ID   K1_VACCC                Reviewed;         284 AA.
AC   P20632; P21118;
DT   01-FEB-1991, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1991, sequence version 1.
DT   23-FEB-2022, entry version 85.
DE   RecName: Full=Interferon antagonist K1L;
DE   AltName: Full=32.5 kDa protein;
DE   AltName: Full=Host range protein 1;
GN   Name=HR; ORFNames=K1L;
OS   Vaccinia virus (strain Copenhagen) (VACV).
OC   Viruses; Varidnaviria; Bamfordvirae; Nucleocytoviricota; Pokkesviricetes;
OC   Chitovirales; Poxviridae; Chordopoxvirinae; Orthopoxvirus; Vaccinia virus.
OX   NCBI_TaxID=10249;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=2219722; DOI=10.1016/0042-6822(90)90294-2;
RA   Goebel S.J., Johnson G.P., Perkus M.E., Davis S.W., Winslow J.P.,
RA   Paoletti E.;
RT   "The complete DNA sequence of vaccinia virus.";
RL   Virology 179:247-266(1990).
RN   [2]
RP   FUNCTION.
RX   PubMed=2171207; DOI=10.1016/0042-6822(90)90296-4;
RA   Perkus M.E., Goebel S.J., Davis S.W., Johnson G.P., Limbach K.,
RA   Norton E.K., Paoletti E.;
RT   "Vaccinia virus host range genes.";
RL   Virology 179:276-286(1990).
CC   -!- FUNCTION: Inhibits antiviral activity induced by type I interferons.
CC       Does not block signal transduction of IFN, but is important to counter
CC       the host antiviral state induced by a pre-treatment with IFN (By
CC       similarity). {ECO:0000250, ECO:0000269|PubMed:2171207}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; M35027; AAA48005.1; -; Genomic_DNA.
DR   PIR; I42504; I42504.
DR   SMR; P20632; -.
DR   Proteomes; UP000008269; Genome.
DR   GO; GO:0039503; P:suppression by virus of host innate immune response; IEA:UniProtKB-KW.
DR   Gene3D; 1.25.40.20; -; 1.
DR   InterPro; IPR002110; Ankyrin_rpt.
DR   InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR   Pfam; PF12796; Ank_2; 1.
DR   SMART; SM00248; ANK; 6.
DR   SUPFAM; SSF48403; SSF48403; 1.
DR   PROSITE; PS50297; ANK_REP_REGION; 1.
DR   PROSITE; PS50088; ANK_REPEAT; 2.
PE   3: Inferred from homology;
KW   ANK repeat; Early protein; Host-virus interaction;
KW   Inhibition of host innate immune response by virus; Reference proteome;
KW   Repeat; Viral immunoevasion.
FT   CHAIN           1..284
FT                   /note="Interferon antagonist K1L"
FT                   /id="PRO_0000067080"
FT   REPEAT          29..58
FT                   /note="ANK 1"
FT   REPEAT          60..89
FT                   /note="ANK 2"
FT   REPEAT          93..122
FT                   /note="ANK 3"
FT   REPEAT          127..157
FT                   /note="ANK 4"
FT   REPEAT          159..188
FT                   /note="ANK 5"
FT   REPEAT          193..222
FT                   /note="ANK 6"
SQ   SEQUENCE   284 AA;  32561 MW;  8CCEE3913F9B6277 CRC64;
     MDLSRINTWK SKQLKSFLSS KDTFKADVHG HSALYYAIAD NNVRLVCTLL NAGALKNLLE
     NEFPLHQAAT LEDTKIVKIL LFSGMDDSQF DDKGNTALYY AVDSGNMQTV KLFVKKNWRL
     MFYGKTGWKT SFYHAVMLND VSIVSYFLSE IPSTFDLAIL LSCIHTTIKN GHVDMMILLL
     DYMTSTNTNN SLLFIPDIKL AIDNKDIEML QALFKYDINI YSVNLENVLL DDAEITKMII
     EKHVEYKSDS YTKDLDIVKN NKLDEIISKN KELRLMYVNC VKKN