HC52: CBX8; NbExp=3; IntAct=EBI-948001, EBI-712912;
CC Q15323; Q8NEF3: CCDC112; NbExp=3; IntAct=EBI-948001, EBI-745040;
CC Q15323; Q8IYX3: CCDC116; NbExp=3; IntAct=EBI-948001, EBI-744311;
CC Q15323; Q96HB5: CCDC120; NbExp=3; IntAct=EBI-948001, EBI-744556;
CC Q15323; Q96HB5-4: CCDC120; NbExp=4; IntAct=EBI-948001, EBI-10185348;
CC Q15323; Q8IYE0: CCDC146; NbExp=3; IntAct=EBI-948001, EBI-10749669;
CC Q15323; Q96LX7: CCDC17; NbExp=3; IntAct=EBI-948001, EBI-719840;
CC Q15323; A0A1B0GWI1: CCDC196; NbExp=6; IntAct=EBI-948001, EBI-10181422;
CC Q15323; E9PSE9: CCDC198; NbExp=3; IntAct=EBI-948001, EBI-11748295;
CC Q15323; Q8TC90: CCER1; NbExp=3; IntAct=EBI-948001, EBI-746041;
CC Q15323; Q8TD31-3: CCHCR1; NbExp=6; IntAct=EBI-948001, EBI-10175300;
CC Q15323; P24863: CCNC; NbExp=6; IntAct=EBI-948001, EBI-395261;
CC Q15323; P20138: CD33; NbExp=6; IntAct=EBI-948001, EBI-3906571;
CC Q15323; Q86Y33: CDC20B; NbExp=3; IntAct=EBI-948001, EBI-10260504;
CC Q15323; Q07002: CDK18; NbExp=6; IntAct=EBI-948001, EBI-746238;
CC Q15323; P38936: CDKN1A; NbExp=6; IntAct=EBI-948001, EBI-375077;
CC Q15323; P42773: CDKN2C; NbExp=3; IntAct=EBI-948001, EBI-711290;
CC Q15323; Q86X02: CDR2L; NbExp=3; IntAct=EBI-948001, EBI-11063830;
CC Q15323; Q86XR8: CEP57; NbExp=3; IntAct=EBI-948001, EBI-308614;
CC Q15323; Q8IYX8: CEP57L1; NbExp=3; IntAct=EBI-948001, EBI-1104570;
CC Q15323; Q8IYX8-2: CEP57L1; NbExp=3; IntAct=EBI-948001, EBI-10181988;
CC Q15323; Q8NHQ1: CEP70; NbExp=3; IntAct=EBI-948001, EBI-739624;
CC Q15323; Q8IYR0: CFAP206; NbExp=3; IntAct=EBI-948001, EBI-749051;
CC Q15323; Q96M91: CFAP53; NbExp=3; IntAct=EBI-948001, EBI-742422;
CC Q15323; Q9Y6H1: CHCHD2; NbExp=3; IntAct=EBI-948001, EBI-2321769;
CC Q15323; P07510: CHRNG; NbExp=4; IntAct=EBI-948001, EBI-9008836;
CC Q15323; P07510-2: CHRNG; NbExp=6; IntAct=EBI-948001, EBI-11979451;
CC Q15323; P51800-3: CLCNKA; NbExp=3; IntAct=EBI-948001, EBI-11980535;
CC Q15323; Q8N6F1-2: CLDN19; NbExp=3; IntAct=EBI-948001, EBI-12256978;
CC Q15323; P57739: CLDN2; NbExp=3; IntAct=EBI-948001, EBI-751440;
CC Q15323; A5D8T8: CLEC18A; NbExp=3; IntAct=EBI-948001, EBI-10173491;
CC Q15323; Q8NE01: CNNM3; NbExp=3; IntAct=EBI-948001, EBI-741032;
CC Q15323; P26441: CNTF; NbExp=3; IntAct=EBI-948001, EBI-1050897;
CC Q15323; Q86WW8: COA5; NbExp=3; IntAct=EBI-948001, EBI-5458774;
CC Q15323; P21964-2: COMT; NbExp=3; IntAct=EBI-948001, EBI-10200977;
CC Q15323; P20674: COX5A; NbExp=3; IntAct=EBI-948001, EBI-715032;
CC Q15323; P10606: COX5B; NbExp=3; IntAct=EBI-948001, EBI-1053725;
CC Q15323; Q9BSW2: CRACR2A; NbExp=3; IntAct=EBI-948001, EBI-739773;
CC Q15323; Q02930-3: CREB5; NbExp=3; IntAct=EBI-948001, EBI-10192698;
CC Q15323; P06850: CRH; NbExp=3; IntAct=EBI-948001, EBI-3870390;
CC Q15323; P08311: CTSG; NbExp=3; IntAct=EBI-948001, EBI-5462635;
CC Q15323; A8MQ03: CYSRT1; NbExp=3; IntAct=EBI-948001, EBI-3867333;
CC Q15323; Q9H4E7: DEF6; NbExp=3; IntAct=EBI-948001, EBI-745369;
CC Q15323; Q9BY27: DGCR6L; NbExp=3; IntAct=EBI-948001, EBI-742953;
CC Q15323; Q9NQL9: DMRT3; NbExp=6; IntAct=EBI-948001, EBI-9679045;
CC Q15323; Q92608: DOCK2; NbExp=3; IntAct=EBI-948001, EBI-448771;
CC Q15323; O60941: DTNB; NbExp=3; IntAct=EBI-948001, EBI-740402;
CC Q15323; O60941-5: DTNB; NbExp=3; IntAct=EBI-948001, EBI-11984733;
CC Q15323; O60573: EIF4E2; NbExp=3; IntAct=EBI-948001, EBI-398610;
