K2C1B_HUMAN
ID K2C1B_HUMAN Reviewed; 578 AA.
AC Q7Z794; Q7RTS8;
DT 24-MAY-2005, integrated into UniProtKB/Swiss-Prot.
DT 05-OCT-2010, sequence version 3.
DT 03-AUG-2022, entry version 153.
DE RecName: Full=Keratin, type II cytoskeletal 1b;
DE AltName: Full=Cytokeratin-1B;
DE Short=CK-1B;
DE AltName: Full=Keratin-77;
DE Short=K77;
DE AltName: Full=Type-II keratin Kb39;
GN Name=KRT77; Synonyms=KRT1B;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1] {ECO:0000305, ECO:0000312|EMBL:CAD91892.1}
RP NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RC TISSUE=Skin {ECO:0000312|EMBL:CAD91892.1};
RX PubMed=15737194; DOI=10.1111/j.0022-202x.2004.23530.x;
RA Rogers M.A., Edler L., Winter H., Langbein L., Beckmann I., Schweizer J.;
RT "Characterization of new members of the human type II keratin gene family
RT and a general evaluation of the keratin gene domain on chromosome
RT 12q13.13.";
RL J. Invest. Dermatol. 124:536-544(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16541075; DOI=10.1038/nature04569;
RA Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y.,
RA Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C.,
RA Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C.,
RA Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R.,
RA Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E.,
RA Song X.-Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y.,
RA Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G.,
RA Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H.,
RA Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S.,
RA Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M.,
RA Nguyen B.-V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H.,
RA Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q.,
RA Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V.,
RA Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E.,
RA Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K.,
RA Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D.,
RA Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R.,
RA David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E.,
RA D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N.,
RA Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N.,
RA Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R.,
RA Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S.,
RA LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H.,
RA Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P.,
RA Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G.,
RA Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E.,
RA Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S.,
RA Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O.,
RA Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J.,
RA Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A.,
RA Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M.,
RA Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I.,
RA Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A.,
RA Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y.,
RA Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A.,
RA Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F.,
RA Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L.,
RA Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G.,
RA Gibbs R.A.;
RT "The finished DNA sequence of human chromosome 12.";
RL Nature 440:346-351(2006).
RN [3] {ECO:0000305, ECO:0000312|EMBL:DAA00402.1}
RP IDENTIFICATION.
RX PubMed=11683385; DOI=10.1242/jcs.114.14.2569;
RA Hesse M., Magin T.M., Weber K.;
RT "Genes for intermediate filament proteins and the draft sequence of the
RT human genome: novel keratin genes and a surprisingly high number of
RT pseudogenes related to keratin genes 8 and 18.";
RL J. Cell Sci. 114:2569-2575(2001).
CC -!- INTERACTION:
CC Q7Z794; P19012: KRT15; NbExp=3; IntAct=EBI-3045529, EBI-739566;
CC Q7Z794; P08727: KRT19; NbExp=3; IntAct=EBI-3045529, EBI-742756;
CC Q7Z794; Q7Z3Y8: KRT27; NbExp=3; IntAct=EBI-3045529, EBI-3044087;
CC Q7Z794; Q15323: KRT31; NbExp=3; IntAct=EBI-3045529, EBI-948001;
CC Q7Z794; Q92764: KRT35; NbExp=3; IntAct=EBI-3045529, EBI-1058674;
CC Q7Z794; O76013-2: KRT36; NbExp=3; IntAct=EBI-3045529, EBI-11958506;
CC Q7Z794; Q99750: MDFI; NbExp=3; IntAct=EBI-3045529, EBI-724076;
CC -!- TISSUE SPECIFICITY: Expressed exclusively in skin.
CC {ECO:0000269|PubMed:15737194}.
CC -!- PTM: Undergoes deimination of some arginine residues (citrullination).
CC {ECO:0000250|UniProtKB:Q6IFZ6}.
