K2013_HUMAN
ID K2013_HUMAN Reviewed; 634 AA.
AC Q8IYS2; Q5JXC1; Q8IVF8; Q8NDI7; Q9BSY1;
DT 10-JUL-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 03-AUG-2022, entry version 132.
DE RecName: Full=Uncharacterized protein KIAA2013;
DE Flags: Precursor;
GN Name=KIAA2013;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Brain;
RA Nagase T., Kikuno R., Ohara O.;
RT "The nucleotide sequence of a long cDNA clone isolated from human.";
RL Submitted (NOV-2002) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16710414; DOI=10.1038/nature04727;
RA Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A.,
RA Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C.,
RA Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.,
RA Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C.,
RA Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W.,
RA Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J.,
RA Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J.,
RA Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y.,
RA Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J.,
RA Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S.,
RA Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K.,
RA Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R.,
RA Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M.,
RA Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S.,
RA Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J.,
RA Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W.,
RA McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N.,
RA Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V.,
RA Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J.,
RA Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E.,
RA Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S.,
RA Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M.,
RA White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H.,
RA Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E.,
RA Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G.,
RA Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.;
RT "The DNA sequence and biological annotation of human chromosome 1.";
RL Nature 441:315-321(2006).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Brain, and Ovary;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 349-634 (ISOFORM 1).
RC TISSUE=Testis;
RX PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D.,
RA Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A.,
RA Wiemann S., Schupp I.;
RT "The full-ORF clone resource of the German cDNA consortium.";
RL BMC Genomics 8:399-399(2007).
RN [5]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=25944712; DOI=10.1002/pmic.201400617;
RA Vaca Jacome A.S., Rabilloud T., Schaeffer-Reiss C., Rompais M., Ayoub D.,
RA Lane L., Bairoch A., Van Dorsselaer A., Carapito C.;
RT "N-terminome analysis of the human mitochondrial proteome.";
RL Proteomics 15:2519-2524(2015).
CC -!- INTERACTION:
CC Q8IYS2; P24593: IGFBP5; NbExp=3; IntAct=EBI-2866116, EBI-720480;
CC Q8IYS2; Q9H2L4: TMEM60; NbExp=3; IntAct=EBI-2866116, EBI-2852148;
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I
CC membrane protein {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q8IYS2-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8IYS2-2; Sequence=VSP_026487;
CC -!- SEQUENCE CAUTION:
CC Sequence=BAC23109.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AB095933; BAC23109.1; ALT_INIT; mRNA.
DR EMBL; AL096840; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL021155; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC004501; AAH04501.2; -; mRNA.
DR EMBL; BC035033; AAH35033.1; -; mRNA.
DR EMBL; AL833891; CAD38747.1; -; mRNA.
DR CCDS; CCDS141.1; -. [Q8IYS2-1]
DR RefSeq; NP_612355.1; NM_138346.2. [Q8IYS2-1]
DR RefSeq; XP_005263588.1; XM_005263531.4.
DR AlphaFoldDB; Q8IYS2; -.
DR BioGRID; 124680; 158.
DR IntAct; Q8IYS2; 57.
DR MINT; Q8IYS2; -.
DR STRING; 9606.ENSP00000365756; -.
DR GlyGen; Q8IYS2; 1 site.
DR iPTMnet; Q8IYS2; -.
DR PhosphoSitePlus; Q8IYS2; -.
DR SwissPalm; Q8IYS2; -.
DR BioMuta; KIAA2013; -.
DR DMDM; 74750773; -.
DR EPD; Q8IYS2; -.
DR jPOST; Q8IYS2; -.
DR MassIVE; Q8IYS2; -.
DR MaxQB; Q8IYS2; -.
DR PaxDb; Q8IYS2; -.
DR PeptideAtlas; Q8IYS2; -.
DR PRIDE; Q8IYS2; -.
DR ProteomicsDB; 71221; -. [Q8IYS2-1]
DR ProteomicsDB; 71222; -. [Q8IYS2-2]
DR Antibodypedia; 65397; 36 antibodies from 10 providers.
DR DNASU; 90231; -.
DR Ensembl; ENST00000376572.8; ENSP00000365756.3; ENSG00000116685.16. [Q8IYS2-1]
DR Ensembl; ENST00000376576.3; ENSP00000365760.3; ENSG00000116685.16. [Q8IYS2-2]
DR Ensembl; ENST00000616327.1; ENSP00000480577.1; ENSG00000116685.16. [Q8IYS2-1]
DR GeneID; 90231; -.