CC Q15323; Q04637-9: EIF4G1; NbExp=3; IntAct=EBI-948001, EBI-12012124;
CC Q15323; Q9H0I2: ENKD1; NbExp=3; IntAct=EBI-948001, EBI-744099;
CC Q15323; Q9UM22: EPDR1; NbExp=3; IntAct=EBI-948001, EBI-946972;
CC Q15323; Q8IYI6: EXOC8; NbExp=3; IntAct=EBI-948001, EBI-742102;
CC Q15323; Q9NQT4: EXOSC5; NbExp=3; IntAct=EBI-948001, EBI-371876;
CC Q15323; O95864-3: FADS2; NbExp=3; IntAct=EBI-948001, EBI-12057609;
CC Q15323; Q9BQ89: FAM110A; NbExp=6; IntAct=EBI-948001, EBI-1752811;
CC Q15323; Q9H5Z6: FAM124B; NbExp=3; IntAct=EBI-948001, EBI-741626;
CC Q15323; Q9H5Z6-2: FAM124B; NbExp=3; IntAct=EBI-948001, EBI-11986315;
CC Q15323; Q9Y247: FAM50B; NbExp=3; IntAct=EBI-948001, EBI-742802;
CC Q15323; Q8NEG0: FAM71C; NbExp=6; IntAct=EBI-948001, EBI-752049;
CC Q15323; Q5TZK3: FAM74A6; NbExp=3; IntAct=EBI-948001, EBI-10247271;
CC Q15323; Q86YD7: FAM90A1; NbExp=6; IntAct=EBI-948001, EBI-6658203;
CC Q15323; O95363: FARS2; NbExp=3; IntAct=EBI-948001, EBI-2513774;
CC Q15323; Q8TES7-6: FBF1; NbExp=3; IntAct=EBI-948001, EBI-10244131;
CC Q15323; Q969U6: FBXW5; NbExp=6; IntAct=EBI-948001, EBI-741068;
CC Q15323; O43320: FGF16; NbExp=3; IntAct=EBI-948001, EBI-11479104;
CC Q15323; P68106: FKBP1B; NbExp=3; IntAct=EBI-948001, EBI-6693977;
CC Q15323; P68106-2: FKBP1B; NbExp=3; IntAct=EBI-948001, EBI-11998976;
CC Q15323; Q99853: FOXB1; NbExp=3; IntAct=EBI-948001, EBI-3916225;
CC Q15323; O43559: FRS3; NbExp=3; IntAct=EBI-948001, EBI-725515;
CC Q15323; A0A0S2Z4D9: GAD1; NbExp=3; IntAct=EBI-948001, EBI-16430771;
CC Q15323; Q8TAE8: GADD45GIP1; NbExp=3; IntAct=EBI-948001, EBI-372506;
CC Q15323; P55040: GEM; NbExp=6; IntAct=EBI-948001, EBI-744104;
CC Q15323; P14136: GFAP; NbExp=3; IntAct=EBI-948001, EBI-744302;
CC Q15323; Q9NXC2: GFOD1; NbExp=3; IntAct=EBI-948001, EBI-8799578;
CC Q15323; O76003: GLRX3; NbExp=3; IntAct=EBI-948001, EBI-374781;
CC Q15323; P04899: GNAI2; NbExp=3; IntAct=EBI-948001, EBI-353997;
CC Q15323; Q9Y223: GNE; NbExp=3; IntAct=EBI-948001, EBI-4291090;
CC Q15323; Q9Y223-2: GNE; NbExp=3; IntAct=EBI-948001, EBI-11975289;
CC Q15323; P50151: GNG10; NbExp=3; IntAct=EBI-948001, EBI-10211741;
CC Q15323; P63218: GNG5; NbExp=3; IntAct=EBI-948001, EBI-10220734;
CC Q15323; Q8N9W4-2: GOLGA6L2; NbExp=3; IntAct=EBI-948001, EBI-10268729;
CC Q15323; Q13227: GPS2; NbExp=7; IntAct=EBI-948001, EBI-713355;
CC Q15323; P09211: GSTP1; NbExp=6; IntAct=EBI-948001, EBI-353467;
CC Q15323; Q9GZV7: HAPLN2; NbExp=3; IntAct=EBI-948001, EBI-11956675;
CC Q15323; Q96CS2: HAUS1; NbExp=3; IntAct=EBI-948001, EBI-2514791;
CC Q15323; P69905: HBA2; NbExp=3; IntAct=EBI-948001, EBI-714680;
CC Q15323; P02008: HBZ; NbExp=3; IntAct=EBI-948001, EBI-719843;
CC Q15323; P08631-2: HCK; NbExp=3; IntAct=EBI-948001, EBI-9834454;
CC Q15323; P56524: HDAC4; NbExp=3; IntAct=EBI-948001, EBI-308629;
CC Q15323; P56524-2: HDAC4; NbExp=3; IntAct=EBI-948001, EBI-11953488;
CC Q15323; O14964: HGS; NbExp=6; IntAct=EBI-948001, EBI-740220;
CC Q15323; P49639: HOXA1; NbExp=7; IntAct=EBI-948001, EBI-740785;
CC Q15323; P09067: HOXB5; NbExp=3; IntAct=EBI-948001, EBI-3893317;
CC Q15323; O60243: HS6ST1; NbExp=3; IntAct=EBI-948001, EBI-12294537;
CC Q15323; Q9H2F3: HSD3B7; NbExp=3; IntAct=EBI-948001, EBI-3918847;
CC Q15323; Q9ULV5-2: HSF4; NbExp=3; IntAct=EBI-948001, EBI-12056251;
CC Q15323; Q96MM6: HSPA12B; NbExp=6; IntAct=EBI-948001, EBI-10291310;
