K1H2_MOUSE
ID K1H2_MOUSE Reviewed; 407 AA.
AC Q62168; Q148N4;
DT 15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT 27-JUL-2011, sequence version 2.
DT 25-MAY-2022, entry version 134.
DE RecName: Full=Keratin, type I cuticular Ha2;
DE AltName: Full=Hair keratin, type I Ha2;
DE AltName: Full=Keratin-32;
DE Short=K32;
GN Name=Krt32; Synonyms=Hka2, Krt1-2, Krtha2;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=NMRI; TISSUE=Hair;
RX PubMed=7514534; DOI=10.1006/excr.1994.1134;
RA Winter H., Siry P., Tobiasch E., Schweizer J.;
RT "Sequence and expression of murine type I hair keratins mHa2 and mHa3.";
RL Exp. Cell Res. 212:190-200(1994).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Liver;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- TISSUE SPECIFICITY: Cuticle of the hair shaft.
CC -!- MISCELLANEOUS: There are two types of hair/microfibrillar keratin, I
CC (acidic) and II (neutral to basic).
CC -!- SIMILARITY: Belongs to the intermediate filament family.
CC {ECO:0000255|PROSITE-ProRule:PRU01188}.
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DR EMBL; X75649; CAA53304.1; -; mRNA.
DR EMBL; CH466662; EDL02584.1; -; Genomic_DNA.
DR EMBL; BC117553; AAI17554.1; -; mRNA.
DR EMBL; BC118064; AAI18065.1; -; mRNA.
DR PIR; I48739; I48739.
DR RefSeq; NP_001152846.2; NM_001159374.2.
DR AlphaFoldDB; Q62168; -.
DR SMR; Q62168; -.
DR BioGRID; 201025; 2.
DR STRING; 10090.ENSMUSP00000103042; -.
DR iPTMnet; Q62168; -.
DR PhosphoSitePlus; Q62168; -.
DR jPOST; Q62168; -.
DR MaxQB; Q62168; -.
DR PaxDb; Q62168; -.
DR PRIDE; Q62168; -.
DR ProteomicsDB; 269443; -.
DR DNASU; 16670; -.
DR GeneID; 16670; -.
DR KEGG; mmu:16670; -.
DR CTD; 3882; -.
DR MGI; MGI:1309995; Krt32.
DR eggNOG; ENOG502SJJS; Eukaryota.
DR InParanoid; Q62168; -.
DR OrthoDB; 798081at2759; -.
DR Reactome; R-MMU-6805567; Keratinization.
DR Reactome; R-MMU-6809371; Formation of the cornified envelope.
DR BioGRID-ORCS; 16670; 2 hits in 68 CRISPR screens.
DR ChiTaRS; Krt32; mouse.
DR PRO; PR:Q62168; -.
DR Proteomes; UP000000589; Unplaced.
DR RNAct; Q62168; protein.
DR GO; GO:0005856; C:cytoskeleton; IBA:GO_Central.
DR GO; GO:0005882; C:intermediate filament; IEA:UniProtKB-KW.
DR GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
DR GO; GO:0030855; P:epithelial cell differentiation; IBA:GO_Central.
DR GO; GO:0045109; P:intermediate filament organization; IBA:GO_Central.
DR InterPro; IPR018039; IF_conserved.
DR InterPro; IPR039008; IF_rod_dom.
DR InterPro; IPR002957; Keratin_I.
DR PANTHER; PTHR23239; PTHR23239; 1.
DR Pfam; PF00038; Filament; 1.
DR PRINTS; PR01248; TYPE1KERATIN.
DR SMART; SM01391; Filament; 1.
DR PROSITE; PS00226; IF_ROD_1; 1.
DR PROSITE; PS51842; IF_ROD_2; 1.
PE 1: Evidence at protein level;
KW Coiled coil; Intermediate filament; Keratin; Reference proteome.
FT CHAIN 1..407
FT /note="Keratin, type I cuticular Ha2"
FT /id="PRO_0000063687"
FT DOMAIN 55..366
FT /note="IF rod"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01188"
FT REGION 1..55
FT /note="Head"
FT REGION 56..90
FT /note="Coil 1A"
FT REGION 91..101
FT /note="Linker 1"
FT REGION 102..202
FT /note="Coil 1B"
FT REGION 203..218
FT /note="Linker 12"
FT REGION 219..362
FT /note="Coil 2"
FT REGION 363..407
FT /note="Tail"
FT SITE 304
FT /note="Stutter"
FT CONFLICT 227
FT /note="M -> V (in Ref. 1; CAA53304)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 407 AA; 46422 MW; 32D4D9FC1F1D642B CRC64;
MPSVCMPTTY RPASCLSKTY LSSSCQPSNR RPTGCISSSM GTYGLFCEGA FNGNEKETMQ
VLNDRLANYL EKVRQLEKEN AELEGKIQDV YQGQVLTMCP DYQSYFQTIE ELQQKVLCTK
AENARMIVHI DNAKLAADDF RTKYETELAL RQLVEADTNG LRRILDELTL NKADLEAQVE
SLKEELLCLK RNHEEEVGVL RQQLGDRLNI EVDAAPPVDL TRMLEEMRCQ YETMVETNHR
DVEEWFNMQM EELNKQVATS SEQLQSYQSD IIDLRRTVNT LEIELQAQHS LRDSLENTLG
ETEGRFTSQL SQMQCMITNV ESQLSDIRCD LERQNQEYKV LLDVKARLEC EIDTYRGLLE
SEDSKLPCNP CSTPSCQPCA PSPGVSRTVC VPHTVCVPCS PCLQTRY
