K22O_MOUSE
ID K22O_MOUSE Reviewed; 594 AA.
AC Q3UV17;
DT 10-FEB-2009, integrated into UniProtKB/Swiss-Prot.
DT 11-OCT-2005, sequence version 1.
DT 03-AUG-2022, entry version 127.
DE RecName: Full=Keratin, type II cytoskeletal 2 oral {ECO:0000250|UniProtKB:Q01546};
DE AltName: Full=Keratin-76 {ECO:0000312|MGI:MGI:1924305};
DE Short=K76;
DE AltName: Full=Type-II keratin Kb9;
GN Name=Krt76 {ECO:0000312|MGI:MGI:1924305};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1] {ECO:0000312|EMBL:BAE23456.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J {ECO:0000312|EMBL:BAE23456.1};
RC TISSUE=Vagina {ECO:0000312|EMBL:BAE23456.1};
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brain, Brown adipose tissue, Heart, Kidney, Liver, Lung, Pancreas,
RC Spleen, and Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- FUNCTION: Probably contributes to terminal cornification.
CC {ECO:0000250|UniProtKB:Q01546}.
CC -!- SUBUNIT: Heterotetramer of two type I and two type II keratins.
CC {ECO:0000305}.
CC -!- MISCELLANEOUS: There are two types of cytoskeletal and microfibrillar
CC keratin: I (acidic; 40-55 kDa) and II (neutral to basic; 56-70 kDa).
CC {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the intermediate filament family.
CC {ECO:0000255|PROSITE-ProRule:PRU01188}.
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DR EMBL; AK137676; BAE23456.1; -; mRNA.
DR CCDS; CCDS27866.1; -.
DR RefSeq; NP_001028349.1; NM_001033177.2.
DR AlphaFoldDB; Q3UV17; -.
DR SMR; Q3UV17; -.
DR BioGRID; 218485; 12.
DR STRING; 10090.ENSMUSP00000097754; -.
DR iPTMnet; Q3UV17; -.
DR PhosphoSitePlus; Q3UV17; -.
DR CPTAC; non-CPTAC-3705; -.
DR EPD; Q3UV17; -.
DR jPOST; Q3UV17; -.
DR MaxQB; Q3UV17; -.
DR PaxDb; Q3UV17; -.
DR PeptideAtlas; Q3UV17; -.
DR PRIDE; Q3UV17; -.
DR ProteomicsDB; 268941; -.
DR Antibodypedia; 14669; 511 antibodies from 24 providers.
DR DNASU; 77055; -.
DR Ensembl; ENSMUST00000100179; ENSMUSP00000097754; ENSMUSG00000075402.
DR GeneID; 77055; -.
DR KEGG; mmu:77055; -.
DR UCSC; uc007xue.1; mouse.
DR CTD; 51350; -.
DR MGI; MGI:1924305; Krt76.
DR VEuPathDB; HostDB:ENSMUSG00000075402; -.
DR eggNOG; ENOG502QURK; Eukaryota.
DR GeneTree; ENSGT00940000162365; -.
DR HOGENOM; CLU_012560_6_1_1; -.
DR InParanoid; Q3UV17; -.
DR OMA; MSHSGMG; -.
DR OrthoDB; 824246at2759; -.
DR PhylomeDB; Q3UV17; -.
DR TreeFam; TF317854; -.
DR Reactome; R-MMU-6805567; Keratinization.
DR Reactome; R-MMU-6809371; Formation of the cornified envelope.
DR BioGRID-ORCS; 77055; 4 hits in 71 CRISPR screens.
DR PRO; PR:Q3UV17; -.
DR Proteomes; UP000000589; Chromosome 15.
DR RNAct; Q3UV17; protein.
DR Bgee; ENSMUSG00000075402; Expressed in molar tooth and 9 other tissues.
DR Genevisible; Q3UV17; MM.
DR GO; GO:0045095; C:keratin filament; IBA:GO_Central.
DR GO; GO:0030280; F:structural constituent of skin epidermis; IBA:GO_Central.