CC Q15323; P10809: HSPD1; NbExp=3; IntAct=EBI-948001, EBI-352528;
CC Q15323; Q12891: HYAL2; NbExp=3; IntAct=EBI-948001, EBI-2806068;
CC Q15323; Q14773-3: ICAM4; NbExp=6; IntAct=EBI-948001, EBI-10233928;
CC Q15323; Q14005-2: IL16; NbExp=3; IntAct=EBI-948001, EBI-17178971;
CC Q15323; Q92835: INPP5D; NbExp=3; IntAct=EBI-948001, EBI-1380477;
CC Q15323; Q9BT40: INPP5K; NbExp=6; IntAct=EBI-948001, EBI-749162;
CC Q15323; P06213: INSR; NbExp=3; IntAct=EBI-948001, EBI-475899;
CC Q15323; P05107: ITGB2; NbExp=3; IntAct=EBI-948001, EBI-300173;
CC Q15323; P16144-2: ITGB4; NbExp=3; IntAct=EBI-948001, EBI-11051601;
CC Q15323; P18084: ITGB5; NbExp=3; IntAct=EBI-948001, EBI-1223434;
CC Q15323; Q15040: JOSD1; NbExp=3; IntAct=EBI-948001, EBI-2510602;
CC Q15323; Q7L273: KCTD9; NbExp=3; IntAct=EBI-948001, EBI-4397613;
CC Q15323; O60341: KDM1A; NbExp=3; IntAct=EBI-948001, EBI-710124;
CC Q15323; Q5T5P2-6: KIAA1217; NbExp=3; IntAct=EBI-948001, EBI-10188326;
CC Q15323; Q9BVG8: KIFC3; NbExp=3; IntAct=EBI-948001, EBI-2125614;
CC Q15323; Q9BVG8-5: KIFC3; NbExp=3; IntAct=EBI-948001, EBI-14069005;
CC Q15323; Q07866: KLC1; NbExp=3; IntAct=EBI-948001, EBI-721019;
CC Q15323; Q9NSK0: KLC4; NbExp=6; IntAct=EBI-948001, EBI-949319;
CC Q15323; Q2WGJ6: KLHL38; NbExp=6; IntAct=EBI-948001, EBI-6426443;
CC Q15323; O60259: KLK8; NbExp=3; IntAct=EBI-948001, EBI-3915857;
CC Q15323; P04264: KRT1; NbExp=3; IntAct=EBI-948001, EBI-298429;
CC Q15323; P35908: KRT2; NbExp=10; IntAct=EBI-948001, EBI-1247312;
CC Q15323; P35900: KRT20; NbExp=3; IntAct=EBI-948001, EBI-742094;
CC Q15323; P12035: KRT3; NbExp=3; IntAct=EBI-948001, EBI-2430095;
CC Q15323; P19013: KRT4; NbExp=3; IntAct=EBI-948001, EBI-2371606;
CC Q15323; P13647: KRT5; NbExp=6; IntAct=EBI-948001, EBI-702187;
CC Q15323; P02538: KRT6A; NbExp=12; IntAct=EBI-948001, EBI-702198;
CC Q15323; P04259: KRT6B; NbExp=6; IntAct=EBI-948001, EBI-740907;
CC Q15323; P48668: KRT6C; NbExp=6; IntAct=EBI-948001, EBI-2564105;
CC Q15323; Q3SY84: KRT71; NbExp=6; IntAct=EBI-948001, EBI-2952676;
CC Q15323; Q14CN4: KRT72; NbExp=3; IntAct=EBI-948001, EBI-1221280;
CC Q15323; Q86Y46-2: KRT73; NbExp=3; IntAct=EBI-948001, EBI-12039441;
CC Q15323; Q7RTS7: KRT74; NbExp=3; IntAct=EBI-948001, EBI-968660;
CC Q15323; O95678: KRT75; NbExp=3; IntAct=EBI-948001, EBI-2949715;
CC Q15323; Q01546: KRT76; NbExp=5; IntAct=EBI-948001, EBI-2952745;
CC Q15323; Q0IIN1: KRT77; NbExp=3; IntAct=EBI-948001, EBI-2511085;
CC Q15323; Q7Z794: KRT77; NbExp=3; IntAct=EBI-948001, EBI-3045529;
CC Q15323; Q8N1N4: KRT78; NbExp=3; IntAct=EBI-948001, EBI-1056564;
CC Q15323; Q5XKE5: KRT79; NbExp=6; IntAct=EBI-948001, EBI-2514135;
CC Q15323; P05787: KRT8; NbExp=6; IntAct=EBI-948001, EBI-297852;
CC Q15323; Q6KB66-2: KRT80; NbExp=3; IntAct=EBI-948001, EBI-11999246;
CC Q15323; Q14533: KRT81; NbExp=8; IntAct=EBI-948001, EBI-739648;
CC Q15323; Q9NSB4: KRT82; NbExp=3; IntAct=EBI-948001, EBI-1045341;
CC Q15323; P78385: KRT83; NbExp=6; IntAct=EBI-948001, EBI-10221390;
CC Q15323; P78386: KRT85; NbExp=3; IntAct=EBI-948001, EBI-1049371;
CC Q15323; O43790: KRT86; NbExp=3; IntAct=EBI-948001, EBI-9996498;
CC Q15323; Q9BQ66: KRTAP4-12; NbExp=3; IntAct=EBI-948001, EBI-739863;
CC Q15323; Q6L8G9: KRTAP5-6; NbExp=3; IntAct=EBI-948001, EBI-10250562;
CC Q15323; Q9BYQ4: KRTAP9-2; NbExp=3; IntAct=EBI-948001, EBI-1044640;
CC Q15323; Q9BYQ3: KRTAP9-3; NbExp=3; IntAct=EBI-948001, EBI-1043191;
