K2C4_RAT
ID K2C4_RAT Reviewed; 536 AA.
AC Q6IG00;
DT 22-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 03-AUG-2022, entry version 110.
DE RecName: Full=Keratin, type II cytoskeletal 4;
DE AltName: Full=Cytokeratin-4;
DE Short=CK-4;
DE AltName: Full=Keratin-4;
DE Short=K4;
DE AltName: Full=Type-II keratin Kb4;
GN Name=Krt4 {ECO:0000250|UniProtKB:P19013};
GN Synonyms=Kb4 {ECO:0000312|RGD:1359272};
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1] {ECO:0000305}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Brown Norway {ECO:0000269|PubMed:15057822};
RX PubMed=15057822; DOI=10.1038/nature02426;
RA Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J.,
RA Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G.,
RA Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G.,
RA Morgan M., Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G.,
RA Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S.,
RA Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T.,
RA Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D.,
RA Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L.,
RA Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D.,
RA Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M.,
RA Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C.,
RA Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J.,
RA Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H.,
RA Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X.,
RA Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q.,
RA Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P.,
RA Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A.,
RA Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C.,
RA Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J.,
RA Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J.,
RA Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F.,
RA Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A.,
RA Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A.,
RA Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J.,
RA Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E.,
RA Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M.,
RA Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C.,
RA Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L.,
RA Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W.,
RA Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y.,
RA Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V.,
RA Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M.,
RA Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S.,
RA Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B.,
RA Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R.,
RA Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J.,
RA Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D.,
RA Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S.,
RA Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S.,
RA Mockrin S., Collins F.S.;
RT "Genome sequence of the Brown Norway rat yields insights into mammalian
RT evolution.";
RL Nature 428:493-521(2004).
RN [2] {ECO:0000305, ECO:0000312|EMBL:DAA02230.1}
RP IDENTIFICATION.
RX PubMed=15085952; DOI=10.1078/0171-9335-00354;
RA Hesse M., Zimek A., Weber K., Magin T.M.;
RT "Comprehensive analysis of keratin gene clusters in humans and rodents.";
RL Eur. J. Cell Biol. 83:19-26(2004).
CC -!- SUBUNIT: Heterotetramer of two type I and two type II keratins.
CC keratin-4 is generally associated with keratin-13.
CC -!- MISCELLANEOUS: There are two types of cytoskeletal and microfibrillar
CC keratin: I (acidic; 40-55 kDa) and II (neutral to basic; 56-70 kDa).
CC -!- SIMILARITY: Belongs to the intermediate filament family.
CC {ECO:0000255|PROSITE-ProRule:PRU01188}.
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DR EMBL; AABR03057015; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BK003985; DAA02230.1; -; mRNA.
DR RefSeq; NP_001008806.1; NM_001008806.1.
DR AlphaFoldDB; Q6IG00; -.
DR SMR; Q6IG00; -.
DR BioGRID; 260992; 1.
DR IntAct; Q6IG00; 1.
DR STRING; 10116.ENSRNOP00000012943; -.
DR iPTMnet; Q6IG00; -.
DR PhosphoSitePlus; Q6IG00; -.
DR jPOST; Q6IG00; -.
DR PaxDb; Q6IG00; -.
DR PRIDE; Q6IG00; -.
DR GeneID; 315323; -.
DR KEGG; rno:315323; -.
DR UCSC; RGD:1359272; rat.
DR CTD; 3851; -.
DR RGD; 1359272; Krt4.
DR eggNOG; ENOG502QURK; Eukaryota.
DR InParanoid; Q6IG00; -.
DR OMA; QYEDIIQ; -.
DR OrthoDB; 824246at2759; -.
DR PhylomeDB; Q6IG00; -.
DR Reactome; R-RNO-6805567; Keratinization.
DR Reactome; R-RNO-6809371; Formation of the cornified envelope.
DR PRO; PR:Q6IG00; -.
DR Proteomes; UP000002494; Chromosome 7.
DR Bgee; ENSRNOG00000032332; Expressed in esophagus and 13 other tissues.
DR ExpressionAtlas; Q6IG00; baseline and differential.
