K1H1_PANTR
ID K1H1_PANTR Reviewed; 416 AA.
AC A5A6M5;
DT 24-JUL-2007, integrated into UniProtKB/Swiss-Prot.
DT 12-JUN-2007, sequence version 1.
DT 03-AUG-2022, entry version 79.
DE RecName: Full=Keratin, type I cuticular Ha1;
DE AltName: Full=Hair keratin, type I Ha1;
DE AltName: Full=Keratin-31;
DE Short=K31;
GN Name=KRT31; Synonyms=KRTHA1;
OS Pan troglodytes (Chimpanzee).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pan.
OX NCBI_TaxID=9598;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Skin;
RX PubMed=17574350; DOI=10.1016/j.gene.2007.04.013;
RA Sakate R., Suto Y., Imanishi T., Tanoue T., Hida M., Hayasaka I.,
RA Kusuda J., Gojobori T., Hashimoto K., Hirai M.;
RT "Mapping of chimpanzee full-length cDNAs onto the human genome unveils
RT large potential divergence of the transcriptome.";
RL Gene 399:1-10(2007).
CC -!- MISCELLANEOUS: There are two types of hair/microfibrillar keratin, I
CC (acidic) and II (neutral to basic).
CC -!- SIMILARITY: Belongs to the intermediate filament family.
CC {ECO:0000255|PROSITE-ProRule:PRU01188}.
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DR EMBL; AB222153; BAF62398.1; -; mRNA.
DR RefSeq; NP_001092021.1; NM_001098551.1.
DR AlphaFoldDB; A5A6M5; -.
DR SMR; A5A6M5; -.
DR STRING; 9598.ENSPTRP00000015607; -.
DR PaxDb; A5A6M5; -.
DR PRIDE; A5A6M5; -.
DR Ensembl; ENSPTRT00000016863; ENSPTRP00000015607; ENSPTRG00000009161.
DR GeneID; 454661; -.
DR KEGG; ptr:454661; -.
DR CTD; 3881; -.
DR VGNC; VGNC:50416; KRT31.
DR eggNOG; ENOG502SNBF; Eukaryota.
DR GeneTree; ENSGT00940000163841; -.
DR HOGENOM; CLU_012560_8_0_1; -.
DR InParanoid; A5A6M5; -.
DR OrthoDB; 772040at2759; -.
DR TreeFam; TF332742; -.
DR Proteomes; UP000002277; Chromosome 17.
DR Bgee; ENSPTRG00000009161; Expressed in dorsolateral prefrontal cortex and 5 other tissues.
DR GO; GO:0005856; C:cytoskeleton; IBA:GO_Central.
DR GO; GO:0005882; C:intermediate filament; IEA:UniProtKB-KW.
DR GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
DR GO; GO:0030855; P:epithelial cell differentiation; IBA:GO_Central.
DR GO; GO:0045109; P:intermediate filament organization; IBA:GO_Central.
DR InterPro; IPR018039; IF_conserved.
DR InterPro; IPR039008; IF_rod_dom.
DR InterPro; IPR002957; Keratin_I.
DR PANTHER; PTHR23239; PTHR23239; 1.
DR Pfam; PF00038; Filament; 1.
DR PRINTS; PR01248; TYPE1KERATIN.
DR SMART; SM01391; Filament; 1.
DR PROSITE; PS00226; IF_ROD_1; 1.
DR PROSITE; PS51842; IF_ROD_2; 1.
PE 2: Evidence at transcript level;
KW Coiled coil; Intermediate filament; Keratin; Reference proteome.
FT CHAIN 1..416
FT /note="Keratin, type I cuticular Ha1"
FT /id="PRO_0000296970"
FT DOMAIN 56..367
FT /note="IF rod"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01188"
FT REGION 1..56
FT /note="Head"
FT REGION 57..91
FT /note="Coil 1A"
FT REGION 92..102
FT /note="Linker 1"
FT REGION 103..203
FT /note="Coil 1B"
FT REGION 204..219
FT /note="Linker 12"
FT REGION 220..363
FT /note="Coil 2"
FT REGION 364..416
FT /note="Tail"
FT SITE 305
FT /note="Stutter"
SQ SEQUENCE 416 AA; 47247 MW; C1B4EE33A4896009 CRC64;
MPYNFCLPSL SCRTSCSSRP CVPPSCHSCT LPGACNIPAN VSNCNWFCEG SFNGSEKETM
QFLNDRLASY LEKVRQLERD NAELENLIRE RSQQQEPLLC PSYQSYFKTI EELQQKILCT
KSENARLVVQ IDNAKLAADD FRTKYQTELS LRQLVESDIN GLRRILDELT LCKSDLEAQV
ESLKEELLCL KSNHEQEVNT LRCQLGDRLN VEVDAAPTVD LNRVLNETRS QYEALVETNR
REVEQWFTTQ TEELNKQVVS SSEQLQSYQA EIIELRRTVN ALEIELQAQH NLRDSLENTL
TESEARYSSQ LSQVQSLITN VESQLAEIRS DLERQNQEYQ VLLDVRARLE CEINTYRSLL
ESEDCNLPSN PCATTNACSK PIGPCLSNPC TPCVPPAPCT PCAPRPRCGP CNSFVR