CC -!- MISCELLANEOUS: There are two types of cytoskeletal and microfibrillar
CC keratin: I (acidic; 40-55 kDa) and II (neutral to basic; 56-70 kDa).
CC -!- SIMILARITY: Belongs to the intermediate filament family.
CC {ECO:0000255|PROSITE-ProRule:PRU01188}.
CC -!- SEQUENCE CAUTION:
CC Sequence=DAA00402.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AJ564104; CAD91892.1; -; mRNA.
DR EMBL; AC055716; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BK000975; DAA00402.1; ALT_SEQ; Genomic_DNA.
DR CCDS; CCDS8837.1; -.
DR RefSeq; NP_778253.2; NM_175078.2.
DR AlphaFoldDB; Q7Z794; -.
DR SMR; Q7Z794; -.
DR BioGRID; 131903; 40.
DR IntAct; Q7Z794; 23.
DR STRING; 9606.ENSP00000342710; -.
DR iPTMnet; Q7Z794; -.
DR PhosphoSitePlus; Q7Z794; -.
DR SwissPalm; Q7Z794; -.
DR BioMuta; KRT77; -.
DR DMDM; 308153590; -.
DR EPD; Q7Z794; -.
DR jPOST; Q7Z794; -.
DR MassIVE; Q7Z794; -.
DR PaxDb; Q7Z794; -.
DR PeptideAtlas; Q7Z794; -.
DR PRIDE; Q7Z794; -.
DR ProteomicsDB; 69492; -.
DR Antibodypedia; 51312; 609 antibodies from 23 providers.
DR DNASU; 374454; -.
DR Ensembl; ENST00000341809.8; ENSP00000342710.3; ENSG00000189182.10.
DR GeneID; 374454; -.
DR KEGG; hsa:374454; -.
DR MANE-Select; ENST00000341809.8; ENSP00000342710.3; NM_175078.3; NP_778253.2.
DR UCSC; uc001saw.4; human.
DR CTD; 374454; -.
DR DisGeNET; 374454; -.
DR GeneCards; KRT77; -.
DR HGNC; HGNC:20411; KRT77.
DR HPA; ENSG00000189182; Tissue enriched (skin).
DR MIM; 611158; gene.
DR neXtProt; NX_Q7Z794; -.
DR OpenTargets; ENSG00000189182; -.
DR VEuPathDB; HostDB:ENSG00000189182; -.
DR eggNOG; ENOG502QQIF; Eukaryota.
DR GeneTree; ENSGT00940000162397; -.
DR HOGENOM; CLU_012560_6_1_1; -.
DR InParanoid; Q7Z794; -.
DR OMA; VGSVCHA; -.
DR OrthoDB; 824246at2759; -.
DR PhylomeDB; Q7Z794; -.
DR TreeFam; TF317854; -.
DR PathwayCommons; Q7Z794; -.
DR Reactome; R-HSA-6805567; Keratinization.
DR Reactome; R-HSA-6809371; Formation of the cornified envelope.
DR SignaLink; Q7Z794; -.
DR BioGRID-ORCS; 374454; 6 hits in 1057 CRISPR screens.
DR ChiTaRS; KRT77; human.
DR GenomeRNAi; 374454; -.
DR Pharos; Q7Z794; Tbio.
DR PRO; PR:Q7Z794; -.
DR Proteomes; UP000005640; Chromosome 12.
DR RNAct; Q7Z794; protein.
DR Bgee; ENSG00000189182; Expressed in upper arm skin and 73 other tissues.
DR ExpressionAtlas; Q7Z794; baseline and differential.
DR Genevisible; Q7Z794; HS.
DR GO; GO:0001533; C:cornified envelope; IEA:Ensembl.
DR GO; GO:0005856; C:cytoskeleton; IDA:UniProtKB.
DR GO; GO:0005829; C:cytosol; TAS:Reactome.
DR GO; GO:0070062; C:extracellular exosome; HDA:UniProtKB.
