K2012_HUMAN
ID K2012_HUMAN Reviewed; 1180 AA.
AC Q0VF49; Q8IVF9;
DT 29-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT 26-NOV-2014, sequence version 2.
DT 03-AUG-2022, entry version 99.
DE RecName: Full=Uncharacterized protein KIAA2012 {ECO:0000305};
GN Name=KIAA2012 {ECO:0000312|HGNC:HGNC:51250};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Brain;
RA Nagase T., Kikuno R., Ohara O.;
RT "The nucleotide sequence of a long cDNA clone isolated from human.";
RL Submitted (NOV-2002) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15815621; DOI=10.1038/nature03466;
RA Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P.,
RA Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C.,
RA Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L.,
RA Du H., Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A.,
RA Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J.,
RA Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M.,
RA Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T.,
RA Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S.,
RA Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K.,
RA McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C.,
RA Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S.,
RA Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C.,
RA Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M.,
RA Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C.,
RA Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J.,
RA Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E.,
RA Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X.,
RA Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M.,
RA Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C.,
RA Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S.,
RA Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H.,
RA Wilson R.K.;
RT "Generation and annotation of the DNA sequences of human chromosomes 2 and
RT 4.";
RL Nature 434:724-731(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q0VF49-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q0VF49-2; Sequence=VSP_057140, VSP_057141;
CC -!- SEQUENCE CAUTION:
CC Sequence=BAC23108.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
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DR EMBL; AB095932; BAC23108.1; ALT_INIT; mRNA.
DR EMBL; AC069148; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC079354; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC118982; AAI18983.1; -; mRNA.
DR AlphaFoldDB; Q0VF49; -.
DR SMR; Q0VF49; -.
DR BioGRID; 1530199; 2.
DR STRING; 9606.ENSP00000437957; -.
DR iPTMnet; Q0VF49; -.
DR PhosphoSitePlus; Q0VF49; -.
DR BioMuta; KIAA2012; -.
DR DMDM; 121940491; -.
DR EPD; Q0VF49; -.
DR jPOST; Q0VF49; -.
DR MassIVE; Q0VF49; -.
DR PaxDb; Q0VF49; -.
DR PeptideAtlas; Q0VF49; -.
DR PRIDE; Q0VF49; -.
DR UCSC; uc031rqt.1; human. [Q0VF49-1]
DR GeneCards; KIAA2012; -.
DR HGNC; HGNC:51250; KIAA2012.
DR neXtProt; NX_Q0VF49; -.
DR eggNOG; KOG0181; Eukaryota.
DR HOGENOM; CLU_296460_0_0_1; -.
DR InParanoid; Q0VF49; -.
DR ChiTaRS; KIAA2012; human.
DR Pharos; Q0VF49; Tdark.
DR PRO; PR:Q0VF49; -.
DR Proteomes; UP000005640; Unplaced.
DR RNAct; Q0VF49; protein.
DR Genevisible; Q0VF49; HS.
DR InterPro; IPR031440; DUF4670.
DR PANTHER; PTHR21937; PTHR21937; 1.
DR Pfam; PF15709; DUF4670; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Coiled coil; Reference proteome.
FT CHAIN 1..1180
FT /note="Uncharacterized protein KIAA2012"
FT /id="PRO_0000332200"
FT REGION 229..280
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 431..465
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 484..575
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 730..758
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 810..986
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1045..1109
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1125..1152
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 988..1171
FT /evidence="ECO:0000255"
FT COMPBIAS 264..278
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 431..454
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 486..502
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 520..534
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 730..747
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 827..857
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 873..887
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 935..958
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 959..986
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 1..627
FT /note="Missing (in isoform 2)"
FT /id="VSP_057140"
FT VAR_SEQ 628..645
FT /note="NSNISHEEEGPSSQHFLK -> MRSRSDHLDLFSSLIFTT (in isoform
FT 2)"
FT /id="VSP_057141"
SQ SEQUENCE 1180 AA; 135305 MW; D3DD908BD7D101BC CRC64;
MFTLSLLSRG HGKLGQDKQK LEVYFEPEDY LNWRSPEDYV PVSKPQDKNN ASQHSWSLFL
PKTFSTRKGA LILYSEGFAI SAWTPKERRK GPYCPRGPWR KLDLELHTLQ DLKEAILAYG
RQQGEQDRAW QPYLHFRSQL ESQAQRQIQP GHSAKRYLRG LLRTWPPDAM YRLWCAGYIK
DSVLLQDSQL NVPKKLRPQQ DLSGVPPKYH LLPVFPSFWI QQGKSFEQRQ QGLDEGEAGA
AGHVDQGPLA KNHGSQGTRL PPRRKQPWQE DETQAEDTSI ENHLCLYASK ESYNEKTQQT
SRKAFGHGRI DHSWLPSDKS HITFCGGAFP NRKADLSDKQ RNVKLHKARS SHLLQVLPAE
RSLFPPVASA TGSRIITPGE VKKKKAPKAL KLPPISEEPP RVLEPLKSQF KANEPPTELF
ILPVEIHYHT KQPPKEKAHR RGAPHPESEP ESSEESTPVW RPPLKHASLE TPWELTVHLP
VDASRDTLSP QGSSSLPPAS LGNLTLKGSK ARHTRVHSQG KGVWKGDDDA PPHDVAPPLD
LLPPIKGKKS PESQKGVDSP RTSDHNSPPS LPNMRVPRRA LPAAQEDSSD PTLGHFLLGP
DGEKVCLSLP GHTQTEALPS GKAYESVNSN ISHEEEGPSS QHFLKANTEP RANLHMNLYE
TSPLTQTTEK QGAQQSLEAA AQKTGEPQSC INKALICSNR KEFYTRKLHI DMTPFLKESG
NALDYQEEAG RPLRETHHND QDPEPRSMTL DSPRASRTEH IQTPEADIVQ KVGRDYDVHH
LHRGLLGYGP ESPERLSAVY TSLLPREREG KAEPRLFSQE TSANISHERD LINEAKRKEK
PKKDKTKGPK SEREGKVYGQ AEAAIGKSKD SKAKKKLEKK TRPQRKRTQK ERNLEIAAEL
SGPDVSYEET EDTSNRGSFA SDSFVEDPWL SPKYDAQESQ VSLDGRSSPS QIATVTGNME
SKEERRCEDP SKALLTKREQ EKASWDRLRA ERAEMRWLEV EKKRREQEEQ RQLQQEQLER
AKKMEEELEL EQQRRTEEIR LRKQRLQEEQ QRQEEEERKQ QLRLKAAQER ARQQQEEFRR
KLRELQRKKQ QEEAERAEAE KQRQEELEMQ LEEEQKHLME MAEEERLEYQ RRKQEAEEKA
RLEAEERRQK EEEAARLALE EATKQAQEQA RYWIFGQQLP
