K2C4_HUMAN
ID K2C4_HUMAN Reviewed; 520 AA.
AC P19013; B4DRS2; F8VS64; Q6GTR8; Q96LA7; Q9BTL1;
DT 01-NOV-1990, integrated into UniProtKB/Swiss-Prot.
DT 26-FEB-2020, sequence version 5.
DT 03-AUG-2022, entry version 198.
DE RecName: Full=Keratin, type II cytoskeletal 4;
DE AltName: Full=Cytokeratin-4;
DE Short=CK-4;
DE AltName: Full=Keratin-4;
DE Short=K4;
DE AltName: Full=Type-II keratin Kb4;
GN Name=KRT4; Synonyms=CYK4;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Cassidy A.J., Morley S.M., McLean W.H.I.;
RT "A mutation detection strategy for oral mucosal keratins K4, K13, and K2p
RT in white sponge nevus.";
RL Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Tongue;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND VARIANT 83-GLY--THR-96
RP DEL.
RX PubMed=16541075; DOI=10.1038/nature04569;
RA Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y.,
RA Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C.,
RA Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C.,
RA Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R.,
RA Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E.,
RA Song X.-Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y.,
RA Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G.,
RA Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H.,
RA Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S.,
RA Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M.,
RA Nguyen B.-V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H.,
RA Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q.,
RA Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V.,
RA Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E.,
RA Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K.,
RA Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D.,
RA Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R.,
RA David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E.,
RA D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N.,
RA Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N.,
RA Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R.,
RA Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S.,
RA LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H.,
RA Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P.,
RA Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G.,
RA Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E.,
RA Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S.,
RA Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O.,
RA Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J.,
RA Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A.,
RA Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M.,
RA Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I.,
RA Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A.,
RA Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y.,
RA Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A.,
RA Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F.,
RA Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L.,
RA Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G.,
RA Gibbs R.A.;
RT "The finished DNA sequence of human chromosome 12.";
RL Nature 440:346-351(2006).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain, and Ovary;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 1-144, AND VARIANTS VAL-72 AND
RP GLY-GLY-PHE-GLY-ALA-GLY-GLY-PHE-GLY-ALA-GLY-PHE-GLY-THR-82 INS.
RX PubMed=7684424; DOI=10.1111/1523-1747.ep12475671;
RA Wanner R., Foerster H.-H., Tilmans I., Mischke D.;
RT "Allelic variations of human keratins K4 and K5 provide polymorphic markers
RT within the type II keratin gene cluster on chromosome 12.";
RL J. Invest. Dermatol. 100:735-741(1993).
RN [6]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 113-520, AND TISSUE SPECIFICITY.
RX PubMed=2452170; DOI=10.1083/jcb.106.4.1249;
RA Leube R.E., Bader B.L., Bosch F.X., Zimbelmann R., Achtstaetter T.,
RA Franke W.W.;
RT "Molecular characterization and expression of the stratification-related
RT cytokeratins 4 and 15.";
RL J. Cell Biol. 106:1249-1261(1988).
RN [7]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 397-520.
RA Wanner R., Tilmans I., Mischke D.;
RL Submitted (JUL-1991) to the EMBL/GenBank/DDBJ databases.
RN [8]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T.,
RA Bennett K.L., Superti-Furga G., Colinge J.;
RT "Initial characterization of the human central proteome.";
RL BMC Syst. Biol. 5:17-17(2011).
RN [9]
RP VARIANT WSN1 GLN-139 INS.
RX PubMed=10652003; DOI=10.1046/j.1523-1747.2000.00890.x;
RA Terrinoni A., Candi E., Oddi S., Gobello T., Camaione D.B., Mazzanti C.,
RA Zambruno G., Knight R., Melino G.;
RT "A glutamine insertion in the 1A alpha helical domain of the keratin 4 gene
RT in a familial case of white sponge nevus.";
RL J. Invest. Dermatol. 114:388-391(2000).
RN [10]
RP VARIANT WSN1 LYS-435.
RX PubMed=12828738; DOI=10.1046/j.1365-2133.2003.05337.x;
RA Chao S.C., Tsai Y.M., Yang M.H., Lee Jy J.Y.;
RT "A novel mutation in the keratin 4 gene causing white sponge naevus.";
RL Br. J. Dermatol. 148:1125-1128(2003).
CC -!- SUBUNIT: Heterotetramer of two type I and two type II keratins.
CC Keratin-4 is generally associated with keratin-13.