CC Q15323; Q6PJG3: LATS1; NbExp=3; IntAct=EBI-948001, EBI-10253976;
CC Q15323; Q5T7P3: LCE1B; NbExp=3; IntAct=EBI-948001, EBI-10245913;
CC Q15323; Q5T5A8: LCE3C; NbExp=3; IntAct=EBI-948001, EBI-10245291;
CC Q15323; Q9BYE3: LCE3D; NbExp=3; IntAct=EBI-948001, EBI-6658837;
CC Q15323; Q5T5B0: LCE3E; NbExp=3; IntAct=EBI-948001, EBI-10245456;
CC Q15323; Q5TA78: LCE4A; NbExp=3; IntAct=EBI-948001, EBI-10246358;
CC Q15323; Q96BZ8: LENG1; NbExp=6; IntAct=EBI-948001, EBI-726510;
CC Q15323; P15018: LIF; NbExp=3; IntAct=EBI-948001, EBI-1037189;
CC Q15323; Q96GY3: LIN37; NbExp=3; IntAct=EBI-948001, EBI-748884;
CC Q15323; Q96FQ7: LINC00526; NbExp=3; IntAct=EBI-948001, EBI-10286106;
CC Q15323; Q9BU23: LMF2; NbExp=3; IntAct=EBI-948001, EBI-10298556;
CC Q15323; Q8IXW0: LMNTD2; NbExp=3; IntAct=EBI-948001, EBI-12028858;
CC Q15323; Q8TAP4-4: LMO3; NbExp=3; IntAct=EBI-948001, EBI-11742507;
CC Q15323; P61968: LMO4; NbExp=6; IntAct=EBI-948001, EBI-2798728;
CC Q15323; Q17RB8: LONRF1; NbExp=6; IntAct=EBI-948001, EBI-2341787;
CC Q15323; Q15345: LRRC41; NbExp=3; IntAct=EBI-948001, EBI-721408;
CC Q15323; Q9Y586: MAB21L2; NbExp=3; IntAct=EBI-948001, EBI-6659161;
CC Q15323; P57077-4: MAP3K7CL; NbExp=3; IntAct=EBI-948001, EBI-10215880;
CC Q15323; O60336: MAPKBP1; NbExp=6; IntAct=EBI-948001, EBI-947402;
CC Q15323; Q6IPE9: MARK4; NbExp=3; IntAct=EBI-948001, EBI-10250211;
CC Q15323; Q96L34: MARK4; NbExp=3; IntAct=EBI-948001, EBI-302319;
CC Q15323; Q4ZG74: MGC13033; NbExp=3; IntAct=EBI-948001, EBI-10241963;
CC Q15323; Q8IVT4: MGC50722; NbExp=3; IntAct=EBI-948001, EBI-14086479;
CC Q15323; Q9UJV3-2: MID2; NbExp=3; IntAct=EBI-948001, EBI-10172526;
CC Q15323; P00540: MOS; NbExp=3; IntAct=EBI-948001, EBI-1757866;
CC Q15323; Q9NQ50: MRPL40; NbExp=3; IntAct=EBI-948001, EBI-1053902;
CC Q15323; Q8IXL7-2: MSRB3; NbExp=3; IntAct=EBI-948001, EBI-10699187;
CC Q15323; Q13330: MTA1; NbExp=3; IntAct=EBI-948001, EBI-714236;
CC Q15323; Q9BW11: MXD3; NbExp=3; IntAct=EBI-948001, EBI-741574;
CC Q15323; P50539-3: MXI1; NbExp=3; IntAct=EBI-948001, EBI-10211940;
CC Q15323; P52179-2: MYOM1; NbExp=3; IntAct=EBI-948001, EBI-12010196;
CC Q15323; Q8NEY1-3: NAV1; NbExp=3; IntAct=EBI-948001, EBI-11953718;
CC Q15323; Q8NEY1-4: NAV1; NbExp=3; IntAct=EBI-948001, EBI-10270828;
CC Q15323; Q8IW45: NAXD; NbExp=3; IntAct=EBI-948001, EBI-8650724;
CC Q15323; Q9HC98: NEK6; NbExp=3; IntAct=EBI-948001, EBI-740364;
CC Q15323; Q9HC98-4: NEK6; NbExp=3; IntAct=EBI-948001, EBI-11750983;
CC Q15323; Q96S42: NODAL; NbExp=3; IntAct=EBI-948001, EBI-12386190;
CC Q15323; P48146: NPBWR2; NbExp=6; IntAct=EBI-948001, EBI-10210114;
CC Q15323; Q96HA8: NTAQ1; NbExp=3; IntAct=EBI-948001, EBI-741158;
CC Q15323; Q9BRJ7: NUDT16L1; NbExp=3; IntAct=EBI-948001, EBI-2949792;
CC Q15323; Q7Z417: NUFIP2; NbExp=3; IntAct=EBI-948001, EBI-1210753;
CC Q15323; Q9BWI9: OTUB2; NbExp=3; IntAct=EBI-948001, EBI-10300896;
CC Q15323; P32242: OTX1; NbExp=3; IntAct=EBI-948001, EBI-740446;
CC Q15323; Q99572: P2RX7; NbExp=6; IntAct=EBI-948001, EBI-1753251;
CC Q15323; Q8IVL6-2: P3H3; NbExp=3; IntAct=EBI-948001, EBI-12149899;
CC Q15323; Q96AL5: PBX3; NbExp=3; IntAct=EBI-948001, EBI-741171;
CC Q15323; P09619: PDGFRB; NbExp=3; IntAct=EBI-948001, EBI-641237;
CC Q15323; Q9HCN3: PGAP6; NbExp=3; IntAct=EBI-948001, EBI-10310808;
CC Q15323; B7ZLY0: PHC2; NbExp=3; IntAct=EBI-948001, EBI-14568740;