DR KEGG; hsa:90231; -.
DR MANE-Select; ENST00000376572.8; ENSP00000365756.3; NM_138346.3; NP_612355.1.
DR UCSC; uc001atk.4; human. [Q8IYS2-1]
DR CTD; 90231; -.
DR DisGeNET; 90231; -.
DR GeneCards; KIAA2013; -.
DR HGNC; HGNC:28513; KIAA2013.
DR HPA; ENSG00000116685; Low tissue specificity.
DR neXtProt; NX_Q8IYS2; -.
DR OpenTargets; ENSG00000116685; -.
DR PharmGKB; PA142671593; -.
DR VEuPathDB; HostDB:ENSG00000116685; -.
DR eggNOG; KOG3778; Eukaryota.
DR GeneTree; ENSGT00390000007643; -.
DR HOGENOM; CLU_023338_0_0_1; -.
DR InParanoid; Q8IYS2; -.
DR OMA; RIANPTE; -.
DR OrthoDB; 882934at2759; -.
DR PhylomeDB; Q8IYS2; -.
DR TreeFam; TF314999; -.
DR PathwayCommons; Q8IYS2; -.
DR SignaLink; Q8IYS2; -.
DR BioGRID-ORCS; 90231; 35 hits in 1080 CRISPR screens.
DR ChiTaRS; KIAA2013; human.
DR GenomeRNAi; 90231; -.
DR Pharos; Q8IYS2; Tdark.
DR PRO; PR:Q8IYS2; -.
DR Proteomes; UP000005640; Chromosome 1.
DR RNAct; Q8IYS2; protein.
DR Bgee; ENSG00000116685; Expressed in ileal mucosa and 189 other tissues.
DR Genevisible; Q8IYS2; HS.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; HDA:UniProtKB.
DR InterPro; IPR018795; K2013-like.
DR PANTHER; PTHR31386; PTHR31386; 1.
DR Pfam; PF10222; DUF2152; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Glycoprotein; Membrane; Reference proteome; Signal;
KW Transmembrane; Transmembrane helix.
FT SIGNAL 1..40
FT /evidence="ECO:0000255"
FT CHAIN 41..634
FT /note="Uncharacterized protein KIAA2013"
FT /id="PRO_0000293468"
FT TOPO_DOM 41..589
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 590..610
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 611..634
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 363
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT VAR_SEQ 630..634
FT /note="EDPSV -> VGSRHLVETRGLGLALSPVSRKGLAWRGGVRPGQEWVS (in
FT isoform 2)"
FT /evidence="ECO:0000303|Ref.1"
FT /id="VSP_026487"
SQ SEQUENCE 634 AA; 69157 MW; CC63D7B1CDB33C5E CRC64;
MWLQQRLKGL PGLLSSSWAR RLLCLLGLLL LLLWFGGSGA RRAAGGLHLL PWSRGEPGAA
EPSACLEAAT RAWRGLRERG EVVPLGPGVP ALVANGFLAL DVAANRLWVT PGEREPAVAP
DFVPFVQLRP LSALAEAGEA VLLLREGLLR RVRCLQLGSP GPGPVAAGPG PASVSGLAAG
SGRDCVLLQE DFLAHRGRPH VYLQRIQLNN PTERVAALQT VGPTAGPAPK AFTSTLEKVG
DHQFLLYSGR SPPTPTGLVH LVVVAAKKLV NRLQVAPKTQ LDETVLWVVH VSGPINPQVL
KSKAAKELKA LQDLARKEML ELLDMPAAEL LQDHQLLWAQ LFSPGVEMKK ITDTHTPSGL
TVNLTLYYML SCSPAPLLSP SLSHRERDQM ESTLNYEDHC FSGHATMHAE NLWPGRLSSV
QQILQLSDLW RLTLQKRGCK GLVKVGAPGI LQGMVLSFGG LQFTENHLQF QADPDVLHNS
YALHGIRYKN DHINLAVLAD AEGKPYLHVS VESRGQPVKI YACKAGCLDE PVELTSAPTG
HTFSVMVTQP ITPLLYISTD LTHLQDLRHT LHLKAILAHD EHMAQQDPGL PFLFWFSVAS
LITLFHLFLF KLIYNEYCGP GAKPLFRSKE DPSV