CC -!- INTERACTION:
CC P19013; Q9NWQ9: C14orf119; NbExp=3; IntAct=EBI-2371606, EBI-725606;
CC P19013; Q2TAC2-2: CCDC57; NbExp=3; IntAct=EBI-2371606, EBI-10961624;
CC P19013; Q86XR8-3: CEP57; NbExp=3; IntAct=EBI-2371606, EBI-11752486;
CC P19013; A1A4E9: KRT13; NbExp=3; IntAct=EBI-2371606, EBI-10171552;
CC P19013; P13646: KRT13; NbExp=4; IntAct=EBI-2371606, EBI-1223876;
CC P19013; P19012: KRT15; NbExp=6; IntAct=EBI-2371606, EBI-739566;
CC P19013; P08779: KRT16; NbExp=3; IntAct=EBI-2371606, EBI-356410;
CC P19013; P08727: KRT19; NbExp=3; IntAct=EBI-2371606, EBI-742756;
CC P19013; Q2M2I5: KRT24; NbExp=3; IntAct=EBI-2371606, EBI-2952736;
CC P19013; Q7Z3Z0: KRT25; NbExp=3; IntAct=EBI-2371606, EBI-11980019;
CC P19013; Q7Z3Y8: KRT27; NbExp=3; IntAct=EBI-2371606, EBI-3044087;
CC P19013; Q7Z3Y7: KRT28; NbExp=3; IntAct=EBI-2371606, EBI-11980489;
CC P19013; Q15323: KRT31; NbExp=3; IntAct=EBI-2371606, EBI-948001;
CC P19013; Q14525: KRT33B; NbExp=7; IntAct=EBI-2371606, EBI-1049638;
CC P19013; Q92764: KRT35; NbExp=3; IntAct=EBI-2371606, EBI-1058674;
CC P19013; O76013-2: KRT36; NbExp=5; IntAct=EBI-2371606, EBI-11958506;
CC P19013; O76014: KRT37; NbExp=3; IntAct=EBI-2371606, EBI-1045716;
CC P19013; O76015: KRT38; NbExp=9; IntAct=EBI-2371606, EBI-1047263;
CC P19013; Q6A162: KRT40; NbExp=7; IntAct=EBI-2371606, EBI-10171697;
CC P19013; Q96KQ4: PPP1R13B; NbExp=3; IntAct=EBI-2371606, EBI-1105153;
CC P19013; Q9BYV2: TRIM54; NbExp=4; IntAct=EBI-2371606, EBI-2130429;
CC P19013; Q9UGJ1-2: TUBGCP4; NbExp=3; IntAct=EBI-2371606, EBI-10964469;
CC P19013; P14079: tax; Xeno; NbExp=3; IntAct=EBI-2371606, EBI-9675698;
CC -!- TISSUE SPECIFICITY: Detected in the suprabasal layer of the stratified
CC epithelium of the esophagus, exocervix, vagina, mouth and lingual
CC mucosa, and in cells and cell clusters in the mucosa and serous gland
CC ducts of the esophageal submucosa (at protein level). Expressed widely
CC in the exocervix and esophageal epithelium, with lowest levels detected
CC in the basal cell layer. {ECO:0000269|PubMed:2452170}.
CC -!- POLYMORPHISM: Three alleles of K4 are known: K4A1, K4A2 and K4B
CC (displayed here). {ECO:0000269|PubMed:7684424}.
CC -!- DISEASE: White sponge nevus 1 (WSN1) [MIM:193900]: A rare disorder
CC characterized by the presence of soft, white, and spongy plaques in the
CC oral mucosa. The characteristic histopathologic features are epithelial
CC thickening, parakeratosis, and vacuolization of the suprabasal layer of
CC oral epithelial keratinocytes. Less frequently the mucous membranes of
CC the nose, esophagus, genitalia and rectum are involved.
CC {ECO:0000269|PubMed:10652003, ECO:0000269|PubMed:12828738}. Note=The
CC disease is caused by variants affecting the gene represented in this
CC entry.
CC -!- MISCELLANEOUS: There are two types of cytoskeletal and microfibrillar
CC keratin: I (acidic; 40-55 kDa) and II (neutral to basic; 56-70 kDa).
CC -!- SIMILARITY: Belongs to the intermediate filament family.
CC {ECO:0000255|PROSITE-ProRule:PRU01188}.
CC -!- WEB RESOURCE: Name=Human Intermediate Filament Mutation Database;
CC URL="http://www.interfil.org";
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DR EMBL; AY043326; AAL14196.1; -; Genomic_DNA.