CC Q15323; A2BDE7: PHLDA1; NbExp=3; IntAct=EBI-948001, EBI-14084211;
CC Q15323; Q13526: PIN1; NbExp=6; IntAct=EBI-948001, EBI-714158;
CC Q15323; Q16512: PKN1; NbExp=6; IntAct=EBI-948001, EBI-602382;
CC Q15323; Q6P5Z2: PKN3; NbExp=3; IntAct=EBI-948001, EBI-1384335;
CC Q15323; Q99959-2: PKP2; NbExp=3; IntAct=EBI-948001, EBI-10987518;
CC Q15323; Q494U1-3: PLEKHN1; NbExp=3; IntAct=EBI-948001, EBI-12014286;
CC Q15323; Q8WUT1: POLDIP3; NbExp=3; IntAct=EBI-948001, EBI-10276663;
CC Q15323; Q12837: POU4F2; NbExp=3; IntAct=EBI-948001, EBI-17236143;
CC Q15323; Q15319: POU4F3; NbExp=3; IntAct=EBI-948001, EBI-12033574;
CC Q15323; Q6NYC8: PPP1R18; NbExp=6; IntAct=EBI-948001, EBI-2557469;
CC Q15323; Q7Z5V6-2: PPP1R32; NbExp=3; IntAct=EBI-948001, EBI-12000762;
CC Q15323; P14222: PRF1; NbExp=6; IntAct=EBI-948001, EBI-724466;
CC Q15323; P54646: PRKAA2; NbExp=3; IntAct=EBI-948001, EBI-1383852;
CC Q15323; O43741: PRKAB2; NbExp=3; IntAct=EBI-948001, EBI-1053424;
CC Q15323; Q99633: PRPF18; NbExp=3; IntAct=EBI-948001, EBI-2798416;
CC Q15323; Q8WWY3: PRPF31; NbExp=3; IntAct=EBI-948001, EBI-1567797;
CC Q15323; P41219: PRPH; NbExp=3; IntAct=EBI-948001, EBI-752074;
CC Q15323; A6NJB7: PRR19; NbExp=3; IntAct=EBI-948001, EBI-10174045;
CC Q15323; A6NJB7-2: PRR19; NbExp=3; IntAct=EBI-948001, EBI-11998870;
CC Q15323; P0CG20: PRR35; NbExp=3; IntAct=EBI-948001, EBI-11986293;
CC Q15323; P25786: PSMA1; NbExp=3; IntAct=EBI-948001, EBI-359352;
CC Q15323; P20618: PSMB1; NbExp=3; IntAct=EBI-948001, EBI-372273;
CC Q15323; P62195: PSMC5; NbExp=3; IntAct=EBI-948001, EBI-357745;
CC Q15323; Q969U7: PSMG2; NbExp=6; IntAct=EBI-948001, EBI-723276;
CC Q15323; Q8WXF1: PSPC1; NbExp=3; IntAct=EBI-948001, EBI-1392258;
CC Q15323; P43115-12: PTGER3; NbExp=3; IntAct=EBI-948001, EBI-10234038;
CC Q15323; Q8WUK0: PTPMT1; NbExp=6; IntAct=EBI-948001, EBI-7199479;
CC Q15323; Q9Y2K5: R3HDM2; NbExp=3; IntAct=EBI-948001, EBI-948428;
CC Q15323; Q14088: RAB33A; NbExp=3; IntAct=EBI-948001, EBI-744685;
CC Q15323; Q96JH8: RADIL; NbExp=6; IntAct=EBI-948001, EBI-744267;
CC Q15323; Q9BTL3: RAMAC; NbExp=6; IntAct=EBI-948001, EBI-744023;
CC Q15323; Q9P2K3: RCOR3; NbExp=3; IntAct=EBI-948001, EBI-743428;
CC Q15323; Q9P2K3-2: RCOR3; NbExp=3; IntAct=EBI-948001, EBI-1504830;
CC Q15323; Q8TCX5: RHPN1; NbExp=3; IntAct=EBI-948001, EBI-746325;
CC Q15323; Q8N443: RIBC1; NbExp=6; IntAct=EBI-948001, EBI-10265323;
CC Q15323; Q86WX3: RPS19BP1; NbExp=3; IntAct=EBI-948001, EBI-4479407;
CC Q15323; Q6P087: RPUSD3; NbExp=3; IntAct=EBI-948001, EBI-5458784;
CC Q15323; Q9UHP6: RSPH14; NbExp=6; IntAct=EBI-948001, EBI-748350;
CC Q15323; Q14D33: RTP5; NbExp=3; IntAct=EBI-948001, EBI-10217913;
CC Q15323; Q96NU1: SAMD11; NbExp=3; IntAct=EBI-948001, EBI-14067109;
CC Q15323; Q9BWG6: SCNM1; NbExp=6; IntAct=EBI-948001, EBI-748391;
CC Q15323; Q9UDX3: SEC14L4; NbExp=3; IntAct=EBI-948001, EBI-10320311;
CC Q15323; Q9C0C4: SEMA4C; NbExp=6; IntAct=EBI-948001, EBI-10303490;
CC Q15323; Q6NXQ0: SFRS2; NbExp=3; IntAct=EBI-948001, EBI-10251550;
CC Q15323; Q92529: SHC3; NbExp=6; IntAct=EBI-948001, EBI-79084;
CC Q15323; Q9NUL5-4: SHFL; NbExp=3; IntAct=EBI-948001, EBI-11955083;
CC Q15323; Q6ZSJ9: SHISA6; NbExp=3; IntAct=EBI-948001, EBI-12037847;
CC Q15323; Q05CH4: SLC15A3; NbExp=3; IntAct=EBI-948001, EBI-10223741;
