ID   K2C71_BOVIN             Reviewed;         525 AA.
AC   Q148H5;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   22-AUG-2006, sequence version 1.
DT   03-AUG-2022, entry version 96.
DE   RecName: Full=Keratin, type II cytoskeletal 71;
DE   AltName: Full=Cytokeratin-71;
DE            Short=CK-71;
DE   AltName: Full=Keratin-71;
DE            Short=K71;
DE   AltName: Full=Type II inner root sheath-specific keratin-K6irs1;
DE   AltName: Full=Type-II keratin Kb34;
GN   Name=KRT71;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Fetal skin;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (JUN-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Plays a central role in hair formation. Essential component
CC       of keratin intermediate filaments in the inner root sheath (IRS) of the
CC       hair follicle. {ECO:0000250|UniProtKB:Q3SY84}.
CC   -!- SUBUNIT: Heterodimer of a type I and a type II keratin. Associates with
CC       KRT16 and/or KRT17 (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton
CC       {ECO:0000250|UniProtKB:Q3SY84}.
CC   -!- MISCELLANEOUS: There are two types of cytoskeletal and microfibrillar
CC       keratin, I (acidic) and II (neutral to basic) (40-55 and 56-70 kDa,
CC       respectively).
CC   -!- SIMILARITY: Belongs to the intermediate filament family.
CC       {ECO:0000255|PROSITE-ProRule:PRU01188}.
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DR   EMBL; BC118317; AAI18318.1; -; mRNA.
DR   RefSeq; NP_001069438.1; NM_001075970.1.
DR   AlphaFoldDB; Q148H5; -.
DR   SMR; Q148H5; -.
DR   IntAct; Q148H5; 1.
DR   STRING; 9913.ENSBTAP00000015264; -.
DR   PaxDb; Q148H5; -.
DR   PRIDE; Q148H5; -.
DR   GeneID; 532644; -.
DR   KEGG; bta:532644; -.
DR   CTD; 112802; -.
DR   eggNOG; ENOG502SK67; Eukaryota.
DR   HOGENOM; CLU_012560_6_1_1; -.
DR   InParanoid; Q148H5; -.
DR   OrthoDB; 671547at2759; -.
DR   TreeFam; TF317854; -.
DR   Proteomes; UP000009136; Unplaced.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0045095; C:keratin filament; ISS:UniProtKB.
DR   GO; GO:0031069; P:hair follicle morphogenesis; ISS:UniProtKB.
DR   GO; GO:0045109; P:intermediate filament organization; ISS:UniProtKB.
DR   InterPro; IPR018039; IF_conserved.
DR   InterPro; IPR039008; IF_rod_dom.
DR   InterPro; IPR032444; Keratin_2_head.
DR   InterPro; IPR003054; Keratin_II.
DR   Pfam; PF00038; Filament; 1.
DR   Pfam; PF16208; Keratin_2_head; 2.
DR   PRINTS; PR01276; TYPE2KERATIN.
DR   SMART; SM01391; Filament; 1.
DR   PROSITE; PS00226; IF_ROD_1; 1.
DR   PROSITE; PS51842; IF_ROD_2; 1.
PE   2: Evidence at transcript level;
KW   Coiled coil; Cytoplasm; Cytoskeleton; Intermediate filament; Keratin;
KW   Reference proteome.
FT   CHAIN           1..525
FT                   /note="Keratin, type II cytoskeletal 71"
FT                   /id="PRO_0000314873"
FT   DOMAIN          132..445
FT                   /note="IF rod"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01188"
FT   REGION          1..131
FT                   /note="Head"
FT   REGION          132..167
FT                   /note="Coil 1A"
FT   REGION          168..186
FT                   /note="Linker 1"
FT   REGION          187..278
FT                   /note="Coil 1B"
FT   REGION          279..302
FT                   /note="Linker 12"
FT   REGION          303..441
FT                   /note="Coil 2"
FT   REGION          442..525
FT                   /note="Tail"
FT   REGION          492..525
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   SITE            383
FT                   /note="Stutter"
SQ   SEQUENCE   525 AA;  57408 MW;  8598F693F37DAA9D CRC64;
     MSRQFTCKSG AAAKGGFSGC SAVLSGGSTS SYRAGGKGLS GGFGSRSLYN LGGVRSISFN
     VASGSGKSGG YGFGRGRASG FAGSMFGSVA LGPMCPTVCP PGGIHQVTVN ESLLAPLNVE
     LDPEIQKVRA QEREQIKALN NKFASFIDKV RFLEQQNQVL ETKWELLQQL DLNNCKNNLE
     PILEGYISNL RKQLETLSGD RVRLDSELRS VRDVVEDYKK RYEEEINRRT AAENEFVLLK
     KDVDAAYANK VELQAKVDSM DQEIKFFKCL YEAEIAQIQS HISDMSVILS MDNNRDLNLD
     SIIDEVRAQY EDIALKSKAE AEALYQTKFQ ELQLAAGRHG DDLKNTKNEI SELTRLIQRI
     RSEIENVKKQ ASNLETAIAD AEQRGDNALK DARAKLDELE AALHQSKEEL ARMMREYQEL
     MSLKLALDME IATYRKLLES EECRMSGEFP SPVSISIISS TSGSGGYGFR PSSVSGGYVA
     NSGSCISGVC SVRGGESRSR SSTTDYKDAL GKGSSLSAPS KKASR