ID   K1M2_SHEEP              Reviewed;         404 AA.
AC   P25690;
DT   01-MAY-1992, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2007, sequence version 2.
DT   25-MAY-2022, entry version 83.
DE   RecName: Full=Keratin, type I microfibrillar, 47.6 kDa;
DE   AltName: Full=Low-sulfur keratin;
OS   Ovis aries (Sheep).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Caprinae; Ovis.
OX   NCBI_TaxID=9940;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   TISSUE=Wool follicle;
RX   PubMed=2468578; DOI=10.1016/0378-1119(88)90309-5;
RA   Wilson B.W., Edwards K.J., Sleigh M.J., Byrne C.R., Ward K.A.;
RT   "Complete sequence of a type-I microfibrillar wool keratin gene.";
RL   Gene 73:21-31(1988).
CC   -!- FUNCTION: Wool microfibrillar keratin.
CC   -!- MISCELLANEOUS: There are two types of cytoskeletal and microfibrillar
CC       keratin: I (acidic; 40-55 kDa) and II (neutral to basic; 56-70 kDa).
CC   -!- MISCELLANEOUS: The low-sulfur proteins, derived from the microfibrillar
CC       fraction of wool extracts, are composed of two families, each
CC       consisting of 4 homologous subunits: the type I components (8C-1, 8C-2,
CC       8A and 8B) and the type II components (5, 7A, 7B, and 7C).
CC   -!- SIMILARITY: Belongs to the intermediate filament family.
CC       {ECO:0000255|PROSITE-ProRule:PRU01188}.
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DR   EMBL; M23912; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   PIR; JS0073; JS0073.
DR   AlphaFoldDB; P25690; -.
DR   SMR; P25690; -.
DR   STRING; 9940.ENSOARP00000017221; -.
DR   PRIDE; P25690; -.
DR   eggNOG; ENOG502SNBF; Eukaryota.
DR   Proteomes; UP000002356; Unplaced.
DR   GO; GO:0005882; C:intermediate filament; IEA:UniProtKB-KW.
DR   GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
DR   InterPro; IPR018039; IF_conserved.
DR   InterPro; IPR039008; IF_rod_dom.
DR   InterPro; IPR002957; Keratin_I.
DR   PANTHER; PTHR23239; PTHR23239; 1.
DR   Pfam; PF00038; Filament; 1.
DR   PRINTS; PR01248; TYPE1KERATIN.
DR   SMART; SM01391; Filament; 1.
DR   PROSITE; PS00226; IF_ROD_1; 1.
DR   PROSITE; PS51842; IF_ROD_2; 1.
PE   3: Inferred from homology;
KW   Coiled coil; Intermediate filament; Keratin; Reference proteome.
FT   CHAIN           1..404
FT                   /note="Keratin, type I microfibrillar, 47.6 kDa"
FT                   /id="PRO_0000063707"
FT   DOMAIN          56..367
FT                   /note="IF rod"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01188"
FT   REGION          1..56
FT                   /note="Head"
FT   REGION          57..91
FT                   /note="Coil 1A"
FT   REGION          92..102
FT                   /note="Linker 1"
FT   REGION          103..203
FT                   /note="Coil 1B"
FT   REGION          204..219
FT                   /note="Linker 12"
FT   REGION          220..363
FT                   /note="Coil 2"
FT   REGION          364..404
FT                   /note="Tail"
FT   SITE            305
FT                   /note="Stutter"
SQ   SEQUENCE   404 AA;  46063 MW;  5AF05C603E05E8F8 CRC64;
     MSFNFCLPNL SFRSSCSSRP CVPSSCCGTT LPGACNIPAS VGSCNWFCEG SFNGNEKETM
     QFLNDRLASY LEKVRQLERE NAELERRILE RSQQQEPLVC PNYQSYFRTI EELQQKILCG
     KSENARLVVQ IDNAKLASDD FRTKYETEVS LRQLVEADLN GLRRILDELT LCKSDLEARV
     ESLKEELICL KQNHEQEVNT LRSQLGDRLN VEVDAAPTVD LNHVLNETRA QYEALVETNR
     RDVEEWYIRQ TEELNKQVVS SSEQLQSCQA EIIELRRTVN ALEVELQAQH NLRDSLENTL
     TETEARYSCQ LNQVQSLIVS VESQLAEIRS DLERQNQEYQ VLLDVRARLE CEINTYRGLL
     DSEDCKLPCN PCATTNTCGK PIGPCISNPC VSRTRCGPCN TFVH