DR GO; GO:0008544; P:epidermis development; IMP:MGI.
DR GO; GO:0045109; P:intermediate filament organization; IBA:GO_Central.
DR GO; GO:0031424; P:keratinization; IBA:GO_Central.
DR GO; GO:0043473; P:pigmentation; IMP:MGI.
DR GO; GO:0048733; P:sebaceous gland development; IMP:MGI.
DR InterPro; IPR018039; IF_conserved.
DR InterPro; IPR039008; IF_rod_dom.
DR InterPro; IPR032444; Keratin_2_head.
DR InterPro; IPR003054; Keratin_II.
DR Pfam; PF00038; Filament; 1.
DR Pfam; PF16208; Keratin_2_head; 1.
DR PRINTS; PR01276; TYPE2KERATIN.
DR SMART; SM01391; Filament; 1.
DR PROSITE; PS00226; IF_ROD_1; 1.
DR PROSITE; PS51842; IF_ROD_2; 1.
PE 1: Evidence at protein level;
KW Coiled coil; Intermediate filament; Keratin; Methylation;
KW Reference proteome.
FT CHAIN 1..594
FT /note="Keratin, type II cytoskeletal 2 oral"
FT /id="PRO_0000361693"
FT DOMAIN 165..480
FT /note="IF rod"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01188"
FT REGION 1..164
FT /note="Head"
FT /evidence="ECO:0000255"
FT REGION 165..200
FT /note="Coil 1A"
FT /evidence="ECO:0000255"
FT REGION 201..221
FT /note="Linker 1"
FT /evidence="ECO:0000255"
FT REGION 222..313
FT /note="Coil 1B"
FT /evidence="ECO:0000255"
FT REGION 314..337
FT /note="Linker 12"
FT /evidence="ECO:0000255"
FT REGION 338..476
FT /note="Coil 2"
FT /evidence="ECO:0000255"
FT REGION 477..594
FT /note="Tail"
FT /evidence="ECO:0000255"
FT REGION 497..594
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 85
FT /note="Omega-N-methylarginine"
FT /evidence="ECO:0000250|UniProtKB:Q6IFZ6"
FT MOD_RES 104
FT /note="Omega-N-methylarginine"
FT /evidence="ECO:0000250|UniProtKB:Q6IFZ6"
FT MOD_RES 541
FT /note="Omega-N-methylarginine"
FT /evidence="ECO:0000250|UniProtKB:Q6IFZ6"
SQ SEQUENCE 594 AA; 62845 MW; 00998F2B496DF612 CRC64;
MSRQACKKSF SCGSQGFSGH SAVVSGSSRS SCVARSGAAS GGACGFRSGA GSLGSHSLYS
LGGSKSISIS VAAGGSRAGG FSGGRSSCGS GFGSGYGGSL GGSRGMGAGF GGPSGFGGAG
GFGRPGSFGP GSCPGGIQEV TINQSLLQPL NVEIDPQIGQ VKAQEREQIK TLNNKFASFI
DKVRFLEQQN KVLETKWELL QQQTIRSGSG PQNLEPFFES YISCLRKQLD SLLGAKGSLE
GELKSMQDLV EDFKKKYEEE INRRTAAENE FVGLKKDVDG AFMNKVELQA KVDSLTDEIN
FLRTLYDMEL SQIQSHVSDT SVVLSMDNNR CLDLDSIIAE VKAQYEDIAQ KSKAEAEALY
QTKLGELQTT AGRHGDDLRS TKSEIMDLNR MIQRLRAEIE NVKKQNTNMQ TSIAEAEQRG
ERALKDADTK FQDLQVALQK AKEDMARLLK EYQELMNVKL ALDVEIATYR KLLEGEECRL
SGEFQNAVSI SVVSNVTSTS SSGSFRGTGG SNYGGDSSGR SGGSSSSSSR GSSSRGSSGS
RLGSGGSISV SQQRMGFNSG GSQTSVGSSY KSGRGGSSSV QFSQTTSSSQ QRSK
