ID   K2C72_BOVIN             Reviewed;         524 AA.
AC   Q148H8;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   22-AUG-2006, sequence version 1.
DT   03-AUG-2022, entry version 90.
DE   RecName: Full=Keratin, type II cytoskeletal 72;
DE   AltName: Full=Cytokeratin-72;
DE            Short=CK-72;
DE   AltName: Full=Keratin-72;
DE            Short=K72;
DE   AltName: Full=Type II inner root sheath-specific keratin-K6irs2;
DE   AltName: Full=Type-II keratin Kb35;
GN   Name=KRT72;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Fetal skin;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (JUN-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Has a role in hair formation. Specific component of keratin
CC       intermediate filaments in the inner root sheath (IRS) of the hair
CC       follicle (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Heterotetramer of two type I and two type II keratins.
CC   -!- MISCELLANEOUS: There are two types of cytoskeletal and microfibrillar
CC       keratin, I (acidic) and II (neutral to basic) (40-55 and 56-70 kDa,
CC       respectively).
CC   -!- SIMILARITY: Belongs to the intermediate filament family.
CC       {ECO:0000255|PROSITE-ProRule:PRU01188}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; BC118311; AAI18312.1; -; mRNA.
DR   RefSeq; NP_001069412.1; NM_001075944.1.
DR   AlphaFoldDB; Q148H8; -.
DR   SMR; Q148H8; -.
DR   STRING; 9913.ENSBTAP00000010391; -.
DR   PaxDb; Q148H8; -.
DR   PRIDE; Q148H8; -.
DR   Ensembl; ENSBTAT00000010391; ENSBTAP00000010391; ENSBTAG00000007904.
DR   GeneID; 531057; -.
DR   KEGG; bta:531057; -.
DR   CTD; 140807; -.
DR   VEuPathDB; HostDB:ENSBTAG00000007904; -.
DR   VGNC; VGNC:30736; KRT72.
DR   eggNOG; ENOG502T3SC; Eukaryota.
DR   GeneTree; ENSGT00940000162105; -.
DR   HOGENOM; CLU_012560_6_1_1; -.
DR   InParanoid; Q148H8; -.
DR   OMA; CKKRYEV; -.
DR   OrthoDB; 671547at2759; -.
DR   TreeFam; TF317854; -.
DR   Reactome; R-BTA-6805567; Keratinization.
DR   Proteomes; UP000009136; Chromosome 5.
DR   Bgee; ENSBTAG00000007904; Expressed in zone of skin and 8 other tissues.
DR   GO; GO:0045095; C:keratin filament; IBA:GO_Central.
DR   GO; GO:0030280; F:structural constituent of skin epidermis; IBA:GO_Central.
DR   GO; GO:0045109; P:intermediate filament organization; IBA:GO_Central.
DR   GO; GO:0031424; P:keratinization; IBA:GO_Central.
DR   InterPro; IPR018039; IF_conserved.
DR   InterPro; IPR039008; IF_rod_dom.
DR   InterPro; IPR032444; Keratin_2_head.
DR   InterPro; IPR003054; Keratin_II.
DR   Pfam; PF00038; Filament; 1.
DR   Pfam; PF16208; Keratin_2_head; 1.
DR   PRINTS; PR01276; TYPE2KERATIN.
DR   SMART; SM01391; Filament; 1.
DR   PROSITE; PS00226; IF_ROD_1; 1.
DR   PROSITE; PS51842; IF_ROD_2; 1.
PE   2: Evidence at transcript level;
KW   Coiled coil; Intermediate filament; Keratin; Reference proteome.
FT   CHAIN           1..524
FT                   /note="Keratin, type II cytoskeletal 72"
FT                   /id="PRO_0000314876"
FT   DOMAIN          137..450
FT                   /note="IF rod"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01188"
FT   REGION          1..136
FT                   /note="Head"
FT   REGION          137..172
FT                   /note="Coil 1A"
FT   REGION          173..191
FT                   /note="Linker 1"
FT   REGION          192..283
FT                   /note="Coil 1B"
FT   REGION          284..307
FT                   /note="Linker 12"
FT   REGION          308..446
FT                   /note="Coil 2"
FT   REGION          447..524
FT                   /note="Tail"
FT   REGION          495..524
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        509..524
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   SITE            388
FT                   /note="Stutter"
SQ   SEQUENCE   524 AA;  56930 MW;  C65468E3518D5DAE CRC64;
     MSRQLNLYPG GERLAFSGCS AIISSRVSSS TASFRASGIK GTATFGSRSL FNCGGGRRPA
     LSSAAGRGGS ALGSCAATGG GRRGGFVGTV FGSAGLGPAC PSVCPPGGIP QVTVNKSLLS
     PLNVELDPEI QKVRAQEREQ IKALNNKFAS FIDKVRFLEQ QNQVLGTKWE LLQQLDLNNC
     KNNLEPILEG YTSNLRKQLE MLSGDRVRLD SELRSMRDVV EEYKKRYEVE INRRTAAENE
     FVMLKKDVDA AYMNKVELQA KVDSLTDEIK FLKCLYEGEI AQLQSHISDT SVILSMDNNR
     DLDLDSIIAQ VRAQYEEIAL KSKAEAEALY QTKIQELQAT AGQHGDDLKL TKAEISDLNR
     MIQRIRSEIG NVKKQCSNLE MAIADAEQRG DCALKDARAK LDELDAALLQ AKEELARMMR
     EYQELMSTKL ALDMEIATYR KLLEGEECRM SGEYPNSVSI SVISNTSTGA GGTGFSMGFG
     ALSSYSYKSS AVDVKTKGSC GGSELKDAPA KTSGSSCATK KASR