DR GO; GO:0045095; C:keratin filament; IBA:GO_Central.
DR GO; GO:0030280; F:structural constituent of skin epidermis; IBA:GO_Central.
DR GO; GO:0045109; P:intermediate filament organization; IBA:GO_Central.
DR GO; GO:0031424; P:keratinization; IBA:GO_Central.
DR InterPro; IPR018039; IF_conserved.
DR InterPro; IPR039008; IF_rod_dom.
DR InterPro; IPR032444; Keratin_2_head.
DR InterPro; IPR003054; Keratin_II.
DR Pfam; PF00038; Filament; 1.
DR Pfam; PF16208; Keratin_2_head; 1.
DR PRINTS; PR01276; TYPE2KERATIN.
DR SMART; SM01391; Filament; 1.
DR PROSITE; PS00226; IF_ROD_1; 1.
DR PROSITE; PS51842; IF_ROD_2; 1.
PE 1: Evidence at protein level;
KW Citrullination; Coiled coil; Intermediate filament; Keratin; Methylation;
KW Reference proteome.
FT CHAIN 1..578
FT /note="Keratin, type II cytoskeletal 1b"
FT /id="PRO_0000063711"
FT DOMAIN 164..477
FT /note="IF rod"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01188"
FT REGION 1..163
FT /note="Head"
FT REGION 164..200
FT /note="Coil 1A"
FT REGION 201..219
FT /note="Linker 1"
FT REGION 220..311
FT /note="Coil 1B"
FT REGION 312..335
FT /note="Linker 12"
FT REGION 336..474
FT /note="Coil 2"
FT REGION 475..578
FT /note="Tail"
FT REGION 547..578
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 553..578
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT SITE 418
FT /note="Stutter"
FT MOD_RES 95
FT /note="Omega-N-methylarginine"
FT /evidence="ECO:0000250|UniProtKB:Q6IFZ6"
FT MOD_RES 523
FT /note="Omega-N-methylarginine"
FT /evidence="ECO:0000250|UniProtKB:Q6IFZ6"
FT VARIANT 10
FT /note="A -> T (in dbSNP:rs17118224)"
FT /id="VAR_056022"
FT CONFLICT 336
FT /note="D -> N (in Ref. 1; CAD91892)"
FT /evidence="ECO:0000305"
FT CONFLICT 533
FT /note="R -> G (in Ref. 1; CAD91892)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 578 AA; 61901 MW; 232F92351DF0FDCA CRC64;
MSHQFSSQSA FSSMSRRVYS TSSSAGSGGG SPAVGSVCYA RGRCGGGGYG IHGRGFGSRS
LYNLGGSRSI SINLMGRSTS GFCQGGGVGG FGGGRGFGVG STGAGGFGGG GFGGAGFGTS
NFGLGGFGPY CPPGGIQEVT INQSLLEPLH LEVDPEIQRI KTQEREQIMV LNNKFASFID
KVRFLEQQNQ VLQTKWELLQ QVNTSTGTNN LEPLLENYIG DLRRQVDLLS AEQMRQNAEV
RSMQDVVEDY KSKYEDEINK RTGSENDFVV LKKDVDAAYV SKVDLESRVD TLTGEVNFLK
YLFLTELSQV QTHISDTNVI LSMDNNRSLD LDSIIDAVRT QYELIAQRSK DEAEALYQTK
YQELQITAGR HGDDLKNSKM EIAELNRTVQ RLQAEISNVK KQIEQMQSLI SDAEERGEQA
LQDAWQKLQD LEEALQQSKE ELARLLRDYQ AMLGVKLSLD VEIATYRQLL EGEESRMSGE
LQSHVSISVQ NSQVSVNGGA GGGGSYGSGG YGGGSGGGYG GGRSYRGGGA RGRSGGGYGS
GCGGGGGSYG GSGRSGRGSS RVQIIQTSTN TSHRRILE
