ID   K1_HHV8P                Reviewed;         279 AA.
AC   Q2HRD5;
DT   16-OCT-2013, integrated into UniProtKB/Swiss-Prot.
DT   15-MAY-2007, sequence version 1.
DT   25-MAY-2022, entry version 55.
DE   RecName: Full=Protein K1;
DE   Flags: Precursor;
GN   Name=K1;
OS   Human herpesvirus 8 type P (isolate GK18) (HHV-8) (Kaposi's
OS   sarcoma-associated herpesvirus).
OC   Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC   Herpesvirales; Herpesviridae; Gammaherpesvirinae; Rhadinovirus.
OX   NCBI_TaxID=868565;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=10400794; DOI=10.1128/jvi.73.8.6953-6963.1999;
RA   Glenn M., Rainbow L., Aurade F., Davison A., Schulz T.F.;
RT   "Identification of a spliced gene from Kaposi's sarcoma-associated
RT   herpesvirus encoding a protein with similarities to latent membrane
RT   proteins 1 and 2A of Epstein-Barr virus.";
RL   J. Virol. 73:6953-6963(1999).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16760382; DOI=10.1099/vir.0.81919-0;
RA   Rezaee S.A.R., Cunningham C., Davison A.J., Blackbourn D.J.;
RT   "Kaposi's sarcoma-associated herpesvirus immune modulation: an overview.";
RL   J. Gen. Virol. 87:1781-1804(2006).
RN   [3]
RP   FUNCTION.
RX   PubMed=9710606; DOI=10.1128/mcb.18.9.5219;
RA   Lee H., Guo J., Li M., Choi J.K., DeMaria M., Rosenzweig M., Jung J.U.;
RT   "Identification of an immunoreceptor tyrosine-based activation motif of K1
RT   transforming protein of Kaposi's sarcoma-associated herpesvirus.";
RL   Mol. Cell. Biol. 18:5219-5228(1998).
RN   [4]
RP   FUNCTION, AND SUBUNIT.
RX   PubMed=10318948; DOI=10.1073/pnas.96.10.5704;
RA   Lagunoff M., Majeti R., Weiss A., Ganem D.;
RT   "Deregulated signal transduction by the K1 gene product of Kaposi's
RT   sarcoma-associated herpesvirus.";
RL   Proc. Natl. Acad. Sci. U.S.A. 96:5704-5709(1999).
RN   [5]
RP   FUNCTION.
RX   PubMed=14747556; DOI=10.1128/jvi.78.4.1918-1927.2004;
RA   Tomlinson C.C., Damania B.;
RT   "The K1 protein of Kaposi's sarcoma-associated herpesvirus activates the
RT   Akt signaling pathway.";
RL   J. Virol. 78:1918-1927(2004).
CC   -!- FUNCTION: Promotes host cell survival pathways and may contribute to
CC       pathogenesis by preventing infected cells from undergoing apoptosis.
CC       Acts in host B-cells by mimicking the activated B-cell receptor
CC       complex. The cytoplasmic tail of K1 can induce the phosphorylation of a
CC       number of different kinases, leading to the activation of survival
CC       signaling pathways. {ECO:0000269|PubMed:10318948,
CC       ECO:0000269|PubMed:14747556, ECO:0000269|PubMed:9710606}.
CC   -!- SUBUNIT: Homooligomer. {ECO:0000269|PubMed:10318948}.
CC   -!- SUBCELLULAR LOCATION: Host membrane {ECO:0000305}; Single-pass type I
CC       membrane protein {ECO:0000305}.
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DR   EMBL; AF148805; ABD28852.1; -; Genomic_DNA.
DR   RefSeq; YP_001129350.1; NC_009333.1.
DR   BioGRID; 1777014; 9.
DR   PRIDE; Q2HRD5; -.
DR   DNASU; 4961511; -.
DR   GeneID; 4961511; -.
DR   KEGG; vg:4961511; -.
DR   Proteomes; UP000000942; Genome.
DR   GO; GO:0033644; C:host cell membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0039526; P:modulation by virus of host apoptotic process; IEA:UniProtKB-KW.
DR   InterPro; IPR021022; HHSV-8_K1_cytoplasmic_dom.
DR   InterPro; IPR004121; K1_C.
DR   Pfam; PF02960; K1; 1.
DR   Pfam; PF11049; KSHV_K1; 1.
PE   1: Evidence at protein level;
KW   Host membrane; Host-virus interaction; Membrane;
KW   Modulation of host cell apoptosis by virus; Reference proteome; Signal;
KW   Transmembrane; Transmembrane helix.
FT   SIGNAL          1..18
FT                   /evidence="ECO:0000255"
FT   CHAIN           19..279
FT                   /note="Protein K1"
FT                   /id="PRO_0000423776"
FT   TOPO_DOM        19..220
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        221..241
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        242..279
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   279 AA;  31162 MW;  2AF4EF505D1F3BD5 CRC64;
     MFLYVVCSLA VCFRGLLSLS LQSSPNLCPG VISTPYTLTC PSNTSLPTSW YCNDTRLLRV
     TQGTLTVDTL ICNFSCVGQS GHRYSLWITW YAQPVLQTFC GQPSNTVTCG QHVTLYCSTS
     GNNVTVWHLP NGQNETVSQT KYYNFTLMNQ TEGCYACSNG LSSRLSNRLC FSARCANITP
     ETHTVSVSST TGFRTFATAP TLFVMKEVKS TYLYIQEHLL VFMTLVALIG TMCGILGTII
     FAHCQKQRDS NKTVPQQLQD YYSLHDLCTE DYTQPVDWY