K1H1_MOUSE
ID K1H1_MOUSE Reviewed; 416 AA.
AC Q61765; A2A5Y0;
DT 15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT 20-JAN-2009, sequence version 2.
DT 03-AUG-2022, entry version 150.
DE RecName: Full=Keratin, type I cuticular Ha1;
DE AltName: Full=HKA-1;
DE AltName: Full=Hair keratin, type I Ha1;
DE AltName: Full=Keratin-31;
DE Short=K31;
GN Name=Krt31; Synonyms=Hka1, Krt1-1, Krtha1;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=C57BL/6J; TISSUE=Hair root;
RX PubMed=2461417; DOI=10.1111/1523-1747.ep12476901;
RA Bertolino A.P., Checkla D.M., Notterman R., Sklaver I., Schiff T.A.,
RA Freedberg I.M., Didona G.J.;
RT "Cloning and characterization of a mouse type I hair keratin cDNA.";
RL J. Invest. Dermatol. 91:541-546(1988).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [3]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Heart, Kidney, and Liver;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- MISCELLANEOUS: There are two types of hair/microfibrillar keratin, I
CC (acidic) and II (neutral to basic).
CC -!- SIMILARITY: Belongs to the intermediate filament family.
CC {ECO:0000255|PROSITE-ProRule:PRU01188}.
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DR EMBL; M27734; AAA39372.1; -; mRNA.
DR EMBL; AL592545; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR CCDS; CCDS25405.1; -.
DR PIR; A46559; A46559.
DR PIR; A61404; A61404.
DR RefSeq; NP_034789.2; NM_010659.2.
DR AlphaFoldDB; Q61765; -.
DR SMR; Q61765; -.
DR BioGRID; 201016; 5.
DR STRING; 10090.ENSMUSP00000007318; -.
DR iPTMnet; Q61765; -.
DR PhosphoSitePlus; Q61765; -.
DR SwissPalm; Q61765; -.
DR jPOST; Q61765; -.
DR MaxQB; Q61765; -.
DR PaxDb; Q61765; -.
DR PeptideAtlas; Q61765; -.
DR PRIDE; Q61765; -.
DR ProteomicsDB; 268940; -.
DR DNASU; 16660; -.
DR Ensembl; ENSMUST00000007318; ENSMUSP00000007318; ENSMUSG00000048981.
DR GeneID; 16660; -.
DR KEGG; mmu:16660; -.
DR UCSC; uc007lkd.1; mouse.
DR CTD; 3881; -.
DR MGI; MGI:1309993; Krt31.
DR VEuPathDB; HostDB:ENSMUSG00000048981; -.
DR eggNOG; ENOG502SNBF; Eukaryota.
DR GeneTree; ENSGT00940000153980; -.
DR HOGENOM; CLU_012560_8_0_1; -.
DR InParanoid; Q61765; -.
DR OMA; ACNISAN; -.
DR OrthoDB; 772040at2759; -.
DR PhylomeDB; Q61765; -.
DR TreeFam; TF332742; -.
DR Reactome; R-MMU-6805567; Keratinization.
DR Reactome; R-MMU-6809371; Formation of the cornified envelope.
DR BioGRID-ORCS; 16660; 3 hits in 71 CRISPR screens.
DR PRO; PR:Q61765; -.
DR Proteomes; UP000000589; Chromosome 11.
DR RNAct; Q61765; protein.
DR Bgee; ENSMUSG00000048981; Expressed in lip and 23 other tissues.
DR Genevisible; Q61765; MM.
DR GO; GO:0005856; C:cytoskeleton; IBA:GO_Central.
DR GO; GO:0005882; C:intermediate filament; IEA:UniProtKB-KW.
DR GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
DR GO; GO:0030855; P:epithelial cell differentiation; IBA:GO_Central.
DR GO; GO:0045109; P:intermediate filament organization; IBA:GO_Central.
DR InterPro; IPR018039; IF_conserved.
DR InterPro; IPR039008; IF_rod_dom.
DR InterPro; IPR002957; Keratin_I.
DR PANTHER; PTHR23239; PTHR23239; 1.
DR Pfam; PF00038; Filament; 1.
DR PRINTS; PR01248; TYPE1KERATIN.
DR SMART; SM01391; Filament; 1.
DR PROSITE; PS00226; IF_ROD_1; 1.
DR PROSITE; PS51842; IF_ROD_2; 1.
PE 1: Evidence at protein level;
KW Coiled coil; Intermediate filament; Keratin; Reference proteome.
FT CHAIN 1..416
FT /note="Keratin, type I cuticular Ha1"
FT /id="PRO_0000063685"
FT DOMAIN 56..367
FT /note="IF rod"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01188"
FT REGION 2..56
FT /note="Head"
FT REGION 57..91
FT /note="Coil 1A"
FT REGION 92..102
FT /note="Linker 1"
FT REGION 103..203
FT /note="Coil 1B"
FT REGION 204..219
FT /note="Linker 12"
FT REGION 220..363
FT /note="Coil 2"
FT REGION 364..416
FT /note="Tail"
FT SITE 305
FT /note="Stutter"
FT CONFLICT 153..154
FT /note="QL -> HV (in Ref. 1; AAA39372)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 416 AA; 47117 MW; 1ABE55EAA4CA3BCC CRC64;
MPYNCCLPAL SCRTSCSSRP CVPPSCHGCT LPGACNIPAN VGNCNWFCEG SFNGNEKETM
QFLNDRLASY MEKVRQLERE NAELECRIQE RNQQQDPLVC PAYQAYFRTI EELQQKILCS
KSENARLVVQ IDNAKLAADD FRTKYETELG LRQLVESDIN GLRRILDELT LCKSDLEAQV
ESLKEELLCL KRNHEEEVNT LRCQLGDRLN VEVDAAPTVD LNRVLNETRC QYEAMVETNR
REVEEWFTTQ TEELNKQVVS SSEQLQSCQA EIIELRRTVN ALEIELQAQH CMRNSLENTL
TESEARYSSQ LSQVQCLITN VESQLGEIRA DLERQNQEYQ VLLDVKARLE CEINTYRGLL
ESEDCKLPCN PCATSNACGK PIGPCVSNPC VPCPPPAPCT PCVPRPRCGP CNSFVR