CC Q15323; Q9UHI7: SLC23A1; NbExp=3; IntAct=EBI-948001, EBI-1759386;
CC Q15323; Q9UHI7-3: SLC23A1; NbExp=3; IntAct=EBI-948001, EBI-11998660;
CC Q15323; Q86VD7: SLC25A42; NbExp=3; IntAct=EBI-948001, EBI-6598313;
CC Q15323; P12236: SLC25A6; NbExp=3; IntAct=EBI-948001, EBI-356254;
CC Q15323; Q96GM5: SMARCD1; NbExp=3; IntAct=EBI-948001, EBI-358489;
CC Q15323; Q969G3: SMARCE1; NbExp=6; IntAct=EBI-948001, EBI-455078;
CC Q15323; P49901: SMCP; NbExp=6; IntAct=EBI-948001, EBI-750494;
CC Q15323; Q9H0W8: SMG9; NbExp=6; IntAct=EBI-948001, EBI-2872322;
CC Q15323; O95863: SNAI1; NbExp=4; IntAct=EBI-948001, EBI-1045459;
CC Q15323; Q9BV90: SNRNP25; NbExp=3; IntAct=EBI-948001, EBI-9675976;
CC Q15323; Q86W54: SPATA24; NbExp=3; IntAct=EBI-948001, EBI-3916986;
CC Q15323; Q9NZD8: SPG21; NbExp=3; IntAct=EBI-948001, EBI-742688;
CC Q15323; Q9BUD6: SPON2; NbExp=6; IntAct=EBI-948001, EBI-10298801;
CC Q15323; Q9H741: SPRING1; NbExp=3; IntAct=EBI-948001, EBI-2836158;
CC Q15323; O43609: SPRY1; NbExp=3; IntAct=EBI-948001, EBI-3866665;
CC Q15323; Q9Y2D8: SSX2IP; NbExp=3; IntAct=EBI-948001, EBI-2212028;
CC Q15323; O75716: STK16; NbExp=3; IntAct=EBI-948001, EBI-749295;
CC Q15323; Q9BSH4: TACO1; NbExp=3; IntAct=EBI-948001, EBI-747797;
CC Q15323; Q9BX59: TAPBPL; NbExp=3; IntAct=EBI-948001, EBI-12017416;
CC Q15323; Q8N8B7-2: TCEANC; NbExp=3; IntAct=EBI-948001, EBI-11955057;
CC Q15323; Q15561: TEAD4; NbExp=3; IntAct=EBI-948001, EBI-747736;
CC Q15323; Q96N21: TEPSIN; NbExp=3; IntAct=EBI-948001, EBI-11139477;
CC Q15323; O15482: TEX28P2; NbExp=3; IntAct=EBI-948001, EBI-751954;
CC Q15323; O43247-2: TEX33; NbExp=3; IntAct=EBI-948001, EBI-12093053;
CC Q15323; Q7Z6R9: TFAP2D; NbExp=3; IntAct=EBI-948001, EBI-11952651;
CC Q15323; Q9BT49: THAP7; NbExp=6; IntAct=EBI-948001, EBI-741350;
CC Q15323; Q08117: TLE5; NbExp=3; IntAct=EBI-948001, EBI-717810;
CC Q15323; Q9BVX2: TMEM106C; NbExp=6; IntAct=EBI-948001, EBI-2821497;
CC Q15323; Q8WUU8: TMEM174; NbExp=3; IntAct=EBI-948001, EBI-10276729;
CC Q15323; Q9H6L2: TMEM231; NbExp=3; IntAct=EBI-948001, EBI-10307654;
CC Q15323; P62328: TMSB4X; NbExp=3; IntAct=EBI-948001, EBI-712598;
CC Q15323; Q0P5Q0: TMSB4X; NbExp=3; IntAct=EBI-948001, EBI-10226570;
CC Q15323; Q9BUZ4: TRAF4; NbExp=6; IntAct=EBI-948001, EBI-3650647;
CC Q15323; Q8N7C3: TRIML2; NbExp=3; IntAct=EBI-948001, EBI-11059915;
CC Q15323; Q12815: TROAP; NbExp=3; IntAct=EBI-948001, EBI-2349743;
CC Q15323; Q7Z6J9: TSEN54; NbExp=3; IntAct=EBI-948001, EBI-2559824;
CC Q15323; Q99816: TSG101; NbExp=6; IntAct=EBI-948001, EBI-346882;
CC Q15323; Q63HK5: TSHZ3; NbExp=3; IntAct=EBI-948001, EBI-9053916;
CC Q15323; Q99598: TSNAX; NbExp=3; IntAct=EBI-948001, EBI-742638;
CC Q15323; Q5W5X9: TTC23; NbExp=3; IntAct=EBI-948001, EBI-6447954;
CC Q15323; Q5W5X9-3: TTC23; NbExp=3; IntAct=EBI-948001, EBI-9090990;
CC Q15323; Q8N5M4: TTC9C; NbExp=3; IntAct=EBI-948001, EBI-2851213;
CC Q15323; P40222: TXLNA; NbExp=6; IntAct=EBI-948001, EBI-359793;
CC Q15323; P29597: TYK2; NbExp=3; IntAct=EBI-948001, EBI-1383454;
CC Q15323; Q9BZF9: UACA; NbExp=3; IntAct=EBI-948001, EBI-350510;
CC Q15323; P57075-2: UBASH3A; NbExp=3; IntAct=EBI-948001, EBI-7353612;
CC Q15323; Q8N6Y0: USHBP1; NbExp=3; IntAct=EBI-948001, EBI-739895;
CC Q15323; O75604: USP2; NbExp=3; IntAct=EBI-948001, EBI-743272;
CC Q15323; Q9BRU9: UTP23; NbExp=3; IntAct=EBI-948001, EBI-5457544;
