K2013_MOUSE
ID K2013_MOUSE Reviewed; 634 AA.
AC Q91X21; B2KFU4; Q3U5A6; Q69Z34; Q9CY11;
DT 10-JUL-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-2001, sequence version 1.
DT 03-AUG-2022, entry version 108.
DE RecName: Full=Uncharacterized protein KIAA2013;
DE Flags: Precursor;
GN Name=Kiaa2013;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
RC TISSUE=Fetal brain;
RX PubMed=15368895; DOI=10.1093/dnares/11.3.205;
RA Okazaki N., Kikuno R., Ohara R., Inamoto S., Koseki H., Hiraoka S.,
RA Saga Y., Seino S., Nishimura M., Kaisho T., Hoshino K., Kitamura H.,
RA Nagase T., Ohara O., Koga H.;
RT "Prediction of the coding sequences of mouse homologues of KIAA gene: IV.
RT The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs
RT identified by screening of terminal sequences of cDNA clones randomly
RT sampled from size-fractionated libraries.";
RL DNA Res. 11:205-218(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC STRAIN=C57BL/6J; TISSUE=Liver, and Thymus;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC STRAIN=FVB/N; TISSUE=Salivary gland;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I
CC membrane protein {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=1;
CC IsoId=Q91X21-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q91X21-2; Sequence=VSP_026489;
CC Name=3;
CC IsoId=Q91X21-3; Sequence=VSP_026488, VSP_026489;
CC -!- SEQUENCE CAUTION:
CC Sequence=BAD32610.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AK173332; BAD32610.1; ALT_INIT; mRNA.
DR EMBL; AK011059; BAB27367.1; -; mRNA.
DR EMBL; AK153761; BAE32173.1; -; mRNA.
DR EMBL; AL607066; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CU207406; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC012878; AAH12878.1; -; mRNA.
DR CCDS; CCDS18925.1; -. [Q91X21-1]
DR RefSeq; NP_084117.2; NM_029841.3. [Q91X21-1]
DR AlphaFoldDB; Q91X21; -.
DR STRING; 10090.ENSMUSP00000099522; -.
DR GlyGen; Q91X21; 1 site.
DR PhosphoSitePlus; Q91X21; -.
DR SwissPalm; Q91X21; -.
DR EPD; Q91X21; -.
DR MaxQB; Q91X21; -.
DR PaxDb; Q91X21; -.
DR PeptideAtlas; Q91X21; -.
DR PRIDE; Q91X21; -.
DR ProteomicsDB; 269142; -. [Q91X21-1]
DR ProteomicsDB; 269143; -. [Q91X21-2]
DR Antibodypedia; 65397; 36 antibodies from 10 providers.
DR Ensembl; ENSMUST00000103232; ENSMUSP00000099522; ENSMUSG00000044496. [Q91X21-1]
DR GeneID; 77034; -.
DR KEGG; mmu:77034; -.
DR UCSC; uc008vtm.1; mouse. [Q91X21-1]
DR UCSC; uc008vtn.1; mouse. [Q91X21-2]
DR MGI; MGI:1924284; 2510039O18Rik.
DR VEuPathDB; HostDB:ENSMUSG00000044496; -.
DR eggNOG; KOG3778; Eukaryota.
DR GeneTree; ENSGT00390000007643; -.
DR HOGENOM; CLU_023338_0_0_1; -.
DR InParanoid; Q91X21; -.
DR OMA; RIANPTE; -.
DR OrthoDB; 882934at2759; -.
DR PhylomeDB; Q91X21; -.
DR TreeFam; TF314999; -.
DR BioGRID-ORCS; 77034; 6 hits in 71 CRISPR screens.
DR ChiTaRS; 2510039O18Rik; mouse.
DR PRO; PR:Q91X21; -.
DR Proteomes; UP000000589; Chromosome 4.
DR RNAct; Q91X21; protein.
DR Bgee; ENSMUSG00000044496; Expressed in paneth cell and 257 other tissues.
DR Genevisible; Q91X21; MM.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR InterPro; IPR018795; K2013-like.
DR PANTHER; PTHR31386; PTHR31386; 1.
DR Pfam; PF10222; DUF2152; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Glycoprotein; Membrane; Reference proteome; Signal;
KW Transmembrane; Transmembrane helix.
FT SIGNAL 1..40
FT /evidence="ECO:0000255"
FT CHAIN 41..634
FT /note="Uncharacterized protein KIAA2013"
FT /id="PRO_0000293469"
FT TOPO_DOM 41..589
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 590..610
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 611..634
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 363
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT VAR_SEQ 1..318
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:15368895"
FT /id="VSP_026488"
FT VAR_SEQ 630..634
FT /note="EDPSV -> VGYLDS (in isoform 2 and isoform 3)"
FT /evidence="ECO:0000303|PubMed:15368895,
FT ECO:0000303|PubMed:16141072"
FT /id="VSP_026489"
FT CONFLICT 1..25
FT /note="MWLQQRLKGLPGLLSSSWARRLLCL -> GGRGDAARGV (in Ref. 1;
FT BAD32610)"
FT /evidence="ECO:0000305"
FT CONFLICT 109
FT /note="V -> E (in Ref. 2; BAE32173)"
FT /evidence="ECO:0000305"
FT CONFLICT 378
FT /note="L -> F (in Ref. 2; BAE32173)"
FT /evidence="ECO:0000305"
FT CONFLICT 480
FT /note="S -> T (in Ref. 2; BAB27367)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 634 AA; 69425 MW; 626EDDF1975AC5B0 CRC64;
MWLQQRLKGL PGLLSSSWAR RLLCLLGLLV LLLWFASSGA RRAAGGLHLP SWARSEPGAA
EPSACLEAAT RAWRGLRDRG EAVPLGPGVP ALVANGFLAL DASNNRLWVT PGEREPAVTP
DFVPFVQLRP LNVVAEAGEA VLLLREGLLR RVRCLQLGTP GSGPAAGVPG PASASGLSAG
SGRDCVLLQE DFLAHRGRPH VYLQRIQLNN PTERVAALQT VGPTAGPVPK SFTSTLEKVG
DHQFLLYSGR STPLPSGLVH LVVVTSKKLV NRLQVAPKTQ LDETVLWVVH ISGPIHPQVL
KSKGAKELKA LQDLARKEML ELLEMPASEL LQDHQYLWAQ LFSPGVEMKR ITDAHTPSGL
TVNLTLYYML SCSPAPLLSP SLSHREREQM EATLNYEDHC FSGHATMHAE NLWPGQLSSV
QQILQLADLW KLTLQKRGCK GLVKVGAPGI LQGMVLSFGG LQFTENHLQF QADPEVLHNS
YALHGIRYKN DHINLAVLVD AEGKPYLHVS LESRGQPVKI YACEAGCLHD PVELTSEPGG
HTFSVMVTQP ITPLLYISTD LTHLQDLRHT LHLKAILAHD EHMAQQDPGL PFLFWFSVAS
LITLFHLFLF KLIYNEYCGP GAKPLFRSKE DPSV