DR Genevisible; Q6IG00; RN.
DR GO; GO:0009986; C:cell surface; ISO:RGD.
DR GO; GO:0045111; C:intermediate filament cytoskeleton; ISO:RGD.
DR GO; GO:0045095; C:keratin filament; ISO:RGD.
DR GO; GO:0030280; F:structural constituent of skin epidermis; IBA:GO_Central.
DR GO; GO:0007010; P:cytoskeleton organization; ISO:RGD.
DR GO; GO:0030855; P:epithelial cell differentiation; ISS:UniProtKB.
DR GO; GO:0045109; P:intermediate filament organization; IBA:GO_Central.
DR GO; GO:0031424; P:keratinization; IBA:GO_Central.
DR GO; GO:0050680; P:negative regulation of epithelial cell proliferation; ISS:UniProtKB.
DR InterPro; IPR018039; IF_conserved.
DR InterPro; IPR039008; IF_rod_dom.
DR InterPro; IPR032444; Keratin_2_head.
DR InterPro; IPR003054; Keratin_II.
DR Pfam; PF00038; Filament; 1.
DR Pfam; PF16208; Keratin_2_head; 1.
DR PRINTS; PR01276; TYPE2KERATIN.
DR SMART; SM01391; Filament; 1.
DR PROSITE; PS00226; IF_ROD_1; 1.
DR PROSITE; PS51842; IF_ROD_2; 1.
PE 3: Inferred from homology;
KW Coiled coil; Intermediate filament; Keratin; Methylation;
KW Reference proteome.
FT CHAIN 1..536
FT /note="Keratin, type II cytoskeletal 4"
FT /id="PRO_0000063724"
FT DOMAIN 146..457
FT /note="IF rod"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01188"
FT REGION 1..145
FT /note="Head"
FT /evidence="ECO:0000255"
FT REGION 146..181
FT /note="Coil 1A"
FT /evidence="ECO:0000255"
FT REGION 182..200
FT /note="Linker 1"
FT /evidence="ECO:0000255"
FT REGION 201..293
FT /note="Coil 1B"
FT /evidence="ECO:0000255"
FT REGION 294..316
FT /note="Linker 12"
FT /evidence="ECO:0000255"
FT REGION 317..454
FT /note="Coil 2"
FT /evidence="ECO:0000255"
FT REGION 455..524
FT /note="Tail"
FT /evidence="ECO:0000255"
FT REGION 515..536
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT SITE 395
FT /note="Stutter"
FT /evidence="ECO:0000255"
FT MOD_RES 13
FT /note="Omega-N-methylarginine"
FT /evidence="ECO:0000250|UniProtKB:P07744"
SQ SEQUENCE 536 AA; 57667 MW; 5D1AC47FA0477DE4 CRC64;
MISRQSSVRG VSRGFSSGSA VAGGVKRVAF SSASMSGGAG RCSSGGFGSR SLYNLGGHKS
ISMSVAGSCQ GGGYGGAGGF GVGGYGAGFG AGGFGGGFGG SFNGRGGPGF PVCPAGGIQE
VTINQSLLTP LQVEIDPEIQ KIRTAEREQI KTLNNKFASF IDKVRFLEQQ NKVLETKWNL
LQQQTTTTSP RNLDPFFETY INALRKNLDT LSNDKGRLQS ELKLMQDSVE DFKTKYEEEI
NKRTAAENDF VVLKKDVDAA YMIKVELEAK MESLKDEINF MRVLYEAELS QMQTHVSDTS
VVLSMDNNRN LDLDGIIAEV RAQYEEIARK SKAEVESWYQ IKVQQLQMSA DQHGDSLKST
KNEISELNRM IQRIRSEIEN IKKQTLQASV ADAEQRGELA LKDAYTKRAD LETALQKAKE
DLARLMRDYQ ELMNVKLALD VEIATYRKLL EGEECRMSGE CKSAVSISVV GGSASIGGSG
GIGLGLGSGF GSGSCSGSGF GFGGGIYGSS GTKITSSATI TKRSPRTRQD PDGLQP