CC Q15323; Q9UBK9: UXT; NbExp=6; IntAct=EBI-948001, EBI-357355;
CC Q15323; Q6EMK4: VASN; NbExp=3; IntAct=EBI-948001, EBI-10249550;
CC Q15323; Q9Y2B5: VPS9D1; NbExp=3; IntAct=EBI-948001, EBI-9031083;
CC Q15323; Q64LD2: WDR25; NbExp=3; IntAct=EBI-948001, EBI-744560;
CC Q15323; Q64LD2-2: WDR25; NbExp=3; IntAct=EBI-948001, EBI-12032042;
CC Q15323; Q9BQY6-2: WFDC6; NbExp=3; IntAct=EBI-948001, EBI-12176563;
CC Q15323; Q8WTX9: ZDHHC1; NbExp=3; IntAct=EBI-948001, EBI-2818796;
CC Q15323; Q15911-2: ZFHX3; NbExp=3; IntAct=EBI-948001, EBI-10237226;
CC Q15323; Q9BQ24: ZFYVE21; NbExp=3; IntAct=EBI-948001, EBI-2849569;
CC Q15323; Q8N5A5-2: ZGPAT; NbExp=3; IntAct=EBI-948001, EBI-10183064;
CC Q15323; Q15915: ZIC1; NbExp=3; IntAct=EBI-948001, EBI-11963196;
CC Q15323; Q15973: ZNF124; NbExp=3; IntAct=EBI-948001, EBI-2555767;
CC Q15323; Q9UQR1: ZNF148; NbExp=3; IntAct=EBI-948001, EBI-2688184;
CC Q15323; P17024: ZNF20; NbExp=3; IntAct=EBI-948001, EBI-717634;
CC Q15323; P15622-3: ZNF250; NbExp=3; IntAct=EBI-948001, EBI-10177272;
CC Q15323; Q96IQ9: ZNF414; NbExp=3; IntAct=EBI-948001, EBI-744257;
CC Q15323; Q8TAU3: ZNF417; NbExp=3; IntAct=EBI-948001, EBI-740727;
CC Q15323; Q9NWS9-2: ZNF446; NbExp=3; IntAct=EBI-948001, EBI-740232;
CC Q15323; Q8TBZ8: ZNF564; NbExp=3; IntAct=EBI-948001, EBI-10273713;
CC Q15323; Q5MCW4: ZNF569; NbExp=6; IntAct=EBI-948001, EBI-4395687;
CC Q15323; Q7Z3I7: ZNF572; NbExp=3; IntAct=EBI-948001, EBI-10172590;
CC Q15323; Q96SQ5: ZNF587; NbExp=3; IntAct=EBI-948001, EBI-6427977;
CC Q15323; A0A0S2Z5X4: ZNF688; NbExp=3; IntAct=EBI-948001, EBI-16429014;
CC Q15323; A0A0S2Z6P0: ZNF688; NbExp=3; IntAct=EBI-948001, EBI-16429989;
CC Q15323; Q9UC07: ZNF69; NbExp=3; IntAct=EBI-948001, EBI-10320266;
CC Q15323; Q9UC07-2: ZNF69; NbExp=3; IntAct=EBI-948001, EBI-12310821;
CC Q15323; Q9Y2P0: ZNF835; NbExp=3; IntAct=EBI-948001, EBI-5667516;
CC Q15323; Q53FW8; NbExp=3; IntAct=EBI-948001, EBI-10242473;
CC Q15323; Q8N9J2; NbExp=3; IntAct=EBI-948001, EBI-10268244;
CC Q15323; PRO_0000449633 [P0DTD1]: rep; Xeno; NbExp=3; IntAct=EBI-948001, EBI-25492395;
CC -!- TISSUE SPECIFICITY: Present in scalp but not in hairless skin.
CC Abundantly expressed in the differentiating cortex of growing (anagen)
CC hair. Expression is restricted to the keratinocytes of the hair cortex
CC and is absent from inner root sheath and medulla.
CC {ECO:0000269|PubMed:9457912, ECO:0000269|PubMed:9756910}.
CC -!- MISCELLANEOUS: There are two types of hair/microfibrillar keratin, I
CC (acidic) and II (neutral to basic).
CC -!- SIMILARITY: Belongs to the intermediate filament family.
CC {ECO:0000255|PROSITE-ProRule:PRU01188}.
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DR EMBL; X86570; CAA60378.1; -; mRNA.
DR EMBL; Y16787; CAA76383.1; -; Genomic_DNA.
DR EMBL; CH471152; EAW60730.1; -; Genomic_DNA.
DR EMBL; BC114468; AAI14469.1; -; mRNA.
DR CCDS; CCDS11391.1; -.
DR PIR; S60034; S60034.
DR RefSeq; NP_002268.2; NM_002277.2.
DR AlphaFoldDB; Q15323; -.
DR SMR; Q15323; -.
DR BioGRID; 110079; 461.
DR IntAct; Q15323; 366.
DR STRING; 9606.ENSP00000251645; -.
DR GlyGen; Q15323; 1 site, 1 O-linked glycan (1 site).
DR iPTMnet; Q15323; -.
DR PhosphoSitePlus; Q15323; -.
DR SwissPalm; Q15323; -.
DR BioMuta; KRT31; -.
DR DMDM; 209572740; -.
DR jPOST; Q15323; -.
DR MassIVE; Q15323; -.
DR PaxDb; Q15323; -.
DR PeptideAtlas; Q15323; -.
DR PRIDE; Q15323; -.
