ID   K2026_HUMAN             Reviewed;        2103 AA.
AC   Q5HYC2; A8MTP2; B9EGW7; Q4VXA2; Q8IVE5;
DT   29-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   15-JUN-2010, sequence version 2.
DT   03-AUG-2022, entry version 121.
DE   RecName: Full=Uncharacterized protein KIAA2026;
GN   Name=KIAA2026;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15164053; DOI=10.1038/nature02465;
RA   Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L.,
RA   Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R.,
RA   Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S.,
RA   Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K.,
RA   Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y.,
RA   Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C.,
RA   Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E.,
RA   Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M.,
RA   Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J.,
RA   Frankish A., Frankland J.A., French L., Fricker D.G., Garner P.,
RA   Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S.,
RA   Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E.,
RA   Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D.,
RA   Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E.,
RA   Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K.,
RA   Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S.,
RA   Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J.,
RA   Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E.,
RA   McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V.,
RA   Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S.,
RA   Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K.,
RA   Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J.,
RA   Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M.,
RA   West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L.,
RA   Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M.,
RA   Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J.,
RA   Dunham I.;
RT   "DNA sequence and analysis of human chromosome 9.";
RL   Nature 429:369-374(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 738-2103 (ISOFORM 2).
RC   TISSUE=Esophageal carcinoma;
RX   PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA   Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA   Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D.,
RA   Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A.,
RA   Wiemann S., Schupp I.;
RT   "The full-ORF clone resource of the German cDNA consortium.";
RL   BMC Genomics 8:399-399(2007).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 819-2103 (ISOFORM 1).
RC   TISSUE=Testis;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1246-2103 (ISOFORM 1).
RC   TISSUE=Brain;
RA   Nagase T., Kikuno R., Ohara O.;
RT   "The nucleotide sequence of a long cDNA clone isolated from human.";
RL   Submitted (NOV-2002) to the EMBL/GenBank/DDBJ databases.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=Q5HYC2-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q5HYC2-2; Sequence=VSP_039334;
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAI36847.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC       Sequence=CAI45993.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
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DR   EMBL; AL162384; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AL353606; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AL365360; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BX648372; CAI45993.1; ALT_INIT; mRNA.
DR   EMBL; BC136846; AAI36847.1; ALT_INIT; mRNA.
DR   EMBL; AB095946; BAC23122.1; -; mRNA.
DR   RefSeq; NP_001017969.2; NM_001017969.2. [Q5HYC2-1]
DR   RefSeq; XP_005251442.1; XM_005251385.2. [Q5HYC2-2]
DR   RefSeq; XP_011516063.1; XM_011517761.2.
DR   RefSeq; XP_016869821.1; XM_017014332.1.
DR   RefSeq; XP_016869822.1; XM_017014333.1.
DR   RefSeq; XP_016869823.1; XM_017014334.1.
DR   AlphaFoldDB; Q5HYC2; -.
DR   SMR; Q5HYC2; -.
DR   BioGRID; 127672; 9.
DR   IntAct; Q5HYC2; 7.
DR   STRING; 9606.ENSP00000382815; -.
DR   GlyGen; Q5HYC2; 1 site, 1 O-linked glycan (1 site).
DR   iPTMnet; Q5HYC2; -.
DR   PhosphoSitePlus; Q5HYC2; -.
DR   BioMuta; KIAA2026; -.
DR   DMDM; 298286816; -.
DR   EPD; Q5HYC2; -.
DR   jPOST; Q5HYC2; -.
DR   MassIVE; Q5HYC2; -.
DR   MaxQB; Q5HYC2; -.
DR   PaxDb; Q5HYC2; -.
DR   PeptideAtlas; Q5HYC2; -.
DR   PRIDE; Q5HYC2; -.
DR   ProteomicsDB; 62929; -. [Q5HYC2-1]
DR   ProteomicsDB; 62930; -. [Q5HYC2-2]
DR   Antibodypedia; 955; 13 antibodies from 8 providers.
DR   DNASU; 158358; -.
DR   Ensembl; ENST00000381461.6; ENSP00000370870.2; ENSG00000183354.12. [Q5HYC2-2]
DR   Ensembl; ENST00000399933.8; ENSP00000382815.3; ENSG00000183354.12. [Q5HYC2-1]
DR   GeneID; 158358; -.
