ID   K2C2_XENLA              Reviewed;         419 AA.
AC   P04265;
DT   20-MAR-1987, integrated into UniProtKB/Swiss-Prot.
DT   20-MAR-1987, sequence version 1.
DT   03-AUG-2022, entry version 90.
DE   RecName: Full=Keratin, type II cytoskeletal I;
DE   AltName: Full=Clone PUF164;
DE   Flags: Fragment;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=2413219; DOI=10.1016/0022-2836(85)90315-8;
RA   Hoffmann W., Franz J.K., Franke W.W.;
RT   "Amino acid sequence microheterogeneities of basic (type II) cytokeratins
RT   of Xenopus laevis epidermis and evolutionary conservativity of helical and
RT   non-helical domains.";
RL   J. Mol. Biol. 184:713-724(1985).
CC   -!- SUBUNIT: Heterotetramer of two type I and two type II keratins.
CC   -!- MISCELLANEOUS: There are two types of cytoskeletal and microfibrillar
CC       keratin: I (acidic; 40-55 kDa) and II (neutral to basic; 56-70 kDa).
CC   -!- SIMILARITY: Belongs to the intermediate filament family.
CC       {ECO:0000255|PROSITE-ProRule:PRU01188}.
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DR   EMBL; X02895; CAA26654.1; -; mRNA.
DR   PIR; A02952; KRXL2B.
DR   AlphaFoldDB; P04265; -.
DR   SMR; P04265; -.
DR   PRIDE; P04265; -.
DR   Proteomes; UP000186698; Genome assembly.
DR   GO; GO:0045095; C:keratin filament; IEA:InterPro.
DR   GO; GO:0046982; F:protein heterodimerization activity; ISS:UniProtKB.
DR   GO; GO:0051290; P:protein heterotetramerization; ISS:UniProtKB.
DR   InterPro; IPR018039; IF_conserved.
DR   InterPro; IPR039008; IF_rod_dom.
DR   InterPro; IPR003054; Keratin_II.
DR   Pfam; PF00038; Filament; 1.
DR   PRINTS; PR01276; TYPE2KERATIN.
DR   SMART; SM01391; Filament; 1.
DR   PROSITE; PS00226; IF_ROD_1; 1.
DR   PROSITE; PS51842; IF_ROD_2; 1.
PE   2: Evidence at transcript level;
KW   Coiled coil; Intermediate filament; Keratin; Reference proteome.
FT   CHAIN           <1..419
FT                   /note="Keratin, type II cytoskeletal I"
FT                   /id="PRO_0000063719"
FT   DOMAIN          <1..275
FT                   /note="IF rod"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01188"
FT   REGION          <1..16
FT                   /note="Linker 1"
FT   REGION          17..108
FT                   /note="Coil 1B"
FT   REGION          109..132
FT                   /note="Linker 12"
FT   REGION          133..271
FT                   /note="Coil 2"
FT   REGION          272..419
FT                   /note="Tail"
FT   SITE            215
FT                   /note="Stutter"
FT   NON_TER         1
SQ   SEQUENCE   419 AA;  44595 MW;  15D79584FC31DF15 CRC64;
     KGSTKRANLD PLFEKYISDL KRYLDNLINE KGRLQQELRT LQDLVEDFKK KYEDEINKRT
     KAENDFVVLK KDVDAAYMIK TELEAKVDTL TSEINFFRTL FAAELSQVHD QVTDTSVVLT
     MDNNRDLNLD SIIKEVKCQY EQIAQRSKLE AEALYDQRYK QLQQTVEGHG DSIKNSKTEI
     SDLNLKIQRL KAEIENVKKQ IAFLNQSIAG AEERGNLALK DAERKLKDLE DAERKLKADM
     ARQLKEYQEL MSAKLALNLE ISTYRYMLEG EEGRMSGQIS NNVSISVISG GSSVYTALGG
     AAGGMGGGGG MGGGMGGGMG MGGGMGMGGG MGMGGGMGMG GGMGGGMGMG GGMGMGGGMG
     MGDGMGSGHG GGYGNEACFG GGMGYEGGSM HGGGSSYGHS GGKTSVAIAS TTSTTKRSY