DR ProteomicsDB; 60528; -.
DR Antibodypedia; 55450; 196 antibodies from 23 providers.
DR DNASU; 3881; -.
DR Ensembl; ENST00000251645.3; ENSP00000251645.2; ENSG00000094796.5.
DR Ensembl; ENST00000573281.1; ENSP00000460739.1; ENSG00000262993.1.
DR GeneID; 3881; -.
DR KEGG; hsa:3881; -.
DR MANE-Select; ENST00000251645.3; ENSP00000251645.2; NM_002277.3; NP_002268.2.
DR UCSC; uc002hwn.4; human.
DR CTD; 3881; -.
DR DisGeNET; 3881; -.
DR GeneCards; KRT31; -.
DR HGNC; HGNC:6448; KRT31.
DR HPA; ENSG00000094796; Tissue enriched (skin).
DR MIM; 601077; gene.
DR neXtProt; NX_Q15323; -.
DR OpenTargets; ENSG00000094796; -.
DR PharmGKB; PA30237; -.
DR VEuPathDB; HostDB:ENSG00000094796; -.
DR eggNOG; ENOG502SNBF; Eukaryota.
DR GeneTree; ENSGT00940000163841; -.
DR HOGENOM; CLU_012560_8_0_1; -.
DR InParanoid; Q15323; -.
DR OMA; CGKTITP; -.
DR OrthoDB; 772040at2759; -.
DR PhylomeDB; Q15323; -.
DR TreeFam; TF332742; -.
DR PathwayCommons; Q15323; -.
DR Reactome; R-HSA-6805567; Keratinization.
DR Reactome; R-HSA-6809371; Formation of the cornified envelope.
DR SignaLink; Q15323; -.
DR BioGRID-ORCS; 3881; 22 hits in 1065 CRISPR screens.
DR GeneWiki; KRT31; -.
DR GenomeRNAi; 3881; -.
DR Pharos; Q15323; Tbio.
DR PRO; PR:Q15323; -.
DR Proteomes; UP000005640; Chromosome 17.
DR RNAct; Q15323; protein.
DR Bgee; ENSG00000094796; Expressed in cerebellum and 76 other tissues.
DR Genevisible; Q15323; HS.
DR GO; GO:0005856; C:cytoskeleton; IBA:GO_Central.
DR GO; GO:0005829; C:cytosol; TAS:Reactome.
DR GO; GO:0070062; C:extracellular exosome; HDA:UniProtKB.
DR GO; GO:0005615; C:extracellular space; HDA:UniProtKB.
DR GO; GO:0005882; C:intermediate filament; TAS:ProtInc.
DR GO; GO:0005200; F:structural constituent of cytoskeleton; TAS:ProtInc.
DR GO; GO:0008544; P:epidermis development; TAS:ProtInc.
DR GO; GO:0030855; P:epithelial cell differentiation; IBA:GO_Central.
DR GO; GO:0045109; P:intermediate filament organization; IBA:GO_Central.
DR InterPro; IPR018039; IF_conserved.
DR InterPro; IPR039008; IF_rod_dom.
DR InterPro; IPR002957; Keratin_I.
DR PANTHER; PTHR23239; PTHR23239; 1.
DR Pfam; PF00038; Filament; 1.
DR PRINTS; PR01248; TYPE1KERATIN.
DR SMART; SM01391; Filament; 1.
DR PROSITE; PS00226; IF_ROD_1; 1.
DR PROSITE; PS51842; IF_ROD_2; 1.
PE 1: Evidence at protein level;
KW Coiled coil; Intermediate filament; Keratin; Reference proteome.
FT CHAIN 1..416
FT /note="Keratin, type I cuticular Ha1"
FT /id="PRO_0000063684"
FT DOMAIN 56..367
FT /note="IF rod"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01188"
FT REGION 1..56
FT /note="Head"
FT REGION 57..91
FT /note="Coil 1A"
FT REGION 92..102
FT /note="Linker 1"
FT REGION 103..203
FT /note="Coil 1B"
FT REGION 204..219
FT /note="Linker 12"
FT REGION 220..363
FT /note="Coil 2"
FT REGION 364..416
FT /note="Tail"
FT SITE 305
FT /note="Stutter"
FT VARIANT 39
FT /note="A -> G (in dbSNP:rs6503628)"
FT /id="VAR_046989"
FT VARIANT 82
FT /note="A -> V (in dbSNP:rs6503627)"
FT /id="VAR_046990"
FT VARIANT 377
FT /note="A -> V (in dbSNP:rs34293483)"
FT /id="VAR_046991"
FT CONFLICT 153..154
FT /note="QL -> HV (in Ref. 1; CAA60378)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 416 AA; 47237 MW; C284DD33A4896009 CRC64;
MPYNFCLPSL SCRTSCSSRP CVPPSCHSCT LPGACNIPAN VSNCNWFCEG SFNGSEKETM
QFLNDRLASY LEKVRQLERD NAELENLIRE RSQQQEPLLC PSYQSYFKTI EELQQKILCT
KSENARLVVQ IDNAKLAADD FRTKYQTELS LRQLVESDIN GLRRILDELT LCKSDLEAQV
ESLKEELLCL KSNHEQEVNT LRCQLGDRLN VEVDAAPTVD LNRVLNETRS QYEALVETNR
REVEQWFTTQ TEELNKQVVS SSEQLQSYQA EIIELRRTVN ALEIELQAQH NLRDSLENTL
TESEARYSSQ LSQVQSLITN VESQLAEIRS DLERQNQEYQ VLLDVRARLE CEINTYRSLL
ESEDCNLPSN PCATTNACSK PIGPCLSNPC TSCVPPAPCT PCAPRPRCGP CNSFVR