DR   KEGG; hsa:158358; -.
DR   MANE-Select; ENST00000399933.8; ENSP00000382815.3; NM_001017969.3; NP_001017969.2.
DR   UCSC; uc003zjq.5; human. [Q5HYC2-1]
DR   CTD; 158358; -.
DR   DisGeNET; 158358; -.
DR   GeneCards; KIAA2026; -.
DR   HGNC; HGNC:23378; KIAA2026.
DR   HPA; ENSG00000183354; Low tissue specificity.
DR   neXtProt; NX_Q5HYC2; -.
DR   OpenTargets; ENSG00000183354; -.
DR   PharmGKB; PA134907262; -.
DR   VEuPathDB; HostDB:ENSG00000183354; -.
DR   eggNOG; ENOG502QQC8; Eukaryota.
DR   GeneTree; ENSGT00390000011483; -.
DR   HOGENOM; CLU_001633_0_0_1; -.
DR   InParanoid; Q5HYC2; -.
DR   OMA; HIDHPEI; -.
DR   OrthoDB; 27354at2759; -.
DR   PhylomeDB; Q5HYC2; -.
DR   TreeFam; TF336184; -.
DR   PathwayCommons; Q5HYC2; -.
DR   SignaLink; Q5HYC2; -.
DR   BioGRID-ORCS; 158358; 15 hits in 259 CRISPR screens.
DR   ChiTaRS; KIAA2026; human.
DR   GenomeRNAi; 158358; -.
DR   Pharos; Q5HYC2; Tdark.
DR   PRO; PR:Q5HYC2; -.
DR   Proteomes; UP000005640; Chromosome 9.
DR   RNAct; Q5HYC2; protein.
DR   Bgee; ENSG00000183354; Expressed in epithelial cell of pancreas and 193 other tissues.
DR   ExpressionAtlas; Q5HYC2; baseline and differential.
DR   Genevisible; Q5HYC2; HS.
DR   Gene3D; 1.20.920.10; -; 1.
DR   InterPro; IPR036427; Bromodomain-like_sf.
DR   InterPro; IPR040214; KIAA2026.
DR   PANTHER; PTHR31095; PTHR31095; 1.
DR   SUPFAM; SSF47370; SSF47370; 1.
PE   2: Evidence at transcript level;
KW   Alternative splicing; Reference proteome.
FT   CHAIN           1..2103
FT                   /note="Uncharacterized protein KIAA2026"
FT                   /id="PRO_0000288922"
FT   REGION          1..61
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          730..750
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          853..881
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          933..956
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1224..1244
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1770..1817
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        853..876
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        934..956
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1771..1817
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   VAR_SEQ         765..794
FT                   /note="Missing (in isoform 2)"
FT                   /evidence="ECO:0000303|PubMed:17974005"
FT                   /id="VSP_039334"
SQ   SEQUENCE   2103 AA;  228087 MW;  211E99364884045A CRC64;