DR EMBL; AK299400; BAG61384.1; -; mRNA.
DR EMBL; AC107016; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC003630; AAH03630.2; -; mRNA.
DR EMBL; BC042174; AAH42174.1; -; mRNA.
DR EMBL; X67683; CAA47914.1; -; mRNA.
DR EMBL; X07695; CAA30534.1; -; mRNA.
DR EMBL; X61028; CAA43362.1; -; Genomic_DNA.
DR CCDS; CCDS41787.2; -.
DR PIR; I37942; I37942.
DR RefSeq; NP_002263.3; NM_002272.3.
DR AlphaFoldDB; P19013; -.
DR SMR; P19013; -.
DR IntAct; P19013; 43.
DR MINT; P19013; -.
DR STRING; 9606.ENSP00000448220; -.
DR iPTMnet; P19013; -.
DR PhosphoSitePlus; P19013; -.
DR SwissPalm; P19013; -.
DR BioMuta; KRT4; -.
DR DMDM; 82654947; -.
DR jPOST; P19013; -.
DR MassIVE; P19013; -.
DR PaxDb; P19013; -.
DR PeptideAtlas; P19013; -.
DR PRIDE; P19013; -.
DR ProteomicsDB; 28550; -.
DR ProteomicsDB; 53621; -.
DR Antibodypedia; 3687; 494 antibodies from 38 providers.
DR DNASU; 3851; -.
DR Ensembl; ENST00000551956.2; ENSP00000448220.1; ENSG00000170477.13.
DR GeneID; 3851; -.
DR KEGG; hsa:3851; -.
DR MANE-Select; ENST00000551956.2; ENSP00000448220.1; NM_002272.4; NP_002263.3.
DR UCSC; uc031qhk.2; human.
DR CTD; 3851; -.
DR DisGeNET; 3851; -.
DR GeneCards; KRT4; -.
DR HGNC; HGNC:6441; KRT4.
DR HPA; ENSG00000170477; Tissue enriched (esophagus).
DR MalaCards; KRT4; -.
DR MIM; 123940; gene.
DR MIM; 193900; phenotype.
DR neXtProt; NX_P19013; -.
DR OpenTargets; ENSG00000170477; -.
DR Orphanet; 171723; White sponge nevus.
DR PharmGKB; PA30229; -.
DR VEuPathDB; HostDB:ENSG00000170477; -.
DR eggNOG; ENOG502QURK; Eukaryota.
DR GeneTree; ENSGT00940000161550; -.
DR HOGENOM; CLU_012560_6_1_1; -.
DR InParanoid; P19013; -.
DR OMA; QYEDIIQ; -.
DR OrthoDB; 824246at2759; -.
DR PhylomeDB; P19013; -.
DR TreeFam; TF317854; -.
DR PathwayCommons; P19013; -.
DR Reactome; R-HSA-6805567; Keratinization.
DR Reactome; R-HSA-6809371; Formation of the cornified envelope.
DR SignaLink; P19013; -.
DR SIGNOR; P19013; -.
DR BioGRID-ORCS; 3851; 10 hits in 1068 CRISPR screens.
DR ChiTaRS; KRT4; human.
DR GenomeRNAi; 3851; -.
DR Pharos; P19013; Tbio.
DR PRO; PR:P19013; -.
DR Proteomes; UP000005640; Chromosome 12.
DR RNAct; P19013; protein.
DR Bgee; ENSG00000170477; Expressed in tongue squamous epithelium and 107 other tissues.
DR ExpressionAtlas; P19013; baseline and differential.
DR Genevisible; P19013; HS.
DR GO; GO:0009986; C:cell surface; IDA:UniProtKB.
DR GO; GO:0005829; C:cytosol; TAS:Reactome.
DR GO; GO:0005882; C:intermediate filament; NAS:UniProtKB.
DR GO; GO:0045111; C:intermediate filament cytoskeleton; IDA:UniProtKB.
DR GO; GO:0045095; C:keratin filament; IDA:UniProtKB.
DR GO; GO:0005634; C:nucleus; HDA:UniProtKB.
DR GO; GO:0030280; F:structural constituent of skin epidermis; IBA:GO_Central.
DR GO; GO:0007010; P:cytoskeleton organization; IMP:UniProtKB.
DR GO; GO:0030855; P:epithelial cell differentiation; ISS:UniProtKB.
DR GO; GO:0045109; P:intermediate filament organization; IBA:GO_Central.