     MSVPGTPGAM EPAGEEERPP PAAEGEDDEE EVAAAAQTSG PAHGRSASSL EDADDQEEEM
     EAMVIGGGCC KEQELTYELQ QGYRILGEFL QEKHRGLTAP FLQPLGGVAT AEEEVAEGPR
     SGGRGGRAFP QQPGQGMCLL QMEEKFASGQ YGGITEFVAD FRLMLETCYR LHGVDHWISK
     QGQKLEMMLE QKLALLSRHL REKTTIAVTS RGYYGLEDEK GTACTSTRRR STPRSLAGLT
     SGVFESIMVQ VLRQEEQLRA KEEKRLREQE RKEAEEASQK EIEEWERKLL AQAAPTCMET
     MWEIPAIGHF LCLAQQILNL PEIVFYELER CLLMPQCNAF LSKIMTSLLS PPHRRPTLHR
     RPTLPYRTWE AALRQKVQQW YTAVGQTENP DNCAEKLGLC PQFFKVLGEV NPLEEKPFHE
     LPFYQKVWLL KGLCDFVYET QKEVQDAVLG QPIHECREVI LGYDYLENAY VHFPQFCGAD
     VRIYKQRPFQ APEFPIPPIK IQRVPRIKLE KLKCDYVSTS NGEHRCSRDS LPSSFKKEQE
     NNFDPACCPA KMILDNHDIS VEMGVKSNYE IRIRRPCEIK KTDCCKENLE KPRSPGEVTG
     FGEPLSPGEI RFIENQEKYG EASRIKIEPS PLKENTLKSC QIHVNGSHSD HPEINCHKVV
     RDILLEQSLQ SHKKLKLTKM RAKKKKKKKK KLKDVLNENL QRKREGLHSL AFKSYKPEIQ
     NKLLIIKKKA KHKKHKSGKK SVSKKAITKK RKTVIKSPTV PEFQLICTNL DELRELITKI
     ENELKDLENS RKKSGKWYHR RQAVKELHST LIRLLNELLP WEPKLMKAFQ RNRSRLKKDY
     DDFRRQPDHD TFNRELWTTD EGEGDLGKDS PKGEISKSID STEPLDILEK DHFDSDDMKL
     SEIDFPMARS KLLKKELPSK DLPKTLLKTL KRQSKQTDYV DDSTKELSPR KKAKLSTNET
     TVENLESDVQ IDCFSESKHT EPSFPESFAS LDSVPVSTLQ KGTKPIQALL AKNIGNKVTL
     TNQLPPSTGR NALAVEKPVL SPPEASPIKP ALTCHTNTKG PLQMVYKMPC GQWLPIDLQN
     SSVKIQVQPM VDPKTGEKIM QQVLILPKNF VIQHKEGKAV AKEVPPLQQK GTEQHCSSFP
     QTTNINSSLA SVFVNSPGTV STQLPNTAFN KTITPLSNIS SARPQPLSPV TSVSNLLTPS
     VKTSQSEAGK AKNAVSAATF SLPSASPTIS STGQPLSSTT TLNGSTNPGS SFNCFAQQTA
     DSSEAKQELK TVCIRDSQSI LVRTRGGNTG VVKVQTNPDQ NSPNTVSSSS VFTFAPQLQA
     FLVPKSTTSS SAFSPVAGTT TTSSLSPFSQ TPTSVSIPAS FAPSMGKNLK LTLGHTTGSG
     DLGHVIDKTS HMPSSPLKSS ICSSTLLPST TSSSVSVISI SAANFGQNNA NIIHTPTKQQ
     QVDYITKSYP VTRSEATAAT NGDVISGTPV QKLMLVSAPS ILSSGNGTAI NMTPALTSTG
     VSAQKLVFIN APVPSGTSTP TLVAESLKQT LPPPLHKAYV KTPEQPQIVL IPSTVGTPIK
     INSSPAVSQI KDVKIGLNIG QAIVNTSGTV PAIPSINILQ NVTPKGEDKS SKGYILPLST
     SGNSVPVSSN FVSQNITPVN ESVVSSARAV NVLSVTGANL SLGSFPVTSA SASAGAQPPV
     LVSGNDTSSR IMPILSNRLC SSSLGNTVAI STVKTGHLAS SVLISTTQPV VSPKCLTSAL
     QIPVTVALPT PATTSPKIIN TVPHSAAVPG ATRSVSISKR QSRTSLQFHS PGISTTVPTN
     VNTNKPQTEL SSLSTSPGKI TNTSNFASLP NQQALVKTPS YSSAPGGTTI HTASAPSNVT
     SLVGSQFSEP CIQQKIVINT STPLAPGTQI MINGTRFIVP PQGLGAGSHV LLISTNPKYG
     APLVLNSGQG IQSTPIDNSA QKITLASNNS LSGQPLQHPL RSPTKFINSF GNASSIPTVH
     TSPQLINTTA KVPVPPPVPT VSLTSVIKSP ATLLAKTSLV SAICPSNPPL PSSTSVFHLD
     PPVKKLLVSP EGAILNTINT PASKVSSLSP SLSQIVVSAS RSPASVFPAF QSSGLEKPDR
     AAS