DR GO; GO:0031424; P:keratinization; IBA:GO_Central.
DR GO; GO:0050680; P:negative regulation of epithelial cell proliferation; ISS:UniProtKB.
DR InterPro; IPR018039; IF_conserved.
DR InterPro; IPR039008; IF_rod_dom.
DR InterPro; IPR032444; Keratin_2_head.
DR InterPro; IPR003054; Keratin_II.
DR Pfam; PF00038; Filament; 1.
DR Pfam; PF16208; Keratin_2_head; 2.
DR PRINTS; PR01276; TYPE2KERATIN.
DR SMART; SM01391; Filament; 1.
DR PROSITE; PS00226; IF_ROD_1; 1.
DR PROSITE; PS51842; IF_ROD_2; 1.
PE 1: Evidence at protein level;
KW Coiled coil; Disease variant; Intermediate filament; Keratin; Methylation;
KW Reference proteome.
FT CHAIN 1..520
FT /note="Keratin, type II cytoskeletal 4"
FT /id="PRO_0000063722"
FT DOMAIN 137..450
FT /note="IF rod"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01188"
FT REGION 1..136
FT /note="Head"
FT REGION 137..172
FT /note="Coil 1A"
FT REGION 173..191
FT /note="Linker 1"
FT REGION 192..284
FT /note="Coil 1B"
FT REGION 285..307
FT /note="Linker 12"
FT REGION 308..447
FT /note="Coil 2"
FT REGION 448..520
FT /note="Tail"
FT REGION 500..520
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT SITE 388
FT /note="Stutter"
FT MOD_RES 13
FT /note="Omega-N-methylarginine"
FT /evidence="ECO:0000250|UniProtKB:P07744"
FT VARIANT 72
FT /note="A -> V (in allele K4A1; dbSNP:rs2638525)"
FT /evidence="ECO:0000269|PubMed:7684424"
FT /id="VAR_003869"
FT VARIANT 82
FT /note="T -> TGGFGAGGFGAGFGT (in alleles K4A1 and K4A2)"
FT /evidence="ECO:0000269|PubMed:7684424"
FT /id="VAR_083057"
FT VARIANT 139
FT /note="E -> EQ (in WSN1)"
FT /evidence="ECO:0000269|PubMed:10652003"
FT /id="VAR_012845"
FT VARIANT 435
FT /note="E -> K (in WSN1; dbSNP:rs62642055)"
FT /evidence="ECO:0000269|PubMed:12828738"
FT /id="VAR_016038"
FT CONFLICT 68
FT /note="S -> L (in Ref. 2; BAG61384)"
FT /evidence="ECO:0000305"
FT CONFLICT 91
FT /note="G -> D (in Ref. 2; BAG61384)"
FT /evidence="ECO:0000305"
FT CONFLICT 104
FT /note="C -> L (in Ref. 5; CAA47914)"
FT /evidence="ECO:0000305"
FT CONFLICT 113..114
FT /note="TI -> SL (in Ref. 6; CAA30534)"
FT /evidence="ECO:0000305"
FT CONFLICT 222
FT /note="D -> Y (in Ref. 4; AAH03630)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 520 AA; 56144 MW; 3997CA71E7586F4C CRC64;
MIARQQCVRG GPRGFSCGSA IVGGGKRGAF SSVSMSGGAG RCSSGGFGSR SLYNLRGNKS
ISMSVAGSRQ GACFGGAGGF GTGGFGGGFG GSFSGKGGPG FPVCPAGGIQ EVTINQSLLT
PLHVEIDPEI QKVRTEEREQ IKLLNNKFAS FIDKVQFLEQ QNKVLETKWN LLQQQTTTTS
SKNLEPLFET YLSVLRKQLD TLGNDKGRLQ SELKTMQDSV EDFKTKYEEE INKRTAAEND
FVVLKKDVDA AYLNKVELEA KVDSLNDEIN FLKVLYDAEL SQMQTHVSDT SVVLSMDNNR
NLDLDSIIAE VRAQYEEIAQ RSKAEAEALY QTKVQQLQIS VDQHGDNLKN TKSEIAELNR
MIQRLRAEIE NIKKQCQTLQ VSVADAEQRG ENALKDAHSK RVELEAALQQ AKEELARMLR
EYQELMSVKL ALDIEIATYR KLLEGEEYRM SGECQSAVSI SVVSGSTSTG GISGGLGSGS
GFGLSSGFGS GSGSGFGFGG SVSGSSSSKI ISTTTLNKRR
